Contact

Prof. Dr. Jens Pietzsch
Head Radiopharmaceutical Biology / TU Dresden
Head Radiopharmaceutical and Chemical Biology
j.pietzschAthzdr.de
Phone: +49 351 260 - 2622
Fax: 12622, 3661

Marita Kersten
Secretariat / Administration
Institute of Radiopharmaceutical Cancer Research
m.kerstenAthzdr.de
Phone: +49 351 260 - 3223
Fax: 13223, 3232

Eye catcher

Department of Radiopharmaceutical and Chemical Biology

Our efforts focus on biochemistry, biology, imaging, and therapy of malignant solid tumors and metastases, with emphasis placed on melanoma and pheochromocytoma. The discovery and functional characterization of tumor-specific membrane and intracellular proteins, and subset parameters of tumor microenvironment in vitro and in vivo are objectives of several projects and collaborations. This topic implicates pre-clinical research intended to evaluate the theragnostic potential of recent discoveries in the basic mechanisms of both solid tumor pathogenesis and metastasis. Therefore, our research encompasses a broad spectrum of laboratory activities, directed on pharmacological characterization of novel radiolabeled and non-radioactive compounds for either diagnostic or therapeutic use in cell, organ and animal models to determine a) biodistribution, kinetics, and metabolism of novel radiotracers, b) pharmacodynamics of cognate candidate compounds for targeted radionuclide therapy, and c) therapeutic potential of natural and synthetic compounds for application as adjuvant targeted radioprotective or radiosensitizing agents. The resulting data including information obtained by multimodal small animal imaging techniques are used in elucidation of structure-activity relationships as well as providing a basis for assessing potential clinical utility. The best compounds identified in initial screening are subsequently examined in more sophisticated models that allow, under a variety of physiological conditions, direct evaluation of the relationship between compound action and specific aspects of both tissue pathobiochemistry and pathophysiology. For promising compounds identified in this manner, we have productive collaborative relationships with a number of investigators that allow for additional preclinical and clinical assessment of theragnostic performance.


Research Topics

  • Receptor/enzyme targeting of solid tumors and metastases
  • Target molecules for theragnostics of malignant cancers, e.g., melanoma and pheochromocytoma
  • Multimodal imaging to understand the in vivo behavior of polymeric biomaterials

Groups

  • Organic and Radiochemistry (Torsten Kniess, Ph.D.)
  • Tumor-specific PET Radiotracers (Reik Löser, Ph.D.)
  • Radiopharmacology and Imaging (Ralf Bergmann, Ph.D. and Christin Neuber, Ph.D.)
  • Molecular Mechanisms in Solid Tumors (Birgit Mosch, Ph.D.)
  • Biomaterials and Imaging (Jens Pietzsch, Ph.D., M.D., Prof.)

Contact

Prof. Dr. Jens Pietzsch
Head Radiopharmaceutical Biology / TU Dresden
Head Radiopharmaceutical and Chemical Biology
j.pietzschAthzdr.de
Phone: +49 351 260 - 2622
Fax: 12622, 3661

Marita Kersten
Secretariat / Administration
Institute of Radiopharmaceutical Cancer Research
m.kerstenAthzdr.de
Phone: +49 351 260 - 3223
Fax: 13223, 3232