Publications of Institute of Radiopharmaceutical Cancer Research
191 Publications2012
The Synthesis and Molecular Structure of 2-(4-Methoxybenzyl)-4-nitro-2H-indazole
Ebert, K.; Köckerling, M.; Mamat, C.
Involved research facilities
- PET-Center
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Crystals 2(2012), 176-181
DOI: 10.3390/cryst2020176
Cited 1 times in Scopus
The Molecular Structure of 1,2:5,6-Di-O-isopropylidene-3-O-toluenesulfonyl-a-D-glucofuranose
Mamat, C.; Peppel, T.; Köckerling, M.
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Crystals 2(2012), 105-109
DOI: 10.3390/cryst2010105
ISSN: 2073-4352
Cited 6 times in Scopus
2011
Impact of functionalized coligands on the pharmacokinetics of 99mTc(III) ‘4+1’ mixed-ligand complexes conjugated to bombesin
Künstler, J.-U.; Bergmann, R.; Gniazdowska, E.; Kozminski, P.; Walther, M.; Pietzsch, H.-J.
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Journal of Inorganic Biochemistry 105(2011), 1383-1390
DOI: 10.1016/j.jinorgbio.2011.07.002
Cited 13 times in Scopus
Maleimido-Functionalized NOTA Derivatives as Bifunctional Chelators for Site-Specific Radiolabeling
Förster, C.; Schubert, M.; Pietzsch, H.-J.; Steinbach, J.
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Molecules 16(2011), 5228-5240
DOI: 10.3390/molecules16065228
ISSN: 1420-3049
Cited 10 times in Scopus
Synthesis, characterization and biological evaluation of [188Re(N)(cys∼)(PNP)]+/0 mixed-ligand complexes as prototypes for the development of 188Re(N)-based target-specific radiopharmaceuticals
Thieme, S.; Agostini, S.; Bergmann, R.; Pietzsch, J.; Pietzsch, H.-J.; Carta, D.; Salvarese, N.; Refosco, F.; Bolzati, C.
Involved research facilities
- PET-Center
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Nuclear Medicine and Biology 38(2011), 399-415
DOI: 10.1016/j.nucmedbio.2010.09.006
Cited 13 times in Scopus
Synthesis, structure determination and (radio-) fluorination of novel functionalized phosphanes suitable for the traceless Staudinger ligation
Mamat, C.; Franke, M.; Peppel, T.; Köckerling, M.; Steinbach, J.
Involved research facilities
- PET-Center
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Tetrahedron 67(2011), 4521-4529
DOI: 10.1016/j.tet.2011.04.091
Cited 19 times in Scopus
Synthesis and biological evaluation of new [Tc(N)(PS)]-based mixed-ligand compounds useful in design of target-specific radiopharmaceuticas: the 2-methoxyphenylpiperazine dithiocarbamate derivatives as example
Bolzati, C.; Salvarese, N.; Carta, D.; Refosco, F.; Dolmella, A.; Pietzsch, H.-J.; Bergmann, R.; Bandoli, G.
Involved research facilities
- PET-Center
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Journal of Biological Inorganic Chemistry 16(2011), 137-155
DOI: 10.1007/s00775-010-0712-4
Cited 14 times in Scopus
[18F]1-(3-fluoropropyl)piperazines as model compounds for the radiofluorination of pyrido[2,3-d]pyrimidines
Grosse-Gehling, P.; Wuest, F. R.; Peppel, T.; Köckerling, M.; Mamat, C.
Involved research facilities
- PET-Center
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Radiochimica Acta 99(2011), 365-373
DOI: 10.1524/ract.2011.1834
Cited 8 times in Scopus
Cross-Coupling Reactions as Valuable Tool for the Preparation of PET Radiotracers
Pretze, M.; Große-Gehling, P.; Mamat, C.
Involved research facilities
- PET-Center
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Molecules 16(2011), 1129-1165
DOI: 10.3390/molecules16021129
Cited 44 times in Scopus
2010
Sugar-decorated dendritic nanocarriers: Encapsulation and release of the octahedral rhenium cluster complex [Re6S8(OH)6]4-
Kubeil, M.; Stephan, H.; Pietzsch, H.-J.; Geipel, G.; Appelhans, D.; Voit, B.; Hoffmann, J.; Brutschy, B.; Mironov, Y. V.; Brylev, K. A.; Fedorov, V. E.
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Chemistry - An Asian Journal 5(2010), 2507-2514
DOI: 10.1002/asia.201000284
Cited 32 times in Scopus
Comparison of the stability of Y-90-, Lu-177- and Ga-68- labeled human serum albumin microspheres (DOTA-HSAM)
Wunderlich, G.; Schiller, E.; Bergmann, R.; Pietzsch, H.-J.
Involved research facilities
- PET-Center
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Nuclear Medicine and Biology 37(2010), 861-867
DOI: 10.1016/j.nucmedbio.2010.05.004
Cited 30 times in Scopus
The traceless Staudinger ligation with fluorine-18: a novel and versatile labeling technique for the synthesis of PET-radiotracers
Pretze, M.; Wuest, F.; Peppel, T.; Köckerling, M.; Mamat, C.
Involved research facilities
- PET-Center
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Tetrahedron Letters 51(2010), 6410-6414
DOI: 10.1016/j.tetlet.2010.09.134
Cited 43 times in Scopus
A novel Dibenzoazacyclooctyne precursor in regioselective Copper-free click chemistry. An innovative 3-step synthesis.
Starke, F.; Walther, M.; Pietzsch, H.-J.
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ARKIVOC (2010), 350-359
ISSN: 1551-7012
Synthesis and Radiofluorination of Iodophenyl Esters as Tool for the Traceless Staudinger Ligation
Pretze, M.; Flemming, A.; Köckerling, M.; Mamat, C.
Involved research facilities
- PET-Center
- Zeitschrift für Naturforschung Section B - A Journal of Chemical Sciences 65(2010), 1128-1136
A new hexanuclear rhenium cluster complex with six terminal acetate ligands: Synthesis, structure, and properties of K4[Re6S8(CH3COO)6]·8H2O
Brylev, K. A.; Mironov, Y. V.; Fedorov, V. E.; Kim, S.-J.; Pietzsch, H.-J.; Stephan, H.; Ito, A.; Kitamura, N.
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Inorganica Chimica Acta 363(2010)11, 2686-2691
DOI: 10.1016/j.ica.2010.04.042
Cited 36 times in Scopus
Novel 99mTc '4 + 1' peptide conjugates: Tuning the biodistribution by variation of coligands
Künstler, J.-U.; Seidel, G.; Bergmann, R.; Gniazdowska, E.; Walther, M.; Schiller, E.; Decristoforo, C.; Stephan, H.; Haubner, R.; Steinbach, J.; Pietzsch, H.-J.
Involved research facilities
- PET-Center
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European Journal of Medicinal Chemistry 45(2010), 3645-3655
DOI: 10.1016/j.ejmech.2010.05.010
Cited 17 times in Scopus
Crystal structure of N-benzyl-4-fluorobenzamide, C14H12FNO, at 173 K
Mamat, C.; Flemming, A.; Köckerling, M.
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Zeitschrift für Kristallographie - New Crystal Structures 225(2010), 345-346
DOI: 10.1524/ncrs.2010.0150
Cited 1 times in Scopus
Efficient preparation of 99mTc(III) 4+1 mixed-ligand complexes for peptide labeling with high specific activity
Künstler, J.-U.; Seidel, G.; Pietzsch, H.-J.
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Applied Radiation and Isotopes 68(2010), 1728-1733
DOI: 10.1016/j.apradiso.2010.04.008
Cited 8 times in Scopus
2009
Recent Application of Click Chemistry for the Synthesis of Radiotracers for Molecular Imaging
Mamat, C.; Ramenda, T.; Wuest, F.
- Mini-Reviews in Organic Chemistry 6(2009), 21-34
NMR Studies and Crystal Structure Determinations of CF3 Group-containing Bicyclic phenolates
Mamat, C.; Reinke, H.; Langer, P.
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Zeitschrift für Naturforschung Section B - A Journal of Chemical Sciences 64(2009)4, 423-426
ISSN: 0932-0776
Synthesis and characterization of rhenium and technetium-99m tricarbonyl complexes bearing the 4-[3-bromophenyl]quinazoline moiety as a biomarker for EGFR-TK imaging
Bourkoula, A.; Paravatou-Petsotas, M.; Papadopoulos, A.; Santos, I.; Pietzsch, H.-J.; Livaniou, E.; Pelecanou, M.; Papadopoulos, M.; Pirmettis, I.
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European Journal of Medicinal Chemistry 44(2009), 4021-4027
DOI: 10.1016/j.ejmech.2009.04.033
Cited 41 times in Scopus
Isomerism in tetrahedral rhenium cluster complexes [Re4Q4(PMe2sub>Ph)4X8]·nCH2Cl2 (Q = Se, X = Br; Q = Te, X = Cl, Br).
Efremova, O. A.; Mironov, Y. V.; Brylev, K. A.; Fedorov, V. E.; Pietzsch, H.-J.; Stephan, H.
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Polyhedron 28(2009), 2973-2976
DOI: 10.1016/j.poly.2009.07.003
Cited 3 times in Scopus
Synthesis of Benzoate-Functionalized Phosphanes as Novel Building Blocks for the Traceless Staudinger Ligation
Mamat, C.; Flemming, A.; Köckerling, M.; Steinbach, J.; Wuest, F.
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Synthesis 19(2009), 3311-3321
DOI: 10.1055/s-0029-1216947
Cited 26 times in Scopus
Radiosynthesis of New [90Y]-DOTA-Based Maleimide Reagents Suitable for the Prelabeling of Thiol-Bearing L-Oligonucleotides and Peptides
Schlesinger, J.; Fischer, C.; Közle, I.; Vonhoff, S.; Klussmann, S.; Bergmann, R.; Pietzsch, H.-J.; Steinbach, J.
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Bioconjugate Chemistry 20(2009), 1340-1348
DOI: 10.1021/bc900095k
Cited 19 times in Scopus
Two Coordination Modes of Bidentate Aminopyrazine Ligands in Cubane-type Cluster Complex Re4Te4Cl8(C4N3H4)4 . 2DMF
Efremova, O. A.; Mironov, Y. V.; Pietzsch, H.-J.; Stephan, H.; Perrin, C.; Fedorov, V. E.
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Journal of Cluster Science 20(2009), 77-81
DOI: 10.1007/s10876-008-0219-0
Cited 2 times in Scopus
The First Octahedral Cluster Complexes With Terminal Formate Ligands: Synthesis, Structure, and Properties of K4[Re6S8(HCOO)6] and Cs4[Re6S8(HCOO)6]
Brylev, K. A.; Mironov, Y. V.; Kozlova, S. G.; Fedorov, V. E.; Kim, S.-J.; Pietzsch, H.-J.; Stephan, H.; Ito, A.; Ishizaka, S.; Kitamura, N.
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Inorganic Chemistry 48(2009), 2309-2315
DOI: 10.1021/ic802178q
Cited 55 times in Scopus
Validation of 99mTc-labeled "4+1" fatty acids for myocardial metabolism and flow imaging Part 2: Subcellular distribution
Mirtschink, P.; Stehr, S. N.; Walther, M.; Pietzsch, J.; Bergmann, R.; Pietzsch, H.-J.; Weichsel, J.; Pexa, A.; Dieterich, P.; Wunderlich, G.; Binas, B.; Kropp, J.; Deussen, A.
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Nuclear Medicine and Biology 36(2009), 845-852
DOI: 10.1016/j.nucmedbio.2009.06.003
Cited 9 times in Scopus
Validation of 99mTc-labeled "4+1" fatty acids for myocardial metabolism and flow imaging Part 1: Myocardial extraction and biodistribution
Mirtschink, P.; Stehr, S. N.; Walther, M.; Pietzsch, J.; Bergmann, R.; Pietzsch, H.-J.; Weichsel, J.; Pexa, A.; Dieterich, P.; Wunderlich, G.; Binas, B.; Kropp, J.; Deussen, A.
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Nuclear Medicine and Biology 36(2009), 833-843
DOI: 10.1016/j.nucmedbio.2009.06.009
Cited 12 times in Scopus
2008
Rhenium and technetium complexes bearing quinazoline derivatives: progress towards a 99mTc biomarker for EGFR-TK imaging
Fernandes, C.; Santos, I. C.; Santos, I.; Pietzsch, H.-J.; Künstler, J.-U.; Kraus, W.; Rey, A.; Margaritis, N.; Bourkoula, A.; Chiotellis, A.; Paravatou-Petsotase, M.; Pirmettis, I.
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Dalton Transactions (2008), 3215-3225
DOI: 10.1039/b802021c
Cited 42 times in Scopus
Yttrium-86-labelled human serum albumin microspheres: relation of surface structure with in vivo stability
Schiller, E.; Bergmann, R.; Pietzsch, J.; Noll, B.; Sterger, A.; Johannsen, B.; Wunderlich, G.; Pietzsch, H.-J.
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Nuclear Medicine and Biology 35(2008), 227-232
DOI: 10.1016/j.nucmedbio.2007.10.008
Cited 25 times in Scopus
An 86Y-Labeled Mirror-Image Oligonucleotide: Influence of Y-DOTA Isomers on the Biodistribution in Rats
Schlesinger, J.; Közle, I.; Bergmann, R.; Tamburini, S.; Bolzati, C.; Tisato, F.; Noll, B.; Klussmann, S.; Vonhoff, S.; Wüst, F.; Pietzsch, H.-J.; Steinbach, J.
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Bioconjugate Chemistry 19(2008), 928-939
DOI: 10.1021/bc700453h
Cited 31 times in Scopus -
Lecture (Conference)
Turku PET Symposium New Targets in Molecular Imaging, 24.-27.05.2008, Turku, Finland -
Contribution to proceedings
Turku PET Symposium New Targets in Molecular Imaging, 24.-27.05.2008, Turku, Finland
Abstracts of the XI Turku PET Symposium, Kaarina, Finland: Painola, 978-951-29-3563-5, 11
Labeling of Fatty Acid Ligands with the Strong Electrophilic Metal Fragment [99mTc(N)(PNP)]2+ (PNP = Diphosphane Ligand)
Cazzola, E.; Benini, E.; Pasquali, M.; Mirtschink, P.; Walther, M.; Pietzsch, H.-J.; Uccelli, L.; Boschi, A.; Bolzati, C.; Duatti, A.
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Bioconjugate Chemistry 19(2008), 450-460
DOI: 10.1021/bc7002378
Cited 24 times in Scopus
Modified 4+1 Mixed Ligand Technetium Labeled Fatty Acids for Myocardial Imaging: Evaluation of Myocardial Uptake and Biodistribution
Mirtschink, P.; Stehr, S. N.; Pietzsch, H.-J.; Bergmann, R.; Pietzsch, J.; Wunderlich, G.; Heintz, A. C.; Kropp, J.; Spies, H.; Kraus, W.; Deussen, A.; Walther, M.
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Bioconjugate Chemistry 19(2008), 97-108
DOI: 10.1021/bc700164c
Cited 22 times in Scopus
2007
Two mononuclear Tc complexes: [2,2′-(3-phenylpropylimino)- and [2,2′-(propylimino)-bis(ethanethiolato)](4-methoxybenzenethiolato)-oxidotechnetate(V)
Emmerling, F.; Kraus, W.; Noll, B.; Noll, S.; Pietzsch, H.-J.
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Acta Crystallographica Section C 63(2007), m579-m582
DOI: 10.1107/S0108270107052870
Cited 1 times in Scopus
(4-Methoxybenzenethiolato-κS)oxido-[2,2-propylimino)-bis(ethanethiolato)- κ3S,N,S]rhenium(V)
Kraus, W.; Emmerling, F.; Noll, B.; Noll, S.; Pietzsch, H.-J.
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Acta Crystallographica Section E 63(2007), m3018
DOI: 10.1107/S1600536807056814
Myocardial uptake and biodistribution of newly designed technetium-labelled fatty acid analogues
Heintz, A. C.; Jung, C. M.; Stehr, S. N.; Mirtschink, P.; Walther, M.; Pietzsch, J.; Bergmann, R.; Pietzsch, H.-J.; Spies, H.; Wunderlich, G.; Kropp, J.; Deussen, A.
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Nuclear Medicine Communications 28(2007)8, 637-647
ISSN: 0143-3636
Cluster Core Controlled Reactions of Substitution of Terminal Bromide Ligands by Triphenylphosphine in Octahedral Rhenium Chalcobromide Complexes
Shestopalov, M. A.; Brylev, K. A.; Kozlova, S. G.; Fedorov, V. E.; Spies, H.; Pietzsch, H.-J.; Stephan, H.; Geipel, G.; Bernhard, G.
- Journal of the American Chemical Society 129(2007), 3714-3721
Very stable 188Re-S4 chelates for labelling biomolecules, prepared with highly concentrated perrhenate eluates
Seifert, S.; Jentschel, C.; Bergmann, R.; Pietzsch, H.-J.; Wunderlich, G.; Kotzerke, J.; Steinbach, J.
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Nuklearmedizin 5(2007), 181-184
ISSN: 0029-5566
Organometallic 99mTc(III) 4+1 Bombesin(7-14) Conjugates: Synthesis, Radiolabeling and In Vitro/In Vivo Studies
Künstler, J.-U.; Veerendra, B.; Figueroa, S. D.; Sieckmann, G. L.; Rold, T. L.; Hoffman, T. J.; Smith, C. J.; Pietzsch, H.-J.
- Bioconjugate Chemistry 18(2007), 1651-1661
Comparison of in vitro and in vivo properties of 99mTc-cRGD peptides labelled using different novel Tc-cores
Decristoforo, C.; Santos, I.; Pietzsch, H.-J.; Duatti, A.; Smith, C. J.; Rey, A.; Alberto, R.; von Guggenberg, E.; Haubner, R.
- Quarterly Journal of Nuclear Medicine and Molecular Imaging 51(2007), 33-41
Synthesis and biological evaluation of a new type of 99mTechnetium-labeled fatty acid for myocardial metabolism imaging
Walther, M.; Jung, C.; Bergmann, R.; Pietzsch, J.; Rode, K.; Fahmy, K.; Mirtschink, P.; Stehr, S.; Heintz, A.; Wunderlich, G.; Kraus, W.; Pietzsch, H.-J.; Kropp, J.; Deussen, A.; Spies, H.
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Bioconjugate Chemistry 18(2007), 216-230
ISSN: 10.1021/bc0601222
2006
Preparation and Biological Characterization of Isomeric 188Re(V) Oxocomplexes with Tetradentate S4 Ligands Derived from DMSA for Labeling of Biomolecules
Seifert, S.; Heinrich, T.; Jentschel, C.; Smuda, C.; Bergmann, R.; Pietzsch, H.-J.
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Bioconjugate Chemistry 17(2006), 1601-1606
DOI: 10.1021/bc0602331
Cited 9 times in Scopus
Bromo(tricarbonyl) (15-{[2-(methylthio-S)ethylthio-S} pentadecanoic acid)rhenium(l)
Kraus, W.; Walther, M.; Jung, C. M.; Emmerling, F.; Pietzsch, H.-J.
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Acta Crystallographica Section E 62(2006), m1660-m1662
DOI: 10.1107/S1600536806024081
Cited 1 times in Scopus
Novel and Efficient Preparation of Precursor [188Re(OH2)3(CO)3]+ for the Labeling of Biomolecules
Park, S. H.; Seifert, S.; Pietzsch, H.-J.
- Bioconjugate Chemistry 17(2006), 223-225
A new molecular mechanics force field for the design of oxotechnetium(V) and oxorhenium(V) radiopharmaceuticals
Comba, P.; Daubinet, A.; Martin, B.; Pietzsch, H.-J.; Stephan, H.
- Journal of Organometallic Chemistry 691(2006)11, 2495-2502
Octahedral rhenium cluster complexes with inner organic ligands: synthesis, structure and properties of [Re6Q8(3,5-Me2PzH)6]Br2·2(3,5-Me2PzH) (Q = S, Se)
Mironov, Y.; Bryleva, K.; Shestopalova, M.; Yarovoia, S.; Fedorova, V.; Spies, H.; Pietzsch, H.-J.; Stephan, H.; Geipel, G.; Bernhard, G.; Kraus, W.
- Inorganica Chimica Acta (2006)359, 1129-1134
188Re(III)-EDTA - a Multipurpose Starting Material for the Preparation of Relevant 188Re Complexes under Mild Conditions
Seifert, S.; Pietzsch, H.-J.
- Applied Radiation and Isotopes 64(2006), 223-227
2005
[Re6Q7O(3,5-Me2PzH)6]Br2·3,5-Me2PzH (Q = S, Se) new octahedral rhenium cluster complexes with organic ligands: original synthetic approach and unexpected ligand exchange in cluster core
Mironov, Y. V.; Shestopalov, M. A.; Brylev, K. A.; Yarovoi, A. S.; Romanenko, G. V.; Fedorov, V. E.; Spies, H.; Pietzsch, H.-J.; Stephan, H.; Geipel, G.; Bernhard, G.; Kraus, W.
- European Journal of Inorganic Chemistry (2005), 657-661
{2-Carboxy-2-{bis[(2-thiolato-_S)ethyl]amino-_N}ethanthiolato-_S} (triphenylphosphin-_P)rhenium(III)
Schiller, E.; Kraus, W.; Reck, G.; Spies, H.; Pietzsch, H.-J.
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Acta Crystallographica Section E 61(2005), M1373-M1375
ISSN: 1600-5368
A novel rhenium chelate system derived from dimercaptosuccinic acid for the selective labeling of biomolecules
Heinrich, T.; Kraus, W.; Pietzsch, H.-J.; Smuda, C.; Spies, H.
- Inorganic Chemistry 44(2005)26, 9930-9937
Disruption of unprecedented B-H...M agostic interactions: An alternative approach for labeling bioactive molecules
Garcia, R.; Paulo, A.; Domingos, A.; Santos, I.; Pietzsch, H.-J.
- Synthesis and Reactivity in Inorganic, Metal-Organic and Nano-Metal Chemistry 35(2005)1, 35-42
Mixed-Ligand Rhenium-188 Complexes with Tetradentate/Monodentate NS3/P (4+1) Coordination: Relation of structure with antioxidation stability
Schiller, E.; Seifert, S.; Tisato, F.; Refosco, F.; Bolzati, C.; Kraus, W.; Spies, H.; Pietzsch, H.-J.
- Bioconjugate Chemistry 16(2005), 634-643
[Re6Q7O(3,5-Me2PzH)6]Br2*3,5-Me2PzH (Q = S, Se) - new octahedral rhenium cluster complexes with organic ligands: original synthetic approach and unexpected ligand exchange in cluster core
Mironov, Y. V.; Shestopalov, M. A.; Brylev, K. A.; Yarovoi, S. S.; Romanenko, G.; Fedorov, V. E.; Spies, H.; Pietzsch, H.-J.; Stephan, H.; Geipel, G.; Bernhard, G.; Kraus, W.
- European Journal of Inorganic Chemistry (2005)4, 657-661
2004
The crucial role of the diphosphine heteroatom X in the stereochemistry and stabilization of the substitution-inert [M(N)(PXP)]2+ metal fragments (M = Tc, Re; PXP = diphosphine ligand)
Tisato, F.; Refosco, F.; Porchia, M.; Bolzati, C.; Bandoli, G.; Dolmella, A.; Duatti, A.; Boschi, A.; Jung, C. M.; Pietzsch, H.-J.; Kraus, W.
- Inorganic Chemistry 43(2004), 8617-8625
Cyclopentadienyl tricarbonyl complexes of 99mTC for the in vivo imaging of the serotonin 5-HT1A receptor in the brain
Saidi, M.; Kretzschmar, M.; Seifert, S.; Bergmann, R.; Pietzsch, H.-J.
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Invited lecture (Conferences)
2. International Symposium on Bioorganometallic Chemistry (ISBOMC04), 14.-19.07.2004, Zürich, Swizerland -
Journal of Organometallic Chemistry 689(2004)25, 4739-4744
DOI: 10.1016/j.jorganchem.2004.09.004
Cited 36 times in Scopus
Novel Procedures for Preparing 99mTc(III) Complexes with Tetradentate/Monodentate Coordination of Varying Lipophilicity and Adaptation to 188Re Analogues
Seifert, S.; Künstler, J.-U.; Pietzsch, H.-J.; Pawelke, B.; Bergmann, R.; Spies, H.
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Bioconjugate Chemistry 15(2004)4, 856-863
DOI: 10.1021/bc0300798
Cited 59 times in Scopus
Synthesis, Characterization, and Biological Evaluation of Neutral Nitrido Technetium(V) Mixed Ligand Complexes Containing Dithiolates and Aminodiphosphines. A Novel System for Linking Technetium to Biomolecules
Bolzati, C.; Benini, E.; Cazzola, E.; Jung, C.; Tisato, F.; Refosco, F.; Pietzsch, H.-J.; Spies, H.; Uccelli, L.; Duatti, A.
- Bioconjugate Chemistry 15(2004), 628-637
2003
Aqueous synthesis of derivatized cyclopentadienyl complexes of technetium and rhenium directed towards radiopharmaceutical application
Bernard, J.; Ortner, K.; Spingler, B.; Pietzsch, H.-J.; Alberto, R.
- Inorganic Chemistry 42 (2003) 1014-1022
Synthesis, characterization and biological evaluation of technetium(III) complexes with tridendate/bidendate S,E,S/P,S coordination (E = O, N(CH3), S): A novel approach to robust technetium chelates suitable for linking the metal to biomolecules
Pietzsch, H.-J.; Seifert, S.; Syhre, R.; Tisato, F.; Refosco, F.; Leibnitz, P.; Spies, H.
- Bioconjugate Chemistry 14 (2003) 136-143
2002
A novel technetium-99m radioligand for the 5-HT1A receptor derived from desmethyl-WAY-100635 (DWAY)
Heimbold, I.; Drews, A.; Syhre, R.; Kretzschmar, M.; Pietzsch, H.-J.; Johannsen, B.
- European Journal of Nuclear Medicine 29 (2002) 82-87
Syntheses and first crystal structures of rhenium complexes derived from omega-functionalized fatty acids as model compounds of technetium tracers for myocardial metabolism imaging
Jung, C. M.; Kraus, W.; Leibnitz, P.; Pietzsch, H.-J.; Kropp, J.; Spies, H.
- European Journal of Inorganic Chemistry (2002) 1219-1225
Synthesis and biological evaluation of technetium(III) mixed-ligand complexes with high affinity for the cerebral 5-HT1A receptor and the alpha1-adrenergic receptor
Drews, A.; Pietzsch, H.-J.; Syhre, R.; Seifert, S.; Varnäs, K.; Hall, H.; Halldin, C.; Kraus, W.; Karlsson, P.; Johnsson, C.; Spies, H.; Johannsen, B.
- Nuclear Medicine and Biology 29 (2002) 389-398
Development of technetium-99m-based CNS receptor ligands: have there been any advances?
Johannsen, B.; Pietzsch, H.-J.
- Eur. J. Nucl. Med. 29 (2002) 263-275
Synthesis , biological and autoradiographic evaluation of a novel Tc-99m radioligand derived from WAY 100635 with high-affinity for the 5-HT1A receptor and the alpha1-adrenergic receptor
Heimbold, I.; Drews, A.; Kretzschmar, M.; Varnäs, K.; Hall, H.; Halldin, C.; Syhre, R.; Kraus, W.; Pietzsch, H.-J.; Seifert, S.; Brust, P.; Johannsen, B.
- Nuclear Medicine and Biology 29 (2002) 375-387
2001
Synthesis and properties of triethyl(triphenyl)siloxyalkyl(aryl)thiolato(3-thiapentane-1,5-dithialato)oxorhenium(V)- potential brain seeking agents
Abedin, M. Z.; Spies, H.; Pietzsch, H.-J.; Zablotskaya, A.
- Bangladesh Journal of Nuclear Medicine (2001) 1-6.
Reactivity of Technetium(I) Thioether Carbonyl Complexes towards Histidine - An EXAFS Study in Solution
Seifert, S.; Künstler, J.-U.; Gupta, A.; Funke, H.; Reich, T.; Pietzsch, H.-J.; Alberto, R.; Johannsen, B.
- Inorganica Chimica Acta 322 (2001) 79-86
Mixed-ligand technetium(III) complexes with tetra-dendate/monodendate NS3/isocyanide coordination: A new nonpolar Technetium chelate system for the design of neutral and lipophilic complexes stable in vivo
Pietzsch, H.-J.; Gupta, A.; Syhre, R.; Leibnitz, P.; Spies, H.
- Bioconjugate Chem. Vol.12 Nr. 4 (2001) 538-544
Synthesis and characterization of novel trigonal-bipyramidal technetium(III) mixed-ligand complexes with SES/S/P coordination (E = O, N(CH3), S)
Pietzsch, H.-J.; Tisato, F.; Refosco, F.; Leibnitz, P.; Drews, A.; Seifert, S.; Spies, H.
- Inorg. Chem. 40 (2001), 40, 59-64
2000
Glutathione interaction with SNS/S mixed ligand complexes of oxorhenium(V): Kinetic aspects and characterization of the products
Nock, B.; Maina, T.; Tsortos, A.; Pelecanou, M.; Raptopoulou, C. P.; Papadopoulos, M.; Pietzsch, H.-J.; Stassinopoulou, C.; Terzis, A.; Spies, H.; Nounesis, G.; Chiotellis, E.
- Inorganic Chemistry 39 (2000) 4433-4441
EXAFS Analyses of Technetium(I) Carbonyl Complexes - Stability Studies in Solutions
Seifert, S.; Kuenstler, J.-U.; Gupta, A.; Funke, H.; Reich, T.; Hennig, C.; Rossberg, A.; Pietzsch, H.-J.; Alberto, R.; Johannsen, B.
- Radiochim. Acta 88 (2000) 239-245
Chemical and biological characterization of technetium(I) and rhenium(I) tricarbonyl complexes with dithioether ligands serving as linkers for coupling the Tc(CO)3 and Re(CO)3 moieties to biologically active molecules
Pietzsch, H.-J.; Gupta, A.; Reisgys, M.; Drews, A.; Seifert, S.; Syhre, R.; Spies, H.; Alberto, R.; Abram, U.; Schubiger, P. A.
- Bioconjugate Chem. 11 (2000) 414-424
Oxorhenium mixed-ligand complexes with the 2,6-dimercaptomethylpyridine ligand. Crystal structure of [2,6-dimercaptomethylpyridinato][p-methoxybenzenethiolato]oxorhenium(V)
Nock, B.; Pietzsch, H.-J.; Tisato, F.; Maina, T.; Leibnitz, P.; Spies, H.; Chiotellis, E.
- Inorg. Chim. Acta 304 (2000) 26-32
Stability Studies on 99mTechnetium(III) Complexes with Tridentate/Monodentate Thiol Ligands and Phosphine ("3+1+1" Complexes)
Seifert, S.; Drews, A.; Gupta, A.; Pietzsch, H.-J.; Spies, H.; Johannsen, B.
- Appl. Radiat. Isot. 53 (2000) 431-438
Assessment of the in vitro and in vivo properties of a 99mTc-labeled inhibitor of the multidrug resistant gene product P-glycoprotein.
Bergmann, R.; Brust, P.; Scheunemann, M.; Pietzsch, H.-J.; Seifert, S.; Roux, F.; Johannsen, B.
- Nucl. Med. Biol. 27 (2000) 135-141
1999
Study on the formation of mixed ligand oxorhenium and oxotechnetium complexes (SNS/S combination)
Papadopoulos, M.; Pirmettis, I.; Tsoukalas, C.; Nock, B.; Maina, T.; Raptopoulou, C. P.; Terzis, A.; Pietzsch, H.-J.; Friebe, M.; Spies, H.; Johannsen, B.; Chiotellis, E.
- Inorg. Chim. Acta 295 (1999) 1-8
First Application of fac-[99mTc(OH2)3(CO)3]+ in Bioorganometallic Chemistry: Design, Structure, and in Vitro Affinity of a 5-HT1A Receptor Ligand Labeled with 99mTc
Alberto, R.; Schibli, R.; Schubiger, P. A.; Abram, U.; Pietzsch, H.-J.; Johannsen, B.
- J. Am. Chem. Soc. 121, 25, 1999, 6076-6077
Synthesis and Autoradiographical Evaluation of a Novel High-Affinity Tc-99m Ligand for the 5-HT2A Receptor
Pietzsch, H.-J.; Scheunemann, M.; Kretzschmar, M.; Elz, S.; Pertz, H. H.; Seifert, S.; Brust, P.; Spies, H.; Syhre, R.; Johannsen, B.
- Nuclear Medicine and Biology, 26 (1999) 865-875
1998
No Carrier Added Preparations of '3+1' Mixed-Ligand 99mTc Complexes
Seifert, S.; Pietzsch, H.-J.; Scheunemann, M.; Spies, H.; Syhre, R.; Johannsen, B.
-
Appl. Radiat. Isot. Vol. 49, Nos 1-2, pp. 5-11, 1998
DOI: 10.1016/S0969-8043(97)00221-2
Cited 29 times in Scopus
1997
Technetium and rhenium complexes with thioether ligands. VI. Synthesis and structural characterization of mixed-ligand oxorhenium(V) complexes containing bidentate dithioethers and monothiolato ligands.
Reisgys, M.; Spies, H.; Johannsen, B.; Leibnitz, P.; Pietzsch, H.-J.
- Chem. Ber. 130 (1997) 1343-1347
Synthesis of Rhenium(I) and Technetium(I) Carbonyl/Dithioether Ligand Complexes Bearing 3,17-BETA-Estradiol
Reisgys, M.; Wüst, F.; Alberto, R.; Schibli, R.; Schubiger, P. A.; Pietzsch, H.-J.; Spies, H.; Johannsen, B.
-
Bioorganic and Medicinal Chemistry Letters, Vol. 7, No. 17, pp 2243-2246, 1997
DOI: 10.1016/S0960-894X(97)00396-X
Cited 28 times in Scopus
Synthesis and Structural Characterization of Neutral Oxorhenium(V) Complexes with Tridentate Dithioethers
Pietzsch, H.-J.; Reisgys, M.; Spies, H.; Leibnitz, P.; Johannsen, B.
- Chemische Berichte 130 (1997) pp. 357-361
Structural modification of receptor binding 99m-Tc complexes in order to improve brain uptake
Johannsen, B.; Berger, R.; Brust, P.; Pietzsch, H.-J.; Scheunemann, M.; Seifert, S.; Spies, H.; Syhre, R.
- European Journal of Nuclear Medicine 24 (1997) 3 pp. 316-319
Technetium and Rhenium Complexes with Thioether Ligands, 5 Synthesis and Structural Characterization of Neutral Oxorhenium (V) Complexes with Tridentate Dithioethers
Pietzsch, H.-J.; Reisgys, M.; Spies, H.; Leibnitz, P.; Johannsen, B.
- Chemische Berichte, Recueil 1997, 130, 357-361
1996
Technetium(V) and Rhenium(V) Complexes for 5-HT2A Serotonin Receptor Binding: Structure-Affinity Considerations
Johannsen, B.; Scheunemann, M.; Spies, H.; Brust, P.; Wober, J.; Syhre, R.; Pietzsch, H.-J.
-
Journal of Nuclear Medicine and Biology 23 (1996) 429-438
DOI: 10.1016/0969-8051(96)00015-7
Cited 61 times in Scopus
1995
Synthesis and reactions of trigonal-bipyramidal rhenium and technetium complexes with a tripodal, tetradentate NS3 ligand*
Spies, H.; Glaser, M.; Pietzsch, H.-J.; Hahn, F. E.; Lügger, T.
- Inorganica Chimica Acta 240 (1995) pp. 465-478
Neutral Oxorhenium(V) Complexes with Tridentate Dithiolates and Monodentate Alkane- or Arene-thiolate Coligands
Spies, H.; Fietz, T.; Pietzsch, H.-J.; Johannsen, B.; Leibnitz, P.; Reck, G.; Scheller, D.; Klostermann, K.
-
Journal of the Chemical Society Dalton Transactions (1995) 13 pp. 2277-2280
DOI: 10.1039/dt9950002277
Cited 59 times in Scopus
Technetium- and Rhenium Complexes with Thioether Ligands-IV. Synthesis and Structural Characterization of Binuclear Oxorhenium (V) Complexes with Bidentate Thioether Coordination
Pietzsch, H.-J.; Spies, H.; Leibnitz, P.; Reck, G.
-
Polyhedron 14 (1995) 13-14 pp.1849-1853
DOI: 10.1016/0277-5387(94)00470-Y
Cited 22 times in Scopus
Synthesis and molecular structure of chlore(3-thiapentane-1.5-dithiolato)oxorhenium(V)
Fietz, T.; Spies, H.; Pietzsch, H.-J.; Leibnitz, P.
-
Inorganica Chimica Acta 231 (1995) pp. 233-236
DOI: 10.1016/0020-1693(94)04351-U
Cited 61 times in Scopus
1994
Trigonal-bipyramidale Technetium- und Rhenium-Komplexe mit vierzähnigen tripodalen NS3-Liganden
Spies, H.; Glaser, M.; Pietzsch, H.-J.; Hahn, F. E.; Kintzel, O.; Lügger, T.
- Angewandte Chemie 106 (1994) 13 pp. 1416-1419
1993
Technetium Complexes with Thioether Ligands
Pietzsch, H.-J.; Spies, H.; Leibnitz, P.; Reck, G.; Johannsen, B.
-
Radiochimica Acta 63 (1993) pp. 163-166
DOI: 10.1524/ract.1993.63.special-issue.163
Technetium Complexes with Thioether Ligands - III. Synthesis and Structural Characterization of Cationic Nitridotechnetium(V) Complexes with Thiacrown ethers
Pietzsch, H.-J.; Spies, H.; Leibnitz, P.; Reck, G.
- Polyhedron 12 (1993) 24 pp. 2995-3002