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Synthesis of Upconverting Nanoparticles as biomedicinal imaging probes (Id 213)

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Foto: Dalton Transaction Cover ©Copyright: Dalton Transaction CoverThe Department of Radionuclide Theragnostics (https://www.hzdr.de/db/Cms?pNid=2629) offers a position for the following topic: "Synthesis of Upconverting Nanoparticles as biomedicinal imaging probes" The position will be available from mid of January 2019. The employment contract is flexible, but limited to a maximum of 3 months for full-time position. The topic can be part of master thesis.

Upconverting nanoparticles (UCNPs) are lanthanide-doped photoluminescent nanomaterials, which exhibit the upconversion of photons. They absorb two or more near-infrared photons and emit them to higher energy. Due to their excellent (long-lived and anti-Stokes) luminescence properties, low cytoxicity and photostability, UCNPs are promising candidates for biomedical applications acting as luminescent imaging probes. The colour output can be easily tuned by lanthanide ions (“activators”). In addition, a tailor-made surface functionalisation strategy gives not only the opportunity to make them water-dispersible but also to attach tumour-specific molecules (e.g. peptides, antibodies,…).

The work aims to provide ultrasmall upconverting nanoparticles (<10 nm) using well-established protocols from our group– with focus on the size, luminescence properties and stability. Our group (https://www.hzdr.de/db/Cms?pNid=499) offers years of experience and excellent skills dealing with the synthesis, characterisation as well as surface functionalisation startegies of nanoparticles.

We are looking forward to your application!

Department: Radionuclide Theragnostics

Contact: Dr. Kubeil, Manja

Requirements

  • Degree in chemistry with good marks
  • Experimental skills in synthesis and characterization of nanoparticles
  • Experience with Schlenk-technique/ working under inert atmosphere
  • personal commitment, ability to work in a team
  • good written and oral communication skills in English

Conditions

  • Flexible working hours
  • Full- or part-time possible