Work Experience and Research Topics   -   Education   -   Selected Publications

Work Experience and Research Topics

since 2002 Senior Scientist

Institut für Interdisziplinäre Isotopenforschung, Leipzig


  • In vitro evaluation of potential PET ligands (radioligand binding, autoradiography)
  • In vivo and ex vivo evaluation of potential PET ligands (biodistribution, autoradiography)
2000-2002 Research Scientist

Interdisziplinäres Zentrum für Klinische Forschung,

Universität Leipzig

IZKF Junior Group Neuroimmunological Cell Biology

  • Investigation on the molecular effects of AGE-modified ß-Amyloid (cell and molecular biology)
  • Analyses of inflammatory processes, signal transduction, redox imbalances in cell systems (protein biochemistry, immunohistochemistry)
  • Impact of AGEs on the pathogenesis of Alzheimer’s disease
1997-2000 Postdoc

Innere Medizin III, Universitätsklinik Jena


  • Investigation on the degradation of AGE-modified protein (protein biochemistry)
  • Fibrosis in diabetic nephropathy (cell biology, primary cell culture, immunohistochemistry)


1990-1996 PhD student

Fachbereich Biologie, Universität Halle-Wittenberg

Institut für Pflanzen- und Zellbiologie

  • Structure-function relationship in Photosystem II (atomic emission spectroscopy, fluorescence and polarographic assays)
1985-1990 Diploma student

Biochemie, Universität Halle-Wittenberg

Institut für Pflanzen- und Zellbiologie

  • Investigation on the binding sites of different herbicides in chloroplasts (radioligand assays, protein biochemistry)

Selected Publications


  • Friemel A., Bert B, Hutson PH, Brust P, Nieber K, Deuther-Conrad W
    Postnatal development and kinetics of [3H]gaboxadol binding in rat brain: in vitro homogenate binding and quantitative autoradiography
    Brain Research, in press
  • Deuther-Conrad W, Patt JT, Lockman PR, Allen DD, Patt M, Schildan A, Ganapathy V, Steinbach J, Sabri O, Brust P
    Norchloro-fluoro-homoepibatidine (NCFHEB) - a Promising Radioligand for Neuroimaging Nicotinic Acetylcholine Receptors with PET
    European Neuropsychopharmacology, in press
  • Hoepping A, Scheunemann M, Fischer S, Deuther-Conrad W, Hiller A, Wegner F, Diekers M, Steinbach J, Brust P
    Radiosynthesis and biological evaluation of an 18F-labeled derivative of the novel pyrazolopyrimidine sedative-hypnotic agent indiplon
    Nucl Med Biol. 2007 Jul;34(5):559-70


  • Fan C, Jia H, Deuther-Conrad W, Brust P, Steinbach J, Liu B
    Novel 99mTc labeled s receptor ligand as a potential tumor imaging agent
    Science in China: Series B Chemistry. 2006,49(2):169-176.
  • Zessin J, Deuther-Conrad W, Kretzschmar M, Wust F, Pawelke B, Brust P, Steinbach J, Bergmann R
    [11C]SMe-ADAM, an imaging agent for the brain serotonin transporter: synthesis, pharmacological characterization and microPET studies in rats
    Nucl Med Biol. 2006 Jan;33(1):53-63
  • Deuther-Conrad W, Wevers A, Becker G, Schildan A, Patt M, Sabri O, Steinbach J, Brust P Autoradiography of 2-[18F]F-A-85380 on nicotinic acetylcholine receptors in the porcine brain in vitro
    Synapse 2006 Mar 15;59(4):201-10


  • Deuther-Conrad W, Patt JT, Feuerbach D, Wegner F, Brust P, Steinbach J
    Norchloro-fluoro-homoepibatidine: specificity to neuronal nicotinic acetylcholine receptor subtypes in vitro
    Farmaco. 2004 Oct;59(10):785-92


  • Dukic-Stefanovic S, Gasic-Milenkovic J, Deuther-Conrad W, Munch G
    Signal transduction pathways in mouse microglia N-11 cells activated by advanced glycation endproducts (AGEs)
    J Neurochem. 2003 Oct;87(1):44-55
  • Gasic-Milenkovic J, Dukic-Stefanovic S, Deuther-Conrad W, Gartner U, Munch G
    beta-Amyloid peptide potentiates inflammatory responses induced by lipopolysaccharide, interferon -gamma and 'advanced glycation endproducts' in a murine microglia cell line
    Eur J Neurosci 2003 Feb;17(4):813-21


  • Munch G, Deuther-Conrad W, Gasic-Milenkovic J
    Glycoxidative stress creates a vicious cycle of neurodegeneration in Alzheimer's disease-a target for neuroprotective treatment strategies?
    J Neural Transm Suppl. 2002;(62):303-7


  • Gasic-Milenkovic J, Loske C, Deuther-Conrad W, Münch G
    Protein "AGEing"-cytotoxicity of a glycated protein increases with its degree of AGE-modification
    Z Gerontol Geriatr. 2001 Dec;34(6):457-60
  • Deuther-Conrad W, Loske C, Schinzel R, Dringen R, Riederer P, Münch G
    Advanced glycation endproducts change glutathione redox status in SH-SY5Y human neuroblastoma cells by a hydrogen peroxide dependent mechanism
    Neurosci Lett. 2001 Oct 12;312(1):29-32
  • Wong A, Lüth HJ, Deuther-Conrad W, Dukic-Stefanovic S, Gasic-Milenkovic J, Arendt T, Münch G Advanced glycation endproducts co-localize with inducible nitric oxide synthase in Alzheimer´s disease
    Brain Res. 2001 Nov 30;920(1-2):32-40
  • Deuther-Conrad W, Franke S, Henle T, Sommer M, Stein G
    In vitro-prepared advanced glycation end products and the modulating potential of their low molecular weight degradation products in IRPTC-a rat proximal-tubular derived kidney epithelial cell line
    Cell Mol Biol. 2001, 47, N 26, 187-196
  • Deuther-Conrad W, Franke S, Sommer M, Henle T, Stein G
    Differences in the modulating potential of advanced glycation end product (AGE) peptides versus AGE proteins
    Kidney Int. 2001 Feb;59(Suppl 78):63-66


  • Franke S, Niwa T, Deuther-Conrad W, Sommer M, Hein G, Stein G
    Immunochemical detection of imidazolone in uremia and rheumatoid arthritis
    Clin Chim Acta. 2000 Oct;300(1-2):29-41
  • Sommer M, Eismann U, Deuther-Conrad W, Wendt T, Mohorn T, Funfstuck R, Stein G
    Time course of cytokine mRNA expression in kidneys of rats with unilateral ureteral obstruction
    Nephron. 2000 Jan;84(1):49-57