Publications of Institute of Radiopharmaceutical Cancer Research

149 Publications

2017

Maternal immune activation results in complex microglial transcriptome signature in the adult offspring that is reversed by minocycline treatment
Mattei, D.; Ivanov, A.; Ferrai, C.; Jordan, P.; Guneykaya, D.; Buonfiglioli, A.; Schaafsma, W.; Przanowski, P.; Deuther-Conrad, W.; Brust, P.; Hesse, S.; Patt, M.; Sabri, O.; Ross, T. L.; Eggen, B. J. L.; Bodecke, E. W. G. M.; Kaminska, B.; Beule, D.; Pombo, A.; Kettenmann, H.; Wolf, S. A.

PET Imaging Evaluation of Four sigma1 Radiotracers in Nonhuman Primates
Baum, E.; Cai, Z.; Bois, F.; Holden, D.; Lin, S.-F.; Lara-Jaime, T.; Kapinos, M.; Chen, Y.; Deuther-Conrad, W.; Fischer, S.; Dukic-Stefanovic, S.; Bunse, P.; Wünsch, B.; Brust, P.; Jia, H.; Huang, Y.
  • Open Access LogoJournal of Nuclear Medicine 58(2017)6, 982

1‑(4‑[18F]Fluorobenzyl)-4-[(tetrahydrofuran-2-yl)methyl]piperazine: A Novel Suitable Radioligand with Low Lipophilicity for Imaging σ1 Receptors in the Brain
He, Y.; Xie, F.; Ye, J.; Deuther-Conrad, W.; Cui, B.; Wang, L.; Lu, J.; Steinbach, J.; Brust, P.; Huang, Y.; Lu, J.; Jia, H.

18F-Labeled indole-based analogs as highly selective radioligands for imaging sigma-2 receptors in the brain
Wang, L.; Ye, J.; He, Y.; Deuther-Conrad, W.; Zhang, J.; Zhang, X.; Cui, M.; Steinbach, J.; Huang, Y.; Brust, P.; Jia, H.

Synthesis and in vitro evaluation of 5-substituted benzovesamicol analogs containing N-substituted amides as potential positron emission tomography tracers for the vesicular acetylcholine transporter
Roslin, S.; de Rosa, M.; Deuther-Conrad, W.; Eriksson, J.; Odell, L. R.; Antoni, G.; Brust, P.; Larhed, M.

Radiosynthesis of (S)-[18F]T1: The first PET radioligand for molecular imaging of α3β4 nicotinic acetylcholine receptors
Sarasamkan, J.; Fischer, S.; Deuther-Conrad, W.; Ludwig, F.-A.; Scheunemann, M.; Arunrungvichian, K.; Vajragupta, O.; Brust, P.

Do spiroindolines have the potential to replace vesamicol as lead compound for the development of radioligands targeting the vesicular acetylcholine transporter?
Lindemann, M.; Deuther-Conrad, W.; Moldovan, R.; Sekhar, K. V. G. C.; Brust, P.; Wenzel, B.

Development of highly affine and selective fluorinated cannabinoid receptor type 2 ligands
Moldovan, R.-P.; Hausmann, K.; Deuther-Conrad, W.; Brust, P.

Development of Fluorinated Non-Peptidic Ghrelin Receptor Ligands for Potential Use in Molecular Imaging
Moldovan, R.-P.; Els-Heindl, S.; Worm, D. J.; Kniess, T.; Kluge, M.; Beck-Sickinger, A. G.; Deuther-Conrad, W.; Krügel, U.; Brust, P.

PET Imaging of α7 Nicotinic Acetylcholine Receptors: A comparative study of [18F]ASEM and [18F]DBT-10 in non-human primates, and further evaluation of [18F]ASEM in humans
Hillmer, A. T.; Li, S.; Zheng, M.-Q.; Scheunemann, M.; Lin, S.-F.; Nabulsi, N.; Holden, D.; Pracitto, R.; Labaree, D.; Ropchan, J.; Teodoro, R.; Deuther-Conrad, W.; Esterlis, I.; Cosgrove, K. P.; Carson, R. E.; Brust, P.; Huang, Y.

Suppressed Fat Appetite after Roux-en-Y Gastric Bypass Surgery Associates with Reduced Brain µ-opioid Receptor Availability in Diet-Induced Obese Male Rats
Hankir, M.; Patt, M.; Patt, J.; Becker, G.; Rullmann, M.; Kranz, M.; Deuther-Conrad, W.; Schichke, K.; Seyfried, F.; Brust, P.; Hesse, S.; Sabri, O.; Krügel, U.; Fenske, W.

Synthesis and in vitro evaluation of new fluorinated quinoline derivatives with high affinity for PDE5: Towards the development of new PET neuroimaging probes
Liu, J.; Maisonial-Besset, A.; Wenzel, B.; Canitrot, D.; Baufond, A.; Chezal, J. M.; Brust, P.; Moreau, E.

Gender Differences in Neural Networks for Color Processing in Mice: A PET/MR Study
Njemanze, P. C.; Kranz, M.; Amend, M.; Wehrl, H.; Brust, P.

Dissociation between brown adipose tissue 18F-FDG uptake and thermogenesis in uncoupling protein deficient mice
Hankir, M. K.; Kranz, M.; Keipert, S.; Andreasen, S.; Kern, M.; Patt, M.; Klöting, N.; Hesse, S.; Brust, P.; Jastroch, M.; Fenske, W. K.

Synthesis and Preliminary Biological Evaluation of Indol-3-yl-oxoacetamides as Potent Cannabinoid Receptor Type 2 Ligands
Moldovan, R.-P.; Deuther-Conrad, W.; Horti, A. G.; Brust, P.

Gastric Bypass Surgery Recruits a Gut – Striatal Dopamine Pathway to Reduce Fat Appetite in Obese Rats
Hankir, M. K.; Seyfried, F.; Hintschich, C. A.; Diep, T. A.; Kleberg, K.; Kranz, M.; Deuther-Conrad, W.; Tellez, L. A.; Rullmann, M.; Patt, M.; Teichert, S.; Sabri, O.; Brust, P.; Hansen, H. S.; de Araujo, I. E.; Krügel, U.; Fenske, W. K.

Radiosynthesis and biological evaluation of the new PDE10A radioligand [18F]AQ28A
Wagner, S.; Teodoro, R.; Deuther-Conrad, W.; Kranz, M.; Scheunemann, M.; Fischer, S.; Wenzel, B.; Egerland, U.; Hoefgen, N.; Steinbach, J.; Brust, P.
  • Open Access LogoJournal of Labelled Compounds and Radiopharmaceuticals 60(2017)1, 36-48
    DOI: 10.1002/jlcr.3471

2016

Targetting microglia activation in schizophrenia by minocycline treatment
Mattei, D.; Ivanov, A.; Ferrai, G.; Jordan, P.; Guneykaya, D.; Schaafsma, W.; Przanowski, P.; Deuther-Conrad, W.; Brust, P.; Hesse, S.; Eggen, B.; Bodekke, E.; Kaminska, B.; Pombo, A.; Kettenmann, H.; Wolf, S. A.
  • Lecture (Conference)
    29th ECNP Congress, 17.-20.09.2016, Vienna, Österreich
  • European Neuropsychopharmacology 26(2016), 134

Evaluation of the enantiomer specific biokinetics and radiation doses of [18-F]-fluspidine – a new tracer in clinical translation for imaging of σ1 receptors
Kranz, M.; Sattler, B.; Wüst, N.; Deuther-Conrad, W.; Patt, M.; Meyer, P. M.; Fischer, S.; Donat, C. K.; Wünsch, B.; Hesse, S.; Steinbach, J.; Brust, P.; Sabri, O.

Synthesis and evaluation of a 18F-labeled 4-phenylpiperidine-4-carbonitrile radioligand for σ1 receptor imaging
Ye, J.; Wang, X.; Deuther-Conrad, W.; Zhang, J.; Li, J.; Zhang, X.; Wang, L.; Steinbach, J.; Brust, P.; Jia, H.
  • Open Access LogoJournal of Labelled Compounds and Radiopharmaceuticals (2016), 332-339
    DOI: 10.1002/jlcr.3408

Tos-Nos-Mos: Synthesis of different aryl sulfonate precursors for the radiosynthesis of the alpha7 nicotinic acetylcholine receptor radioligand [18F]NS14490
Rötering, S.; Scheunemann, M.; Günther, R.; Löser, R.; Hiller, A.; Peters, D.; Brust, P.; Fischer, S.; Steinbach, J.

Radiation dosimetry of the α4β2 nicotinic receptor ligand (+)-[18F]Flubatine, comparing preclinical PET/MRI and PET/CT to first-in-human PET/CT results
Kranz, M.; Sattler, B.; Tiepolt, S.; Wilke, S.; Deuther-Conrad, W.; Donat, C.; Fischer, S.; Patt, M.; Schildan, A.; Patt, J.; Smits, R.; Hoepping, A.; Steinbach, J.; Sabri, O.; Brust, P.

Novel radioligands for cyclic nucleotide phosphodiesterase imaging with positron emission tomography: An update on developments since 2012
Schröder, S.; Wenzel, B.; Deuther-Conrad, W.; Scheunemann, M.; Brust, P.

Varying Chirality Across Nicotinic Acetylcholine Receptor Subtypes: Selective Binding of Quinuclidine Triazole Compounds
Sarasamkan, J.; Scheunemann, M.; Apaijai, N.; Palee, S.; Parichatikanond, W.; Arunrungvichian, K.; Fischer, S.; Chattipakorn, S.; Deuther-Conrad, W.; Schüürmann, G.; Brust, P.; Vajragupta, O.

Comparison of in silico, electrochemical, in vitro and in vivo metabolism of a homologous series of (radio)fluorinated sigma1 receptor ligands designed for positron emission tomography
Wiese, C.; Große Maestrup, E.; Galla, F.; Schepmann, D.; Hiller, A.; Fischer, S.; Ludwig, F. A.; Deuther-Conrad, W.; Donat, C. K.; Brust, P.; Büter, L.; Karst, U.; Wünsch, B.

Beta-Amyloid-PET-Bildgebung des Gehirns - DGN-Handlungsempfehlung
Barthel, H.; Meyer, P. T.; Drzezga, A.; Bartenstein, P.; Boecker, H.; Brust, P.; Buchert, R.; Coenen, H. H.; Fougère, C. L.; Gründer, G.; Grünwald, F.; Krause, B. J.; Kuwert, T.; Schreckenberger, M.; Tatsch, K.; Langen, K. J.; Sabri, O.

99mTc-Cyclopentadienyl Tricarbonyl Chelate-Labeled Compounds as Selective Sigma‑2 Receptor Ligands for Tumor Imaging
Li, D.; Chen, Y.; Wang, X.; Deuther-Conrad, W.; Chen, X.; Jia, B.; Dong, C.; Steinbach, J.; Brust, P.; Liu, B.; Jia, H.

LC-MS supported Studies on the in vitro Metabolism of both Enantiomers of Flubatine and the in vivo Metabolism of (+)-[18F]Flubatine – a Positron Emission Tomography Radioligand for Imaging α4β2-Nicotinic Acetylcholine Receptors
Ludwig, F.-A.; Smits, R.; Fischer, S.; Donat, C. K.; Hoepping, A.; Brust, P.; Steinbach, J.

Thyroid hormone status defines brown adipose tissue activity and browning of white adipose tissues in mice
Weiner, J.; Kranz, M.; Klöting, N.; Kunath, A.; Steinhoff, K.; Rijntjes, E.; Köhrle, J.; Zeisig, V.; Hankir, M.; Gebhardt, C.; Deuther-Conrad, W.; Heiker, J.; Kralisch, S.; Stumvoll, M.; Bluher, M.; Sabri, O.; Hesse, S.; Brust, P.; Tönjes, A.; Krause, K.

Changes in Binding of [123I]CLINDE, a High-Affinity Translocator Protein 18 kDa (TSPO) Selective Radioligand in a Rat Model of Traumatic Brain Injury
Donat, C. K.; Gaber, K.; Meixensberger, J.; Brust, P.; Pinborg, L. H.; Hansen, H. H.; Mikkelsen, J. D.

Development of a High-Affinity PET Radioligand for Imaging Cannabinoid Subtype 2 Receptor
Moldovan, R.-P.; Teodoro, R.; Deuther-Conrad, W.; Kranz, M.; Wang, Y.; Nakano, M.; Valentine, H.; Fischer, S.; Pomper, M.; Wong, D. F.; Dannals, R. F.; Brust, P.; Horti, A. G.

Development of a new radiofluorinated quinoline analog for PET imaging of phosphodiesterase 5 (PDE5) in brain.
Liu, J.; Wenzel, B.; Dukic-Stefanovic, S.; Teodoro, R.; Ludwig, F.-A.; Deuther-Conrad, W.; Schröder, S.; Chezal, J.-M.; Moreau, E.; Brust, P.; Maisonial-Besset, A.

PET imaging evaluation of [18F]DBT-10, a novel radioligand specific to α7 nicotinic acetylcholine receptors, in nonhuman primates
Hillmer, A. T.; Zheng, M.-Q.; Li, S.; Scheunemann, M.; Lin, S.-F.; Holden, D.; Labaree, D.; Ropchan, J.; Teodoro, R.; Deuther-Conrad, W.; Carson, R. E.; Brust, P.; Huang, Y.

A novel thermoregulatory role for PDE10A in mouse and human adipocytes
Hankir, M.; Kranz, M.; Gnad, T.; Wagner, S.; Deuther-Conrad, W.; Bronisch, F.; Steinhoff, K.; Luthardt, J.; Klöting, N.; Hesse, S.; Seibyl, J.; Blüher, M.; Sabri, O.; Pfeifer, A.; Brust, P.; Fenske, W.

Development of highly potent phosphodiesterase 10A (PDE10A) inhibitors: Synthesis and in vitro evaluation of 1,8-dipyridyl- and 1-pyridinol-substituted imidazo[1,5-a]quinoxalines
Wagner, S.; Scheunemann, M.; Dipper, K.; Egerland, U.; Hoefgen, N.; Steinbach, J.; Brust, P.

On the development of a novel non-peptidic 18F-labeled radiotracer for in vivo imaging of oxytocin receptors with positron emission tomography
Wenzel, B.; Mollitor, J.; Deuther-Conrad, W.; Kranz, M.; Dukic-Stefanovic, S.; Günther, R.; Teodoro, R.; Ludwig, F.-A.; Fischer, S.; Smits, R.; Steinbach, J.; Hoepping, A.; Brust, P.
  • Poster
    ISRS2015 - 21st International Symposium on Radiopharmaceutical Sciences, 26.-31.05.2015, Columbia, Missouri, USA
  • Open Access LogoAbstract in refereed journal
    Journal of Labelled Compounds and Radiopharmaceuticals 58(2015)1, 173
    DOI: 10.1002/jlcr.3302_2
  • Journal of Medicinal Chemistry 59(2016)5, 1800-1817
    DOI: 10.1021/acs.jmedchem.5b01080

2015

18F-Labeled 1,4-Dioxa-8-azaspiro[4.5]decane Derivative: Synthesis and Biological Evaluation of a σ1 Receptor Radioligand with Low Lipophilicity as Potent Tumor Imaging Agent
Xie, F.; Bergmann, R.; Kniess, T.; Deuther-Conrad, W.; Mamat, C.; Neuber, C.; Liu, B.; Steinbach, J.; Brust, P.; Pietzsch, J.; Jia, H.

2-[18F]Fluoroethyl tosylate - a versatile tool for building 18F-based radiotracers for positron emission tomography
Knieß, T.; Laube, M.; Brust, P.; Steinbach, J.

Novel indole-based sigma-2 receptor ligands: synthesis, structure–affinity relationship and antiproliferative activity
Xie, F.; Kniess, T.; Neuber, C.; Deuther-Conrad, W.; Mamat, C.; Liebermann, Brain P.; Liu, B.; Mach, Robert H.; Brust, P.; Steinbach, J.; Pietzsch, J.; Jia, H.

First-in-human PET quantification study of cerebral α4β2* nicotinic acetylcholine receptors using the novel specific radioligand (−)-[18F]Flubatine
Sabri, O.; Becker, G.-A.; Meyer, P. M.; Hesse, S.; Wilke, S.; Graef, S.; Patt, M.; Luthardt, J.; Wagenknecht, G.; Hoepping, A.; Smits, R.; Franke, A.; Sattler, B.; Habermann, B.; Neuhaus, P.; Fischer, S.; Tiepolt, S.; Deuther-Conrad, W.; Barthel, H.; Schönknecht, P.; Brust, P.

A promising PET tracer for imaging of α7 nicotinic acetylcholine receptors in the brain: Design, synthesis, and in vivo evaluation of a dibenzothiophene-based radioligand
Teodoro, R.; Scheunemann, M.; Deuther-Conrad, W.; Wenzel, B.; Colombo, S.; Gotti, C.; Kranz, M.; Donat, C.; Patt, M.; Hillmer, A.; Zheng, M.; Peters, D.; Steinbach, J.; Sabri, O.; Huang, Y.; Brust, P.

Synthesis, 18F-radiolabelling and biological characterization of novel fluoroalkylated triazine derivatives for in vivo imaging of phosphodiesterase 2A in brain via positron emission tomography
Schröder, S.; Wenzel, B.; Deuther-Conrad, W.; Teodoro, R.; Egerland, U.; Kranz, M.; Scheunemann, M.; Höfgen, N.; Steinbach, J.; Brust, P.

New systematically modified vesamicol analogs and their affinity and selectivity for the vesicular acetylcholine transporter – A critical examination of the lead structure.
Barthel, C.; Sorger, D.; Deuther-Conrad, W.; Scheunemann, M.; Schweiger, S.; Jäckel, P.; Roghani, A.; Steinbach, J.; Schüürmann, G.; Sabri, O.; Brust, P.; Wenzel, B.

A high-yield automated radiosynthesis of the alpha-7 nicotinic receptor radioligand [18F]NS10743
Teodoro, R.; Wenzel, B.; Oh-Nishi, A.; Fischer, S.; Peters, D.; Suhara, T.; Deuther-Conrad, W.; Brust, P.

Convenient recycling and reuse of bombarded [18O]H2O for the production and the application of [18F]F
Rötering, S.; Franke, K.; Zessin, J.; Brust, P.; Füchtner, F.; Fischer, S.; Steinbach, J.

2014

Internal Dose Assessment of (-)-18F-Flubatine, Comparing Animal Model Datasets of Mice and Piglets with First-in-Human Results
Sattler, B.; Kranz, M.; Starke, A.; Wilke, S.; Donat, C. K.; Deuther-Conrad, W.; Patt, M.; Schildan, A.; Patt, J.; Smits, R.; Hoepping, A.; Schoenknecht, P.; Steinbach, J.; Brust, P.; Sabri, O.

Synthesis and evaluation of a 18F-labeled spirocyclic piperidine derivative as promising σ1 receptor imaging agent
Chen, Y.-Y.; Wang, X.; Zhang, J.-M.; Deuther-Conrad, W.; Zhang, X.-J.; Huang, Y.; Li, Y.; Ye, J.-J.; Cui, M.-C.; Steinbach, J.; Brust, P.; Liu, B.-L.

Novel Cyclopentadienyl Tricarbonyl 99mTc Complexes Containing 1‑Piperonylpiperazine Moiety: Potential Imaging Probes for Sigma‑1 Receptors
Wang, X.; Li, D.; Deuther-Conrad, W.; Lu, J.; Xie, Y.; Jia, B.; Cui, M.; Steinbach, J.; Brust, P.; Liu, B.; Jia, H.

Adenosine activates brown adipose tissue and recruits beige adipocytes via A2A receptors
Gnad, T.; Scheibler, S.; von Kügelgen, I.; Scheele, C.; Kilic, A.; Glöde, A.; Hoffmann, L.; Reverte, L.; Horn, P.; Mutlu, S.; El-Tayeb, A.; Kranz, M.; Deuther-Conrad, W.; Brust, P.; Lidell, M.; Betz, M.; Enerbäck, S.; Schrader, J.; Yegutkin, G.; Mueller, C.; Pfeifer, A.

Evaluation of metabolism, plasma protein binding and other biological parameters after administration of (−)-[18 F]Flubatine in humans
Patt, M.; Becker, G. A.; Grossmann, U.; Habermann, B.; Schildan, A.; Wilke, S.; Deuther-Conrad, W.; Graefe, S.; Fischer, S.; Smits, R.; Wagenknecht, G.; Steinbach, J.; Gertze, H.-J.; Hesse, S.; Schönknecht, P.; Brust, P.; Sabri, O.

Imaging of α7 nicotinic acetylcholine receptors in brain and cerebral vasculature of juvenile pigs with [18F]NS14490
Rötering, S.; Deuther-Conrad, W.; Cumming, P.; Donat, C. K.; Scheunemann, M.; Fischer, S.; Xiong, G.; Steinbach, J.; Peters, D.; Sabri, O.; Bucerius, J.; Brust, P.

Early increase of cannabinoid receptor density after experimental traumatic brain injury in the newborn piglet
Donat, C. K.; Fischer, F.; Walter, B.; Deuther-Conrad, W.; Brodhun, M.; Bauer, R.; Brust, P.
  • Open Access LogoActa Neurobiologiae Experimentalis 74(2014), 197-210

Distinctive In Vivo Kinetics of the New Sigma1 Receptor Ligands (R)-(+) and (S)-(-)- 18F-Fluspidine in Porcine Brain
Brust, P.; Deuther-Conrad, W.; Becker, G.; Patt, M.; Dont, C. K.; Stittsworth, S.; Fischer, S.; Hiller, A.; Wenzel, B.; Dukic-Stefanovic, S.; Hesse, S.; Steinbach, J.; Wünsch, B.; Lever, S. Z.; Sabri, O.

Asymmetric Synthesis of Spirocyclic 2-Benzopyrans for Positron Emission Tomography of σ1 Receptors in the Brain
Holl, K.; Schepmann, D.; Fischer, S.; Ludwig, F. A.; Hiller, A.; Donat, C. K.; Deuther-Conrad, W.; Brust, P.; Wünsch, B.

Synthesis and biological evaluation of both enantiomers of [18F]flubatine, promising radiotracers with fas kinetics for the imaging of α4β2-nicotinic acetylcholine receptors
Smits, R.; Fischer, S.; Hiller, A.; Deuther-Conrad, W.; Wenzel, B.; Patt, M.; Cumming, P.; Steinbach, J.; Sabri, O.; Brust, P.; Hoepping, A.

Development of 18F-labeled radiotracers for neuroreceptor imaging with positron emission tomography
Brust, P.; van den Hoff, J.; Steinbach, J.

Hydroxyalkylation with Cyclic Sulfates: Synthesis of Carbazole Derived CB2 Ligands with Increased Polarity
Lueg, C.; Galla, F.; Frehland, B.; Schepmann, D.; Daniliuc, C. G.; Deuther-Conrad, W.; Brust, P.; Wünsch, B.

Automation of the radiosynthesis and purification procedures for [18F]Fluspidine preparation, a new radiotracer for clinical investigations in PET imaging of σ1 receptors in brain.
Maisonial-Besset, A.; Funke, U.; Wenzel, B.; Fischer, S.; Holl, K.; Wünsch, B.; Steinbach, J.; Brust, P.

Molecular Imaging of σ1 Receptors In Vivo: Current Status and Perspectives
Brust, P.; Deuther-Conrad, W.; Lehmkuhl, K.; Jia, H.; Wünsch, B.

Fluorine containing 6,7-dialkoxybiaryl-based inhibitors for phosphodiesterase 10A: Synthesis and in vitro evaluation of inhibition potency, selectivity and metabolism
Schwan, G.; Asskar, G. B.; Höfgen, N.; Kubicova, L.; Funke, U.; Egerland, U.; Zahn, M.; Nieber, K.; Scheunemann, M.; Sträter, N.; Brust, P.; Briel, D.

2013

Development of fluorinated CB2 receptor agonists for PET studies
Lueg, C.; Schepmann, D.; Günther, R.; Brust, P.; Wünsch, B.

Synthesis, Characterization, and Metabolism Studies of Fluspidine Enantiomers
Holl, K.; Falck, E.; Köhler, J.; Schepmann, D.; Humpf, H.-U.; Brust, P.; Wünsch, B.

Radiofluorination and biological evaluation of N-aryl-oxadiazolyl-propionamides as potential radioligands for PET imaging of cannabinoid CB2 receptors
Teodoro, R.; Moldovan, R.-P.; Lueg, C.; Günther, R.; Donat, C. K.; Ludwig, F.-A.; Fischer, S.; Deuther-Conrad, W.; Wünsch, B.; Brust, P.

Fully automated radiosynthesis of both enantiomers of [18F]Flubatine under GMP conditions for human application
Patt, M.; Schildan, A.; Habermann, B.; Fischer, S.; Hiller, A.; Deuther-Conrad, W.; Wilke, S.; Smits, R.; Hoepping, A.; Wagenknecht, G.; Steinbach, J.; Brust, P.; Sabri, O.

Use of 3-[18F]fluoropropanesulfonyl chloride as prosthetic agent for the radiolabelling of amines: Investigation of precursor molecules, labelling conditions and enzymatic stability of the corresponding sulfonamides
Löser, R.; Fischer, S.; Hiller, A.; Köckerling, M.; Funke, U.; Maisonial, A.; Brust, P.; Steinbach, J.

Synthesis and Evaluation of Novel 18F-Labeled Spirocyclic Piperidine Derivatives as σ1 Receptor Ligands for Positron Emission Tomography Imaging
Li, Y.; Wang, X.; Zhang, J.; Deuther-Conrad, W.; Xie, F.; Zhang, X.; Liu, J.; Qiao, J.; Cui, M.; Steinbach, J.; Brust, P.; Liu, B.; Jia, H.

A fluoro versus a nitro derivative - a high-performance liquid chromatography study of two basic analytes with different RP and silica phases as basis for the separation of a positron emission tomography radiotracer
Wenzel, B.; Günther, R.; Brust, P.; Steinbach, J.

Resistance of brain glucose metabolism to thiopental-induced CNS depression in newborn piglets
Bernd, W.; Eiselt, M.; Cumming, P.; Xiong, G.; Hinz, R.; Uthe, S.; Brust, P.; Bauer, R.

Radiosynthesis and first evaluation in mice of [18F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors
Rötering, S.; Scheunemann, M.; Fischer, S.; Hiller, A.; Peters, D.; Deuther-Conrad, W.; Brust, P.

Synthesis and biological evaluation of 18F labeled fluoro-oligo-ethoxylated 4-benzylpiperazine derivatives for sigma-1 receptor imaging
Wang, X.; Li, Y.; Deuther-Conrad, W.; Xie, F.; Chen, X.; Cui, M.-C.; Zhang, X.-J.; Zhang, J.-M.; Steinbach, J.; Brust, P.; Liu, B.-L.; Jia, H.-M.

Leitlinie für die Hirnperfusions-SPECT mit Tc-99m Radiopharmaka / Hirnperfusions-SPECT with 99mTc-labelled Radiopharmaceuticals DGN-Guidance (S1 Guideline)
Kranert, T.; Menzel, C.; Bartenstein, P.; Brust, P.; Coenen, H. H.; Krause, B. J.; Kuwert, T.; Sabri, O.; Schreckenberger, M.; Tatsch, K.; Grünwald, F.

Radiosynthesis of racemic and enantiomerically pure (–)-[18F]flubatine – A promising PET radiotracer for neuroimaging of α4β2 nicotinic acetylcholine receptors
Fischer, S.; Hiller, A.; Smits, R.; Hoepping, A.; Funke, U.; Wenzel, B.; Cumming, P.; Sabri, O.; Steinbach, J.; Brust, P.

Design, synthesis, and preliminary in vitro and in vivo pharmacological evaluation of 4-{4-[2-(4-(2-substitutedquinoxalin-3-yl)piperazin-1-yl)ethyl]phenyl}thiazoles as atypical antipsychotic agents
Chandra Sekhar, K. V. G.; Rao, V. S.; Deuther-Conrad, W.; Sridhar, D.; Nagesh, H. N.; Kumar, V. S.; Brust, P.; Kumar, M. M. K.

2012

Synthesis and biological evaluation of a novel Tc-99m cyclopentadienyl tricarbonyl complex ([(Cp-R)Tc-99m(CO)(3)]) for sigma-2 receptor tumor imaging
Chen, X.; Cui, M. C.; Deuther-Conrad, W.; Tu, Y. F.; Ma, T.; Xie, Y.; Jia, B.; Li, Y.; Xie, F.; Wang, X.; Steinbach, J.; Brust, P.; Liu, B. L.; Jia, H. M.

Cannabinoid Receptor Type 2 (CB2) Selective N-Aryl-oxadiazolyl-propionamides: Synthesis, Radiolabeling, Molekular Modelling and Biological Evaluation
Rühl, T.; Deuther-Conrad, W.; Fischer, S.; Günther, R.; Hennig, L.; Krautscheid, P.; Brust, P.

Pyrrolovesamicols - Synthesis, structure and VAChT binding of two 4-fluorobenzoyl regioisomers
Wenzel, B.; Li, Y.; Kraus, W.; Sorger, D.; Sabri, O.; Brust, P.; Steinbach, J.

Imaging of the brain serotonin transporters (SERT) with 18F-labelled fluoromethyl-McN5652 and PET in humans
Hesse, S.; Brust, P.; Mäding, P.; Becker, G.-A.; Seese, A.; Patt, M.; Sorger, D.; Zessin, J.; Sacher, J.; Lobsien, D.; Habermann, B.; Meyer, P. M.; Füchtner, F.; Luthardt, J.; Bresch, A.; Steinbach, J.; Sabri, O.

Development of radioligands for α7-nAChR imaging with positron emission tomography
Brust, P.; Peters, D.; Deuther-Conrad, W.

Synthesis, radiofluorination and pharmacological evaluation of fluoromethyl substituted spirocyclic PET tracers for labeling of σ1 receptors in the central nervous system and comparison with longer homologues
Maisonial, A.; Grosse Maestrup, E.; Wiese, C.; Hiller, A.; Schepmann, D.; Deuther-Conrad, W.; Fischer, S.; Brust, P.; Wünsch, B.

Radiosynthesis and Radiotracer Properties of a 7-(2-[F-18]Fluoroethoxy)-6-methoxy-pyrrolidinylquinazoline for Imaging of Phosphodiesterase 10A with PET
Funke, U.; Deuther-Conrad, W.; Schwan, G.; Maisonial, A.; Scheunemann, M.; Fischer, S.; Hiller, A.; Briel, D.; Brust, P.

2011

Design, synthesis, and preliminary in vitro and in vivo pharmacological evaluation of 2-{4-[4-(2,5-disubstituted thiazol-4-yl)phenylethyl]piperazin-1-yl}-1,8-naphthyridine-3-carbonitriles as atypical antipsychotic agents
Chandra Sekhar, K. V. G.; Rao, V. S.; Deuther-Conrad, W.; Reddy, A. S.; Brust, P.; Kumar, M. M. K.

Leitlinie für PET und SPECT–Untersuchungen von Hirntumoren mit radioaktiv markierten Aminosäuren
Langen, K.-J.; Bartenstein, P.; Brust, P.; Coenen, H. H.; Drzezga, A.; Grünwald, F.; Krause, B. J.; Kuwert, T.; Sabri, O.; Tatsch, K.; Weber, W. A.; Schreckenberger, M.

A 18F-labeled Fluorobutyl-substituted spirocyclic piperidine derivative as a selective radioligand for PET imaging of sigma1 receptors
Maisonial, A.; Große Maestrup, E.; Fischer, S.; Hiller, A.; Scheunemann, M.; Wiese, C.; Schepmann, D.; Steinbach, J.; Deuther-Conrad, W.; Wünsch, B.; Brust, P.

Synthesis and biological evaluation of novel 4-benzylpiperazine ligands for sigma-1 receptor imaging
Li, Z.-J.; Ren, H.-Y.; Cui, M.-C.; Deuther-Conrad, W.; Tang, R.-K.; Steinbach, J.; Brust, P.; Liu, B.-L.; Jia, H.-M.

In vitro binding profile and radiosynthesis of a novel 18F-labeled azaspirovesamicol analog as potential ligand for imaging of the vesicular acetylcholine transporter
Wenzel, B.; Hiller, A.; Fischer, S.; Sorger, D.; Deuther-Conrad, W.; Scheunemann, M.; Brust, P.; Sabri, O.; Steinbach, J.
  • Journal of Labelled Compounds and Radiopharmaceuticals 54(2011), 426-432
    DOI: 10.1002/jlcr.1891

Assessment of alpha 7 nicotinic acetylcholine receptor availability in juvenile pig brain with [18F]NS10743
Deuther-Conrad, W.; Fischer, S.; Hiller, A.; Becker, G.; Cumming, P.; Xiong, G.; Funke, U.; Sabri, O.; Peters, D.; Brust, P.
  • European Journal of Nuclear Medicine and Molecular Imaging 38(2011)8, 1541-1549

Synthesis, pharmacological activity and structure affinity relationships of spirocyclic σ1 receptor ligands with a (2-fluoroethyl) residue in 3-position
Große Maestrup, E.; Wiese, C.; Schepmann, D.; Brust, P.; Wünsch, B.

The serotonin transporter availability in untreated early-onset and late-onset patients with obsessive-compulsive disorder
Hesse, S.; Stengler, K.; Regenthal, R.; Patt, M.; Becker, G.-A.; Franke, A.; Knüpfer, H.; Meyer, P. M.; Luthardt, J.; Jahn, I.; Lobsien, D.; Heinke, W.; Brust, P.; Hegerl, U.; Sabri, O.

Molecular imaging of σ receptors: synthesis and evaluation of the potent σ1 selective radioligand [18F]fluspidine
Fischer, S.; Wiese, C.; Grosse Maestrup, E.; Hiller, A.; Deuther-Conrad, W.; Scheunemann, M.; Schepmann, D.; Steinbach, J.; Wünsch, B.; Brust, P.
  • European Journal of Nuclear Medicine and Molecular Imaging 38(2011)3, 540-551

Traumatic Brain Injury Elicits Similar Alterations in α7 Nicotinic Receptor Density in Two Different Experimental Models
Hoffmeister, P.-G.; Donat, C. K.; Schuhmann, M. U.; Voigt, C.; Walter, B.; Nieber, K.; Meixensberger, J.; Bauer, R.; Brust, P.

Enantioselective σ1 receptor binding and biotransformation of the spirocyclic PET tracer 1’-Benzyl-3-(3-fluoropropyl)-3H-spiro[[2]benzofuran-1,4’-piperidine]
Wiese, C.; Große Maestrup, E.; Schepmann, D.; Grimme, S.; Humpf, H.-U.; Brust, P.; Wünsch, B.

2010

Accessible silanol sites - beneficial for the RP-HPLC separation of constitutional and diastereomeric azaspirovesamicol isomers
Wenzel, B.; Fischer, S.; Brust, P.; Steinbach, J.

Design, Synthesis and Preliminary in vitro and in vivo Pharmacological Evaluation of 2-{4-[4-(2,5-disubstituted thiazolyl)phenylethyl] piperazin-1-yl}-1,8-naphthyridine-3- carbonitriles as Atypical Antipsychotic Agents
Chandra Sekhar, K. V. G.; Rao, V. S.; Deuther-Conrad, W.; Reddy, A. S.; Brust, P.; Kumara, M. M. K.

3D QSAR study, synthesis and in vitro evaluation of (+)-5-FBVM as potential PET radioligand for the Vesicular AcetylCholine Transporter (VAChT)
Kovac, M.; Mavel, S.; Deuther-Conrad, W.; Méheux, N.; Glöckner, J.; Wenzel, B.; Anderluh, M.; Brust, P.; Guilloteau, D.; Emond, P.

Synthesis and biological evaluation of a radioiodinated spiropiperidine ligand as a potential σ1 receptor imaging agent
Chen, R.-Q.; Li, Y.; Zhang, Q.-Y.; Jia, H.-M.; Deuther-Conrad, W.; Schepmann, D.; Steinbach, J.; Brust, P.; Wuensch, B.; Liu, B.-L.
  • Journal of Labelled Compounds and Radiopharmaceuticals 53(2010), 569-574
    DOI: 10.1002/jlcr.1777

Design, Synthesis and in Vitro Biological Evaluation of Reference Compounds of 123I and 99Tcm Labeled Indole Radiotracers for σ2 Receptor Imaging
in Chinese
Li, Y.; Jia, H.-M.; Deuther-Conrad, W.; Brust, P.; Steinbach, J.; Liu, B.-L.
  • Open Access LogoJournal of Nuclear and Radiochemistry 32(2010)2, 132-138

Effects of lateral fluid percussion injury on cholinergic markers in the newborn piglet brain
Donat, C. K.; Walter, B.; Kayser, T.; Deuther-Conrad, W.; Schliebs, R.; Nieber, K.; Bauer, R.; Haertig, W.; Brust, P.

Alterations of cholinergic receptors and the vesicular acetylcholine transporter after lateral fluid percussion injury in newborn piglets
Donat, C. K.; Walter, B.; Deuther-Conrad, W.; Nieber, K.; Brust, R.; Bauer, P.

Novel Indole Derivatives as Potential Imaging Agents for Alzheimer’s Disease
Yu, L.; Scheunemann, M.; Deuther-Conrad, W.; Hiller, A.; Fischer, S.; Sorger, D.; Sabri, O.; Jia, H.; Steinbach, J.; Brust, P.; Liu, B.

Enantioseparation of vesamicol and novel vesamicol analogs by high-performance liquid chromatography on different chiral stationary phases
Wenzel, B.; Fischer, S.; Brust, P.; Steinbach, J.

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