Dr. Holger Stephan

Group Leader Nanoscalic Systems

Address Helmholtz-Zentrum Dresden-Rossendorf
Institute of Radiopharmaceutical Cancer Research
P.O. Box 51 01 19
D-01314 Dresden
Room Building 801/C207
Phone +49-351-260 3091
Fax +49-351-260 3232
Email h.stephan@hzdr.de


Curriculum vitae

  • Born in Dresden in 1955
  • Diploma in Chemistry at the Technical University Bergakademie Freiberg in 1981 and a PhD in organic chemistry at the same University in 1989 with Prof Jörg Beger (thesis work: amido podands – synthesis and investigations of solvent extraction of metal salts)
  • Head of a working group (Centre of Research and Technology of Microelectronics Dresden, 1981-1984)
  • Assistant research scientist (Technical University Bergakademie Freiberg/Company of Synthetic Fibres Schwarza, 1984 – 1989)
  • Research fellow (Central Institute of Solid State Physics and Material Research Dresden, 1989-1993)
  • Senior scientist (Technical University Dresden, Institute of Inorganic Chemistry, 1994-1997)
  • Research fellow (Forschungszentrum Dresden-Rossendorf, since 1998)

Spokesperson of the Helmholtz Virtual Institute "Functional nanomaterials for multimodality cancer imaging (NanoTracking)": http://www.hzdr.de/Nanotracking


Research Interests

Development and characterization of new radiotracer and extractants, Supramolecular Chemistry, Dendrimer Chemistry, Coordination Chemistry and Thermodynamics of Liquid Two-phase Systems.


Expertise

The group has comprehensive experiences for undertaking radiotracer experiments, different spectroscopic techniques, characterization of colloid-chemical properties and in vitro/in vivo studies in view of the development and characterization of novel radiotracers, including functionalized nanoparticles. The design and development of chemically, metabolically and radiolytically stable radiometal complexes on the basis of 64Cu/67Cu is of special interest. Furthermore, polynuclear metal compounds (polyoxometalates, Re clusters) for anti-tumor activity, photosensitizing, and radiation-sensitizing properties are under investigation. The characterization of binding and transport behavior of novel receptors by solvent extraction studies represents one main topic.

Collaborations

  • Design and synthesis of highly stable radiocopper complexes (Prof Peter Comba, University of Heidelberg; Prof Leone Spiccia, Dr Bim Graham; Monash University Melbourne – Australia)
  • Development and characterization of ultrasmall nanomaterials for multimodality cancer imaging (Prof Luisa De Cola, University of Münster; Prof Leone Spiccia, Dr Bim Graham; Monash University Melbourne – Australia)
  • Polynuclear metal compounds as metallic drugs (Prof Christa E. Müller, University of Bonn; Prof Vladimir E. Fedorov, Nikolaev Institute of Inorganic Chemistry, Novosibirsk – Russia)
  • Development of metal-bioconjugates (PNAs) for therapeutic purposes (Prof Gilles Gasser, University of Zurich)
  • Photochemical and photo-physical characterization of metal-bioconjugates (Dr Gerhard Geipel, HZDR)