Practical trainings, student assistants and theses
Offer | All | School practical training | Master theses | Research Assistant | Student practical training | | Diploma theses | Bachelor theses | Student Assistant | Compulsory internship |
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Institute/ Dep. | All | FKVF | FWD | FWDC | FWDF | FWDF-P | FWDF-V | FWGR | | FWGT-B | FWIO-N | FWIO-T | FWIZ-N | FWKT | FWPC | FWU |
Formatting | Table | |
MUTATION AND ENRICHMENT STUDIES IN THE CONTEXT OF DIRECTED EVOLUTION USING MULTIPLE PHAGE DISPLAY EXPERIMENTS (Id 442)
Master theses / Diploma theses / Compulsory internship / Volunteer internship
The application of phage surface display (PSD) technology has accelerated developments in the field of biomolecular sensors and materials science. A practical complement to this technology is Next-Generation Sequencing (NGS). In this combination, a more comprehensive view of biopanning rounds with a deep insight into the entire sequence space is made possible. It is possible to identify sequencing artefacts, determine sequence number and structure, recognize binding motifs and observe the evolution of the phage library over the course of an experiment. PSD in combination with biopanning is able to select candidates with high affinity and selectivity to the desired substrates from large peptide libraries. In practice, this specific enrichment of peptides leads to a reduction in library diversity. It should therefore be possible to better visualize this reduction in sequence space using data clustering methods in order to better understand distances between similar sequence families.
The student's task is to find suitable clustering methods for sequencing results from multiple phage display experiments and to apply these if necessary. It should be clear from the results to what extent the sequence space can be grouped into families and whether a mutation profile within and between these families is recognizable.
Department: BioKollekt
Contact: Bloß, Christoph, Dr. Lederer, Franziska
Requirements
Prerequisite is a valid enrollment in a Master's program in bioinformatics, biotechnology, molecular biology, biochemistry, biology or a related natural science program. Furthermore:
- Interest in data cluster methods and bioinformatics
- Basic knowledge of bioinformatics, statistics, stochastics and clustering
- Experience with a programming language (e.g. Python, R, C, C++ or other)
- Ability to work independently and in a team
Conditions
The topic is to be worked on as part of a Master's thesis in conjunction with a voluntary or mandatory internship. This results in a duration of 12 months. The duration can be extended or adjusted in consultation with the supervisor. We can offer you:
- An innovative multidisciplinary research environment related to relevant issues in resource technology
- Supervision by experienced scientists
- Practical experience in the field of bioinformatics and directed evolution
Online application
Please apply online: english / german
Development of peptides for the modification of plastic surfaces prior to metallisation (Id 435)
Master theses / Diploma theses / Compulsory internship / Volunteer internship
The research project ‘Development of tailor-made peptides for the treatment of polymers before the metallization of plastics’ aims to develop a biomolecule-based system that enables the metallization of high-quality engineering plastics. Using phage surface display technology (PSD), peptides are selected and their binding behavior is characterized using suitable technologies to quantify the surface interaction. Our industrial partner tests suitable peptide sequences in practical polymer coating and metallization experiments.
Department: Biotechnology
Contact: Dr. Schönberger, Nora, Dr. Lederer, Franziska, Dr. Jain, Purvi
Requirements
- Studying biotechnology, microbiology, chemistry, chemical engineering, or a comparable subject area
- Interest in practical, interdisciplinary research
- Knowledge of basic molecular biological and microbiological principles and working techniques
- Careful and independent way of working
Conditions
- Work in an interdisciplinary and international team
- The workplace language is English
- Duration of the internship or thesis according to study regulations
- Start of work possible by February 2025 at the latest