Publications of Institute of Radiopharmaceutical Cancer Research
192 Publications2024
The crystal structure of (2-diphenylphosphanylphenyl) 2-[7-(dimethylamino)-2-oxochromen-4-yl]acetate, C31H26NO4P
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Zeitschrift für Kristallographie - New Crystal Structures 239(2024), 511
DOI: 10.1515/ncrs-2024-0065
Alpha-emitting Radionuclides: Current Status and Future Perspectives
Miederer, M.; Benešová-Schäfer, M.; Mamat, C.; Kästner, D.; Pretze, M.; Michler, E.; Brogsitter, C.; Kotzerke, J.; Kopka, K.; Scheinberg, D.; McDevitt, M.
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Pharmaceuticals 17(2024), 76
DOI: 10.3390/ph17010076
Preparation of HOPO-containing lariate ethers based on the diaza-18-crown-6 scaffold
Paßler, F.; Belke, L.; Reissig, F.; Kopka, K.; Mamat, C.
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Chemical Papers (2024)
DOI: 10.1007/s11696-024-03376-8
2023
Equilibrium Thermodynamics of Macropa Complexes with Selected Metal Isotopes of Radiopharmaceutical Interest
Blei, M. K.; Waurick, L.; Reissig, F.; Kopka, K.; Stumpf, T.; Drobot, B.; Kretzschmar, J.; Mamat, C.
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Inorganic Chemistry 62(2023)50, 20699-20709
DOI: 10.1021/acs.inorgchem.3c01983
Preclinical Characterization of the 177Lu-Labeled Prostate Stem Cell Antigen (PSCA)-Specific Monoclonal Antibody 7F5
Striese, F.; Neuber, C.; Gräßel, S.; Arndt, C.; Ullrich, M.; Steinbach, J.; Pietzsch, J.; Bergmann, R.; Pietzsch, H.-J.; Sihver, W.; Frenz, M.; Feldmann, A.; Bachmann, M.
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International Journal of Molecular Sciences 24(2023)11, 9420
DOI: 10.3390/ijms24119420
Cyclotron-based Production of 67Cu for Radionuclide Theranostics Via the 70Zn(p,α)67Cu Reaction
Brühlmann, S. A.; Walther, M.; Kreller, M.; Reissig, F.; Pietzsch, H.-J.; Knieß, T.; Kopka, K.
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Pharmaceuticals 16(2023), 314
DOI: 10.3390/ph16020314
The Impact of Nε-Acryloyllysine Piperazides on the Conformational Dynamics of Transglutaminase 2
Heerwig, A.; Kick, A.; Sommerfeld, P.; Eimermacher, S.; Hartung, F.; Laube, M.; Fischer, D.; Pietzsch, H.-J.; Pietzsch, J.; Löser, R.; Mertig, M.; Pietsch, M.; Wodtke, R.
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International Journal of Molecular Sciences 24(2023), 1650
DOI: 10.3390/ijms24021650
Copper-free click bioconjugation of technetium-99m complexes using strained cyclononyne derivatives
Schlesinger, M.; Jentschel, C.; Pietzsch, H.-J.; Kopka, K.; Mamat, C.
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Dalton Transactions 52(2023), 3024-3032
DOI: 10.1039/D2DT03965F
Enzymological characterization of ⁶⁴Cu-labeled neprilysin substrates and their application for modulating the renal clearance of targeted radiopharmaceuticals
Brandt, F.; Ullrich, M.; Wodtke, J.; Kopka, K.; Bachmann, M.; Löser, R.; Pietzsch, J.; Pietzsch, H.-J.; Wodtke, R.
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Journal of Medicinal Chemistry 66(2023)1, 516-537
DOI: 10.1021/acs.jmedchem.2c01472
Calix[4]crowns with perfluoroalkylsulfonylcarboxamide functions: a complexation approach for heavy group 2 metal ions
Reissig, F.; Bauer, D.; Al-Ameed, K.; Luber, S.; Köckerling, M.; Steinbach, J.; Pietzsch, H.-J.; Mamat, C.
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Inorganic Chemistry Frontiers 10(2023), 370-382
Online First (2022) DOI: 10.1039/d2qi01637k
2022
Synthesis and preclinical evaluation of rhenium and technetium-99m “4 + 1” mixed-ligand complexes bearing quinazoline derivatives as potential EGFR imaging agents
Kiritsis, C.; Shegani, A.; Makrypidi, K.; Roupa, I.; Lazopoulos, A.; Panagiotopoulou, A.; Triantopoulou, S.; Paravatou-Petsotas, M.; Pietzsch, H.-J.; Pelecanou, M.; Papadopoulos, M.; Pirmettis, I.
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Bioorganic & Medicinal Chemistry 73(2022), 117012
DOI: 10.1016/j.bmc.2022.117012
Efficient Production of the PET radionuclide 133La for Theranostic Purposes in Targeted Alpha Therapy using the 134Ba(p,2n)133La Reaction
Brühlmann, S. A.; Kreller, M.; Pietzsch, H.-J.; Kopka, K.; Mamat, C.; Walther, M.; Reissig, F.
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Pharmaceuticals 15(2022), 1167
DOI: 10.3390/ph15101167
Cyclam with a phosphinate-bis(phosphonate) pendant arm is a bone-targeting carrier of copper radionuclides
Pazderová, L.; Benešová, M.; Havlíčková, J.; Vojtíčková, M.; Kotek, J.; Lubal, P.; Ullrich, M.; Walther, M.; Schulze, S.; Neuber, C.; Rammelt, S.; Pietzsch, H.-J.; Pietzsch, J.; Kubíček, V.; Hermann, P.
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Dalton Transactions 51(2022), 9541-9555
DOI: 10.1039/d2dt01172g
Modulating the pharmacokinetic profile of Actinium-225-labeled macropa-derived radioconjugates by dual targeting of PSMA and albumin
Reissig, F.; Zarschler, K.; Novy, Z.; Petrik, M.; Bendova, K.; Kurfurstova, D.; Bouchal, J.; Ludik, M.-C.; Brandt, F.; Kopka, K.; Khoylou, M.; Pietzsch, H.-J.; Hajduch, M.; Mamat, C.
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Theranostics 12(2022), 7203-7215
DOI: 10.7150/thno.78043
Introducing micro physiological systems to evaluate new radiopharmaceuticals: First attempts with radiolabeled cetuximab
Sihver, W.; Nitt-Weber, A.-K.; Behrens, S.; Ullrich, M.; Pietzsch, H.-J.; Namazian Jam, N.; Schmieder, F.; Sonntag, F.
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Current Directions in Biomedical Engineering 8(2022)2, 532-535
DOI: 10.1515/cdbme-2022-1136
Strained Ammonium Precursors for Radiofluorinations
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ChemistryOpen 11(2022), e202200039
DOI: 10.1002/open.202200039
“Clickable” albumin binders for modulating the tumor uptake of targeted radiopharmaceuticals
Brandt, F.; Ullrich, M.; Laube, M.; Kopka, K.; Bachmann, M.; Löser, R.; Pietzsch, J.; Pietzsch, H.-J.; van den Hoff, J.; Wodtke, R.
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Journal of Medicinal Chemistry 66(2022)1, 710-733
Online First (2021) DOI: 10.1021/acs.jmedchem.1c01791
Preparation of calix[4]arenes for chelation of selected divalent cations
Blumberg, M.; Al-Ameed, K.; Eiselt, E.; Luber, S.; Mamat, C.
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Molecules 27(2022)5, 1478
DOI: 10.3390/molecules27051478
2021
Molecular Response to Combined Molecular- and External Radiotherapy in Head and Neck Squamous Cell Carcinoma (HNSCC).
Rassamegevanon, T.; Feindt, L.; Koi, L.; Müller, J.; Freudenberg, R.; Löck, S.; Sihver, W.; Çevik, E.; Christel Kühn, A.; von Neubeck, C.; Linge, A.; Pietzsch, H.-J.; Kotzerke, J.; Baumann, M.; Krause, M.; Dietrich, A.
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Cancers 13(2021)22, 5595
DOI: 10.3390/cancers13225595
Strategic Evaluation of the Traceless Staudinger Ligation for Radiolabeling with the Tricarbonyl Core
Mamat, C.; Jentschel, C.; Köckerling, M.; Steinbach, J.
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Molecules 26(2021), 6629
DOI: 10.3390/molecules26216629
Aktuelle Entwicklungen aus den Radiopharmazeutischen Wissenschaften für theranostische Anwendungen - Editorial
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Der Nuklearmediziner 44(2021), 100
DOI: 10.1055/a-1463-6602
Towards Targeted Alpha Therapy with Actinium 225: Chelators for Mild Condition Radiolabeling and Targeting PSMA – a Proof of Concept Study
Reissig, F.; Bauer, D.; Zarschler, K.; Novy, Z.; Bendova, K.; Kopka, K.; Pietzsch, H.-J.; Petrik, M.; Mamat, C.
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Cancers 13(2021)8, 1974
DOI: 10.3390/cancers13081974
Radiotherapy enhances uptake and efficacy of 90Y-cetuximab: A preclinical trial
Dietrich, A.; Andreeff, M.; Koi, L.; Bergmann, R.; Schubert, M.; Schreiner, L.; Löck, S.; Sihver, W.; Freudenberg, R.; Hering, S.; Pietzsch, H.-J.; Steinbach, J.; Kotzerke, J.; Baumann, M.; Krause, M.
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Radiotherapy and Oncology 155(2021), 285-292
Online First (2020) DOI: 10.1016/j.radonc.2020.11.013
The Impact of Barium Isotopes in Radiopharmacy and Nuclear Medicine – from Past to Presence
Reissig, F.; Kopka, K.; Mamat, C.
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Nuclear Medicine and Biology 98(2021), 59-68
DOI: 10.1016/j.nucmedbio.2021.05.003
Die Bedeutung des Elementes Barium in der Nuklearmedizin
Reissig, F.; Kopka, K.; Mamat, C.
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Der Nuklearmediziner 44(2021), 127-134
DOI: 10.1055/a-1382-2812
Radiolabelled Cyclic Bisarylmercury: High Chemical and in vivo Stability for Theranostics
Gilpin, I. M.; Ullrich, M.; Wünsche, T.; Zarschler, K.; Lebeda, O.; Pietzsch, J.; Pietzsch, H.-J.; Walther, M.
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ChemMedChem 16(2021)17, 2645-2649
DOI: 10.1002/cmdc.202100131
2020
Recent insights in barium-131 as a diagnostic match for radium-223: cyclotron production, separation, labeling and imaging
Reissig, F.; Bauer, D.; Ullrich, M.; Kreller, M.; Pietzsch, J.; Mamat, C.; Kopka, K.; Pietzsch, H.-J.; Walther, M.
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Pharmaceuticals 13(2020)10, 272
DOI: 10.3390/ph13100272
A radiopharmacologist's and radiochemist's view on targeting the Eph/ephrin receptor tyrosine kinase system
Neuber, C.; Belter, B.; Mamat, C.; Pietzsch, J.
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ACS Omega 5(2020)27, 16318-16331
DOI: 10.1021/acsomega.0c01058
Light-Activated Carbon Monoxide Prodrugs Based on Bipyridyl Dicarbonyl Ruthenium(II) Complexes
Geri, S.; Krunclova, T.; Janouskova, O.; Panek, J.; Hruby, M.; Hernandez-Valdes, D.; Probst, B.; Alberto, R.; Mamat, C.; Kubeil, M.; Stephan, H.
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Chemistry - A European Journal 26(2020), 10992-11006
DOI: 10.1002/chem.202002139
Contemporary Synthesis of Ultrasmall (sub-10 nm) Upconverting Nanomaterials
Joshi, T.; Mamat, C.; Stephan, H.
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ChemistryOpen 9(2020), 703-712
DOI: 10.1002/open.202000073
Synthesis, radiolabeling and first biological characterization of 18F-labeled xanthine derivatives for PET imaging of Eph receptors
Pretze, M.; Neuber, C.; Kinski, E.; Belter, B.; Köckerling, M.; Caflisch, A.; Steinbach, J.; Pietzsch, J.; Mamat, C.
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Organic & Biomolecular Chemistry 18(2020)16, 3104-3116
DOI: 10.1039/D0OB00391C
Sub-10 nm Radiolabeled Barium Sulfate Nanoparticles as Carriers for Theranostic Applications and Targeted Alpha Therapy
Reissig, F.; Zarschler, K.; Hübner, R.; Pietzsch, H.-J.; Kopka, K.; Mamat, C.
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ChemistryOpen 9(2020), 797-805
DOI: 10.1002/open.202000126
Formation of calix[4]arenes with acyloxycarboxylate functions
Bauer, D.; Stipurin, S.; Köckerling, M.; Mamat, C.
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Tetrahedron 76(2020), 131395
DOI: 10.1016/j.tet.2020.131395
2019
Introduction of the New Center for Radiopharmaceutical Cancer Research at Helmholtz-Zentrum Dresden-Rossendorf
Kreller, M.; Pietzsch, H.-J.; Walther, M.; Tietze, H.; Kaever, P.; Knieß, T.; Füchtner, F.; Steinbach, J.; Preusche, S.
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Instruments 3(2019)1, 9
DOI: 10.3390/instruments3010009
A comparative evaluation of calix[4]arene-1,3-crown-6 as a ligand for selected divalent cations of radiopharmaceutical interest
Bauer, D.; Blumberg, M.; Köckerling, M.; Mamat, C.
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RSC Advances 7(2019)55, 32357-32366
DOI: 10.1039/C9RA07293D
Editorial for special issue "Jörg Steinbach"
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Journal of Labelled Compounds and Radiopharmaceuticals 62(2019)8, 350-351
DOI: 10.1002/jlcr.3773
A 224Ra-labeled polyoxopalladate as putative radiopharmaceutical
Gott, M.; Yang, P.; Kortz, U.; Stephan, H.; Pietzsch, H.-J.; Mamat, C.
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Chemical Communications 55(2019), 7631-7634
DOI: 10.1039/C9CC02587A
Regulation of A375 melanoma cell adhesion and migration by EphB4 and EphrinB2 –insights from co-culture experiments
Neuber, C.; Laube, M.; Mamat, C.; Belter, B.; Pietzsch, J.
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Journal of Cellular Biotechnology 5(2019)1, 27-42
DOI: 10.3233/JCB-189011
ISSN: 2352-3689
Radiochemical and radiopharmacological characterization of a 64Cu-labeled α-MSH analog conjugated with different chelators
Gao, F.; Sihver, W.; Bergmann, R.; Walther, M.; Stephan, H.; Belter, B.; Neuber, C.; Haase-Kohn, C.; Bolzati, C.; Pietzsch, J.; Pietzsch, H.-J.
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Journal of Labelled Compounds and Radiopharmaceuticals 62(2019)8, 495-509
DOI: 10.1002/jlcr.3728
Facile preparation of radium-doped, functionalized nanoparticles as carriers for targeted alpha therapy
Reissig, F.; Hübner, R.; Steinbach, J.; Pietzsch, H.-J.; Mamat, C.
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Inorganic Chemistry Frontiers 6(2019), 1341-1349
DOI: 10.1039/c9qi00208a
2018
Improved Conjugation, 64-Cu Radiolabeling, in Vivo Stability, and Imaging Using Nonprotected Bifunctional Macrocyclic Ligands: Bis(Phosphinate) Cyclam (BPC) Chelators
David, T.; Hlinová, V.; Kubíček, V.; Bergmann, R.; Striese, F.; Berndt, N.; Szöllösi, D.; Hegedus, N.; Mathe, D.; Bachmann, M.; Pietzsch, H.-J.; Hermann, P.
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Journal of Medicinal Chemistry 61(2018), 8774-8796
DOI: 10.1021/acs.jmedchem.8b00932
NMR-based investigations of acyl-functionalized piperazines concerning their conformational behavior in solution
Steinberg, J.; Köckerling, M.; Wodtke, R.; Löser, R.; Mamat, C.
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RSC Advances 8(2018), 40921-40933
DOI: 10.1039/C8RA09152H
Synthesis, characterization and initial biological evaluation of [⁹⁹ᵐTc]Tc-tricarbonyl labeled DPA-α-MSH peptide derivatives for potential melanoma imaging
Gao, F.; Sihver, W.; Bergmann, R.; Belter, B.; Bolzati, C.; Salvarese, N.; Steinbach, J.; Pietzsch, J.; Pietzsch, H.-J.
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ChemMedChem 13(2018)11, 1146-1158
DOI: 10.1002/cmdc.201800110
Exploring pitfalls of 64Cu‑labeled EGFR‑targeting peptide GE11 as a potential PET tracer
Striese, F.; Sihver, W.; Gao, F.; Bergmann, R.; Walther, M.; Pietzsch, J.; Steinbach, J.; Pietzsch, H.-J.
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Amino Acids 50(2018)10, 1415-1431
DOI: 10.1007/s00726-018-2616-5
Biodistribution studies of ultrasmall silicon nanoparticles and carbon dots in experimental rats and tumor mice
Licciardello, N.; Hunoldt, S.; Bergmann, R.; Singh, G.; Mamat, C.; Faramus, A.; Ddungu, J. L. Z.; Silvestrini, S.; Maggini, M.; de Cola, L.; Stephan, H.
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Nanoscale 10(2018), 9880-9891
DOI: 10.1039/C8NR01063C
Overexpression of receptor tyrosine kinase EphB4 triggers tumor growth and hypoxia in A375 melanoma xenografts: insights from multitracer small animal imaging experiments
Neuber, C.; Belter, B.; Meister, S.; Hofheinz, F.; Bergmann, R.; Pietzsch, H.-J.; Pietzsch, J.
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Molecules 23(2018), 444
DOI: 10.3390/molecules23020444
Modified Calix[4]crowns as Molecular Receptors for Barium
Steinberg, J.; Bauer, D.; Reissig, F.; Köckerling, M.; Pietzsch, H.-J.; Mamat, C.
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ChemistryOpen 7(2018)6, 432-438
DOI: 10.1002/open.201800019
Chelation of heavy group 2 (radio)metals by p-tert-butylcalix[4]arene-1,3-crown-6 and logK determination via NMR
Bauer, D.; Gott, M.; Steinbach, J.; Mamat, C.
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Spectrochimica Acta Part A 199(2018), 50-56
DOI: 10.1016/j.saa.2018.03.029
Facile Silylation of Cyclitols using Silyl-bis(triflates)
Topp, A.; Köckerling, M.; Reinke, H.; Miethchen, R.; Mamat, C.
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European Journal of Inorganic Chemistry (2018), 1302-1308
DOI: 10.1002/ejic.201701327
Recent Progress using the Staudinger Ligation for Radiolabeling Applications
Mamat, C.; Gott, M.; Steinbach, J.
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Journal of Labelled Compounds and Radiopharmaceuticals 61(2018), 165-178
DOI: 10.1002/jlcr.3562
Structural and kinetic considerations for the application of the traceless Staudinger ligation to future 18F radiolabeling using XRD and 19F-NMR
Köckerling, M.; Mamat, C.
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International Journal of Chemical Kinetics 50(2018), 31-40
DOI: 10.1002/kin.21137
2017
Preparation of 18F-labeled building blocks for peptide conjugation using the "minimalist" approach
Omrane, M. A.; Zlatopolskiy, B. D.; Urusova, E.; Mamat, C.; Feni, L.; Neundorf, I.; Neumaier, B.
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Journal of Labelled Compounds and Radiopharmaceuticals 60(2017)S1, S261
DOI: 10.1002/jlcr.3508
Evaluation of Ba/Ra Polyoxopalladates for Radiopharmaceutical Applications
Gott, M.; Yang, P.; Kortz, U.; Pietzsch, H.-J.; Steinbach, J.; Mamat, C.
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Journal of Labelled Compounds and Radiopharmaceuticals 60(2017)S1, S559
DOI: 10.1002/jlcr.3508
Novel Functionalized Calixarenes as Host Molecules for Complexation with Alkaline Earth Metals
Steinberg, J.; Gott, M.; Pietzsch, H.-J.; Steinbach, J.; Mamat, C.
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Journal of Labelled Compounds and Radiopharmaceuticals 60(2017)S1, S488
DOI: 10.1002/jlcr.3508
Detection of Auger Electron Induced Strand Breaks on Plasmid DNA Caused by Technetium-99m Labeled Pyrene Derivatives
Wunderlich, G.; Reissig, F.; Mamat, C.; Pietzsch, H.-J.; Kotzerke, J.; Steinbach, J.
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Journal of Labelled Compounds and Radiopharmaceuticals 60(2017)S1, S365
DOI: 10.1002/jlcr.3508
Preparation of a novel radiotracer targeting the EphB4 receptor via radiofluorination using spiro azetidinium salts as precursor
Wiemer, J.; Steinbach, J.; Pietzsch, J.; Mamat, C.
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Journal of Labelled Compounds and Radiopharmaceuticals 60(2017), 489-498
DOI: 10.1002/jlcr.3526
A novel nanobody-based target module for retargeting of T lymphocytes to EGFR-expressing cancer cells via the modular UniCAR platform
Albert, S.; Arndt, C.; Feldmann, A.; Bergmann, R.; Bachmann, D.; Koristka, S.; Ludwig, F.; Ziller-Walter, P.; Kegler, A.; Gärtner, S.; Schmitz, M.; Ehninger, A.; Cartellieri, M.; Ehninger, G.; Pietzsch, H.-J.; Pietzsch, J.; Steinbach, J.; Bachmann, M.
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OncoImmunology 6(2017)4, e1287246
DOI: 10.1080/2162402X.2017.1287246
ISSN: 2162-402X
A novel tumor pretargeting system based on complementary L-configured oligonucleotides
Schubert, M.; Bergmann, R.; Förster, C.; Sihver, W.; Vonhoff, S.; Klussmann, S.; Bethge, L.; Walther, M.; Schlesinger, J.; Pietzsch, J.; Steinbach, J.; Pietzsch, H.-J.
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Bioconjugate Chemistry 28(2017)4, 1176-1188
DOI: 10.1021/acs.bioconjchem.7b00045
X-ray Structures of Succinimidyl Halobenzoates
Mamat, C.; Weiss, D.-H.; Köckerling, M.
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Crystals 7(2017), 90
DOI: 10.3390/cryst7030090
2016
New insights into the pretargeting approach to image and treat tumours
Patra, M.; Zarschler, K.; Pietzsch, H.-J.; Stephan, H.; Gasser, G.
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Chemical Society Reviews 45(2016), 6415-6431
DOI: 10.1039/c5cs00784d
Melanoma targeting with [99mTc(N)(PNP3)]-labeled α-melanocyte stimulating hormone peptide analogs: Effects of cyclization on the radiopharmaceutical properties
Carta, D.; Salvarese, N.; Morellato, N.; Gao, F.; Sihver, W.; Pietzsch, H.-J.; Biondi, B.; Ruzza, P.; Refosco, F.; Carpanese, D.; Rosato, A.; Bolzati, C.
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Nuclear Medicine and Biology 43(2016)12, 788-801
DOI: 10.1016/j.nucmedbio.2016.08.014
Direct and Auger electron-induced, single- and double-strand breaks on plasmid DNA caused by 99mTc-labeled pyrene derivatives and the effect of bonding distance
Reissig, F.; Mamat, C.; Steinbach, J.; Pietzsch, H.-J.; Freudenberg, R.; Kotzerke, J.; Wunderlich, G.
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PLOS ONE 10(2016)9, e0161973
DOI: 10.1371/journal.pone.0161973
Synthesis, dynamic NMR characterization and XRD studies of novel N,N’-substituted piperazines for bioorthogonal labeling
Mamat, C.; Pretze, M.; Gott, M.; Köckerling, M.
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Beilstein Journal of Organic Chemistry 12(2016), 2479-2489
DOI: 10.3762/bjoc.12.242
The Radiochemical and radiopharmaceutical applications of radium
Gott, M.; Steinbach, J.; Mamat, C.
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Open Chemistry 14(2016), 118-129
DOI: 10.1515/chem-2016-0011
Radiopharmacological characterization of 64Cu-labeled α-MSH analogs for potential use in imaging of malignant melanoma
Gao, F.; Sihver, W.; Jurischka, C.; Bergmann, R.; Haase-Kohn, C.; Belter, B.; Steinbach, J.; Carta, D.; Bolzati, C.; Calderan, A.; Pietzsch, J.; Pietzsch, H.-J.
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Amino Acids 48(2016)3, 833-847
Online First (2015) DOI: 10.1007/s00726-015-2131-x
2015
Cyclam Derivatives with a Bis(phosphinate) or a Phosphinato−Phosphonate Pendant Arm: Ligands for Fast and Efficient Copper(II) Complexation for Nuclear Medical Applications
David, T.; Kubićek, V.; Gutten, O.; Lubal, P.; Kotek, J.; Pietzsch, H.-J.; Rulíśek, L.; Hermann, P.
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Inorganic Chemistry 54(2015), 11751-11766
DOI: 10.1021/acs.inorgchem.5b01791
18F-Labeled 1,4-Dioxa-8-azaspiro[4.5]decane Derivative: Synthesis and Biological Evaluation of a σ1 Receptor Radioligand with Low Lipophilicity as Potent Tumor Imaging Agent
Xie, F.; Bergmann, R.; Kniess, T.; Deuther-Conrad, W.; Mamat, C.; Neuber, C.; Liu, B.; Steinbach, J.; Brust, P.; Pietzsch, J.; Jia, H.
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Journal of Medicinal Chemistry 58(2015), 5395-5407
DOI: 10.1021/acs.jmedchem.5b00593
ISSN: 0022-2623
Methods to increase the metabolic stability of 18F-radiotracers
Kuchar, M.; Mamat, C.
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Molecules 20(2015), 16186-16220
DOI: 10.3390/molecules200916186
In vivo Demonstration of an Active Tumor Pretargeting Approach with Peptide Nucleic Acid Bioconjugates as Complementary System
Leonidova, A.; Foerster, C.; Zarschler, K.; Schubert, M.; Pietzsch, H.-J.; Steinbach, J.; Bergmann, R.; Metzler-Nolte, N.; Stephan, H.; Gasser, G.
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Chemical Science 6(2015), 5601-5616
DOI: 10.1039/c5sc00951k
Novel indole-based sigma-2 receptor ligands: synthesis, structure–affinity relationship and antiproliferative activity
Xie, F.; Kniess, T.; Neuber, C.; Deuther-Conrad, W.; Mamat, C.; Liebermann, B. P.; Liu, B.; Mach, R. H.; Brust, P.; Steinbach, J.; Pietzsch, J.; Jia, H.
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MedChemComm 6(2015), 1093-1103
DOI: 10.1039/c5md00079c
Synthesis and Molecular Structure of 2-(Diphenylphosphano) phenyl Benzoate Borane Adduct
Mamat, C.; Köckerling, M.
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Crystals 5(2015), 9-13
DOI: 10.3390/cryst5010009
ISSN: 2073-4352
Development of indazolylpyrimidine derivatives as high-affine EphB4 receptor ligands and potential PET-radiotracers
Ebert, K.; Wiemer, J.; Caballero, J.; Köckerling, M.; Steinbach, J.; Pietzsch, J.; Mamat, C.
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Bioorganic & Medicinal Chemistry 23(2015), 6025-6035
DOI: 10.1016/j.bmc.2015.06.040
Theranostic mercury: 197(m)Hg with high specific activity for imaging and therapy
Walther, M.; Preusche, S.; Bartel, S.; Wunderlich, G.; Freudenberg, R.; Steinbach, J.; Pietzsch, H.-J.
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Applied Radiation and Isotopes 97(2015), 177-181
DOI: 10.1016/j.apradiso.2015.01.001
Bifunctional Cyclam-Based Ligands with Phosphorus Acid Pendant Moieties for Radiocopper Separation – Thermodynamic and Kinetic Studies
Paúrová, M.; Havlíčková, J.; Pospíšilová, A.; Vetrík, M.; Císařová, I.; Stephan, H.; Pietzsch, H.-J.; Hrubý, M.; Hermann, P.; Kotek, J.
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Chemistry - A European Journal 21(2015), 4671-4687
DOI: 10.1002/chem.201405777
Polyoxometalates - potent and selective ecto-nucleotidase inhibitors
Lee, S.-Y.; Fiene, A.; Li, W.; Hank, T.; Brylev, K.; Fedovrov, V.; Lecka, J.; Haider, A.; Pietzsch, H.-J.; Zimmermann, H.; Sévigny, J.; Kortz, U.; Stephan, H.; Müller, C. E.
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Biochemical Pharmacology 93(2015), 171-181
DOI: 10.1016/j.bcp.2014.11.002
Evaluation of Novel Fluorescence Probes for Conjugation Purposes Using the Traceless Staudinger Ligation
Wodtke, R.; König, J.; Pigorsch, A.; Köckerling, M.; Mamat, C.
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Dyes and Pigments 113(2015), 263-273
Online First (2014) DOI: 10.1016/j.dyepig.2014.08.022
2014
Preparation of 4-Halobenzoate Containing Phosphane Based Building Blocks for Labeling Reactions Using the Traceless Staudinger Ligation
Mamat, C.; Köckerling, M.
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Synthesis 46(2014)2, 387-394
DOI: 10.1055/s-0034-1379487
X-ray structure of 2-(diphenylphosphano)phenyl-4-(hydroxymethyl)benzoate
Mamat, C.; Flemming, A.; Köckerling, M.
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Acta Crystallographica Section E E70(2014), o1288-o1289
DOI: 10.1107/S1600536814024623
ISSN: 1600-5368
Assessment of the best N3− donors in preparation of [M(N)(PNP)]-based (M = 99mTc-; 188Re) target-specific radiopharmaceuticals: Comparison among succinic dihydrazide (SDH), N-methyl-S-methyl dithiocarbazate (HDTCZ) and PEGylated N-methyl-S-methyl dithiocarbazate (HO2C-PEG600-DTCZ)
Carta, D.; Jentschel, C.; Thieme, S.; Salvarese, N.; Morellato, N.; Refosco, F.; Ruzza, P.; Bergmann, R.; Pietzsch, H.-J.; Bolzati, C.
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Nuclear Medicine and Biology 41(2014), 570-581
DOI: 10.1016/j.nucmedbio.2014.04.126
Radiofluorination and first radiopharmacological characterization of a SWLAY peptide-based ligand targeting EphA2
Pretze, M.; Mosch, B.; Bergmann, R.; Steinbach, J.; Pietzsch, J.; Mamat, C.
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Journal of Labelled Compounds and Radiopharmaceuticals 57(2014), 660-665
DOI: 10.1002/jlcr.3237
Visualizing inflammation activity in rheumatoid arthritis with Tc-99 m Anti-CD4-mAb fragment scintigraphy
Steinhoff, K.; Pierer, M.; Siegert, J.; Pigla, U.; Laub, R.; Hesse, S.; Seidel, W.; Sorger, D.; Seese, A.; Künstler, J.-U.; Pietzsch, H.-J.; Lincke, T.; Rullmann, M.; Emmrich, F.; Sabri, O.
-
Nuclear Medicine and Biology 41(2014), 350-354
DOI: 10.1016/j.nucmedbio.2013.12.018
Radiolabeled anti-EGFR-antibody improves local tumor control after external beam radiotherapy and offers theragnostic potential
Koi, L.; Bergmann, R.; Brüchner, K.; Pietzsch, J.; Pietzsch, H.-J.; Krause, M.; Steinbach, J.; Zips, D.; Baumann, M.
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Radiotherapy and Oncology 110(2014), 362-369
DOI: 10.1016/j.radonc.2013.12.001
2013
Regioselective Synthesis of Trichloromethyl-Substituted Salicylates and Cyclohexenones by One-Pot Cyclizations of 1,3-Bis(trimethylsilyloxy)buta-1,3-dienes
Reimann, S.; Bunescu, A.; Petrosyana, A.; Sharif, M.; Erfle, S.; Mamat, C.; Ghochikyan, T. V.; Saghyan, A. S.; Spannenberg, A.; Villinger, A.; Langer, P.
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Helvetica Chimica Acta 96(2013), 1955-1967
DOI: 10.1002/hlca.201200595
Quantitative Structure Property Relationship of logP for Radiopharmaceutical Technetium and Rhenium Complexes by using Molecular Dynamics Calculations
Yoshizuka, K.; Pietzsch, H.-J.; Seifert, S.; Stephan, H.
- Solvent Extraction Research and Development 20(2013), 15-27
Recent Trends in Bioorthogonal Click-Radiolabeling Reactions Using Fluorine-18
Pretze, M.; Pietzsch, D.; Mamat, C.
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Molecules 18(2013), 8618-8665
DOI: 10.3390/molecules18078618
ISSN: 1420-3049
Condensation of the dianion of ethyl acetoacetate with perfluoroalkyl iodides. Application to the synthesis of 3-perfluoroalkylsalicylic acids
Mamat, C.; Langer, P.
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Monatshefte für Chemie 144(2013), 1057-1061
DOI: 10.1007/s00706-013-0985-8
Automated preparation of [18F]AFP and [18F]BFP: Two novel bifunctional 18F-labeling building blocks for Huisgen-click
Pretze, M.; Mamat, C.
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Journal of Fluorine Chemistry 150(2013), 25-35
DOI: 10.1016/j.jfluchem.2013.02.028
An Efficient Bioorthogonal Strategy Using CuAAC Click Chemistry for Radiofluorinations of SNEW Peptides and the Role of Copper Depletion
Pretze, M.; Kuchar, M.; Bergmann, R.; Steinbach, J.; Pietzsch, J.; Mamat, C.
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ChemMedChem 8(2013), 935-945
DOI: 10.1002/cmdc.201300053
Design and Development of 99mTc-‘4 + 1’-Labeled Dextran-Mannose Derivatives as Potential Radiopharmaceuticals for Sentinel Lymph Node Detection
Giglio, J.; Fernandez, S.; Jentschel, C.; Pietzsch, H.-J.; Papadopoulos, M.; Pelecanou, M.; Pirmettis, I.; Paolino, A.; Rey, A.
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Cancer Biotherapy and Radiopharmaceuticals 28(2013), 541-551
DOI: 10.1089/cbr.2012.1440
Ga-68- and Cu-64-Labeled NOTA-Albumin Conjugates for PET Sentinel Lymph Node Imaging
Schiller, E.; Bergmann, R.; Wunderlich, G.; Andreeff, M.; Jacob, A.; Pietzsch, H.-J.
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ISRN Molecular Imaging (2013), 386976
DOI: 10.1155/2013/386976
Synthesis of Short and Versatile Heterobifunctional Linkers for Conjugation Purposes of Bioactive Molecules with (Radio-)Labels
Heldt, J.-M.; Kerzendörfer, O.; Mamat, C.; Starke, F.; Pietzsch, H.-J.; Steinbach, J.
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Synlett 4(2013), 432-436
DOI: 10.1055/s-0032-1318198
Inactivation of HNSCC Cells by 90Y-Labeled Cetuximab Strictly Depends on the Number of Induced DNA Double-Strand Breaks
Saker, J.; Kriegs, M.; Zenker, M.; Heldt, J.-M.; Eke, I.; Pietzsch, H.-J.; Grénman, R.; Cordes, N.; Petersen, C.; Baumann, M.; Steinbach, J.; Dikomey, E.; Kasten-Pisula, U.
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Journal of Nuclear Medicine 54(2013), 416-423
DOI: 10.2967/jnumed.111.101857
[68Ga]NS3-RGD and [68Ga] Oxo-DO3A-RGD for imaging αvβ3 integrin expression: synthesis, evaluation, and comparison
Knetsch, P. A.; Petrik, M.; Rangger, C.; Seidel, G.; Pietzsch, H.-J.; Virgolini, I.; Decristoforo, C.; Haubner, R.
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Nuclear Medicine and Biology 40(2013), 65-72
Online First (2012) DOI: 10.1016/j.nucmedbio.2012.09.006
High specific activity 61Cu via 64Zn(p,α)61Cu reaction at low proton energies
Thieme, S.; Walther, M.; Preusche, S.; Rajander, J.; Pietzsch, H.-J.; Solin, O.; Steinbach, J.
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Applied Radiation and Isotopes 72(2013), 169-176
DOI: 10.1016/j.apradiso.2012.11.007
2012
Cellular and molecular properties of 90Y-labeled cetuximab in combination with radiotherapy on human tumor cells in vitro
Saki, M.; Toulany, M.; Sihver, W.; Zenker, M.; Heldt, J.-M.; Mosch, B.; Pietzsch, H.-J.; Baumann, M.; Steinbach, J.; Rodemann, H. P.
-
Strahlentherapie und Onkologie 9(2012), 823-832
DOI: 10.1007/s00066-012-0121-4
Fluorine-18-Radiolabeling and Radiopharmacological Characterization of a Benzodioxolylpyrimidine as a Radiotracer Targeting the Receptor Tyrosine Kinase EphB4
Mamat, C.; Mosch, B.; Neuber, C.; Köckerling, M.; Bergmann, R.; Pietzsch, J.
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ChemMedChem 7(2012)11, 1991-2003
DOI: 10.1002/cmdc.201200264
Synthesis and characterization of novel tetrahedral copper(I) complexes comprising tridentate PNP-aminodiphosphines and tetradentate PN(X)P-substituted aminodiphosphines (X = O, S)
Peruzzo, V.; Pretzsch, C.; Tisato, F.; Porchia, M.; Refosco, F.; Marzano, C.; Gandin, V.; Schiller, E.; Walther, M.; Pietzsch, H.-J.
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Inorganica Chimica Acta 387(2012), 163-172
DOI: 10.1016/j.ica.2012.01.012
Synthesis, in vitro and in vivo characterization of novel 99mTc-‘4+1’-labeled 5-nitroimidazole derivatives as potential agents for imaging hypoxia
Giglio, J.; Fernández, S.; Pietzsch, H.-J. D.; Dematteis, S.; Moreno, M.; Pacheco, J. P.; Cerecetto, H.; Rey, A.
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Nuclear Medicine and Biology 39(2012), 679-686
DOI: 10.1016/j.nucmedbio.2011.12.012
Module-assisted preparation of 64Cu with high specific activity
Thieme, S.; Walther, M.; Pietzsch, H.-J.; Henniger, J.; Preusche, S.; Mäding, P.; Steinbach, J.
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Applied Radiation and Isotopes 70(2012), 602-608
DOI: 10.1016/j.apradiso.2012.01.019