Porträt Dr. Knieß, Torsten; FWPB

Dr. Torsten Knieß
Radiopharmaceutical and Chemical Biology
Phone: +49 351 260 - 2760, 2932
Fax: 12760, 2915

Torsten Kniess' Publications


  • Kniess, T.; Laube, M.; Brust, P.; Steinbach, J.; 2-[18F]fluoroethyltosylate - a versatile tool of building 18F based radiotracers for positron emission tomography. MedChemComm 2015, 6, 1714-1754.
  • Tondera, C.; Ullm, S.; Laube, M.; Meister, S.; Neuber, C.; Mosch, B.; Kniess, T.; Pietzsch, J.; Optical imaging of COX-2: Studies on an autofluorescent 2,3-diaryl-substituted indole-based Cycloocygenase-2 inhibitor. Biochem. Biophys. Res. Commun. 2015, 458, 40-45.
  • Xie, F.; Kniess, T.; Neuber, C.; Deuther-Conrad, W. Mamat, C.; Lieberman, B.P.; Liu, B.; Mach, R.H.; Brust, P.; Steinbach,J.; Pietzsch, J.; Jia, H.; Novel indole-based sigma-2 receptor ligands: synthesis, structure-affinity relationship and antiproliferative activity. MedChemComm 2015, 6, 1093-1103.
  • Laube, M.; Gassner, C.; Sharma, S.K.; Günther, R.; Pigorsch, A.; König, J.; Köckerling, M.; Wuest, F.; Pietzsch, J.; Kniess, T.; Diaryl-substituted (dihydro)pyrrolo[3,2,1-hi]indoles, a class of potent COX-2 inhibitors with tricyclic core structure. J. Org. Chem. 2015, 80, 5611-5624.
  • Bechmann, N.; Kniess, T.; Köckerling, M.; Pigorsch, A.; Steinbach, J.; Pietzsch, J.; Novel (pyrazolyl)bebzenesulfonamides with nitric oxide-releasing moiety as selective cyclooxygenase-2 inhibitors. Bioorg. Med. Chem. Lett. 2015, 25, 3295-3300.
  • Xie, F.; Bergmann, R.; Kniess, T.; Deuther-Conrad, W.; Mamat, C.; Neuber, C.; Liu, B.; Steinbach, J.; Brust, P.; Pietzsch, J.; Jia, H.; 18F-labeled 1,4-dioxa-8-azaspiro[4.5]decane derivative: Synthesis and biological evaluation of a σ1 receptor radioligand with low lipophilicity as potent tumor imaging agent. J. Med. Chem., 2015, 58, 5395-5407.


  • Kniess, T.; Bergmann, R.; Xie, F.; Jia, H.; Deuther-Conrad, W.; Steinbach, J.; Pietzsch, J.; Radiosynthesis, in vitro and in vivo evaluation of 8-[4-(2-[18F]fluoroethoxy)benzyl]-1,4-dioxa-8-azaspiro[4.5]decane, a spirocyclic σ1 receptor ligand for tumor imaging. Eur. J. Nucl. Med. Mol. Imaging 2014, 41, S2, S416.
  • Laube, M.; Tondera, C.; Sharma, S.K.; Bechmann, N.; Pietzsch F.J.; Pigorsch, A.; Köckerling, M.; Wuest, F.; Pietzsch, J.; Kniess, T.; 2,3-Diaryl-substituted indole based COX-2 inhibitors as leads for imaging tracer development. RSC Advances 2014, 4, 38726-38742.
  • Ullm, S.; Laube, M.; Bechmann, N.; Kniess, T.; Pietzsch, J.; Organotypical vascular model for the characterization of radioprotective compounds: Studies on antioxidant 2,3-diaryl-substituted indole based cyclooxygenase-2 inhibitors. Clinical Hemorheology and Microcirculation 2014, 58, 281-295.


  • Ribeiro Morais, G.; Gano, L.; Kniess, T.; Bergmann, R.; Abrunhosa, A.; Santos, I.; Paulo, A.; Radiosynthesis and in vivo evaluation of a 18F-labelled styryl-benzooxazole derivative for β-amyloid targeting. Appl. Radiat. Isot. 2013, 82, 100-104.
  • Laube, M.; Kniess, T.; Pietzsch, J.; Radiolabeled COX-2 Inhibitors for Non-Invasive Visualization of COX-2 Expression and Activity - A Critical Update. Molecules 2013, 18; 6311-6355.
  • Kniess, T.; Kuchar, M.; Bergmann, R.; Steinbach, J; Pietzsch, J.; Radiosynthesis of 5-(2-[18F]fluoroethyl-Suntinib as an inhibitor of VEGFR-2 - first results. Eur. J. Nucl. Med. Mol. Imaging 2013, 40, S2, S316.
  • Tondera, C.; Laube, M.; Wimmer, C.; Kniess, T.; Mosch, B.; Großmann, K., Pietzsch, J.; Visualization of cyclooxygenase-2 using a 2,3-diarylsubstituted indole-based inhibitor and confocal laser induced cryofluorescence microscopy at 20 K in melanoma cells in vitro. Biochem. Biophys. Res. Commun. 2013, 430, 301-306.
  • Franck, D.; Kniess, T.; Steinbach, J.; Zitzmann-Kolbe, S.; Friebe, M.; Dinkelborg, L.M.; Graham, K.; Investigations into the synthesis, radiofluorination and conjugation of a new [18F]fluorocyclobutyl prosthetic group and its in vitro stability using a tyrosine model system. Bioorg. Med. Chem. 2013, 21, 643-652.
  • Laube, L.; Neumann, W.; Scholz, M.; Lönnecke, P.; Crews, B.; Marnett, L.R.; Pietzsch, J.; Kniess, T.; Hey-Hawkins, E.; 2-Carbaborane-3-phenyl-1H-indoles - Synthesis via McMurry Reaction and Cyclooxygenase (COX) Inhibition Activity. ChemMedChem 2013, 8, 329-335.


  • Kuchar, M.; Pretze, M.; Kniess, T.; Steinbach, J.; Pietzsch, J.; Löser, R. Site-selective radiolabeling of peptides by 18F-fluorobenzoylation with [18F]SFB in solution and on solid phase: a comparative study. Amino Acids 2012, 43, 1431-1443.

  • Kniess, T. Radiolabeled small molecule inhibitors of VEGFR - recent advances. Curr. Pharm. Design 2012, 18, 2867-2874.

  • Kniess, T.; Laube, M.; Bergmann, R.; Sehn, F.; Graf, F.; Steinbach, J.; Wuest, F.; Pietzsch, J., Radiosynthesis of a 18F-labeled 2,3-diarylsubstituted indole via McMurry coupling for functional characterization of cyclooxygenase-2 (COX-2) in vitro and in vivo. Bioorg. Med. Chem. 2012, 20, 3410-3421.

  • Kuchar, M.; Oliveira, M. C.; Gano, L.; Santos, I.; Kniess, T. Radioiodinated sunitinib as a potential radiotracer for imaging angiogenesis - radiosynthesis and first radiopharmacological evaluation of 5-[125I]Iodo-sunitinib. Bioorg. Med. Chem. Lett. 2012, 22, 2850-2855.

  • Neto, C.; Fernandes, C.; Oliveira, M. C.; Gano, L.; Mendes, F.; Kniess, T.; Santos, I. , Radiohalogenated 4-anilinoquinazoline-based EGFR-TK inhibitors as potential cancer imaging agents. Nuclear Medicine and Biology, 2012, 39, 247-260.

  • Caballero, J.; Munoz, C., Alzate-Morales, J.H.; Cunha, S.; Gano, L.; Bermann, R.; Steinbach, J.; Kniess, T.; Synthesis, in silico, in vitro, and in vivo investigation of 5-[11C]methoxy-substituted sunitinib, a tyrosine kinase inhibitor of VEGFR-2. Eur. J. Med. Chem., 2012, 58, 272-280.

  • Munoza, C.; Adasmea, F.; Alzate-Moralesa, Jans H.; Vergara-Jaquea, A.; Kniess, T.; Caballero, J. Study of differences in the VEGFR-2 inhibitory activities between semaxanib and SU5205 using 3D-QSAR, docking, and molecular dynamics simulations. Journal of Molecular Graphics and Modelling, 2012, 32, 39.

  • Neto, C.; Oliveira, M.C.; Gano, L.; Marques, F.; Yasuda, T.; Thiemann, T.; Kniess, T.; Santos, I.; Novel 7α-alkoxy-17α-(4'-halophenylethynyl)estradiols as potential SPECT/PET imaging agents for estrogen receptor expressing tumours: Synthesis and binding affinity evaluation. Steroids, 2012, 77, 1123-1132.


  • Svensson, F., Kniess, T., Bergmann R., Pietzsch J., Wuest F., Synthesis of an 18F-labeled cyclin-dependent kinase-2 inhibitor. J. Labeled Compd.Radiopharm. 2011, 54, 769-774.

  • Al-Hourani B.J., Sharma S.K., Mane J.Y., Tuszynski J., Baracos V., Kniess T., Pietzsch J., Wuest F. Synthesis and evaluation of 1,5-diaryl-substituted tetrazoles as novel selective cyclooxygenase-2 (COX-2) inhibitors. Bioorg. Med. Chem. Lett. 2011, 21, 1823-1826

  • Kapty J., Kniess T., Wuest F., Mercer J.R. Radiolabeling of phosphatidylserine-binding peptides with prosthetic groups N-[6-(4-[18F]fluorobenzylidene)aminooxyhexyl]maleimide ([18F]FBAM) and N-succinimidyl-4-[18F]fluorobenzoate ([18F]SFB]. Appl. Radiat. Isot. 2011, 69, 1218-1225

  • Kniess T., Kuchar M., Pietzsch J. Automated radiosynthesis of the thiol-reactive labeling agent N-[6-(4-[18F]fluorobenzylidene)aminooxyhexyl]maleimide ([18F]FBAM. Appl. Radiat. Isot. 2011, 69, 1226-1230.


  • Kniess, T., Oliveira, C., Kuchar, M., Gano, L., Santos, I., Steinbach, J., Synthesis and first radiopharmacological investigation of 5-[125I]Iodo-SU11248, a potential radiotracer for imaging VEGFR. Eur. J. Nucl. Med. & Mol. Imaging, 2010, 37(S2), S364.

  • Kniess, T., Richter, S., Steinbach, J., Modified synthesis of sodium 2-[18F]fluoroacetate using a Tracerlab FXN synthesizer. Q. J. Nucl. Med. Mol. Imaging, 2010, 52-2(S1), 54.

  • Richter, S., Ramenda, T., Bergmann, R., Kniess, T., Steinbach, J., Pietzsch, J., Wuest, F., Synthesis of neurotensin(8-13)-phosphopeptide heterodimers via click chemistry. Bioorg. Med. Chem. Lett., 2010, 20, 3306-3309.


  • Ramenda, T., Kniess, T., Bergmann, R. Steinbach, J., Wuest, F. Radiolabelling of proteins with fluorine-18 via click chemistry. Chem. Commun. 2009, 7521-7523

  • Wüst, F., Kniess, T., Henry, B., Bernardus W.M.M., Wiegerinck P., Pietzsch, J., Bergmann, R. Radiosynthesis and radiopharmacological evaluation of [N-methyl-11C]ORG34850 as a glucocorticoid receptor (GR)-binding radiotracer. Appl. Radiat. Isot., 2009, 67, 308-312.
  • Kniess, T., Bergmann, R., Kuchar, M.; Steinbach, J., Wüst, F. Synthesis and radiopharmacological investigation of 3-[4'-[18F]fluorobenzylidene-2-one as possible tyrosine kinase inhibitor. Bioorganic & Medicinal Chemistry, 2009, 17, 7732-7742.

  • Wüst, F., Tang,  X., Kniess, T., Pietzsch,  J., Suresh,  M., Synthesis and cyclooxygenase inhibition of various (aryl-1,2,3-triazole-1-yl)-methanesulfonylphenyl derivatives. Bioorganic & Medicinal Chemistry, 2009, 17, 1146-1151.

  • Kniess, T., Steinbach, J., PET-Tracer für die onkologische Diagnostik: Welche radiomarkierten Substanzen sind relevant?, Onkol. Pharmazie, 2009, 11, 4-11.

  • Graf, F., Köhler, L., Kniess, T., Wüst, F., Mosch, B., Pietzsch, J., Cell Cycle Regulating Kinase Cdk4 as Potential Target for Tumor Cell Treatment and Tumor Imaging., Journal of Oncology,
    2009, doi:10.1155/2009/106378.

  • Kniess, T., Bergmann, R., Steinbach, J., Synthesis and Metabolic Stability of 11C-Labelled SU11248 Derivative as Inhibitor of Tyrosine Kinases.  Eur.  J. Nucl. Med. Mol. Imaging, 2009, 36(S2), S310.


Dr. Torsten Knieß
Radiopharmaceutical and Chemical Biology
Phone: +49 351 260 - 2760, 2932
Fax: 12760, 2915