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Development of a Highly Specific 18F-labeled Radioligand for Imaging of Sigma-2 Receptor in Brain Tumor

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Radiosynthesis and biological evaluation of [¹⁸F]AG-120 for PET imaging of the mutant isocitrate dehydrogenase 1 in gliomas

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Development of the High-Affinity Carborane-Based Cannabinoid Receptor Type 2 PET Ligand [¹⁸F]LUZ5-d8

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Radiofluorination of an anionic, azide-functionalized teroligomer by copper-catalyzed azide-alkyne cycloaddition

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Specific and safe targeting of glioblastoma using switchable and logic-gated RevCAR T cells

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• Frontiers in Immunology 14(2023), 1166169
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Nemacol is a Small Molecule Inhibitor of C. elegans Vesicular Acetylcholine Transporter with Anthelmintic Potential

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Imaging of Gαq proteins in mouse and human organs and tissues

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Selective a3b4 nicotinic acetylcholine receptor ligand as a potential tracer for drug addiction

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Synthesis, Structure–Activity Relationships, Radiofluorination, and Biological Evaluation of [¹⁸F]RM365, a Novel Radioligand for Imaging the Human Cannabinoid Receptor Type 2 (CB2R) in the Brain with PET

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Radiosynthesis and preclinical evaluation of an 18F-labeled tri-azolopyridopyrazine-based inhibitor for neuroimaging of the phosphodiesterase 2A (PDE2A)

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PET Imaging of Cholinergic Neurotransmission in Neurodegenerative Disorders

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Novel radioiodinated and radiofluorinated analogues of FT-2102 for SPECT or PET imaging of mIDH1 mutant tumours

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Synthesis and characterization of the two enantiomers of a chiral sigma-1 receptor radioligand: (S)-(+)- and (R)-(-)-[18F]FBFP

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Amphiphilic Anionic Oligomer-Stabilized Calcium Phosphate Nanoparticles with Prospects in siRNA Delivery via Convection-Enhanced Delivery

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Development and Biological Evaluation of the First Highly Potent and Specific Benzamide-Based Radiotracer [¹⁸F]BA3 for Imaging of Histone Deacetylases 1 and 2 in Brain

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Pathophysiological Changes in the Enteric Nervous System of Rotenone-Exposed Mice as Early Radiological Markers for Parkinson's Disease

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Improved in vivo PET imaging of the adenosine A2A receptor in the brain using [18F]FLUDA, a deuterated radiotracer with high metabolic stability

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In vitro and in vivo evaluation of fluorinated indanone derivatives as potential positron emission tomography agents for the imaging of monoamine oxidase B in the brain

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Studies on the affinity of 6-[(: N -(cyclo)aminoalkyl)oxy]-4 H -chromen-4-ones for sigma 1/2 receptors

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Sigma-1 and dopamine D2/D3 receptor occupancy of pridopidine in healthy volunteers and patients with Huntington disease: a [18F] fluspidine and [18F] fallypride PET study

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(+)-[18F]Flubatine as a novel α4β2 nicotinic acetylcholine receptor PET ligand – Results of the first-in-human brain imaging application in patients with β-amyloid PET-confirmed Alzheimer’s disease and healthy controls

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In silico finding of key interaction mediated α3β4 and α7 nicotinic acetylcholine receptor ligand selectivity of quinuclidine-triazole chemotype

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Preclinical incorporation dosimetry of [18F]FACH - a novel 18F-labeled MCT1/MCT4 lactate transporter inhibitor for imaging cancer metabolism with PET

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PET Imaging of the Adenosine A2A Receptor in the Rotenone-Based Mouse Model of Parkinson’s Disease with [18F]FESCH Synthesized by a Simplified Two-Step One-Pot Radiolabeling Strategy

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Radiosynthesis and Biological Investigation of a Novel Fluorine-18 Labeled Benzoimidazotriazine- based Radioligand for Imaging of Phosphodiesterase 2A with Positron Emission Tomography

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One-step radiosynthesis of the MCTs imaging agent [18F]FACH by aliphatic 18F-labelling of a methylsulfonate precursor containing an unprotected carboxylic acid group

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Structure–Affinity Relationships of Fluorinated Spirocyclic Sigma2 Receptor Ligands with an Exocyclic Benzylamino Moiety

Bergkemper, M.; Kronenberg, E.; Schepmann, D.; Ludwig, F.-A.; Brust, P.; Wünsch, B.

• ChemMedChem 14(2019), 1392-1402
  Online First (2019) DOI: 10.1002/cmdc.201900284
  Cited 2 times in Scopus

¹⁸F-Labeled benzylpiperazine derivatives as highly selective ligands for imaging σ1 receptor with positron emission tomography

Ye, J.; Wang, L.; Deuther-Conrad, W.; Chen, Y.; Zhang, X.; Zhang, J.; Huang, Y.; Brust, P.; Jia, H.

• Journal of Labelled Compounds and Radiopharmaceuticals 62(2019)8, 425-437
  DOI: 10.1002/jlcr.3738
  Cited 2 times in Scopus

Synthesis and in vitro evaluation of 8-pyridinyl substituted benzo[e]imidazo[2,1-c][1,2,4]triazines as phosphodiesterase 2A (PDE2A) inhibitors

Ritawidya, R.; Ludwig, F.-A.; Briel, D.; Brust, P.; Scheunemann, M.

• Molecules 24(2019)15, 2791
  DOI: 10.3390/molecules24152791
  Cited 9 times in Scopus

SPECT-Untersuchungen mit dem 123 I-markierten Dopamintransporter-Liganden FP-CIT (DaTSCAN):DGN-Handlungsempfehlung (S1-Leitlinie)

Tatsch, K.; Buchert, R.; Bartenstein, P.; Barthel, H.; Boecker, H.; Brust, P.; Drzezga, A.; La Fougère, C.; Gründer, G.; Grünwald, F.; Krause, B.-J.; Kuwert, T.; Langen, K.-J.; Rominger, A.; Sabri, O.; Schreckenberger, M.; Meyer, P. T.

• Nuklearmedizin 58(2019)1, 5-16

In vitro and in vivo Human Metabolism of (S)-[18F]Fluspidine – a Radioligand for Imaging σ1 Receptors with Positron Emission Tomography (PET)

Ludwig, F.-A.; Fischer, S.; Houska, R.; Hoepping, A.; Deuther-Conrad, W.; Schepmann, D.; Patt, M.; Meyer, P.; Hesse, S.; Becker, G.-A.; Zientek, F. R.; Steinbach, J.; Wünsch, B.; Sabri, O.; Brust, P.

• Frontiers in Pharmacology 10(2019), 534
  DOI: 10.3389/fphar.2019.00534
  Cited 9 times in Scopus

Development and radiosynthesis of the first 18F-labeled inhibitor of monocarboxylate transporters (MCTs)

Sadeghzadeh, M.; Moldovan, R.-P.; Fischer, S.; Wenzel, B.; Ludwig, F.-A.; Teodoro, R.; Deuther-Conrad, W.; Jonnalagadda, S.; K. Jonnalagadda, S.; Gudelis, E.; Šačkus, A.; R. Mereddy, V.; R. Drewes, L.; Brust, P.

• Journal of Labelled Compounds and Radiopharmaceuticals 62(2019)8, 411-424
  DOI: 10.1002/jlcr.3739
  Cited 6 times in Scopus

Targeting cyclic nucleotide phosphodiesterase 5 (PDE5) in brain: Toward the development of a PET radioligand labeled with fluorine-18

Wenzel, B.; Liu, J.; Dukic-Stefanovic, S.; Deuther-Conrad, W.; Teodoro, R.; Ludwig, F.-A.; Chezal, J.-M.; Moreau, E.; Brust, P.; Maisonial-Besset, A.

• Bioorganic Chemistry 86(2019), 346-362
  DOI: 10.1016/j.bioorg.2019.01.037
  Cited 14 times in Scopus

Studies towards the development of a PET radiotracer for imaging of the P2Y1 receptors in the brain: synthesis, 18F-labeling and preliminary biological evaluation

Moldovan, R.-P.; Wenzel, B.; Teodoro, R.; Neumann, W.; Dukic-Stefanovic, S.; Deuther-Conrad, W.; Hey-Hawkins, E.; Krügel, U.; Brust, P.

• European Journal of Medicinal Chemistry (2019), 142-159
  Online First (2019) DOI: 10.1016/j.ejmech.2019.01.006
  Cited 13 times in Scopus

Synthesis, Receptor Affinity, and Antiallodynic Activity of Spirocyclic σ Receptor Ligands with Exocyclic Amino Moiety

Bergkemper, M.; Kronenberg, E.; Thum, S.; Börgel, F.; Daniliuc, C.; Schepmann, D.; Nieto, F. R.; Brust, P.; Reinoso, R. F.; Alvarez, I.; Wünsch, B.

• Journal of Medicinal Chemistry 61(2018), 9666-9690
  DOI: 10.1021/acs.jmedchem.8b01183
  Cited 10 times in Scopus

Fourier Analysis of Cerebral Metabolism of Glucose: Gender Differences in Mechanisms of Color Processing in the Ventral and Dorsal Streams in Mice

Njemanze, P. C.; Kranz, M.; Brust, P.

• Forecasting 1(2018), 135-156
  DOI: 10.3390/forecast1010010
  ISSN: 2571-9394

Contilisant, a Tetratarget Small Molecule for Alzheimer’s Disease Therapy Combining Cholinesterase, Monoamine Oxidase Inhibition and H3R Antagonism with Sigma 1R Agonism Profile

Bautista-Aguilera, O. M.; Budni, J.; Mina, F.; Medeiros, E. B.; Deuther-Conrad, W.; Entrena, J. M.; Moraleda, I.; Iriepa, I.; López-Muñoz, F.; Marco-Contelles, J.

• Journal of Medicinal Chemistry 61(2018), 6937-6943
  DOI: 10.1021/acs.jmedchem.8b00848
  Cited 41 times in Scopus

Cognitive correlates of α4β2 nicotinic acetylcholine receptors in mild Alzheimer's dementia

Sabri, O.; Meyer, P. M.; Gräf, S.; Hesse, S.; Wilke, S.; Becker, G.-A.; Rullmann, M.; Patt, M.; Luthardt, J.; Wagenknecht, G.; Hoepping, A.; Smits, R.; Franke, A.; Sattler, B.; Tiepolt, S.; Fischer, S.; Deuther-Conrad, W.; Hegerl, U.; Barthel, H.; Schönknecht, P.; Brust, P.

• Brain 141(2018)6, 1840-1854
  DOI: 10.1093/brain/awy099
  Cited 54 times in Scopus

Radiosynthesis and in vivo evaluation of a fluorine-18 labeled pyrazine based radioligand for PET imaging of the adenosine A2B receptor

Lindemann, M.; Hinz, S.; Deuther-Conrad, W.; Namasivayam, V.; Dukic-Stefanovic, S.; Teodoro, R.; Toussaint, M.; Kranz, M.; Juhl, C.; Steinbach, J.; Brust, P.; Müller, C. E.; Wenzel, B.

• Bioorganic & Medicinal Chemistry 26(2018), 4650-4663
  DOI: 10.1016/j.bmc.2018.07.045
  Cited 17 times in Scopus

Synthesis and radiofluorination of novel fluoren-9-one based derivatives for the imaging of α7 nicotinic acetylcholine receptor with PET

Teodoro, R.; Scheunemann, M.; Wenzel, B.; Peters, D.; Deuther-Conrad, W.; Brust, P.

Involved research facilities

• PET-Center

• Bioorganic & Medicinal Chemistry Letters 28(2018), 1471-1475
  DOI: 10.1016/j.bmcl.2018.03.081
  Cited 6 times in Scopus

Exploring the Metabolism of (+)-[¹⁸F]Flubatine in vitro and in vivo: LC-MS/MS aided Identification of Radiometabolites in a Clinical PET Study

Ludwig, F.-A.; Fischer, S.; Smits, R.; Deuther-Conrad, W.; Hoepping, A.; Tiepolt, S.; Patt, M.; Sabri, O.; Brust, P.

• Molecules 23(2018)1, 464
  DOI: 10.3390/molecules23020464
  Cited 8 times in Scopus

Investigation of an 18F-labelled Imidazopyridotriazine for Molecular Imaging of Cyclic Nucleotide Phosphodiesterase 2A

Schröder, S.; Wenzel, B.; Deuther-Conrad, W.; Teodoro, R.; Kranz, M.; Scheunemann, M.; Egerland, U.; Höfgen, N.; Briel, D.; Steinbach, J.; Brust, P.

• Molecules 23(2018)3, 556
  DOI: 10.3390/molecules23030556
  Cited 8 times in Scopus

Bridging from Brain to Tumor imaging: (S)- and (R)-[18F]Fluspidine for investigation of Sigma-1 Receptors in Tumor-bearing Mice

Kranz, M.; Bergmann, R.; Kniess, T.; Belter, B.; Neuber, C.; Cai, Z.; Deng, G.; Fischer, S.; Steinbach, J.; Zhou, J.; Huang, H.; Brust, P.; Deuther-Conrad, W.; Pietzsch, J.

Involved research facilities

• PET-Center

• Molecules 23(2018)3, 702
  DOI: 10.3390/molecules23030702
  Cited 7 times in Scopus

Maternal immune activation results in complex microglial transcriptome signature in the adult offspring that is reversed by minocycline treatment

Mattei, D.; Ivanov, A.; Ferrai, C.; Jordan, P.; Guneykaya, D.; Buonfiglioli, A.; Schaafsma, W.; Przanowski, P.; Deuther-Conrad, W.; Brust, P.; Hesse, S.; Patt, M.; Sabri, O.; Ross, T. L.; Eggen, B. J. L.; Bodecke, E. W. G. M.; Kaminska, B.; Beule, D.; Pombo, A.; Kettenmann, H.; Wolf, S. A.

• Translational Psychiatry 7(2017)e1120, 1-13
  DOI: 10.1038/tp.2017.80
  Cited 148 times in Scopus

PET Imaging Evaluation of Four sigma1 Radiotracers in Nonhuman Primates

Baum, E.; Cai, Z.; Bois, F.; Holden, D.; Lin, S.-F.; Lara-Jaime, T.; Kapinos, M.; Chen, Y.; Deuther-Conrad, W.; Fischer, S.; Dukic-Stefanovic, S.; Bunse, P.; Wünsch, B.; Brust, P.; Jia, H.; Huang, Y.

• Journal of Nuclear Medicine 58(2017)6, 982
  DOI: 10.2967/jnumed.116.188052
  Cited 21 times in Scopus

1‑(4‑[18F]Fluorobenzyl)-4-[(tetrahydrofuran-2-yl)methyl]piperazine: A Novel Suitable Radioligand with Low Lipophilicity for Imaging σ1 Receptors in the Brain

He, Y.; Xie, F.; Ye, J.; Deuther-Conrad, W.; Cui, B.; Wang, L.; Lu, J.; Steinbach, J.; Brust, P.; Huang, Y.; Lu, J.; Jia, H.

• Journal of Medicinal Chemistry 60(2017), 4161-4172
  DOI: 10.1021/acs.jmedchem.6b01723
  Cited 24 times in Scopus

18F-Labeled indole-based analogs as highly selective radioligands for imaging sigma-2 receptors in the brain

Wang, L.; Ye, J.; He, Y.; Deuther-Conrad, W.; Zhang, J.; Zhang, X.; Cui, M.; Steinbach, J.; Huang, Y.; Brust, P.; Jia, H.

• Bioorganic & Medicinal Chemistry 25(2017), 3792-3802
  DOI: 10.1016/j.bmc.2017.05.019
  Cited 16 times in Scopus

Synthesis and in vitro evaluation of 5-substituted benzovesamicol analogs containing N-substituted amides as potential positron emission tomography tracers for the vesicular acetylcholine transporter

Roslin, S.; de Rosa, M.; Deuther-Conrad, W.; Eriksson, J.; Odell, L. R.; Antoni, G.; Brust, P.; Larhed, M.

• Bioorganic & Medicinal Chemistry 25(2017)19, 5095-5106
  DOI: 10.1016/j.bmc.2017.01.041
  Cited 5 times in Scopus

Radiosynthesis of (S)-[¹⁸F]T1: The first PET radioligand for molecular imaging of α3β4 nicotinic acetylcholine receptors

Sarasamkan, J.; Fischer, S.; Deuther-Conrad, W.; Ludwig, F.-A.; Scheunemann, M.; Arunrungvichian, K.; Vajragupta, O.; Brust, P.

• Applied Radiation and Isotopes 124(2017), 106-113
  DOI: 10.1016/j.apradiso.2017.03.015
  Cited 5 times in Scopus

Do spiroindolines have the potential to replace vesamicol as lead compound for the development of radioligands targeting the vesicular acetylcholine transporter?

Lindemann, M.; Deuther-Conrad, W.; Moldovan, R.; Sekhar, K. V. G. C.; Brust, P.; Wenzel, B.

• Bioorganic & Medicinal Chemistry 25(2017)19, 5107-5113
  Online First (2017) DOI: 10.1016/j.bmc.2017.03.028
  Cited 7 times in Scopus

Development of highly affine and selective fluorinated cannabinoid receptor type 2 ligands

Moldovan, R.-P.; Hausmann, K.; Deuther-Conrad, W.; Brust, P.

• ACS Medicinal Chemistry Letters (2017), 566-571
  DOI: 10.1021/acsmedchemlett.7b00129
  Cited 10 times in Scopus

Development of Fluorinated Non-Peptidic Ghrelin Receptor Ligands for Potential Use in Molecular Imaging

Moldovan, R.-P.; Els-Heindl, S.; Worm, D. J.; Kniess, T.; Kluge, M.; Beck-Sickinger, A. G.; Deuther-Conrad, W.; Krügel, U.; Brust, P.

• International Journal of Molecular Sciences 18(2017)4, 768
  Online First (2017) DOI: 10.3390/ijms18040768
  Cited 9 times in Scopus

PET Imaging of α7 Nicotinic Acetylcholine Receptors: A comparative study of [18F]ASEM and [18F]DBT-10 in non-human primates, and further evaluation of [18F]ASEM in humans

Hillmer, A. T.; Li, S.; Zheng, M.-Q.; Scheunemann, M.; Lin, S.-F.; Nabulsi, N.; Holden, D.; Pracitto, R.; Labaree, D.; Ropchan, J.; Teodoro, R.; Deuther-Conrad, W.; Esterlis, I.; Cosgrove, K. P.; Carson, R. E.; Brust, P.; Huang, Y.

• European Journal of Nuclear Medicine and Molecular Imaging 44(2017)6, 1042-1050
  DOI: 10.1007/s00259-017-3621-8
  Cited 42 times in Scopus

Suppressed Fat Appetite after Roux-en-Y Gastric Bypass Surgery Associates with Reduced Brain µ-opioid Receptor Availability in Diet-Induced Obese Male Rats

Hankir, M.; Patt, M.; Patt, J.; Becker, G.; Rullmann, M.; Kranz, M.; Deuther-Conrad, W.; Schichke, K.; Seyfried, F.; Brust, P.; Hesse, S.; Sabri, O.; Krügel, U.; Fenske, W.

• Frontiers in Neuroscience 10(2017), 620
  Online First (2016) DOI: 10.3389/fnins.2016.00620
  Cited 16 times in Scopus

Synthesis and in vitro evaluation of new fluorinated quinoline derivatives with high affinity for PDE5: Towards the development of new PET neuroimaging probes

Liu, J.; Maisonial-Besset, A.; Wenzel, B.; Canitrot, D.; Baufond, A.; Chezal, J. M.; Brust, P.; Moreau, E.

• European Journal of Medicinal Chemistry 136(2017), 548-560
  DOI: 10.1016/j.ejmech.2017.03.091
  Cited 21 times in Scopus

Gender Differences in Neural Networks for Color Processing in Mice: A PET/MR Study

Njemanze, P. C.; Kranz, M.; Amend, M.; Wehrl, H.; Brust, P.

• PLOS ONE 12(2017)7, e0179919.
  DOI: 10.1371/journal.pone.0179919
  Cited 3 times in Scopus

Dissociation between brown adipose tissue 18F-FDG uptake and thermogenesis in uncoupling protein deficient mice

Hankir, M. K.; Kranz, M.; Keipert, S.; Andreasen, S.; Kern, M.; Patt, M.; Klöting, N.; Hesse, S.; Brust, P.; Jastroch, M.; Fenske, W. K.

• Journal of Nuclear Medicine 58(2017)7, 1100-1103
  Online First (2017) DOI: 10.2967/jnumed.116.186460
  Cited 69 times in Scopus

Synthesis and Preliminary Biological Evaluation of Indol-3-yl-oxoacetamides as Potent Cannabinoid Receptor Type 2 Ligands

Moldovan, R.-P.; Deuther-Conrad, W.; Horti, A. G.; Brust, P.

• Molecules 22(2017)1, 77
  DOI: 10.3390/molecules22010077
  Cited 3 times in Scopus

Gastric Bypass Surgery Recruits a Gut – Striatal Dopamine Pathway to Reduce Fat Appetite in Obese Rats

Hankir, M. K.; Seyfried, F.; Hintschich, C. A.; Diep, T. A.; Kleberg, K.; Kranz, M.; Deuther-Conrad, W.; Tellez, L. A.; Rullmann, M.; Patt, M.; Teichert, S.; Sabri, O.; Brust, P.; Hansen, H. S.; de Araujo, I. E.; Krügel, U.; Fenske, W. K.

• Cell Metabolism 25(2017)2, 335-344
  Online First (2016) DOI: 10.1016/j.cmet.2016.12.006
  Cited 99 times in Scopus

Radiosynthesis and biological evaluation of the new PDE10A radioligand [¹⁸F]AQ28A

Wagner, S.; Teodoro, R.; Deuther-Conrad, W.; Kranz, M.; Scheunemann, M.; Fischer, S.; Wenzel, B.; Egerland, U.; Hoefgen, N.; Steinbach, J.; Brust, P.

• Journal of Labelled Compounds and Radiopharmaceuticals 60(2017)1, 36-48
  Online First (2016) DOI: 10.1002/jlcr.3471
  Cited 12 times in Scopus

Targetting microglia activation in schizophrenia by minocycline treatment

Mattei, D.; Ivanov, A.; Ferrai, G.; Jordan, P.; Guneykaya, D.; Schaafsma, W.; Przanowski, P.; Deuther-Conrad, W.; Brust, P.; Hesse, S.; Eggen, B.; Bodekke, E.; Kaminska, B.; Pombo, A.; Kettenmann, H.; Wolf, S. A.

• Lecture (Conference)
  29th ECNP Congress, 17.-20.09.2016, Vienna, Österreich
• European Neuropsychopharmacology 26(2016), 134

Evaluation of the enantiomer specific biokinetics and radiation doses of [18-F]-fluspidine – a new tracer in clinical translation for imaging of σ1 receptors

Kranz, M.; Sattler, B.; Wüst, N.; Deuther-Conrad, W.; Patt, M.; Meyer, P. M.; Fischer, S.; Donat, C. K.; Wünsch, B.; Hesse, S.; Steinbach, J.; Brust, P.; Sabri, O.

• Molecules 21(2016), 1164
  DOI: 10.3390/molecules21091164
  Cited 30 times in Scopus

Synthesis and evaluation of a 18F-labeled 4-phenylpiperidine-4-carbonitrile radioligand for σ1 receptor imaging

Ye, J.; Wang, X.; Deuther-Conrad, W.; Zhang, J.; Li, J.; Zhang, X.; Wang, L.; Steinbach, J.; Brust, P.; Jia, H.

• Journal of Labelled Compounds and Radiopharmaceuticals (2016), 332-339
  Online First (2016) DOI: 10.1002/jlcr.3408
  Cited 7 times in Scopus

Tos-Nos-Mos: Synthesis of different aryl sulfonate precursors for the radiosynthesis of the alpha7 nicotinic acetylcholine receptor radioligand [¹⁸F]NS14490

Rötering, S.; Scheunemann, M.; Günther, R.; Löser, R.; Hiller, A.; Peters, D.; Brust, P.; Fischer, S.; Steinbach, J.

• Applied Radiation and Isotopes 114(2016), 57-62
  Online First (2016) DOI: 10.1016/j.apradiso.2016.04.028
  Cited 4 times in Scopus

Radiation dosimetry of the α4β2 nicotinic receptor ligand (+)-[¹⁸F]Flubatine, comparing preclinical PET/MRI and PET/CT to first-in-human PET/CT results

Kranz, M.; Sattler, B.; Tiepolt, S.; Wilke, S.; Deuther-Conrad, W.; Donat, C.; Fischer, S.; Patt, M.; Schildan, A.; Patt, J.; Smits, R.; Hoepping, A.; Steinbach, J.; Sabri, O.; Brust, P.

• EJNMMI Physics (2016), 3-25
  Online First (2016) DOI: 10.1186/s40658-016-0160-5
  Cited 16 times in Scopus

Novel radioligands for cyclic nucleotide phosphodiesterase imaging with positron emission tomography: An update on developments since 2012

Schröder, S.; Wenzel, B.; Deuther-Conrad, W.; Scheunemann, M.; Brust, P.

• Molecules 21(2016)5, 650
  DOI: 10.3390/molecules21050650
  Cited 18 times in Scopus

Varying Chirality Across Nicotinic Acetylcholine Receptor Subtypes: Selective Binding of Quinuclidine Triazole Compounds

Sarasamkan, J.; Scheunemann, M.; Apaijai, N.; Palee, S.; Parichatikanond, W.; Arunrungvichian, K.; Fischer, S.; Chattipakorn, S.; Deuther-Conrad, W.; Schüürmann, G.; Brust, P.; Vajragupta, O.

• ACS Medicinal Chemistry Letters 7(2016)10, 890-895
  DOI: 10.1021/acsmedchemlett.6b00146
  Cited 11 times in Scopus

Comparison of in silico, electrochemical, in vitro and in vivo metabolism of a homologous series of (radio)fluorinated sigma1 receptor ligands designed for positron emission tomography

Wiese, C.; Große Maestrup, E.; Galla, F.; Schepmann, D.; Hiller, A.; Fischer, S.; Ludwig, F. A.; Deuther-Conrad, W.; Donat, C. K.; Brust, P.; Büter, L.; Karst, U.; Wünsch, B.

• ChemMedChem 11(2016), 2445-2458
  Online First (2016) DOI: 10.1002/cmdc.201600366
  Cited 11 times in Scopus

Beta-Amyloid-PET-Bildgebung des Gehirns - DGN-Handlungsempfehlung

Barthel, H.; Meyer, P. T.; Drzezga, A.; Bartenstein, P.; Boecker, H.; Brust, P.; Buchert, R.; Coenen, H. H.; Fougère, C. L.; Gründer, G.; Grünwald, F.; Krause, B. J.; Kuwert, T.; Schreckenberger, M.; Tatsch, K.; Langen, K. J.; Sabri, O.

• Nuklearmedizin 55(2016)4, 129-137
  DOI: 10.3413/Nukmed-0816-16-04
  Cited 6 times in Scopus

99mTc-Cyclopentadienyl Tricarbonyl Chelate-Labeled Compounds as Selective Sigma‑2 Receptor Ligands for Tumor Imaging

Li, D.; Chen, Y.; Wang, X.; Deuther-Conrad, W.; Chen, X.; Jia, B.; Dong, C.; Steinbach, J.; Brust, P.; Liu, B.; Jia, H.

• Journal of Medicinal Chemistry 59(2016)3, 934-946
  DOI: 10.1021/acs.jmedchem.5b01378
  Cited 18 times in Scopus

LC-MS supported Studies on the in vitro Metabolism of both Enantiomers of Flubatine and the in vivo Metabolism of (+)-[18F]Flubatine – a Positron Emission Tomography Radioligand for Imaging α4β2-Nicotinic Acetylcholine Receptors

Ludwig, F.-A.; Smits, R.; Fischer, S.; Donat, C. K.; Hoepping, A.; Brust, P.; Steinbach, J.

• Molecules 21(2016)9, 1200
  DOI: 10.3390/molecules21091200
  Cited 9 times in Scopus

Thyroid hormone status defines brown adipose tissue activity and browning of white adipose tissues in mice

Weiner, J.; Kranz, M.; Klöting, N.; Kunath, A.; Steinhoff, K.; Rijntjes, E.; Köhrle, J.; Zeisig, V.; Hankir, M.; Gebhardt, C.; Deuther-Conrad, W.; Heiker, J.; Kralisch, S.; Stumvoll, M.; Bluher, M.; Sabri, O.; Hesse, S.; Brust, P.; Tönjes, A.; Krause, K.

• Scientific Reports 6(2016), 38124
  DOI: 10.1038/srep38124
  Cited 64 times in Scopus

Changes in Binding of [123I]CLINDE, a High-Affinity Translocator Protein 18 kDa (TSPO) Selective Radioligand in a Rat Model of Traumatic Brain Injury

Donat, C. K.; Gaber, K.; Meixensberger, J.; Brust, P.; Pinborg, L. H.; Hansen, H. H.; Mikkelsen, J. D.

• Neuromolecular Medicine 18(2016)2, 158-169
  Online First (2016) DOI: 10.1007/s12017-016-8385-y
  Cited 21 times in Scopus

Development of a High-Affinity PET Radioligand for Imaging Cannabinoid Subtype 2 Receptor

Moldovan, R.-P.; Teodoro, R.; Deuther-Conrad, W.; Kranz, M.; Wang, Y.; Nakano, M.; Valentine, H.; Fischer, S.; Pomper, M.; Wong, D. F.; Dannals, R. F.; Brust, P.; Horti, A. G.

• Journal of Medicinal Chemistry 59(2016)17, 7840-7855
  DOI: 10.1021/acs.jmedchem.6b00554
  Cited 48 times in Scopus

Development of a new radiofluorinated quinoline analog for PET imaging of phosphodiesterase 5 (PDE5) in brain.

Liu, J.; Wenzel, B.; Dukic-Stefanovic, S.; Teodoro, R.; Ludwig, F.-A.; Deuther-Conrad, W.; Schröder, S.; Chezal, J.-M.; Moreau, E.; Brust, P.; Maisonial-Besset, A.

• Pharmaceuticals 9(2016)2, 22
  Online First (2016) DOI: 10.3390/ph9020022
  ISSN: 1424-8247
  Cited 14 times in Scopus

PET imaging evaluation of [¹⁸F]DBT-10, a novel radioligand specific to α₇ nicotinic acetylcholine receptors, in nonhuman primates

Hillmer, A. T.; Zheng, M.-Q.; Li, S.; Scheunemann, M.; Lin, S.-F.; Holden, D.; Labaree, D.; Ropchan, J.; Teodoro, R.; Deuther-Conrad, W.; Carson, R. E.; Brust, P.; Huang, Y.

• European Journal of Nuclear Medicine and Molecular Imaging 43(2016)3, 537-547
  Online First (2015) DOI: 10.1007/s00259-015-3209-0
  Cited 18 times in Scopus

A novel thermoregulatory role for PDE10A in mouse and human adipocytes

Hankir, M.; Kranz, M.; Gnad, T.; Wagner, S.; Deuther-Conrad, W.; Bronisch, F.; Steinhoff, K.; Luthardt, J.; Klöting, N.; Hesse, S.; Seibyl, J.; Blüher, M.; Sabri, O.; Pfeifer, A.; Brust, P.; Fenske, W.

• EMBO Molecular Medicine 8(2016), 796-812
  Online First (2016) DOI: 10.15252/emmm.201506085
  ISSN: 0021-9738
  Cited 32 times in Scopus

Development of highly potent phosphodiesterase 10A (PDE10A) inhibitors: Synthesis and in vitro evaluation of 1,8-dipyridyl- and 1-pyridinol-substituted imidazo[1,5-a]quinoxalines

Wagner, S.; Scheunemann, M.; Dipper, K.; Egerland, U.; Hoefgen, N.; Steinbach, J.; Brust, P.

• European Journal of Medicinal Chemistry 107(2016), 97-108
  DOI: 10.1016/j.ejmech.2015.10.028
  Cited 10 times in Scopus

On the development of a novel non-peptidic ¹⁸F-labeled radiotracer for in vivo imaging of oxytocin receptors with positron emission tomography

Wenzel, B.; Mollitor, J.; Deuther-Conrad, W.; Kranz, M.; Dukic-Stefanovic, S.; Günther, R.; Teodoro, R.; Ludwig, F.-A.; Fischer, S.; Smits, R.; Steinbach, J.; Hoepping, A.; Brust, P.

• Poster
  ISRS2015 - 21st International Symposium on Radiopharmaceutical Sciences, 26.-31.05.2015, Columbia, Missouri, USA
• Abstract in refereed journal
  Journal of Labelled Compounds and Radiopharmaceuticals 58(2015)1, 173
  DOI: 10.1002/jlcr.3302_2
  ISSN: 1099-1344
• Journal of Medicinal Chemistry 59(2016)5, 1800-1817
  Online First (2016) DOI: 10.1021/acs.jmedchem.5b01080
  ISSN: 0022-2623
  Cited 16 times in Scopus

¹⁸F-Labeled 1,4-Dioxa-8-azaspiro[4.5]decane Derivative: Synthesis and Biological Evaluation of a σ1 Receptor Radioligand with Low Lipophilicity as Potent Tumor Imaging Agent

Xie, F.; Bergmann, R.; Kniess, T.; Deuther-Conrad, W.; Mamat, C.; Neuber, C.; Liu, B.; Steinbach, J.; Brust, P.; Pietzsch, J.; Jia, H.

Involved research facilities

• PET-Center

• Journal of Medicinal Chemistry 58(2015), 5395-5407
  DOI: 10.1021/acs.jmedchem.5b00593
  ISSN: 0022-2623
  Cited 23 times in Scopus

2-[¹⁸F]Fluoroethyl tosylate - a versatile tool for building ¹⁸F-based radiotracers for positron emission tomography

Knieß, T.; Laube, M.; Brust, P.; Steinbach, J.

Involved research facilities

• PET-Center

• MedChemComm 6(2015), 1714-1754
  Online First (2015) DOI: 10.1039/c5md00303b
  Cited 35 times in Scopus

Novel indole-based sigma-2 receptor ligands: synthesis, structure–affinity relationship and antiproliferative activity

Xie, F.; Kniess, T.; Neuber, C.; Deuther-Conrad, W.; Mamat, C.; Liebermann, B. P.; Liu, B.; Mach, R. H.; Brust, P.; Steinbach, J.; Pietzsch, J.; Jia, H.

Involved research facilities

• PET-Center

• MedChemComm 6(2015), 1093-1103
  DOI: 10.1039/c5md00079c
  Cited 15 times in Scopus

First-in-human PET quantification study of cerebral α4β2* nicotinic acetylcholine receptors using the novel specific radioligand (−)-[¹⁸F]Flubatine

Sabri, O.; Becker, G.-A.; Meyer, P. M.; Hesse, S.; Wilke, S.; Graef, S.; Patt, M.; Luthardt, J.; Wagenknecht, G.; Hoepping, A.; Smits, R.; Franke, A.; Sattler, B.; Habermann, B.; Neuhaus, P.; Fischer, S.; Tiepolt, S.; Deuther-Conrad, W.; Barthel, H.; Schönknecht, P.; Brust, P.

• NeuroImage 118(2015), 199-208
  DOI: 10.1016/j.neuroimage.2015.05.065
  Cited 47 times in Scopus

A promising PET tracer for imaging of α₇ nicotinic acetylcholine receptors in the brain: Design, synthesis, and in vivo evaluation of a dibenzothiophene-based radioligand

Teodoro, R.; Scheunemann, M.; Deuther-Conrad, W.; Wenzel, B.; Colombo, S.; Gotti, C.; Kranz, M.; Donat, C.; Patt, M.; Hillmer, A.; Zheng, M.; Peters, D.; Steinbach, J.; Sabri, O.; Huang, Y.; Brust, P.

• Molecules 20(2015), 18387-18421
  DOI: 10.3390/molecules201018387
  ISSN: 1420-3049
  Cited 11 times in Scopus

Synthesis, ¹⁸F-radiolabelling and biological characterization of novel fluoroalkylated triazine derivatives for in vivo imaging of phosphodiesterase 2A in brain via positron emission tomography

Schröder, S.; Wenzel, B.; Deuther-Conrad, W.; Teodoro, R.; Egerland, U.; Kranz, M.; Scheunemann, M.; Höfgen, N.; Steinbach, J.; Brust, P.

• Molecules 20(2015), 9591-9615
  DOI: 10.3390/molecules20069591
  ISSN: 1420-3049
  Cited 14 times in Scopus

New systematically modified vesamicol analogs and their affinity and selectivity for the vesicular acetylcholine transporter – A critical examination of the lead structure.

Barthel, C.; Sorger, D.; Deuther-Conrad, W.; Scheunemann, M.; Schweiger, S.; Jäckel, P.; Roghani, A.; Steinbach, J.; Schüürmann, G.; Sabri, O.; Brust, P.; Wenzel, B.

• European Journal of Medicinal Chemistry 100(2015), 50-67
  DOI: 10.1016/j.ejmech.2015.05.033
  Cited 11 times in Scopus

A high-yield automated radiosynthesis of the alpha-7 nicotinic receptor radioligand [¹⁸F]NS10743

Teodoro, R.; Wenzel, B.; Oh-Nishi, A.; Fischer, S.; Peters, D.; Suhara, T.; Deuther-Conrad, W.; Brust, P.

• Applied Radiation and Isotopes 95(2015), 76-84
  DOI: 10.1016/j.apradiso.2014.09.016
  Cited 10 times in Scopus

Convenient recycling and reuse of bombarded [¹⁸O]H₂O for the production and the application of [¹⁸F]F^‒

Rötering, S.; Franke, K.; Zessin, J.; Brust, P.; Füchtner, F.; Fischer, S.; Steinbach, J.

• Applied Radiation and Isotopes 101(2015), 44-52
  Online First (2015) DOI: 10.1016/j.apradiso.2015.03.009
  Cited 10 times in Scopus

Internal Dose Assessment of (-)-¹⁸F-Flubatine, Comparing Animal Model Datasets of Mice and Piglets with First-in-Human Results

Sattler, B.; Kranz, M.; Starke, A.; Wilke, S.; Donat, C. K.; Deuther-Conrad, W.; Patt, M.; Schildan, A.; Patt, J.; Smits, R.; Hoepping, A.; Schoenknecht, P.; Steinbach, J.; Brust, P.; Sabri, O.

• Journal of Nuclear Medicine 55(2014)11, 1885-1892
  Online First (2014) DOI: 10.2967/jnumed.114.137059
  ISSN: 2159-662X
  Cited 15 times in Scopus

Synthesis and evaluation of a ¹⁸F-labeled spirocyclic piperidine derivative as promising σ₁ receptor imaging agent

Chen, Y.-Y.; Wang, X.; Zhang, J.-M.; Deuther-Conrad, W.; Zhang, X.-J.; Huang, Y.; Li, Y.; Ye, J.-J.; Cui, M.-C.; Steinbach, J.; Brust, P.; Liu, B.-L.

• Bioorganic & Medicinal Chemistry 22(2014), 5270-5278
  DOI: 10.1016/j.bmc.2014.08.003
  Cited 16 times in Scopus

Novel Cyclopentadienyl Tricarbonyl ^99mTc Complexes Containing 1‑Piperonylpiperazine Moiety: Potential Imaging Probes for Sigma‑1 Receptors

Wang, X.; Li, D.; Deuther-Conrad, W.; Lu, J.; Xie, Y.; Jia, B.; Cui, M.; Steinbach, J.; Brust, P.; Liu, B.; Jia, H.

• Journal of Medicinal Chemistry 57(2014), 7113-7125
  DOI: 10.1021/jm5009488
  Cited 24 times in Scopus

Adenosine activates brown adipose tissue and recruits beige adipocytes via A_2A receptors

Gnad, T.; Scheibler, S.; von Kügelgen, I.; Scheele, C.; Kilic, A.; Glöde, A.; Hoffmann, L.; Reverte, L.; Horn, P.; Mutlu, S.; El-Tayeb, A.; Kranz, M.; Deuther-Conrad, W.; Brust, P.; Lidell, M.; Betz, M.; Enerbäck, S.; Schrader, J.; Yegutkin, G.; Mueller, C.; Pfeifer, A.

• Nature 516(2014), 395-399
  Online First (2014) DOI: 10.1038/nature13816
  Cited 300 times in Scopus

Evaluation of metabolism, plasma protein binding and other biological parameters after administration of (−)-[¹⁸ F]Flubatine in humans

Patt, M.; Becker, G. A.; Grossmann, U.; Habermann, B.; Schildan, A.; Wilke, S.; Deuther-Conrad, W.; Graefe, S.; Fischer, S.; Smits, R.; Wagenknecht, G.; Steinbach, J.; Gertze, H.-J.; Hesse, S.; Schönknecht, P.; Brust, P.; Sabri, O.

• Nuclear Medicine and Biology 41(2014), 489-494
  DOI: 10.1016/j.nucmedbio.2014.03.018
  Cited 17 times in Scopus

Imaging of α7 nicotinic acetylcholine receptors in brain and cerebral vasculature of juvenile pigs with [¹⁸F]NS14490

Rötering, S.; Deuther-Conrad, W.; Cumming, P.; Donat, C. K.; Scheunemann, M.; Fischer, S.; Xiong, G.; Steinbach, J.; Peters, D.; Sabri, O.; Bucerius, J.; Brust, P.

• EJNMMI Research 4(2014), 1-11
  Online First (2014) DOI: 10.1186/s13550-014-0043-5
  Cited 17 times in Scopus

Early increase of cannabinoid receptor density after experimental traumatic brain injury in the newborn piglet

Donat, C. K.; Fischer, F.; Walter, B.; Deuther-Conrad, W.; Brodhun, M.; Bauer, R.; Brust, P.

• Acta Neurobiologiae Experimentalis 74(2014), 197-210
  ISSN: 0365-0820

Distinctive In Vivo Kinetics of the New Sigma₁ Receptor Ligands (R)-(+) and (S)-(-)- ¹⁸F-Fluspidine in Porcine Brain

Brust, P.; Deuther-Conrad, W.; Becker, G.; Patt, M.; Dont, C. K.; Stittsworth, S.; Fischer, S.; Hiller, A.; Wenzel, B.; Dukic-Stefanovic, S.; Hesse, S.; Steinbach, J.; Wünsch, B.; Lever, S. Z.; Sabri, O.

• Journal of Nuclear Medicine 55(2014)10, 1730-1736
  DOI: 10.2967/jnumed.114.137562
  ISSN: 0161-5505
  Cited 24 times in Scopus

Asymmetric Synthesis of Spirocyclic 2-Benzopyrans for Positron Emission Tomography of σ₁ Receptors in the Brain

Holl, K.; Schepmann, D.; Fischer, S.; Ludwig, F. A.; Hiller, A.; Donat, C. K.; Deuther-Conrad, W.; Brust, P.; Wünsch, B.

• Pharmaceuticals 7(2014), 78-112
  DOI: 10.3390/ph7010078
  ISSN: 1424-8247
  Cited 2 times in Scopus

Synthesis and biological evaluation of both enantiomers of [¹⁸F]flubatine, promising radiotracers with fas kinetics for the imaging of α4β2-nicotinic acetylcholine receptors

Smits, R.; Fischer, S.; Hiller, A.; Deuther-Conrad, W.; Wenzel, B.; Patt, M.; Cumming, P.; Steinbach, J.; Sabri, O.; Brust, P.; Hoepping, A.

• Bioorganic & Medicinal Chemistry 22(2014), 804-812
  DOI: 10.1016/j.bmc.2013.12.011
  Cited 26 times in Scopus

Development of ¹⁸F-labeled radiotracers for neuroreceptor imaging with positron emission tomography

Brust, P.; van den Hoff, J.; Steinbach, J.

• Neuroscience Bulletin 30(2014)5, 777-811
  Online First (2014) DOI: 10.1007/s12264-014-1460-6
  ISSN: 1995-8218
  Cited 44 times in Scopus

Hydroxyalkylation with Cyclic Sulfates: Synthesis of Carbazole Derived CB₂ Ligands with Increased Polarity

Lueg, C.; Galla, F.; Frehland, B.; Schepmann, D.; Daniliuc, C. G.; Deuther-Conrad, W.; Brust, P.; Wünsch, B.

• Archiv der Pharmazie 347(2014), 21-31
  DOI: 10.1002/ardp.201300255
  Cited 7 times in Scopus

Automation of the radiosynthesis and purification procedures for [¹⁸F]Fluspidine preparation, a new radiotracer for clinical investigations in PET imaging of σ₁ receptors in brain.

Maisonial-Besset, A.; Funke, U.; Wenzel, B.; Fischer, S.; Holl, K.; Wünsch, B.; Steinbach, J.; Brust, P.

• Applied Radiation and Isotopes 84(2014), 1-7
  DOI: 10.1016/j.apradiso.2013.10.015
  Cited 16 times in Scopus

Molecular Imaging of σ1 Receptors In Vivo: Current Status and Perspectives

Brust, P.; Deuther-Conrad, W.; Lehmkuhl, K.; Jia, H.; Wünsch, B.

• Current Medicinal Chemistry 21(2014)1, 35-69
  DOI: 10.2174/09298673113209990214
  Cited 35 times in Scopus

Fluorine containing 6,7-dialkoxybiaryl-based inhibitors for phosphodiesterase 10A: Synthesis and in vitro evaluation of inhibition potency, selectivity and metabolism

Schwan, G.; Asskar, G. B.; Höfgen, N.; Kubicova, L.; Funke, U.; Egerland, U.; Zahn, M.; Nieber, K.; Scheunemann, M.; Sträter, N.; Brust, P.; Briel, D.

• ChemMedChem 9(2014)7, 1476-1487
  DOI: 10.1002/cmdc.201300522
  ISSN: 1860-7187
  Cited 14 times in Scopus

Development of fluorinated CB₂ receptor agonists for PET studies

Lueg, C.; Schepmann, D.; Günther, R.; Brust, P.; Wünsch, B.

• Bioorganic & Medicinal Chemistry 21(2013), 7481-7498
  DOI: 10.1016/j.bmc.2013.09.040
  Cited 22 times in Scopus

Synthesis, Characterization, and Metabolism Studies of Fluspidine Enantiomers

Holl, K.; Falck, E.; Köhler, J.; Schepmann, D.; Humpf, H.-U.; Brust, P.; Wünsch, B.

• ChemMedChem 8(2013)12, 2047-2056
  DOI: 10.1002/cmdc.201300322
  Cited 27 times in Scopus

Radiofluorination and biological evaluation of N-aryl-oxadiazolyl-propionamides as potential radioligands for PET imaging of cannabinoid CB2 receptors

Teodoro, R.; Moldovan, R.-P.; Lueg, C.; Günther, R.; Donat, C. K.; Ludwig, F.-A.; Fischer, S.; Deuther-Conrad, W.; Wünsch, B.; Brust, P.

• Organic and Medicinal Chemistry Letters 3(2013)11
  Online First (2013) DOI: 10.1186/2191-2858-3-11

Fully automated radiosynthesis of both enantiomers of [¹⁸F]Flubatine under GMP conditions for human application

Patt, M.; Schildan, A.; Habermann, B.; Fischer, S.; Hiller, A.; Deuther-Conrad, W.; Wilke, S.; Smits, R.; Hoepping, A.; Wagenknecht, G.; Steinbach, J.; Brust, P.; Sabri, O.

• Applied Radiation and Isotopes 80(2013), 7-11
  Online First (2013) DOI: 10.1016/j.apradiso.2013.05.009
  ISSN: 0969-8043
  Cited 19 times in Scopus

Use of 3-[¹⁸F]fluoropropanesulfonyl chloride as prosthetic agent for the radiolabelling of amines: Investigation of precursor molecules, labelling conditions and enzymatic stability of the corresponding sulfonamides

Löser, R.; Fischer, S.; Hiller, A.; Köckerling, M.; Funke, U.; Maisonial, A.; Brust, P.; Steinbach, J.

Involved research facilities

• PET-Center

• Beilstein Journal of Organic Chemistry 9(2013), 1002-1011
  DOI: 10.3762/bjoc.9.115
  Cited 8 times in Scopus

Synthesis and Evaluation of Novel ¹⁸F-Labeled Spirocyclic Piperidine Derivatives as σ₁ Receptor Ligands for Positron Emission Tomography Imaging

Li, Y.; Wang, X.; Zhang, J.; Deuther-Conrad, W.; Xie, F.; Zhang, X.; Liu, J.; Qiao, J.; Cui, M.; Steinbach, J.; Brust, P.; Liu, B.; Jia, H.

• Journal of Medicinal Chemistry 56(2013), 3478-3491
  DOI: 10.1021/jm301734g
  ISSN: 0022-2623
  Cited 22 times in Scopus

A fluoro versus a nitro derivative - a high-performance liquid chromatography study of two basic analytes with different RP and silica phases as basis for the separation of a positron emission tomography radiotracer

Wenzel, B.; Günther, R.; Brust, P.; Steinbach, J.

• Journal of Chromatography A 1311(2013), 98-105
  DOI: 10.1016/j.chroma.2013.08.068
  Cited 5 times in Scopus

Resistance of brain glucose metabolism to thiopental-induced CNS depression in newborn piglets

Bernd, W.; Eiselt, M.; Cumming, P.; Xiong, G.; Hinz, R.; Uthe, S.; Brust, P.; Bauer, R.

• International Journal of Developmental Neuroscience 31(2013), 157-164
  DOI: 10.1016/j.ijdevneu.2012.12.008
  ISSN: 0736-5748
  Cited 3 times in Scopus

Radiosynthesis and first evaluation in mice of [¹⁸F]NS14490 for molecular imaging of α₇ nicotinic acetylcholine receptors

Rötering, S.; Scheunemann, M.; Fischer, S.; Hiller, A.; Peters, D.; Deuther-Conrad, W.; Brust, P.

• Bioorganic & Medicinal Chemistry 21(2013), 2635-2642
  Online First (2013) DOI: 10.1016/j.bmc.2013.02.018
  Cited 28 times in Scopus

Synthesis and biological evaluation of 18F labeled fluoro-oligo-ethoxylated 4-benzylpiperazine derivatives for sigma-1 receptor imaging

Wang, X.; Li, Y.; Deuther-Conrad, W.; Xie, F.; Chen, X.; Cui, M.-C.; Zhang, X.-J.; Zhang, J.-M.; Steinbach, J.; Brust, P.; Liu, B.-L.; Jia, H.-M.

• Bioorganic & Medicinal Chemistry 21(2013)1, 215-222
  Online First (2012) DOI: 10.1016/j.bmc.2012.10.038
  Cited 18 times in Scopus

Leitlinie für die Hirnperfusions-SPECT mit Tc-99m Radiopharmaka / Hirnperfusions-SPECT with 99mTc-labelled Radiopharmaceuticals DGN-Guidance (S1 Guideline)

Kranert, T.; Menzel, C.; Bartenstein, P.; Brust, P.; Coenen, H. H.; Krause, B. J.; Kuwert, T.; Sabri, O.; Schreckenberger, M.; Tatsch, K.; Grünwald, F.

• Nuklearmedizin 5(2013)52, 157-162
• Contribution to WWW
  AWMF online - Das Portal der wissenschaftlichen Medizin: http://www.awmf.org/leitlinien/detail/ll/031-016.html

Radiosynthesis of racemic and enantiomerically pure (–)-[¹⁸F]flubatine – A promising PET radiotracer for neuroimaging of α₄β₂ nicotinic acetylcholine receptors

Fischer, S.; Hiller, A.; Smits, R.; Hoepping, A.; Funke, U.; Wenzel, B.; Cumming, P.; Sabri, O.; Steinbach, J.; Brust, P.

• Applied Radiation and Isotopes 74(2013), 128-136
  DOI: 10.1016/j.apradiso.2013.01.002
  ISSN: 0969-8043
  Cited 22 times in Scopus
• Contribution to WWW
  Global Medical Discovery [ISSN 1929-8536]: http://globalmedicaldiscovery.com/?s=Radiosynthesis+of+racemic

Design, synthesis, and preliminary in vitro and in vivo pharmacological evaluation of 4-{4-[2-(4-(2-substitutedquinoxalin-3-yl)piperazin-1-yl)ethyl]phenyl}thiazoles as atypical antipsychotic agents

Chandra Sekhar, K. V. G.; Rao, V. S.; Deuther-Conrad, W.; Sridhar, D.; Nagesh, H. N.; Kumar, V. S.; Brust, P.; Kumar, M. M. K.

• Medicinal Chemistry Research 22(2013)4, 1660-1673
  Online First (2012) DOI: 10.1007/s00044-012-0164-1
  Cited 11 times in Scopus

Synthesis and biological evaluation of a novel Tc-99m cyclopentadienyl tricarbonyl complex ([(Cp-R)Tc-99m(CO)(3)]) for sigma-2 receptor tumor imaging

Chen, X.; Cui, M. C.; Deuther-Conrad, W.; Tu, Y. F.; Ma, T.; Xie, Y.; Jia, B.; Li, Y.; Xie, F.; Wang, X.; Steinbach, J.; Brust, P.; Liu, B. L.; Jia, H. M.

• Bioorganic & Medicinal Chemistry Letters 22(2012)20, 6352-6357
  DOI: 10.1016/j.bmcl.2012.08.083
  ISSN: 0960-894X
  Cited 24 times in Scopus

Cannabinoid Receptor Type 2 (CB2) Selective N-Aryl-oxadiazolyl-propionamides: Synthesis, Radiolabeling, Molekular Modelling and Biological Evaluation

Rühl, T.; Deuther-Conrad, W.; Fischer, S.; Günther, R.; Hennig, L.; Krautscheid, P.; Brust, P.

• Organic and Medicinal Chemistry Letters 2(2012), 32
  Online First (2012) DOI: 10.1186/2191-2858-2-32

Pyrrolovesamicols - Synthesis, structure and VAChT binding of two 4-fluorobenzoyl regioisomers

Wenzel, B.; Li, Y.; Kraus, W.; Sorger, D.; Sabri, O.; Brust, P.; Steinbach, J.

• Bioorganic & Medicinal Chemistry Letters 22(2012), 2163-2166
  DOI: 10.1016/j.bmcl.2012.01.127
  Cited 8 times in Scopus

Imaging of the brain serotonin transporters (SERT) with 18F-labelled fluoromethyl-McN5652 and PET in humans

Hesse, S.; Brust, P.; Mäding, P.; Becker, G.-A.; Seese, A.; Patt, M.; Sorger, D.; Zessin, J.; Sacher, J.; Lobsien, D.; Habermann, B.; Meyer, P. M.; Füchtner, F.; Luthardt, J.; Bresch, A.; Steinbach, J.; Sabri, O.

• European Journal of Nuclear Medicine and Molecular Imaging 39(2012)6, 1001-1011
  Online First (2012) DOI: 10.1007/s00259-012-2078-z
  Cited 29 times in Scopus

Development of radioligands for α7-nAChR imaging with positron emission tomography

Brust, P.; Peters, D.; Deuther-Conrad, W.

• Current Drug Targets 13(2012)5, 594-601
  DOI: 10.2174/138945012800398955
  ISSN: 1389-4501
  Cited 28 times in Scopus

Synthesis, radiofluorination and pharmacological evaluation of fluoromethyl substituted spirocyclic PET tracers for labeling of σ1 receptors in the central nervous system and comparison with longer homologues

Maisonial, A.; Grosse Maestrup, E.; Wiese, C.; Hiller, A.; Schepmann, D.; Deuther-Conrad, W.; Fischer, S.; Brust, P.; Wünsch, B.

• Bioorganic & Medicinal Chemistry 20(2012), 257-269
  DOI: 10.1016/j.bmc.2011.11.002
  Cited 21 times in Scopus

Radiosynthesis and Radiotracer Properties of a 7-(2-[F-18]Fluoroethoxy)-6-methoxy-pyrrolidinylquinazoline for Imaging of Phosphodiesterase 10A with PET

Funke, U.; Deuther-Conrad, W.; Schwan, G.; Maisonial, A.; Scheunemann, M.; Fischer, S.; Hiller, A.; Briel, D.; Brust, P.

• Pharmaceuticals 5(2012)2, 169-188
  Online First (2012) DOI: 10.3390/ph5020169
  ISSN: 1424-8247
  Cited 16 times in Scopus

Leitlinie für PET und SPECT–Untersuchungen von Hirntumoren mit radioaktiv markierten Aminosäuren

Langen, K.-J.; Bartenstein, P.; Brust, P.; Coenen, H. H.; Drzezga, A.; Grünwald, F.; Krause, B. J.; Kuwert, T.; Sabri, O.; Tatsch, K.; Weber, W. A.; Schreckenberger, M.

• Nuklearmedizin 50(2011)4, 167-173
  DOI: 10.3413/nuk-2011041
  Cited 87 times in Scopus

A ¹⁸F-labeled Fluorobutyl-substituted spirocyclic piperidine derivative as a selective radioligand for PET imaging of sigma₁ receptors

Maisonial, A.; Große Maestrup, E.; Fischer, S.; Hiller, A.; Scheunemann, M.; Wiese, C.; Schepmann, D.; Steinbach, J.; Deuther-Conrad, W.; Wünsch, B.; Brust, P.

• ChemMedChem 6(2011), 1401-1410
  DOI: 10.1002/cmdc.201100108
  Cited 21 times in Scopus

Synthesis and biological evaluation of novel 4-benzylpiperazine ligands for sigma-1 receptor imaging

Li, Z.-J.; Ren, H.-Y.; Cui, M.-C.; Deuther-Conrad, W.; Tang, R.-K.; Steinbach, J.; Brust, P.; Liu, B.-L.; Jia, H.-M.

• Bioorganic & Medicinal Chemistry 19(2011)9, 2911-2917
  DOI: 10.1016/j.bmc.2011.03.037
  Cited 13 times in Scopus

In vitro binding profile and radiosynthesis of a novel 18F-labeled azaspirovesamicol analog as potential ligand for imaging of the vesicular acetylcholine transporter

Wenzel, B.; Hiller, A.; Fischer, S.; Sorger, D.; Deuther-Conrad, W.; Scheunemann, M.; Brust, P.; Sabri, O.; Steinbach, J.

• Journal of Labelled Compounds and Radiopharmaceuticals 54(2011), 426-432
  DOI: 10.1002/jlcr.1891
  Cited 8 times in Scopus

Assessment of alpha 7 nicotinic acetylcholine receptor availability in juvenile pig brain with [¹⁸F]NS10743

Deuther-Conrad, W.; Fischer, S.; Hiller, A.; Becker, G.; Cumming, P.; Xiong, G.; Funke, U.; Sabri, O.; Peters, D.; Brust, P.

• European Journal of Nuclear Medicine and Molecular Imaging 38(2011)8, 1541-1549

Synthesis, pharmacological activity and structure affinity relationships of spirocyclic σ1 receptor ligands with a (2-fluoroethyl) residue in 3-position

Große Maestrup, E.; Wiese, C.; Schepmann, D.; Brust, P.; Wünsch, B.

• Bioorganic & Medicinal Chemistry 19(2011), 393-405
  DOI: 10.1016/j.bmc.2010.11.013
  Cited 40 times in Scopus

The serotonin transporter availability in untreated early-onset and late-onset patients with obsessive-compulsive disorder

Hesse, S.; Stengler, K.; Regenthal, R.; Patt, M.; Becker, G.-A.; Franke, A.; Knüpfer, H.; Meyer, P. M.; Luthardt, J.; Jahn, I.; Lobsien, D.; Heinke, W.; Brust, P.; Hegerl, U.; Sabri, O.

• International Journal of Neuropsychopharmacology 14(2011), 1-12
  DOI: 10.1017/S1461145710001604
  Cited 53 times in Scopus

Molecular imaging of σ receptors: synthesis and evaluation of the potent σ1 selective radioligand [¹⁸F]fluspidine

Fischer, S.; Wiese, C.; Grosse Maestrup, E.; Hiller, A.; Deuther-Conrad, W.; Scheunemann, M.; Schepmann, D.; Steinbach, J.; Wünsch, B.; Brust, P.

• European Journal of Nuclear Medicine and Molecular Imaging 38(2011)3, 540-551

Traumatic Brain Injury Elicits Similar Alterations in α7 Nicotinic Receptor Density in Two Different Experimental Models

Hoffmeister, P.-G.; Donat, C. K.; Schuhmann, M. U.; Voigt, C.; Walter, B.; Nieber, K.; Meixensberger, J.; Bauer, R.; Brust, P.

• Neuromolecular Medicine 13(2011)1, 44-53
  DOI: 10.1007/s12017-010-8136-4
  ISSN: 1535-1084
  Cited 30 times in Scopus

Enantioselective σ1 receptor binding and biotransformation of the spirocyclic PET tracer 1’-Benzyl-3-(3-fluoropropyl)-3H-spiro[[2]benzofuran-1,4’-piperidine]

Wiese, C.; Große Maestrup, E.; Schepmann, D.; Grimme, S.; Humpf, H.-U.; Brust, P.; Wünsch, B.

• Chirality 23(2011), 148-154
  DOI: 10.1002/chir.20893
  Cited 11 times in Scopus

Design, Synthesis and Preliminary in vitro and in vivo Pharmacological Evaluation of 2-{4-[4-(2,5-disubstituted thiazolyl)phenylethyl] piperazin-1-yl}-1,8-naphthyridine-3- carbonitriles as Atypical Antipsychotic Agents

Chandra Sekhar, K. V. G.; Rao, V. S.; Deuther-Conrad, W.; Reddy, A. S.; Brust, P.; Kumara, M. M. K.

• Journal of Enzyme Inhibition And Medicinal Chemistry 26(2011)4, 561-568
  DOI: 10.3109/14756366.2010.537658
  Cited 4 times in Scopus

Accessible silanol sites - beneficial for the RP-HPLC separation of constitutional and diastereomeric azaspirovesamicol isomers

Wenzel, B.; Fischer, S.; Brust, P.; Steinbach, J.

• Journal of Chromatography A 1217(2010), 7884-7890
  DOI: 10.1016/j.chroma.2010.10.061
  Cited 9 times in Scopus

3D QSAR study, synthesis and in vitro evaluation of (+)-5-FBVM as potential PET radioligand for the Vesicular AcetylCholine Transporter (VAChT)

Kovac, M.; Mavel, S.; Deuther-Conrad, W.; Méheux, N.; Glöckner, J.; Wenzel, B.; Anderluh, M.; Brust, P.; Guilloteau, D.; Emond, P.

• Bioorganic & Medicinal Chemistry 18(2010), 7659-7667
  DOI: 10.1016/j.bmc.2010.08.028
  Cited 24 times in Scopus

Synthesis and biological evaluation of a radioiodinated spiropiperidine ligand as a potential σ1 receptor imaging agent

Chen, R.-Q.; Li, Y.; Zhang, Q.-Y.; Jia, H.-M.; Deuther-Conrad, W.; Schepmann, D.; Steinbach, J.; Brust, P.; Wuensch, B.; Liu, B.-L.

• Journal of Labelled Compounds and Radiopharmaceuticals 53(2010), 569-574
  DOI: 10.1002/jlcr.1777
  Cited 11 times in Scopus

Design, Synthesis and in Vitro Biological Evaluation of Reference Compounds of 123I and 99Tcm Labeled Indole Radiotracers for σ2 Receptor Imaging

Li, Y.; Jia, H.-M.; Deuther-Conrad, W.; Brust, P.; Steinbach, J.; Liu, B.-L.

• Journal of Nuclear and Radiochemistry 32(2010)2, 132-138

Effects of lateral fluid percussion injury on cholinergic markers in the newborn piglet brain

Donat, C. K.; Walter, B.; Kayser, T.; Deuther-Conrad, W.; Schliebs, R.; Nieber, K.; Bauer, R.; Haertig, W.; Brust, P.

• International Journal of Developmental Neuroscience 28(2010), 31-38
  DOI: 10.1016/j.ijdevneu.2009.10.001
  Cited 12 times in Scopus

Alterations of cholinergic receptors and the vesicular acetylcholine transporter after lateral fluid percussion injury in newborn piglets

Donat, C. K.; Walter, B.; Deuther-Conrad, W.; Nieber, K.; Brust, R.; Bauer, P.

• Neuropathology and Applied Neurobiology 36(2010), 225-236
  DOI: 10.1111/j.1365-2990.2009.01050.x
  Cited 13 times in Scopus

Novel Indole Derivatives as Potential Imaging Agents for Alzheimer’s Disease

Yu, L.; Scheunemann, M.; Deuther-Conrad, W.; Hiller, A.; Fischer, S.; Sorger, D.; Sabri, O.; Jia, H.; Steinbach, J.; Brust, P.; Liu, B.

• Bulletin of the Korean Chemical Society 31(2010)1, 177-180
  DOI: 10.5012/bkcs.2010.31.01.177
  Cited 1 times in Scopus

Enantioseparation of vesamicol and novel vesamicol analogs by high-performance liquid chromatography on different chiral stationary phases

Wenzel, B.; Fischer, S.; Brust, P.; Steinbach, J.

• Journal of Chromatography A 1217(2010), 3855-3862
  DOI: 10.1016/j.chroma.2010.04.018
  Cited 15 times in Scopus

Molecular imaging of α7 nicotinic acetylcholine receptors: design and evaluation of the potent radioligand [¹⁸F]NS10743

Deuther-Conrad, W.; Fischer, S.; Hiller, A.; Ostergaard Nielsen, E.; Brunicardi Timmermann, D.; Steinbach, J.; Sabri, O.; Peters, D.; Brust, P.

• European Journal of Nuclear Medicine and Molecular Imaging 36(2009), 791-800
  DOI: 10.1007/s00259-008-1031-7
  Cited 36 times in Scopus

3-(4-(6-Fluoroalkoxy-3,4-dihydroisoquinolin-2(1H)-yl)cyclohexyl)-1H-indole-5-carbonitriles for SERT imaging: chemical synthesis, evaluation in vitro and radiofluorination

Funke, U.; Fischer, S.; Hiller, A.; Scheunemann, M.; Deuther-Conrad, W.; Brust, P.; Steinbach, J.

• Bioorganic & Medicinal Chemistry Letters 18(2008), 4727-4730
  DOI: 10.1016/j.bmcl.2008.06.077
  Cited 12 times in Scopus

Synthesis and in vitro evaluation of new diphenyl ether derivatives as serotonin transporter ligands

Guo, Y.; Chen, X.; Jia, H.; Deuther-Conrad, W.; Brust, P.; Steinbach, J.; Vercouillie, J.; Liu, B.

• Science in China Series B: Chemistry 51(2008)5, 457-463
  DOI: 10.1007/s11426-008-0007-6

Radiosynthesis of novel ¹⁸F-labelled derivatives of indiplon as potential GABA_A receptor imaging tracers for PET

Fischer, S.; Hiller, A.; Scheunemann, M.; Deuther-Conrad, W.; Hoepping, A.; Diekers, M.; Wegner, F.; Brust, P.; Steinbach, J.

• Journal of Labelled Compounds and Radiopharmaceuticals 51(2008), 123-131
  DOI: 10.1002/jlcr.1473
  Cited 8 times in Scopus

[¹¹C]SMe-ADAM, an imaging agent for the brain serotonin transporter: Synthesis, pharmacological characterization and microPET studies in rats

Zessin, J.; Deuther-Conrad, W.; Kretzschmar, M.; Wüst, F.; Pawelke, B.; Brust, P.; Steinbach, J.; Bergmann, R.

• Nuclear Medicine and Biology 33(2006)1, 53-63

Effect of Moderate Hypercapnic Hypoxia on Cerebral Dopaminergic Activity and Brain O₂ Uptake in Intrauterine Growth–Restricted Newborn Piglets

Bauer, R.; Walter, B.; Vorwieger, G.; Fritz, A.; Füchtner, F.; Zwiener, U.; Brust, P.

• Pediatric Research 57(2005)3, 363-370
  DOI: 10.1203/01.PDR.0000150800.19956.F0
  Cited 1 times in Scopus

The Influx of Neutral Amino Acids into the Porcine Brain During Development: A Positron Emission Tomography Study

Brust, P.; Vorwieger, G.; Walter, B.; Füchtner, F.; Stark, H.; Kuwabara, H.; Steinbach, J.; Bauer, R.

• Developmental Brain Research 152(2004), 241-253

Developmental changes in the activity of aromatic amino acid decarboxylase and catechol-O-methyl transferase in pigs: a positron emission tomography study

Brust, P.; Walter, B.; Hinz, R.; Füchtner, F.; Müller, M.; Steinbach, J.; Bauer, R.

• Neuroscience Letters, 364(2004)3, 159-163

Age-dependent effects of severe traumatic brain injury on cerebral dopaminergic activity in newborn and juvenile pigs

Walter, B.; Brust, P.; Füchtner, F.; Müller, M.; Hinz, R.; Kuwabara, H.; Fritz, H.; Zwiener, U.; Bauer, R.

• Journal of Neurotrauma 21(2004)8, 1076-1089

Impact of asymmetric intrauterine growth restriction on organ function in newborn piglets

Bauer, R.; Walter, B.; Brust, P.; Füchtner, F.; Zwiener, U.

• European Journal of Obstetrics and Gynecology and Reproductive Biology 110 (2003) S40-S49

S-[¹⁸F]fluoromethyl-(+)-McN5652, a PET Tracer for the Serotonin Transporter: Evaluation in Rats

Marjamäki, P.; Zessin, J.; Eskola, O.; Grönroos, T.; Haaparanta, M.; Bergman, J.; Lehikoinen, P.; Forsback, S.; Brust, P.; Steinbach, J.; Solin, O.

• Synapse (2003) 47: 45-53

In vivo Measurement of the Serotonin Transporter with (S)-([¹⁸F]fluoromenthyl)-(+)-McN5652

Brust, P.; Hinz, R.; Kuwabara, H.; Hesse, S.; Zessin, J.; Pawelke, B.; Stephan, H.; Bergmann, R.; Steinbach, J.; Sabri, O.

• Neuropsychopharmacology (2003) 28, 2010-2019

Positron Emission Tomography Imaging of the Serotonin Transporter in the Pig Brain Using [¹¹C](+)-McN5652 and S-([¹⁸F]fluoromethyl)-(+)-McN5652

Brust, P.; Zessin, J.; Kuwabara, H.; Pawelke, B.; Kretzschmar, M.; Hinz, R.; Bergman, J.; Eskola, O.; Solin, O.; Steinbach, J.; Johannsen, B.

• Synapse (2003) 47: 143-151

Autoradiographic analyses of 5-HT_1A and 5-HT_2A receptors after social isolation in mice

Schiller, L.; Jähkel, M.; Kretzschmar, M.; Brust, P.; Oehler, J.

• Brain Research 980 (2003) 169-178

Autoradiographic imaging of the serotonin ransporter in the brain of rats and pigs using S-([¹⁸F]Fluoromethyl)-(+)-McN5652

Kretzschmar, M.; Brust, P.; Zessin, J.; Cumming, P.; Bergmann, R.; Johannsen, B.

• European Neuropsychopharmacology 13 (2003) 387-397

Effect of hypoxia/hypercapnia on metabolism of 6-[¹⁸F]fluoro-L-DOPA in newborn piglets

Bauer, R.; Brust, P.; Walter, B.; Vorwieger, G.; Bergmann, R.; Elhalag, E.; Fritz, A.; Steinbach, J.; Füchtner, F.; Hinz, R.; Zwiener, U.; Johannsen, B.

• Brain Research 934 (2002) 22-33

Tc and Re chelates of 8alpha-amino-6-methyl-ergoline: synthesis and affinity to the dopamine D₂ receptor

Spies, H.; Noll, B.; Noll, S.; Findeisen, M.; Brust, P.; Syhre, R.; Berger, R.

• Bioorganic and Medicinal Chemistry 10 (2002) 3523-3528

Distribution of estrone sulfatase in rat brain determined by in vitro autoradiography with 16alpha-[¹⁸F]fluoroestradiol-3,17beta-disulfamate

Rodig, H.; Brust, P.; Römer, J.; Kasch, H.; Bergmann, R.; Füchtner, F.; Steinbach, J.; Johannsen, B.

• Applied Radiation and Isotopes 56 (2002) 773-780

Distribution of 16alpha-[¹⁸F]fluoro-estradiol-3,17beta-disulfamate (FESDS) in rats, tumour-bearing mice and piglets

Brust, P.; Rodig, H.; Römer, J.; Kasch, H.; Bergmann, R.; Füchtner, F.; Zips, D.; Baumann, M.; Steinbach, J.; Johannsen, B.

• Applied Radiation and Isotopes 57 (2002) 687-695

Synthesis , biological and autoradiographic evaluation of a novel Tc-99m radioligand derived from WAY 100635 with high-affinity for the 5-HT_1A receptor and the alpha1-adrenergic receptor

Heimbold, I.; Drews, A.; Kretzschmar, M.; Varnäs, K.; Hall, H.; Halldin, C.; Syhre, R.; Kraus, W.; Pietzsch, H.-J.; Seifert, S.; Brust, P.; Johannsen, B.

• Nuclear Medicine and Biology 29 (2002) 375-387

Comparison of [¹⁸F]FHPG and [^124/125I]FIAU for imaging herpes simplex virus type 1 tymidine kinase gene expression

Brust, P.; Haubner, R.; Friedrich, A.; Scheunemann, M.; Anton, M.; Koufaki, O.-N.; Hauses, M.; Noll, S.; Noll, B.; Haberkorn, U.; Schackert, G.; Schackert, H. K.; Avril, N.; Johannsen, B.

• European Journal of Nuclear Medicine Vol.28, No. 6, (2001) 721-729

Synthesis of S-([¹⁸F]fluoromethyl)-(+)-McN5652 as a potential PET radioligand for the serotonin transporter

Zessin, J.; Eskola, O.; Brust, P.; Bergman, J.; Steinbach, J.; Lehikoinen, P.; Solin, O.; Johannsen, B.

• Nuclear Medicine and Biology 28 (2001) 857-863

Quantitative Radioluminography of Serotonin Uptake Sites in the Porcine Brain

Cumming, P.; Kretzschmar, M.; Brust, P.; Smith, D. F.

• Synapse 39 (2001) 351-355

Intrauterine growth restriction induces up-regulation of cerebral aromatic amino acid decarboxylase activity in newborn piglets: [¹⁸F]fluorodopa positron-emission-tomographic study

Bauer, R.; Walter, B.; Vorwieger, G.; Bergmann, R.; Füchtner, F.; Brust, P.

• Pediatric Research 49 (2001) 474-480

Reactivity of ^99mTc(V) "3+1" mixed-ligand complexes towards glutathione

Gupta, A.; Seifert, S.; Syhre, R.; Scheunemann, M.; Brust, P.; Johannsen, B.

• Radiochimica Acta 89 (2001) 43-49

Assessment of the in vitro and in vivo properties of a ^99mTc-labeled inhibitor of the multidrug resistant gene product P-glycoprotein.

Bergmann, R.; Brust, P.; Scheunemann, M.; Pietzsch, H.-J.; Seifert, S.; Roux, F.; Johannsen, B.

• Nucl. Med. Biol. 27 (2000) 135-141

Relation between brain tissue pO₂ and dopamine synthesis of basal ganglia - A ¹⁸FDOPA-PET study in newborn piglets

Bauer, R.; Brust, P.; Walter, B.; Vorwieger, G.; Bergmann, R.; Füchtner, F.; Steinbach, J.; El-Hallag, E.; Fritz, A.; Johannsen, B.; Zwiener, U.

• J. Perinat. Med. 28 (2000) 54-60

Functional expression of the serotonin transporter in immortalized rat brain microvessel endothelial cells

Brust, P.; Friedrich, A.; Krizbai, I. A.; Bergmann, R.; Roux, F.; Ganapathy, V.; Johannsen, B.

• J.Neurochem. 74, (2000) 1241-1248
• Journal of Cerebral Blood Flow and Metabolism, Vol. 19 (Suppl.1), 245
  DOI: 10.1046/j.1471-4159.2000.741241.x
  Cited 50 times in Scopus

Upregulation of the Aromatic Amino Acid Decarboxylase under Neonatal Asphyxia

Brust, P.; Bauer, R.; Vorieger, G.; Walter, B.; Bergmann, R.; Füchtner, F.; Steinbach, J.; Zwiener, U.; Johannsen, B.

• Neurobiology of Disease 6, (1999) 131-139
  DOI: 10.1006/nbdi.1998.0232
  Cited 6 times in Scopus

Regional distribution of cerebral blood volume and cerebral blood flow in newborn piglets - effect of hypoxia / hypercapnia

Bauer, R.; Bergmann, R.; Walter, B.; Brust, P.; Zwiener, U.; Johannsen, B.

• Developmental Brain Research 112 (1999) 89-98
  DOI: 10.1016/S0165-3806(98)00167-9
  Cited 18 times in Scopus

Synthesis and preliminary pharmacological investigations of 1-(1,2-dihydro-2-acenaphthylenyl)piperazine derivatives as potential atypical antipsychotic agents in mice

Srinivas, P.; Subramanian, A. R.; Brust, P.; Raghavan, S. A. V.; Rangisetty, J. B.; Gupta, C. N. V. H. B.; Sridhar, N.; Veeranjaneyulu, A.; Parimoo, P.

• IL FARMACO 54 (1999) 567-572

Synthesis and Autoradiographical Evaluation of a Novel High-Affinity Tc-99m Ligand for the 5-HT_2A Receptor

Pietzsch, H.-J.; Scheunemann, M.; Kretzschmar, M.; Elz, S.; Pertz, H. H.; Seifert, S.; Brust, P.; Spies, H.; Syhre, R.; Johannsen, B.

• Nuclear Medicine and Biology, 26 (1999) 865-875

Synthesis and preliminary binding affinities of 1(1,2-dihydro-2-acenaphthylenyl)piperazine - a new arylpiperazine

Srinivas, P.; Brust, P.; Subramanian, A. R.; Raghavan, S. A. V.; Rangisetty, J. B.; Gupta, C. N. V. H. B.; Parimoo, P.

• Pharmaceutica Acta Helvetiae 74 (1999) 73-73

Efficient Synthesis of Enantiomerically Pure Thioester Precursors of [¹¹C] MCN-5652 from Racemic MCN-5652

Zessin, J.; Gucker, P.; Ametamey, S. M.; Steinbach, J.; Brust, P.; Vollenweider, T. X.; Johannsen, B.; Schubiger, P. A.

• J. Labelled Cpd. Radiopharm. 42 (1999) 1301-1312

Radioligands for the Study of the 5-HT Transporter in Vivo

Brust, P.; Scheffel, U.; Szabo, Z.

• IDrugs 1999 Vol 2 No 2 , Review Radioligands 129-145

TROTEC-1 a new high affinity ligand for Labeling of the dopamine transporter

Hoepping, A.; Reisgys, M.; Brust, P.; Seifert, S.; Spies, H.; Alberto, R.; Johannsen, B.

• Journal of Medicinal Chemistry, 41(23) (1998) 4429-4432

Differentiation Between Specific and Nonspecific Effects Related to P-Glycoprotein Inhibition in Immortalized Rat Brain Endothelial Cells

Bergmann, R.; Brust, P.; Johannsen, B.

• International Journal of Clinical Pharmacology and Therapeutics, Vol. 36, No. 1, 1998 (46-49)

Simultaneous Measurement of ¹⁸F-FDOPA Metabolism and Cerebral Blood Flow in Newborn Piglets

Brust, P.; Bauer, R.; Walter, B.; Bergmann, R.; Füchtner, F.; Vorwieger, G.; Steinbach, J.; Johannsen, B.; Zwiener, U.

• Int. J. Devl. Neuroscience, Vol. 16, No. 5, pp 353-364, 1998
  DOI: 10.1016/S0736-5748(98)00017-3
  Cited 13 times in Scopus

Novel Rhenium Complexes Derived from ALPHA-Tropanol as Potential Ligands for the Dopamin Transporter

Hoepping, A.; Brust, P.; Berger, R.; Leibnitz, P.; Spies, H.; Machill, S.; Scheller, D.; Johannsen, B.

• Bioorganic & Medicinal Chemistry 6 (1998) 1663-1672
  DOI: 10.1016/S0968-0896(98)00144-8
  Cited 11 times in Scopus

Different response of cerebral and non-cerebral endothelial cells to cytotoxic hypoxia

Ahlemeyer, B.; Brust, P.; Johannsen, B.

• Neurochem. Int. 31 (1997) 39-44

Structural modification of receptor binding 99m-Tc complexes in order to improve brain uptake

Johannsen, B.; Berger, R.; Brust, P.; Pietzsch, H.-J.; Scheunemann, M.; Seifert, S.; Spies, H.; Syhre, R.

• European Journal of Nuclear Medicine 24 (1997) 3 pp. 316-319

High-affinity binding of [3H]paroxetine to caudate nucleus and microvessels from porcine brain

Brust, P.; Bergmann, R.; Johannsen, B.

• NeuroReport 7 (1996) pp. 1405-1408
  DOI: 10.1097/00001756-199605310-00016
  Cited 9 times in Scopus

Technetium(V) and Rhenium(V) Complexes for 5-HT2A Serotonin Receptor Binding: Structure-Affinity Considerations

Johannsen, B.; Scheunemann, M.; Spies, H.; Brust, P.; Wober, J.; Syhre, R.; Pietzsch, H.-J.

• Journal of Nuclear Medicine and Biology 23 (1996) 429-438
  DOI: 10.1016/0969-8051(96)00015-7
  Cited 61 times in Scopus

Specific binding of (3H)imipramine indicates the presence of a specific serotonin transport system on endothelial cells of porcine brain

Brust, P.; Bergmann, R.; Johannsen, B.

• Neuroscience Letters 194 (1995) 21-24
  DOI: 10.1016/0304-3940(95)11709-6
  Cited 10 times in Scopus

Evaluation of Radioselenium Labeled Selenomethionine, a Potential Tracer for Brain Protein Synthesis by PET

Bergmann, R.; Brust, P.; Kampf, G.; Coenen, H. H.; Stöcklin, G.

• J. Nucl. Med. Biol. 22 (1995) 475-481
  DOI: 10.1016/0969-8051(94)00123-2
  Cited 17 times in Scopus

Characterization of serotonin uptake sites on the blood brain barrier

Brust, P.; Bergmann, R.

• Journal of Neurochemistry 63 (1994) (Suppl. 1) S13C

Compartmental analysis of blood brain transfer and protein incorporation of L-[75Se]seleno methionine in rat brain

Bergmann, R.; Brust, P.; Coenen, H. H.; Stöcklin, G.

• Journal of Neurochemistry 63 (1994) (Suppl. 1) S78C

Developmental changes of enzymes involved in peptide degradation in isolated rat brain microvessels

Brust, P.; Bech, A.; Kretzschmar, R.; Bergmann, R.

• Peptides 15 (1994) 6 pp. 1085-1088
  DOI: 10.1016/0196-9781(94)90074-4
  Cited 16 times in Scopus