Publications of Institute of Radiopharmaceutical Cancer Research

191 Publications

2024

Alpha-emitting Radionuclides: Current Status and Future Perspectives

Miederer, M.; Benešová-Schäfer, M.; Mamat, C.; Kästner, D.; Pretze, M.; Michler, E.; Brogsitter, C.; Kotzerke, J.; Kopka, K.; Scheinberg, D.; McDevitt, M.

Preparation of HOPO-containing lariate ethers based on the diaza-18-crown-6 scaffold

Paßler, F.; Belke, L.; Reissig, F.; Kopka, K.; Mamat, C.

2023

Equilibrium Thermodynamics of Macropa Complexes with Selected Metal Isotopes of Radiopharmaceutical Interest

Blei, M. K.; Waurick, L.; Reissig, F.; Kopka, K.; Stumpf, T.; Drobot, B.; Kretzschmar, J.; Mamat, C.

Preclinical Characterization of the 177Lu-Labeled Prostate Stem Cell Antigen (PSCA)-Specific Monoclonal Antibody 7F5

Striese, F.; Neuber, C.; Gräßel, S.; Arndt, C.; Ullrich, M.; Steinbach, J.; Pietzsch, J.; Bergmann, R.; Pietzsch, H.-J.; Sihver, W.; Frenz, M.; Feldmann, A.; Bachmann, M.

Involved research facilities

  • PET-Center

Cyclotron-based Production of 67Cu for Radionuclide Theranostics Via the 70Zn(p,α)67Cu Reaction

Brühlmann, S. A.; Walther, M.; Kreller, M.; Reissig, F.; Pietzsch, H.-J.; Knieß, T.; Kopka, K.

The Impact of Nε-Acryloyllysine Piperazides on the Conformational Dynamics of Transglutaminase 2

Heerwig, A.; Kick, A.; Sommerfeld, P.; Eimermacher, S.; Hartung, F.; Laube, M.; Fischer, D.; Pietzsch, H.-J.; Pietzsch, J.; Löser, R.; Mertig, M.; Pietsch, M.; Wodtke, R.

Involved research facilities

  • ZRT

Copper-free click bioconjugation of technetium-99m complexes using strained cyclononyne derivatives

Schlesinger, M.; Jentschel, C.; Pietzsch, H.-J.; Kopka, K.; Mamat, C.

Enzymological characterization of ⁶⁴Cu-labeled neprilysin substrates and their application for modulating the renal clearance of targeted radiopharmaceuticals

Brandt, F.; Ullrich, M.; Wodtke, J.; Kopka, K.; Bachmann, M.; Löser, R.; Pietzsch, J.; Pietzsch, H.-J.; Wodtke, R.

Involved research facilities

  • ZRT

Related publications

Calix[4]crowns with perfluoroalkylsulfonylcarboxamide functions: a complexation approach for heavy group 2 metal ions

Reissig, F.; Bauer, D.; Al-Ameed, K.; Luber, S.; Köckerling, M.; Steinbach, J.; Pietzsch, H.-J.; Mamat, C.

2022

Synthesis and preclinical evaluation of rhenium and technetium-99m “4 + 1” mixed-ligand complexes bearing quinazoline derivatives as potential EGFR imaging agents

Kiritsis, C.; Shegani, A.; Makrypidi, K.; Roupa, I.; Lazopoulos, A.; Panagiotopoulou, A.; Triantopoulou, S.; Paravatou-Petsotas, M.; Pietzsch, H.-J.; Pelecanou, M.; Papadopoulos, M.; Pirmettis, I.

Efficient Production of the PET radionuclide 133La for Theranostic Purposes in Targeted Alpha Therapy using the 134Ba(p,2n)133La Reaction

Brühlmann, S. A.; Kreller, M.; Pietzsch, H.-J.; Kopka, K.; Mamat, C.; Walther, M.; Reissig, F.

Involved research facilities

  • ZRT

Cyclam with a phosphinate-bis(phosphonate) pendant arm is a bone-targeting carrier of copper radionuclides

Pazderová, L.; Benešová, M.; Havlíčková, J.; Vojtíčková, M.; Kotek, J.; Lubal, P.; Ullrich, M.; Walther, M.; Schulze, S.; Neuber, C.; Rammelt, S.; Pietzsch, H.-J.; Pietzsch, J.; Kubíček, V.; Hermann, P.

Modulating the pharmacokinetic profile of Actinium-225-labeled macropa-derived radioconjugates by dual targeting of PSMA and albumin

Reissig, F.; Zarschler, K.; Novy, Z.; Petrik, M.; Bendova, K.; Kurfurstova, D.; Bouchal, J.; Ludik, M.-C.; Brandt, F.; Kopka, K.; Khoylou, M.; Pietzsch, H.-J.; Hajduch, M.; Mamat, C.

Introducing micro physiological systems to evaluate new radiopharmaceuticals: First attempts with radiolabeled cetuximab

Sihver, W.; Nitt-Weber, A.-K.; Behrens, S.; Ullrich, M.; Pietzsch, H.-J.; Namazian Jam, N.; Schmieder, F.; Sonntag, F.

Strained Ammonium Precursors for Radiofluorinations

Reissig, F.; Mamat, C.

“Clickable” albumin binders for modulating the tumor uptake of targeted radiopharmaceuticals

Brandt, F.; Ullrich, M.; Laube, M.; Kopka, K.; Bachmann, M.; Löser, R.; Pietzsch, J.; Pietzsch, H.-J.; van den Hoff, J.; Wodtke, R.

Involved research facilities

  • PET-Center

Related publications

Preparation of calix[4]arenes for chelation of selected divalent cations

Blumberg, M.; Al-Ameed, K.; Eiselt, E.; Luber, S.; Mamat, C.

2021

Molecular Response to Combined Molecular- and External Radiotherapy in Head and Neck Squamous Cell Carcinoma (HNSCC).

Rassamegevanon, T.; Feindt, L.; Koi, L.; Müller, J.; Freudenberg, R.; Löck, S.; Sihver, W.; Çevik, E.; Christel Kühn, A.; von Neubeck, C.; Linge, A.; Pietzsch, H.-J.; Kotzerke, J.; Baumann, M.; Krause, M.; Dietrich, A.

Strategic Evaluation of the Traceless Staudinger Ligation for Radiolabeling with the Tricarbonyl Core

Mamat, C.; Jentschel, C.; Köckerling, M.; Steinbach, J.

Aktuelle Entwicklungen aus den Radiopharmazeutischen Wissenschaften für theranostische Anwendungen - Editorial

Mamat, C.; Kopka, K.

Towards Targeted Alpha Therapy with Actinium 225: Chelators for Mild Condition Radiolabeling and Targeting PSMA – a Proof of Concept Study

Reissig, F.; Bauer, D.; Zarschler, K.; Novy, Z.; Bendova, K.; Kopka, K.; Pietzsch, H.-J.; Petrik, M.; Mamat, C.

Radiotherapy enhances uptake and efficacy of 90Y-cetuximab: A preclinical trial

Dietrich, A.; Andreeff, M.; Koi, L.; Bergmann, R.; Schubert, M.; Schreiner, L.; Löck, S.; Sihver, W.; Freudenberg, R.; Hering, S.; Pietzsch, H.-J.; Steinbach, J.; Kotzerke, J.; Baumann, M.; Krause, M.

Involved research facilities

  • PET-Center

The Impact of Barium Isotopes in Radiopharmacy and Nuclear Medicine – from Past to Presence

Reissig, F.; Kopka, K.; Mamat, C.

Die Bedeutung des Elementes Barium in der Nuklearmedizin

Reissig, F.; Kopka, K.; Mamat, C.

Radiolabelled Cyclic Bisarylmercury: High Chemical and in vivo Stability for Theranostics

Gilpin, I. M.; Ullrich, M.; Wünsche, T.; Zarschler, K.; Lebeda, O.; Pietzsch, J.; Pietzsch, H.-J.; Walther, M.

2020

Recent insights in barium-131 as a diagnostic match for radium-223: cyclotron production, separation, labeling and imaging

Reissig, F.; Bauer, D.; Ullrich, M.; Kreller, M.; Pietzsch, J.; Mamat, C.; Kopka, K.; Pietzsch, H.-J.; Walther, M.

A radiopharmacologist's and radiochemist's view on targeting the Eph/ephrin receptor tyrosine kinase system

Neuber, C.; Belter, B.; Mamat, C.; Pietzsch, J.

Light-Activated Carbon Monoxide Prodrugs Based on Bipyridyl Dicarbonyl Ruthenium(II) Complexes

Geri, S.; Krunclova, T.; Janouskova, O.; Panek, J.; Hruby, M.; Hernandez-Valdes, D.; Probst, B.; Alberto, R.; Mamat, C.; Kubeil, M.; Stephan, H.

Contemporary Synthesis of Ultrasmall (sub-10 nm) Upconverting Nanomaterials

Joshi, T.; Mamat, C.; Stephan, H.

Synthesis, radiolabeling and first biological characterization of 18F-labeled xanthine derivatives for PET imaging of Eph receptors

Pretze, M.; Neuber, C.; Kinski, E.; Belter, B.; Köckerling, M.; Caflisch, A.; Steinbach, J.; Pietzsch, J.; Mamat, C.

Involved research facilities

  • PET-Center

Sub-10 nm Radiolabeled Barium Sulfate Nanoparticles as Carriers for Theranostic Applications and Targeted Alpha Therapy

Reissig, F.; Zarschler, K.; Hübner, R.; Pietzsch, H.-J.; Kopka, K.; Mamat, C.

Formation of calix[4]arenes with acyloxycarboxylate functions

Bauer, D.; Stipurin, S.; Köckerling, M.; Mamat, C.

2019

Introduction of the New Center for Radiopharmaceutical Cancer Research at Helmholtz-Zentrum Dresden-Rossendorf

Kreller, M.; Pietzsch, H.-J.; Walther, M.; Tietze, H.; Kaever, P.; Knieß, T.; Füchtner, F.; Steinbach, J.; Preusche, S.

A comparative evaluation of calix[4]arene-1,3-crown-6 as a ligand for selected divalent cations of radiopharmaceutical interest

Bauer, D.; Blumberg, M.; Köckerling, M.; Mamat, C.

Editorial for special issue "Jörg Steinbach"

Mamat, C.

A 224Ra-labeled polyoxopalladate as putative radiopharmaceutical

Gott, M.; Yang, P.; Kortz, U.; Stephan, H.; Pietzsch, H.-J.; Mamat, C.

Regulation of A375 melanoma cell adhesion and migration by EphB4 and EphrinB2 –insights from co-culture experiments

Neuber, C.; Laube, M.; Mamat, C.; Belter, B.; Pietzsch, J.

  • Journal of Cellular Biotechnology 5(2019)1, 27-42
    DOI: 10.3233/JCB-189011
    ISSN: 2352-3689

Radiochemical and radiopharmacological characterization of a 64Cu-labeled α-MSH analog conjugated with different chelators

Gao, F.; Sihver, W.; Bergmann, R.; Walther, M.; Stephan, H.; Belter, B.; Neuber, C.; Haase-Kohn, C.; Bolzati, C.; Pietzsch, J.; Pietzsch, H.-J.

Involved research facilities

  • PET-Center

Facile preparation of radium-doped, functionalized nanoparticles as carriers for targeted alpha therapy

Reissig, F.; Hübner, R.; Steinbach, J.; Pietzsch, H.-J.; Mamat, C.

2018

Improved Conjugation, 64-Cu Radiolabeling, in Vivo Stability, and Imaging Using Nonprotected Bifunctional Macrocyclic Ligands: Bis(Phosphinate) Cyclam (BPC) Chelators

David, T.; Hlinová, V.; Kubíček, V.; Bergmann, R.; Striese, F.; Berndt, N.; Szöllösi, D.; Hegedus, N.; Mathe, D.; Bachmann, M.; Pietzsch, H.-J.; Hermann, P.

Involved research facilities

  • PET-Center

NMR-based investigations of acyl-functionalized piperazines concerning their conformational behavior in solution

Steinberg, J.; Köckerling, M.; Wodtke, R.; Löser, R.; Mamat, C.

Synthesis, characterization and initial biological evaluation of [⁹⁹ᵐTc]Tc-tricarbonyl labeled DPA-α-MSH peptide derivatives for potential melanoma imaging

Gao, F.; Sihver, W.; Bergmann, R.; Belter, B.; Bolzati, C.; Salvarese, N.; Steinbach, J.; Pietzsch, J.; Pietzsch, H.-J.

Involved research facilities

  • PET-Center

Exploring pitfalls of 64Cu‑labeled EGFR‑targeting peptide GE11 as a potential PET tracer

Striese, F.; Sihver, W.; Gao, F.; Bergmann, R.; Walther, M.; Pietzsch, J.; Steinbach, J.; Pietzsch, H.-J.

Involved research facilities

  • PET-Center

Biodistribution studies of ultrasmall silicon nanoparticles and carbon dots in experimental rats and tumor mice

Licciardello, N.; Hunoldt, S.; Bergmann, R.; Singh, G.; Mamat, C.; Faramus, A.; Ddungu, J. L. Z.; Silvestrini, S.; Maggini, M.; de Cola, L.; Stephan, H.

Involved research facilities

  • PET-Center

Overexpression of receptor tyrosine kinase EphB4 triggers tumor growth and hypoxia in A375 melanoma xenografts: insights from multitracer small animal imaging experiments

Neuber, C.; Belter, B.; Meister, S.; Hofheinz, F.; Bergmann, R.; Pietzsch, H.-J.; Pietzsch, J.

Modified Calix[4]crowns as Molecular Receptors for Barium

Steinberg, J.; Bauer, D.; Reissig, F.; Köckerling, M.; Pietzsch, H.-J.; Mamat, C.

Chelation of heavy group 2 (radio)metals by p-tert-butylcalix[4]arene-1,3-crown-6 and logK determination via NMR

Bauer, D.; Gott, M.; Steinbach, J.; Mamat, C.

Facile Silylation of Cyclitols using Silyl-bis(triflates)

Topp, A.; Köckerling, M.; Reinke, H.; Miethchen, R.; Mamat, C.

Recent Progress using the Staudinger Ligation for Radiolabeling Applications

Mamat, C.; Gott, M.; Steinbach, J.

Involved research facilities

  • PET-Center

Structural and kinetic considerations for the application of the traceless Staudinger ligation to future 18F radiolabeling using XRD and 19F-NMR

Köckerling, M.; Mamat, C.

Involved research facilities

  • PET-Center

2017

Preparation of 18F-labeled building blocks for peptide conjugation using the "minimalist" approach

Omrane, M. A.; Zlatopolskiy, B. D.; Urusova, E.; Mamat, C.; Feni, L.; Neundorf, I.; Neumaier, B.

  • Poster
    22nd International Symposium on Radiopharmaceutical Sciences (ISRS 2017), Dresden, 14.-19.05.2017, Dresden, Deutschland
  • Open Access Logo Journal of Labelled Compounds and Radiopharmaceuticals 60(2017)S1, S261
    DOI: 10.1002/jlcr.3508
    Cited 3 times in Scopus

Evaluation of Ba/Ra Polyoxopalladates for Radiopharmaceutical Applications

Gott, M.; Yang, P.; Kortz, U.; Pietzsch, H.-J.; Steinbach, J.; Mamat, C.

  • Poster
    22nd International Symposium on Radiopharmaceutical Sciences (ISRS 2017), Dresden, 14.-19.05.2017, Dresden, Deutschland
  • Open Access Logo Journal of Labelled Compounds and Radiopharmaceuticals 60(2017)S1, S559
    DOI: 10.1002/jlcr.3508
    Cited 3 times in Scopus

Novel Functionalized Calixarenes as Host Molecules for Complexation with Alkaline Earth Metals

Steinberg, J.; Gott, M.; Pietzsch, H.-J.; Steinbach, J.; Mamat, C.

  • Poster
    22nd International Symposium on Radiopharmaceutical Sciences (ISRS 2017), Dresden, 14.-19.05.2017, Dresden, Deutschland
  • Open Access Logo Journal of Labelled Compounds and Radiopharmaceuticals 60(2017)S1, S488
    DOI: 10.1002/jlcr.3508
    Cited 3 times in Scopus

Detection of Auger Electron Induced Strand Breaks on Plasmid DNA Caused by Technetium-99m Labeled Pyrene Derivatives

Wunderlich, G.; Reissig, F.; Mamat, C.; Pietzsch, H.-J.; Kotzerke, J.; Steinbach, J.

  • Poster
    22nd International Symposium on Radiopharmaceutical Sciences (ISRS 2017), Dresden, 14.-19.05.2017, Dresden, Deutschland
  • Open Access Logo Journal of Labelled Compounds and Radiopharmaceuticals 60(2017)S1, S365
    DOI: 10.1002/jlcr.3508
    Cited 3 times in Scopus

Preparation of a novel radiotracer targeting the EphB4 receptor via radiofluorination using spiro azetidinium salts as precursor

Wiemer, J.; Steinbach, J.; Pietzsch, J.; Mamat, C.

Involved research facilities

  • PET-Center

A novel nanobody-based target module for retargeting of T lymphocytes to EGFR-expressing cancer cells via the modular UniCAR platform

Albert, S.; Arndt, C.; Feldmann, A.; Bergmann, R.; Bachmann, D.; Koristka, S.; Ludwig, F.; Ziller-Walter, P.; Kegler, A.; Gärtner, S.; Schmitz, M.; Ehninger, A.; Cartellieri, M.; Ehninger, G.; Pietzsch, H.-J.; Pietzsch, J.; Steinbach, J.; Bachmann, M.

A novel tumor pretargeting system based on complementary L-configured oligonucleotides

Schubert, M.; Bergmann, R.; Förster, C.; Sihver, W.; Vonhoff, S.; Klussmann, S.; Bethge, L.; Walther, M.; Schlesinger, J.; Pietzsch, J.; Steinbach, J.; Pietzsch, H.-J.

Involved research facilities

  • PET-Center

X-ray Structures of Succinimidyl Halobenzoates

Mamat, C.; Weiss, D.-H.; Köckerling, M.

Involved research facilities

  • PET-Center

2016

New insights into the pretargeting approach to image and treat tumours

Patra, M.; Zarschler, K.; Pietzsch, H.-J.; Stephan, H.; Gasser, G.

Melanoma targeting with [99mTc(N)(PNP3)]-labeled α-melanocyte stimulating hormone peptide analogs: Effects of cyclization on the radiopharmaceutical properties

Carta, D.; Salvarese, N.; Morellato, N.; Gao, F.; Sihver, W.; Pietzsch, H.-J.; Biondi, B.; Ruzza, P.; Refosco, F.; Carpanese, D.; Rosato, A.; Bolzati, C.

Direct and Auger electron-induced, single- and double-strand breaks on plasmid DNA caused by 99mTc-labeled pyrene derivatives and the effect of bonding distance

Reissig, F.; Mamat, C.; Steinbach, J.; Pietzsch, H.-J.; Freudenberg, R.; Kotzerke, J.; Wunderlich, G.

Nuclear and optical dual-labelled imaging agents: Design and challenges

Singh, G.; Gott, M.; Pietzsch, H.-J.; Stephan, H.

  • Open Access Logo Nuklearmedizin 55(2016)2, 41-50

Synthesis, dynamic NMR characterization and XRD studies of novel N,N’-substituted piperazines for bioorthogonal labeling

Mamat, C.; Pretze, M.; Gott, M.; Köckerling, M.

Involved research facilities

  • PET-Center

The Radiochemical and radiopharmaceutical applications of radium

Gott, M.; Steinbach, J.; Mamat, C.

Radiopharmacological characterization of 64Cu-labeled α-MSH analogs for potential use in imaging of malignant melanoma

Gao, F.; Sihver, W.; Jurischka, C.; Bergmann, R.; Haase-Kohn, C.; Belter, B.; Steinbach, J.; Carta, D.; Bolzati, C.; Calderan, A.; Pietzsch, J.; Pietzsch, H.-J.

2015

Cyclam Derivatives with a Bis(phosphinate) or a Phosphinato−Phosphonate Pendant Arm: Ligands for Fast and Efficient Copper(II) Complexation for Nuclear Medical Applications

David, T.; Kubićek, V.; Gutten, O.; Lubal, P.; Kotek, J.; Pietzsch, H.-J.; Rulíśek, L.; Hermann, P.

18F-Labeled 1,4-Dioxa-8-azaspiro[4.5]decane Derivative: Synthesis and Biological Evaluation of a σ1 Receptor Radioligand with Low Lipophilicity as Potent Tumor Imaging Agent

Xie, F.; Bergmann, R.; Kniess, T.; Deuther-Conrad, W.; Mamat, C.; Neuber, C.; Liu, B.; Steinbach, J.; Brust, P.; Pietzsch, J.; Jia, H.

Involved research facilities

  • PET-Center

Methods to increase the metabolic stability of 18F-radiotracers

Kuchar, M.; Mamat, C.

Involved research facilities

  • PET-Center

In vivo Demonstration of an Active Tumor Pretargeting Approach with Peptide Nucleic Acid Bioconjugates as Complementary System

Leonidova, A.; Foerster, C.; Zarschler, K.; Schubert, M.; Pietzsch, H.-J.; Steinbach, J.; Bergmann, R.; Metzler-Nolte, N.; Stephan, H.; Gasser, G.

Involved research facilities

  • PET-Center

Novel indole-based sigma-2 receptor ligands: synthesis, structure–affinity relationship and antiproliferative activity

Xie, F.; Kniess, T.; Neuber, C.; Deuther-Conrad, W.; Mamat, C.; Liebermann, B. P.; Liu, B.; Mach, R. H.; Brust, P.; Steinbach, J.; Pietzsch, J.; Jia, H.

Involved research facilities

  • PET-Center

Synthesis and Molecular Structure of 2-(Diphenylphosphano) phenyl Benzoate Borane Adduct

Mamat, C.; Köckerling, M.

Development of indazolylpyrimidine derivatives as high-affine EphB4 receptor ligands and potential PET-radiotracers

Ebert, K.; Wiemer, J.; Caballero, J.; Köckerling, M.; Steinbach, J.; Pietzsch, J.; Mamat, C.

Involved research facilities

  • PET-Center

Theranostic mercury: 197(m)Hg with high specific activity for imaging and therapy

Walther, M.; Preusche, S.; Bartel, S.; Wunderlich, G.; Freudenberg, R.; Steinbach, J.; Pietzsch, H.-J.

Involved research facilities

  • PET-Center

Bifunctional Cyclam-Based Ligands with Phosphorus Acid Pendant Moieties for Radiocopper Separation – Thermodynamic and Kinetic Studies

Paúrová, M.; Havlíčková, J.; Pospíšilová, A.; Vetrík, M.; Císařová, I.; Stephan, H.; Pietzsch, H.-J.; Hrubý, M.; Hermann, P.; Kotek, J.

Polyoxometalates - potent and selective ecto-nucleotidase inhibitors

Lee, S.-Y.; Fiene, A.; Li, W.; Hank, T.; Brylev, K.; Fedovrov, V.; Lecka, J.; Haider, A.; Pietzsch, H.-J.; Zimmermann, H.; Sévigny, J.; Kortz, U.; Stephan, H.; Müller, C. E.

Evaluation of Novel Fluorescence Probes for Conjugation Purposes Using the Traceless Staudinger Ligation

Wodtke, R.; König, J.; Pigorsch, A.; Köckerling, M.; Mamat, C.

Involved research facilities

  • PET-Center

2014

Preparation of 4-Halobenzoate Containing Phosphane Based Building Blocks for Labeling Reactions Using the Traceless Staudinger Ligation

Mamat, C.; Köckerling, M.

Involved research facilities

  • PET-Center

X-ray structure of 2-(diphenylphosphano)phenyl-4-(hydroxymethyl)benzoate

Mamat, C.; Flemming, A.; Köckerling, M.

Involved research facilities

  • PET-Center

Assessment of the best N3− donors in preparation of [M(N)(PNP)]-based (M = 99mTc-; 188Re) target-specific radiopharmaceuticals: Comparison among succinic dihydrazide (SDH), N-methyl-S-methyl dithiocarbazate (HDTCZ) and PEGylated N-methyl-S-methyl dithiocarbazate (HO2C-PEG600-DTCZ)

Carta, D.; Jentschel, C.; Thieme, S.; Salvarese, N.; Morellato, N.; Refosco, F.; Ruzza, P.; Bergmann, R.; Pietzsch, H.-J.; Bolzati, C.

Involved research facilities

  • PET-Center

Radiofluorination and first radiopharmacological characterization of a SWLAY peptide-based ligand targeting EphA2

Pretze, M.; Mosch, B.; Bergmann, R.; Steinbach, J.; Pietzsch, J.; Mamat, C.

Involved research facilities

  • PET-Center

Visualizing inflammation activity in rheumatoid arthritis with Tc-99 m Anti-CD4-mAb fragment scintigraphy

Steinhoff, K.; Pierer, M.; Siegert, J.; Pigla, U.; Laub, R.; Hesse, S.; Seidel, W.; Sorger, D.; Seese, A.; Künstler, J.-U.; Pietzsch, H.-J.; Lincke, T.; Rullmann, M.; Emmrich, F.; Sabri, O.

Radiolabeled anti-EGFR-antibody improves local tumor control after external beam radiotherapy and offers theragnostic potential

Koi, L.; Bergmann, R.; Brüchner, K.; Pietzsch, J.; Pietzsch, H.-J.; Krause, M.; Steinbach, J.; Zips, D.; Baumann, M.

Involved research facilities

  • PET-Center

2013

Regioselective Synthesis of Trichloromethyl-Substituted Salicylates and Cyclohexenones by One-Pot Cyclizations of 1,3-Bis(trimethylsilyloxy)buta-1,3-dienes

Reimann, S.; Bunescu, A.; Petrosyana, A.; Sharif, M.; Erfle, S.; Mamat, C.; Ghochikyan, T. V.; Saghyan, A. S.; Spannenberg, A.; Villinger, A.; Langer, P.

Quantitative Structure Property Relationship of logP for Radiopharmaceutical Technetium and Rhenium Complexes by using Molecular Dynamics Calculations

Yoshizuka, K.; Pietzsch, H.-J.; Seifert, S.; Stephan, H.

  • Open Access Logo Solvent Extraction Research and Development 20(2013), 15-27

Recent Trends in Bioorthogonal Click-Radiolabeling Reactions Using Fluorine-18

Pretze, M.; Pietzsch, D.; Mamat, C.

Involved research facilities

  • PET-Center

Condensation of the dianion of ethyl acetoacetate with perfluoroalkyl iodides. Application to the synthesis of 3-perfluoroalkylsalicylic acids

Mamat, C.; Langer, P.

Automated preparation of [18F]AFP and [18F]BFP: Two novel bifunctional 18F-labeling building blocks for Huisgen-click

Pretze, M.; Mamat, C.

Involved research facilities

  • PET-Center

An Efficient Bioorthogonal Strategy Using CuAAC Click Chemistry for Radiofluorinations of SNEW Peptides and the Role of Copper Depletion

Pretze, M.; Kuchar, M.; Bergmann, R.; Steinbach, J.; Pietzsch, J.; Mamat, C.

Involved research facilities

  • PET-Center

Design and Development of 99mTc-‘4 + 1’-Labeled Dextran-Mannose Derivatives as Potential Radiopharmaceuticals for Sentinel Lymph Node Detection

Giglio, J.; Fernandez, S.; Jentschel, C.; Pietzsch, H.-J.; Papadopoulos, M.; Pelecanou, M.; Pirmettis, I.; Paolino, A.; Rey, A.

Ga-68- and Cu-64-Labeled NOTA-Albumin Conjugates for PET Sentinel Lymph Node Imaging

Schiller, E.; Bergmann, R.; Wunderlich, G.; Andreeff, M.; Jacob, A.; Pietzsch, H.-J.

Involved research facilities

  • PET-Center

Synthesis of Short and Versatile Heterobifunctional Linkers for Conjugation Purposes of Bioactive Molecules with (Radio-)Labels

Heldt, J.-M.; Kerzendörfer, O.; Mamat, C.; Starke, F.; Pietzsch, H.-J.; Steinbach, J.

Inactivation of HNSCC Cells by 90Y-Labeled Cetuximab Strictly Depends on the Number of Induced DNA Double-Strand Breaks

Saker, J.; Kriegs, M.; Zenker, M.; Heldt, J.-M.; Eke, I.; Pietzsch, H.-J.; Grénman, R.; Cordes, N.; Petersen, C.; Baumann, M.; Steinbach, J.; Dikomey, E.; Kasten-Pisula, U.

[68Ga]NS3-RGD and [68Ga] Oxo-DO3A-RGD for imaging αvβ3 integrin expression: synthesis, evaluation, and comparison

Knetsch, P. A.; Petrik, M.; Rangger, C.; Seidel, G.; Pietzsch, H.-J.; Virgolini, I.; Decristoforo, C.; Haubner, R.

High specific activity 61Cu via 64Zn(p,α)61Cu reaction at low proton energies

Thieme, S.; Walther, M.; Preusche, S.; Rajander, J.; Pietzsch, H.-J.; Solin, O.; Steinbach, J.

Involved research facilities

  • PET-Center

2012

Cellular and molecular properties of 90Y-labeled cetuximab in combination with radiotherapy on human tumor cells in vitro

Saki, M.; Toulany, M.; Sihver, W.; Zenker, M.; Heldt, J.-M.; Mosch, B.; Pietzsch, H.-J.; Baumann, M.; Steinbach, J.; Rodemann, H. P.

Involved research facilities

  • PET-Center

Fluorine-18-Radiolabeling and Radiopharmacological Characterization of a Benzodioxolylpyrimidine as a Radiotracer Targeting the Receptor Tyrosine Kinase EphB4

Mamat, C.; Mosch, B.; Neuber, C.; Köckerling, M.; Bergmann, R.; Pietzsch, J.

Involved research facilities

  • PET-Center

Synthesis and characterization of novel tetrahedral copper(I) complexes comprising tridentate PNP-aminodiphosphines and tetradentate PN(X)P-substituted aminodiphosphines (X = O, S)

Peruzzo, V.; Pretzsch, C.; Tisato, F.; Porchia, M.; Refosco, F.; Marzano, C.; Gandin, V.; Schiller, E.; Walther, M.; Pietzsch, H.-J.

Synthesis, in vitro and in vivo characterization of novel 99mTc-‘4+1’-labeled 5-nitroimidazole derivatives as potential agents for imaging hypoxia

Giglio, J.; Fernández, S.; Pietzsch, H.-J. D.; Dematteis, S.; Moreno, M.; Pacheco, J. P.; Cerecetto, H.; Rey, A.

Module-assisted preparation of 64Cu with high specific activity

Thieme, S.; Walther, M.; Pietzsch, H.-J.; Henniger, J.; Preusche, S.; Mäding, P.; Steinbach, J.

Involved research facilities

  • PET-Center

Synthesis and Molecular Structure of tert-Butyl 4-(2-tert-butoxy-2-oxoethyl)piperazine-1-carboxylate

Mamat, C.; Flemming, A.; Köckerling, M.

Involved research facilities

  • PET-Center

The Synthesis and Molecular Structure of 2-(4-Methoxybenzyl)-4-nitro-2H-indazole

Ebert, K.; Köckerling, M.; Mamat, C.

Involved research facilities

  • PET-Center

The Molecular Structure of 1,2:5,6-Di-O-isopropylidene-3-O-toluenesulfonyl-a-D-glucofuranose

Mamat, C.; Peppel, T.; Köckerling, M.

2011

Impact of functionalized coligands on the pharmacokinetics of 99mTc(III) ‘4+1’ mixed-ligand complexes conjugated to bombesin

Künstler, J.-U.; Bergmann, R.; Gniazdowska, E.; Kozminski, P.; Walther, M.; Pietzsch, H.-J.

Maleimido-Functionalized NOTA Derivatives as Bifunctional Chelators for Site-Specific Radiolabeling

Förster, C.; Schubert, M.; Pietzsch, H.-J.; Steinbach, J.

Synthesis, characterization and biological evaluation of [188Re(N)(cys∼)(PNP)]+/0 mixed-ligand complexes as prototypes for the development of 188Re(N)-based target-specific radiopharmaceuticals

Thieme, S.; Agostini, S.; Bergmann, R.; Pietzsch, J.; Pietzsch, H.-J.; Carta, D.; Salvarese, N.; Refosco, F.; Bolzati, C.

Involved research facilities

  • PET-Center

Synthesis, structure determination and (radio-) fluorination of novel functionalized phosphanes suitable for the traceless Staudinger ligation

Mamat, C.; Franke, M.; Peppel, T.; Köckerling, M.; Steinbach, J.

Involved research facilities

  • PET-Center

Synthesis and biological evaluation of new [Tc(N)(PS)]-based mixed-ligand compounds useful in design of target-specific radiopharmaceuticas: the 2-methoxyphenylpiperazine dithiocarbamate derivatives as example

Bolzati, C.; Salvarese, N.; Carta, D.; Refosco, F.; Dolmella, A.; Pietzsch, H.-J.; Bergmann, R.; Bandoli, G.

Involved research facilities

  • PET-Center

[18F]1-(3-fluoropropyl)piperazines as model compounds for the radiofluorination of pyrido[2,3-d]pyrimidines

Grosse-Gehling, P.; Wuest, F. R.; Peppel, T.; Köckerling, M.; Mamat, C.

Involved research facilities

  • PET-Center

Cross-Coupling Reactions as Valuable Tool for the Preparation of PET Radiotracers

Pretze, M.; Große-Gehling, P.; Mamat, C.

Involved research facilities

  • PET-Center

2010

Sugar-decorated dendritic nanocarriers: Encapsulation and release of the octahedral rhenium cluster complex [Re6S8(OH)6]4-

Kubeil, M.; Stephan, H.; Pietzsch, H.-J.; Geipel, G.; Appelhans, D.; Voit, B.; Hoffmann, J.; Brutschy, B.; Mironov, Y. V.; Brylev, K. A.; Fedorov, V. E.

Comparison of the stability of Y-90-, Lu-177- and Ga-68- labeled human serum albumin microspheres (DOTA-HSAM)

Wunderlich, G.; Schiller, E.; Bergmann, R.; Pietzsch, H.-J.

Involved research facilities

  • PET-Center

The traceless Staudinger ligation with fluorine-18: a novel and versatile labeling technique for the synthesis of PET-radiotracers

Pretze, M.; Wuest, F.; Peppel, T.; Köckerling, M.; Mamat, C.

Involved research facilities

  • PET-Center

A novel Dibenzoazacyclooctyne precursor in regioselective Copper-free click chemistry. An innovative 3-step synthesis.

Starke, F.; Walther, M.; Pietzsch, H.-J.

  • Open Access Logo ARKIVOC (2010), 350-359
    ISSN: 1551-7012

Synthesis and Radiofluorination of Iodophenyl Esters as Tool for the Traceless Staudinger Ligation

Pretze, M.; Flemming, A.; Köckerling, M.; Mamat, C.

Involved research facilities

  • PET-Center
  • Zeitschrift für Naturforschung Section B - A Journal of Chemical Sciences 65(2010), 1128-1136

A new hexanuclear rhenium cluster complex with six terminal acetate ligands: Synthesis, structure, and properties of K4[Re6S8(CH3COO)6]·8H2O

Brylev, K. A.; Mironov, Y. V.; Fedorov, V. E.; Kim, S.-J.; Pietzsch, H.-J.; Stephan, H.; Ito, A.; Kitamura, N.

Novel 99mTc '4 + 1' peptide conjugates: Tuning the biodistribution by variation of coligands

Künstler, J.-U.; Seidel, G.; Bergmann, R.; Gniazdowska, E.; Walther, M.; Schiller, E.; Decristoforo, C.; Stephan, H.; Haubner, R.; Steinbach, J.; Pietzsch, H.-J.

Involved research facilities

  • PET-Center

Crystal structure of N-benzyl-4-fluorobenzamide, C14H12FNO, at 173 K

Mamat, C.; Flemming, A.; Köckerling, M.

Efficient preparation of 99mTc(III) ‘4+1’ mixed-ligand complexes for peptide labeling with high specific activity

Künstler, J.-U.; Seidel, G.; Pietzsch, H.-J.

2009

Recent Application of Click Chemistry for the Synthesis of Radiotracers for Molecular Imaging

Mamat, C.; Ramenda, T.; Wuest, F.

  • Mini-Reviews in Organic Chemistry 6(2009), 21-34

NMR Studies and Crystal Structure Determinations of CF3 Group-containing Bicyclic phenolates

Mamat, C.; Reinke, H.; Langer, P.

  • Zeitschrift für Naturforschung Section B - A Journal of Chemical Sciences 64(2009)4, 423-426
    ISSN: 0932-0776

Synthesis and characterization of rhenium and technetium-99m tricarbonyl complexes bearing the 4-[3-bromophenyl]quinazoline moiety as a biomarker for EGFR-TK imaging

Bourkoula, A.; Paravatou-Petsotas, M.; Papadopoulos, A.; Santos, I.; Pietzsch, H.-J.; Livaniou, E.; Pelecanou, M.; Papadopoulos, M.; Pirmettis, I.

Isomerism in tetrahedral rhenium cluster complexes [Re4Q4(PMe2sub>Ph)4X8]·nCH2Cl2 (Q = Se, X = Br; Q = Te, X = Cl, Br).

Efremova, O. A.; Mironov, Y. V.; Brylev, K. A.; Fedorov, V. E.; Pietzsch, H.-J.; Stephan, H.

Synthesis of Benzoate-Functionalized Phosphanes as Novel Building Blocks for the Traceless Staudinger Ligation

Mamat, C.; Flemming, A.; Köckerling, M.; Steinbach, J.; Wuest, F.

Radiosynthesis of New [90Y]-DOTA-Based Maleimide Reagents Suitable for the Prelabeling of Thiol-Bearing L-Oligonucleotides and Peptides

Schlesinger, J.; Fischer, C.; Közle, I.; Vonhoff, S.; Klussmann, S.; Bergmann, R.; Pietzsch, H.-J.; Steinbach, J.

Two Coordination Modes of Bidentate Aminopyrazine Ligands in Cubane-type Cluster Complex Re4Te4Cl8(C4N3H4)4 . 2DMF

Efremova, O. A.; Mironov, Y. V.; Pietzsch, H.-J.; Stephan, H.; Perrin, C.; Fedorov, V. E.

The First Octahedral Cluster Complexes With Terminal Formate Ligands: Synthesis, Structure, and Properties of K4[Re6S8(HCOO)6] and Cs4[Re6S8(HCOO)6]

Brylev, K. A.; Mironov, Y. V.; Kozlova, S. G.; Fedorov, V. E.; Kim, S.-J.; Pietzsch, H.-J.; Stephan, H.; Ito, A.; Ishizaka, S.; Kitamura, N.

Validation of 99mTc-labeled "4+1" fatty acids for myocardial metabolism and flow imaging Part 2: Subcellular distribution

Mirtschink, P.; Stehr, S. N.; Walther, M.; Pietzsch, J.; Bergmann, R.; Pietzsch, H.-J.; Weichsel, J.; Pexa, A.; Dieterich, P.; Wunderlich, G.; Binas, B.; Kropp, J.; Deussen, A.

Validation of 99mTc-labeled "4+1" fatty acids for myocardial metabolism and flow imaging Part 1: Myocardial extraction and biodistribution

Mirtschink, P.; Stehr, S. N.; Walther, M.; Pietzsch, J.; Bergmann, R.; Pietzsch, H.-J.; Weichsel, J.; Pexa, A.; Dieterich, P.; Wunderlich, G.; Binas, B.; Kropp, J.; Deussen, A.

2008

Rhenium and technetium complexes bearing quinazoline derivatives: progress towards a 99mTc biomarker for EGFR-TK imaging

Fernandes, C.; Santos, I. C.; Santos, I.; Pietzsch, H.-J.; Künstler, J.-U.; Kraus, W.; Rey, A.; Margaritis, N.; Bourkoula, A.; Chiotellis, A.; Paravatou-Petsotase, M.; Pirmettis, I.

Yttrium-86-labelled human serum albumin microspheres: relation of surface structure with in vivo stability

Schiller, E.; Bergmann, R.; Pietzsch, J.; Noll, B.; Sterger, A.; Johannsen, B.; Wunderlich, G.; Pietzsch, H.-J.

An 86Y-Labeled Mirror-Image Oligonucleotide: Influence of Y-DOTA Isomers on the Biodistribution in Rats

Schlesinger, J.; Közle, I.; Bergmann, R.; Tamburini, S.; Bolzati, C.; Tisato, F.; Noll, B.; Klussmann, S.; Vonhoff, S.; Wüst, F.; Pietzsch, H.-J.; Steinbach, J.

  • Bioconjugate Chemistry 19(2008), 928-939
    DOI: 10.1021/bc700453h
    Cited 31 times in Scopus
  • Lecture (Conference)
    Turku PET Symposium New Targets in Molecular Imaging, 24.-27.05.2008, Turku, Finland
  • Contribution to proceedings
    Turku PET Symposium New Targets in Molecular Imaging, 24.-27.05.2008, Turku, Finland
    Abstracts of the XI Turku PET Symposium, Kaarina, Finland: Painola, 978-951-29-3563-5, 11

Labeling of Fatty Acid Ligands with the Strong Electrophilic Metal Fragment [99mTc(N)(PNP)]2+ (PNP = Diphosphane Ligand)

Cazzola, E.; Benini, E.; Pasquali, M.; Mirtschink, P.; Walther, M.; Pietzsch, H.-J.; Uccelli, L.; Boschi, A.; Bolzati, C.; Duatti, A.

Modified “4+1” Mixed Ligand Technetium Labeled Fatty Acids for Myocardial Imaging: Evaluation of Myocardial Uptake and Biodistribution

Mirtschink, P.; Stehr, S. N.; Pietzsch, H.-J.; Bergmann, R.; Pietzsch, J.; Wunderlich, G.; Heintz, A. C.; Kropp, J.; Spies, H.; Kraus, W.; Deussen, A.; Walther, M.

2007

Two mononuclear Tc complexes: [2,2′-(3-phenylpropylimino)- and [2,2′-(propylimino)-bis(ethanethiolato)](4-methoxybenzenethiolato)-oxidotechnetate(V)

Emmerling, F.; Kraus, W.; Noll, B.; Noll, S.; Pietzsch, H.-J.

(4-Methoxybenzenethiolato-κS)oxido-[2,2’-propylimino)-bis(ethanethiolato)- κ3S,N,S’]rhenium(V)

Kraus, W.; Emmerling, F.; Noll, B.; Noll, S.; Pietzsch, H.-J.

Myocardial uptake and biodistribution of newly designed technetium-labelled fatty acid analogues

Heintz, A. C.; Jung, C. M.; Stehr, S. N.; Mirtschink, P.; Walther, M.; Pietzsch, J.; Bergmann, R.; Pietzsch, H.-J.; Spies, H.; Wunderlich, G.; Kropp, J.; Deussen, A.

  • Nuclear Medicine Communications 28(2007)8, 637-647
    ISSN: 0143-3636

Cluster Core Controlled Reactions of Substitution of Terminal Bromide Ligands by Triphenylphosphine in Octahedral Rhenium Chalcobromide Complexes

Shestopalov, M. A.; Brylev, K. A.; Kozlova, S. G.; Fedorov, V. E.; Spies, H.; Pietzsch, H.-J.; Stephan, H.; Geipel, G.; Bernhard, G.

  • Journal of the American Chemical Society 129(2007), 3714-3721

Very stable 188Re-S4 chelates for labelling biomolecules, prepared with highly concentrated perrhenate eluates

Seifert, S.; Jentschel, C.; Bergmann, R.; Pietzsch, H.-J.; Wunderlich, G.; Kotzerke, J.; Steinbach, J.

  • Nuklearmedizin 5(2007), 181-184
    ISSN: 0029-5566

Organometallic 99mTc(III) ‘4+1’ Bombesin(7-14) Conjugates: Synthesis, Radiolabeling and In Vitro/In Vivo Studies

Künstler, J.-U.; Veerendra, B.; Figueroa, S. D.; Sieckmann, G. L.; Rold, T. L.; Hoffman, T. J.; Smith, C. J.; Pietzsch, H.-J.

  • Bioconjugate Chemistry 18(2007), 1651-1661

Comparison of in vitro and in vivo properties of 99mTc-cRGD peptides labelled using different novel Tc-cores

Decristoforo, C.; Santos, I.; Pietzsch, H.-J.; Duatti, A.; Smith, C. J.; Rey, A.; Alberto, R.; von Guggenberg, E.; Haubner, R.

  • Quarterly Journal of Nuclear Medicine and Molecular Imaging 51(2007), 33-41

Synthesis and biological evaluation of a new type of 99mTechnetium-labeled fatty acid for myocardial metabolism imaging

Walther, M.; Jung, C.; Bergmann, R.; Pietzsch, J.; Rode, K.; Fahmy, K.; Mirtschink, P.; Stehr, S.; Heintz, A.; Wunderlich, G.; Kraus, W.; Pietzsch, H.-J.; Kropp, J.; Deussen, A.; Spies, H.

  • Bioconjugate Chemistry 18(2007), 216-230
    ISSN: 10.1021/bc0601222

2006

Preparation and Biological Characterization of Isomeric 188Re(V) Oxocomplexes with Tetradentate S4 Ligands Derived from DMSA for Labeling of Biomolecules

Seifert, S.; Heinrich, T.; Jentschel, C.; Smuda, C.; Bergmann, R.; Pietzsch, H.-J.

Bromo(tricarbonyl) (15-{[2-(methylthio-S)ethylthio-S} pentadecanoic acid)rhenium(l)

Kraus, W.; Walther, M.; Jung, C. M.; Emmerling, F.; Pietzsch, H.-J.

Novel and Efficient Preparation of Precursor [188Re(OH2)3(CO)3]+ for the Labeling of Biomolecules

Park, S. H.; Seifert, S.; Pietzsch, H.-J.

  • Bioconjugate Chemistry 17(2006), 223-225

A new molecular mechanics force field for the design of oxotechnetium(V) and oxorhenium(V) radiopharmaceuticals

Comba, P.; Daubinet, A.; Martin, B.; Pietzsch, H.-J.; Stephan, H.

  • Journal of Organometallic Chemistry 691(2006)11, 2495-2502

Octahedral rhenium cluster complexes with inner organic ligands: synthesis, structure and properties of [Re6Q8(3,5-Me2PzH)6]Br2·2(3,5-Me2PzH) (Q = S, Se)

Mironov, Y.; Bryleva, K.; Shestopalova, M.; Yarovoia, S.; Fedorova, V.; Spies, H.; Pietzsch, H.-J.; Stephan, H.; Geipel, G.; Bernhard, G.; Kraus, W.

  • Inorganica Chimica Acta (2006)359, 1129-1134

188Re(III)-EDTA - a Multipurpose Starting Material for the Preparation of Relevant 188Re Complexes under Mild Conditions

Seifert, S.; Pietzsch, H.-J.

  • Applied Radiation and Isotopes 64(2006), 223-227

2005

[Re6Q7O(3,5-Me2PzH)6]Br2·3,5-Me2PzH (Q = S, Se) – new octahedral rhenium cluster complexes with organic ligands: original synthetic approach and unexpected ligand exchange in cluster core

Mironov, Y. V.; Shestopalov, M. A.; Brylev, K. A.; Yarovoi, A. S.; Romanenko, G. V.; Fedorov, V. E.; Spies, H.; Pietzsch, H.-J.; Stephan, H.; Geipel, G.; Bernhard, G.; Kraus, W.

  • European Journal of Inorganic Chemistry (2005), 657-661

{2-Carboxy-2-{bis[(2-thiolato-_S)ethyl]amino-_N}ethanthiolato-_S} (triphenylphosphin-_P)rhenium(III)

Schiller, E.; Kraus, W.; Reck, G.; Spies, H.; Pietzsch, H.-J.

  • Open Access Logo Acta Crystallographica Section E 61(2005), M1373-M1375
    ISSN: 1600-5368

A novel rhenium chelate system derived from dimercaptosuccinic acid for the selective labeling of biomolecules

Heinrich, T.; Kraus, W.; Pietzsch, H.-J.; Smuda, C.; Spies, H.

  • Inorganic Chemistry 44(2005)26, 9930-9937

Disruption of unprecedented B-H...M agostic interactions: An alternative approach for labeling bioactive molecules

Garcia, R.; Paulo, A.; Domingos, A.; Santos, I.; Pietzsch, H.-J.

  • Synthesis and Reactivity in Inorganic, Metal-Organic and Nano-Metal Chemistry 35(2005)1, 35-42

Mixed-Ligand Rhenium-188 Complexes with Tetradentate/Monodentate NS3/P (‘4+1’) Coordination: Relation of structure with antioxidation stability

Schiller, E.; Seifert, S.; Tisato, F.; Refosco, F.; Bolzati, C.; Kraus, W.; Spies, H.; Pietzsch, H.-J.

  • Bioconjugate Chemistry 16(2005), 634-643

[Re6Q7O(3,5-Me2PzH)6]Br2*3,5-Me2PzH (Q = S, Se) - new octahedral rhenium cluster complexes with organic ligands: original synthetic approach and unexpected ligand exchange in cluster core

Mironov, Y. V.; Shestopalov, M. A.; Brylev, K. A.; Yarovoi, S. S.; Romanenko, G.; Fedorov, V. E.; Spies, H.; Pietzsch, H.-J.; Stephan, H.; Geipel, G.; Bernhard, G.; Kraus, W.

  • European Journal of Inorganic Chemistry (2005)4, 657-661

2004

The crucial role of the diphosphine heteroatom X in the stereochemistry and stabilization of the substitution-inert [M(N)(PXP)]2+ metal fragments (M = Tc, Re; PXP = diphosphine ligand)

Tisato, F.; Refosco, F.; Porchia, M.; Bolzati, C.; Bandoli, G.; Dolmella, A.; Duatti, A.; Boschi, A.; Jung, C. M.; Pietzsch, H.-J.; Kraus, W.

  • Inorganic Chemistry 43(2004), 8617-8625

Cyclopentadienyl tricarbonyl complexes of 99mTC for the in vivo imaging of the serotonin 5-HT1A receptor in the brain

Saidi, M.; Kretzschmar, M.; Seifert, S.; Bergmann, R.; Pietzsch, H.-J.

Novel Procedures for Preparing 99mTc(III) Complexes with Tetradentate/Monodentate Coordination of Varying Lipophilicity and Adaptation to 188Re Analogues

Seifert, S.; Künstler, J.-U.; Pietzsch, H.-J.; Pawelke, B.; Bergmann, R.; Spies, H.

Synthesis, Characterization, and Biological Evaluation of Neutral Nitrido Technetium(V) Mixed Ligand Complexes Containing Dithiolates and Aminodiphosphines. A Novel System for Linking Technetium to Biomolecules

Bolzati, C.; Benini, E.; Cazzola, E.; Jung, C.; Tisato, F.; Refosco, F.; Pietzsch, H.-J.; Spies, H.; Uccelli, L.; Duatti, A.

  • Bioconjugate Chemistry 15(2004), 628-637

2003

Aqueous synthesis of derivatized cyclopentadienyl complexes of technetium and rhenium directed towards radiopharmaceutical application

Bernard, J.; Ortner, K.; Spingler, B.; Pietzsch, H.-J.; Alberto, R.

  • Inorganic Chemistry 42 (2003) 1014-1022

Synthesis, characterization and biological evaluation of technetium(III) complexes with tridendate/bidendate S,E,S/P,S coordination (E = O, N(CH3), S): A novel approach to robust technetium chelates suitable for linking the metal to biomolecules

Pietzsch, H.-J.; Seifert, S.; Syhre, R.; Tisato, F.; Refosco, F.; Leibnitz, P.; Spies, H.

  • Bioconjugate Chemistry 14 (2003) 136-143

2002

A novel technetium-99m radioligand for the 5-HT1A receptor derived from desmethyl-WAY-100635 (DWAY)

Heimbold, I.; Drews, A.; Syhre, R.; Kretzschmar, M.; Pietzsch, H.-J.; Johannsen, B.

  • European Journal of Nuclear Medicine 29 (2002) 82-87

Syntheses and first crystal structures of rhenium complexes derived from omega-functionalized fatty acids as model compounds of technetium tracers for myocardial metabolism imaging

Jung, C. M.; Kraus, W.; Leibnitz, P.; Pietzsch, H.-J.; Kropp, J.; Spies, H.

  • European Journal of Inorganic Chemistry (2002) 1219-1225

Synthesis and biological evaluation of technetium(III) mixed-ligand complexes with high affinity for the cerebral 5-HT1A receptor and the alpha1-adrenergic receptor

Drews, A.; Pietzsch, H.-J.; Syhre, R.; Seifert, S.; Varnäs, K.; Hall, H.; Halldin, C.; Kraus, W.; Karlsson, P.; Johnsson, C.; Spies, H.; Johannsen, B.

  • Nuclear Medicine and Biology 29 (2002) 389-398

Development of technetium-99m-based CNS receptor ligands: have there been any advances?

Johannsen, B.; Pietzsch, H.-J.

  • Eur. J. Nucl. Med. 29 (2002) 263-275

Synthesis , biological and autoradiographic evaluation of a novel Tc-99m radioligand derived from WAY 100635 with high-affinity for the 5-HT1A receptor and the alpha1-adrenergic receptor

Heimbold, I.; Drews, A.; Kretzschmar, M.; Varnäs, K.; Hall, H.; Halldin, C.; Syhre, R.; Kraus, W.; Pietzsch, H.-J.; Seifert, S.; Brust, P.; Johannsen, B.

  • Nuclear Medicine and Biology 29 (2002) 375-387

2001

Synthesis and properties of triethyl(triphenyl)siloxyalkyl(aryl)thiolato(3-thiapentane-1,5-dithialato)oxorhenium(V)- potential brain seeking agents

Abedin, M. Z.; Spies, H.; Pietzsch, H.-J.; Zablotskaya, A.

  • Bangladesh Journal of Nuclear Medicine (2001) 1-6.

Reactivity of Technetium(I) Thioether Carbonyl Complexes towards Histidine - An EXAFS Study in Solution

Seifert, S.; Künstler, J.-U.; Gupta, A.; Funke, H.; Reich, T.; Pietzsch, H.-J.; Alberto, R.; Johannsen, B.

  • Inorganica Chimica Acta 322 (2001) 79-86

Mixed-ligand technetium(III) complexes with tetra-dendate/monodendate NS3/isocyanide coordination: A new nonpolar Technetium chelate system for the design of neutral and lipophilic complexes stable in vivo

Pietzsch, H.-J.; Gupta, A.; Syhre, R.; Leibnitz, P.; Spies, H.

  • Bioconjugate Chem. Vol.12 Nr. 4 (2001) 538-544

Synthesis and characterization of novel trigonal-bipyramidal technetium(III) mixed-ligand complexes with SES/S/P coordination (E = O, N(CH3), S)

Pietzsch, H.-J.; Tisato, F.; Refosco, F.; Leibnitz, P.; Drews, A.; Seifert, S.; Spies, H.

  • Inorg. Chem. 40 (2001), 40, 59-64

2000

Glutathione interaction with SNS/S mixed ligand complexes of oxorhenium(V): Kinetic aspects and characterization of the products

Nock, B.; Maina, T.; Tsortos, A.; Pelecanou, M.; Raptopoulou, C. P.; Papadopoulos, M.; Pietzsch, H.-J.; Stassinopoulou, C.; Terzis, A.; Spies, H.; Nounesis, G.; Chiotellis, E.

  • Inorganic Chemistry 39 (2000) 4433-4441

EXAFS Analyses of Technetium(I) Carbonyl Complexes - Stability Studies in Solutions

Seifert, S.; Kuenstler, J.-U.; Gupta, A.; Funke, H.; Reich, T.; Hennig, C.; Rossberg, A.; Pietzsch, H.-J.; Alberto, R.; Johannsen, B.

  • Radiochim. Acta 88 (2000) 239-245

Chemical and biological characterization of technetium(I) and rhenium(I) tricarbonyl complexes with dithioether ligands serving as linkers for coupling the Tc(CO)3 and Re(CO)3 moieties to biologically active molecules

Pietzsch, H.-J.; Gupta, A.; Reisgys, M.; Drews, A.; Seifert, S.; Syhre, R.; Spies, H.; Alberto, R.; Abram, U.; Schubiger, P. A.

  • Bioconjugate Chem. 11 (2000) 414-424

Oxorhenium mixed-ligand complexes with the 2,6-dimercaptomethylpyridine ligand. Crystal structure of [2,6-dimercaptomethylpyridinato][p-methoxybenzenethiolato]oxorhenium(V)

Nock, B.; Pietzsch, H.-J.; Tisato, F.; Maina, T.; Leibnitz, P.; Spies, H.; Chiotellis, E.

  • Inorg. Chim. Acta 304 (2000) 26-32

Stability Studies on 99mTechnetium(III) Complexes with Tridentate/Monodentate Thiol Ligands and Phosphine ("3+1+1" Complexes)

Seifert, S.; Drews, A.; Gupta, A.; Pietzsch, H.-J.; Spies, H.; Johannsen, B.

  • Appl. Radiat. Isot. 53 (2000) 431-438

Assessment of the in vitro and in vivo properties of a 99mTc-labeled inhibitor of the multidrug resistant gene product P-glycoprotein.

Bergmann, R.; Brust, P.; Scheunemann, M.; Pietzsch, H.-J.; Seifert, S.; Roux, F.; Johannsen, B.

  • Nucl. Med. Biol. 27 (2000) 135-141

1999

Study on the formation of mixed ligand oxorhenium and oxotechnetium complexes (SNS/S combination)

Papadopoulos, M.; Pirmettis, I.; Tsoukalas, C.; Nock, B.; Maina, T.; Raptopoulou, C. P.; Terzis, A.; Pietzsch, H.-J.; Friebe, M.; Spies, H.; Johannsen, B.; Chiotellis, E.

  • Inorg. Chim. Acta 295 (1999) 1-8

First Application of fac-[99mTc(OH2)3(CO)3]+ in Bioorganometallic Chemistry: Design, Structure, and in Vitro Affinity of a 5-HT1A Receptor Ligand Labeled with 99mTc

Alberto, R.; Schibli, R.; Schubiger, P. A.; Abram, U.; Pietzsch, H.-J.; Johannsen, B.

  • J. Am. Chem. Soc. 121, 25, 1999, 6076-6077

Synthesis and Autoradiographical Evaluation of a Novel High-Affinity Tc-99m Ligand for the 5-HT2A Receptor

Pietzsch, H.-J.; Scheunemann, M.; Kretzschmar, M.; Elz, S.; Pertz, H. H.; Seifert, S.; Brust, P.; Spies, H.; Syhre, R.; Johannsen, B.

  • Nuclear Medicine and Biology, 26 (1999) 865-875

1998

No Carrier Added Preparations of '3+1' Mixed-Ligand 99mTc Complexes

Seifert, S.; Pietzsch, H.-J.; Scheunemann, M.; Spies, H.; Syhre, R.; Johannsen, B.

1997

Technetium and rhenium complexes with thioether ligands. VI. Synthesis and structural characterization of mixed-ligand oxorhenium(V) complexes containing bidentate dithioethers and monothiolato ligands.

Reisgys, M.; Spies, H.; Johannsen, B.; Leibnitz, P.; Pietzsch, H.-J.

  • Chem. Ber. 130 (1997) 1343-1347

Synthesis of Rhenium(I) and Technetium(I) Carbonyl/Dithioether Ligand Complexes Bearing 3,17-BETA-Estradiol

Reisgys, M.; Wüst, F.; Alberto, R.; Schibli, R.; Schubiger, P. A.; Pietzsch, H.-J.; Spies, H.; Johannsen, B.

Synthesis and Structural Characterization of Neutral Oxorhenium(V) Complexes with Tridentate Dithioethers

Pietzsch, H.-J.; Reisgys, M.; Spies, H.; Leibnitz, P.; Johannsen, B.

  • Chemische Berichte 130 (1997) pp. 357-361

Structural modification of receptor binding 99m-Tc complexes in order to improve brain uptake

Johannsen, B.; Berger, R.; Brust, P.; Pietzsch, H.-J.; Scheunemann, M.; Seifert, S.; Spies, H.; Syhre, R.

  • European Journal of Nuclear Medicine 24 (1997) 3 pp. 316-319

Technetium and Rhenium Complexes with Thioether Ligands, 5 Synthesis and Structural Characterization of Neutral Oxorhenium (V) Complexes with Tridentate Dithioethers

Pietzsch, H.-J.; Reisgys, M.; Spies, H.; Leibnitz, P.; Johannsen, B.

  • Chemische Berichte, Recueil 1997, 130, 357-361

1996

Technetium(V) and Rhenium(V) Complexes for 5-HT2A Serotonin Receptor Binding: Structure-Affinity Considerations

Johannsen, B.; Scheunemann, M.; Spies, H.; Brust, P.; Wober, J.; Syhre, R.; Pietzsch, H.-J.

1995

Synthesis and reactions of trigonal-bipyramidal rhenium and technetium complexes with a tripodal, tetradentate NS3 ligand*

Spies, H.; Glaser, M.; Pietzsch, H.-J.; Hahn, F. E.; Lügger, T.

  • Inorganica Chimica Acta 240 (1995) pp. 465-478

Neutral Oxorhenium(V) Complexes with Tridentate Dithiolates and Monodentate Alkane- or Arene-thiolate Coligands

Spies, H.; Fietz, T.; Pietzsch, H.-J.; Johannsen, B.; Leibnitz, P.; Reck, G.; Scheller, D.; Klostermann, K.

Technetium- and Rhenium Complexes with Thioether Ligands-IV. Synthesis and Structural Characterization of Binuclear Oxorhenium (V) Complexes with Bidentate Thioether Coordination

Pietzsch, H.-J.; Spies, H.; Leibnitz, P.; Reck, G.

Synthesis and molecular structure of chlore(3-thiapentane-1.5-dithiolato)oxorhenium(V)

Fietz, T.; Spies, H.; Pietzsch, H.-J.; Leibnitz, P.

1994

Trigonal-bipyramidale Technetium- und Rhenium-Komplexe mit vierzähnigen tripodalen NS3-Liganden

Spies, H.; Glaser, M.; Pietzsch, H.-J.; Hahn, F. E.; Kintzel, O.; Lügger, T.

  • Angewandte Chemie 106 (1994) 13 pp. 1416-1419

1993

Technetium Complexes with Thioether Ligands

Pietzsch, H.-J.; Spies, H.; Leibnitz, P.; Reck, G.; Johannsen, B.

Technetium Complexes with Thioether Ligands - III. Synthesis and Structural Characterization of Cationic Nitridotechnetium(V) Complexes with Thiacrown ethers

Pietzsch, H.-J.; Spies, H.; Leibnitz, P.; Reck, G.

  • Polyhedron 12 (1993) 24 pp. 2995-3002

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