Helmholtz-Zentrum Dresden-Rossendorf

Biophysics

Prof. Dr. Karim Fahmy

Head

Phone:+49 351 260 - 2952, 3601
Fax:12952, 3553
Email: k.fahmyAthzdr.de
Address for visitors:Bautzner Landstraße 400
01328 Dresden
Postal address:POB 51 01 19
01314 Dresden
Germany

Scientific career

  • Seit 2014:
    Honorary Professor "Structural Dynamics of Biomolecules" at the Biotechnology Center of the Technische Universität Dresden
  • Seit 2002:
    Head Biophysics Division at the HZDR
  • 1999:
    Habilitation in Biophysics, University Freiburg
  • 1991-1994:
    Howard Hughes Medical Institute Fellowship, Rockefeller University
  • 1991:
    PhD, University Freiburg
  • 1986:
    Graduation Biology / Physics, Universities of Marburg and Bochum

Research fields

  • Molecular Biophysics of structural dynamics of proteins using Genetic Enigineering Spectroscopy and Calorimetry
  • Metabolic Monitoring for the assessment of radiotoxicity in microorganisms

Projects

  • Metal ion-induced structural transitions in soluble and in membrane proteins
  • Biomolecular dynamics studied by pulsed THz radiation

Teaching

  • Biophysical Methods, Technische Universität Dresden
  • Biological Thermodynamics, Technische Universität Dresden
  • Vibrational Spectroscopy and Fluorescence Spectroscopy (International Master Programme, BIOTEC, Technische Universität Dresden)

Memberships / Board activities

  • Biophysical Society, USA
  • Deutsche Gesellschaft für Biophysik / Speaker "Section Molecular Biophysics"
  • HZDR Project Group XFEL / User Consortium European XFEL
  • HZDR Project Group THz Applications in Life Sciences
  • Dresden-International-Graduate-School for Biomedicine and Bioengineering

Prices

  • Hans-Griesebach Price of the University of Freiburg

Publications

2017

Dipolar Relaxation Dynamics at the Active Site of an ATPase Regulated by Membrane Lateral Pressure
Fischermeier, E.; Pospíšil, P.; Sayed, A.; Hof, M.; Solioz, M.; Fahmy, K.

Analysis of self‑assembly of S‑layer protein slp‑B53 from Lysinibacillus sphaericus
Liu, J.; Falke, S.; Drobot, B.; Oberthuer, D.; Kikhney, A.; Guenther, T.; Fahmy, K.; Svergun, D.; Betzel, C.; Raff, J.

2016

The molecular switching mechanism at the conserved D(E)RY motif in class-A GPCRs
Sandoval, A.; Eichler, S.; Madathil, S.; Reeves, P. J.; Fahmy, K.; Boeckmann, R. A.

Rational Structure-Based Rescaffolding Approach to de Novo Design of Interleukin 10 (IL-10) Receptor-1 Mimetics
Ruiz-Gómez, G.; Hawkins, J. C.; Philipp, J.; Künze, G.; Wodtke, R.; Löser, R.; Fahmy, K.; Pisabarro, M. T.

Mechanism of attenuation of uranyl toxicity by glutathione in Lactococcus lactis
Obeid, M. H.; Oertel, J.; Solioz, M.; Fahmy, K.

Anisotropic metal growth on phospholipid nanodiscs via lipid bilayer expansion
Oertel, J.; Keller, A.; Prinz, J.; Schreiber, B.; Hübner, R.; Kerbusch, J.; Bald, I.; Fahmy, K.
Corresponding author: Keller, Adrian
Corresponding author: Fahmy, Karim

2015

A single-strand annealing protein clamps DNA to detect and secure homology
Ander, M.; Subramaniam, S.; Fahmy, K.; Stewart, F.; Schäffer, E.

2014

The Role of Phospholipid Headgroup Composition and Trehalose in the Desiccation Tolerance of Caenorhabditis elegans
Abusharkh, S. E.; Erkut, C.; Oertel, J.; Kurzchalia, T. V.; Fahmy, K.

Filament formation by metabolic enzymes is a specific adaptation to an advanced state of cellular starvation
Petrovska, I.; Nüske, E.; Munder, Matthias C.; Kulasegaran, G.; Malinovska, L.; Kroschwald, S.; Richter, D.; Fahmy, K.; Gibson, K.; Verbavatz, J.-M.; Alberti, S.

Paramagnetic Decoration of DNA origami Nanostructures by Eu3+ Coordination
Opherden, L.; Oertel, J.; Barkleit, A.; Fahmy, K.; Keller, K.

2013

Formic acid interaction with uranyl(VI) ion: structural and photochemical characterization
Lucks, C.; Roßberg, A.; Tsushima, S.; Foerstendorf, H.; Fahmy, K.; Bernhard, G.

2012

3D Profile-Based Approach to Proteome-Wide Discovery of Novel Human Chemokines
Tomczak, A.; Sontheimer, J.; Drechsel, D.; Hausdorf, R.; Gentzel, M.; Shevchenko, A.; Eichler, S.; Fahmy, K.; Buchholz, F.; Pisabarro, M. Teresa

How worms survive desiccation: Trehalose pro water
Erkut, C.; Penkov, S.; Fahmy, K.; Kurzchalia, T. V.

2011

Trehalose renders dauer larva of Caenorhabditis elegans resistant to extreme desiccation
Erkut, C.; Penkov, S.; Khesbak, H.; Vorkel, D.; Verbavatz, J. M.; Fahmy, K.; Kurzchalia, T. V.
  • Current Biology 21(2011)15, 1331-1336

The role of water H-bond imbalances in B-DNA substate transitions and peptide recognition revealed by time-resolved FTIR spectroscopy
Khesbak, H.; Savchuk, O.; Tsushima, S.; Fahmy, K.
  • Journal of the American Chemical Society 133(2011), 5834-5842

Eu3+-Mediated Polymerization of Benzenetetracarboxylic Acid Studied by Spectroscopy, Temperature-Dependent Calorimetry, and Density Functional Theory
Barkleit, A.; Tsushima, S.; Savchuk, O.; Philipp, J.; Heim, K.; Acker, M.; Taut, S.; Fahmy, K.

2010

S-Layer protein from Lysinibacillus sphaericus JG-A12 as matrix for Au-III sorption and Au-nanoparticle formation
Jankowski, U.; Merroun, M.; Selenska-Pobell, S.; Fahmy, K.

Aqueous coordination chemistry and photochemistry of uranyl(VI) oxalate revisited: a density functional theory study
Tsushima, S.; Brendler, V.; Fahmy, K.

Photoluminescence of uranium(VI): quenching mechanism and role of uranium(V)
Tsushima, S.; Götz, C.; Fahmy, K.

Heterologous expression of the S-layer-like protein SllB induces the formation of long filaments of E. coli consisting of protein stabilized outer membrane
Lederer, F.; Günther, T.; Flemming, K.; Raff, J.; Fahmy, K.; Springer, A.; Pollmann, K.

2009

Lipid Protein Interactions Couple Protonation to Conformation in a Conserved Cytosolic Domain of G-Protein-Coupled Receptors
Madathil, S.; Fahmy, K.
  • Journal of Biological Chemistry 284(2009)42, 28801-28809

2008

Secondary Structure and Compliance of a Predicted Flexible Domain in Kinesin-1 Necessary for Co-operation of Motors
Crevenna, A. H.; Madathil, S.; Cohen, D. N.; Wagenbach, M.; Fahmy, K.; Howard, J.

2007

Flavonoids affect actin functions in cytoplasm and nucleus
Boehl, M.; Tietze, S.; Sokoll, A.; Madathil, S.; Pfennig, F.; Apostolakis, J.; Fahmy, K.; Gutzeit, H. O.

Linkage between the intramembrane H-bond network around aspartic acid 83 and the cytosolic environment of helix 8 in photoactivated rhodopsin
Lehmann, N.; Alexiev, U.; Fahmy, K.

Synthesis and biological evaluation of a new type of 99mTechnetium-labeled fatty acid for myocardial metabolism imaging
Walther, M.; Jung, C.; Bergmann, R.; Pietzsch, J.; Rode, K.; Fahmy, K.; Mirtschink, P.; Stehr, S.; Heintz, A.; Wunderlich, G.; Kraus, W.; Pietzsch, H.-J.; Kropp, J.; Deussen, A.; Spies, H.
  • Bioconjugate Chemistry 18(2007), 216-230

2006

Secondary structure and Pd(II) coordination in S-layer proteins from Bacillus sphaericus studied by infrared and X-ray absorption spectroscopy
Fahmy, K.; Merroun, M.; Pollmann, K.; Raff, J.; Savchuk, O.; Hennig, C.; Selenska-Pobell, S.

Structure and pH-Sensitivity of the Transmembrane Segment 3 of Rhodopsin
Madathil, S.; Furlinski, G.; Fahmy, K.

Metal binding by bacteria from uranium mining waste piles and its technological applications
Pollmann, K.; Raff, J.; Merroun, M.; Fahmy, K.; Selenska-Pobell, S.

2004

Conserved high-affinity ligand binding and membrane association in the native and refolded extracellular domain of the human glycine receptor alpha 1 subunit
Breitinger, U.; Breitinger, H.-G.; Bauer, F.; Fahmy, K.; Glockenhammer, D.; Becker, C.-M.
  • Journal of Biological Chemistry 279(2004)4, 1627-1636

2003

Properties and planned use of the intense THz radiation from ELBE at Dresden-Rossendorf
Fahmy, K.; Furlinski, G.; Gippner, P.; Grosse, E.; Seidel, W.; Sczepan, M.; Wohlfahrt, D.; Wolf, A.; Wünsch, R.
  • Journal of Biological Physics 29:303 -307, 2003
  • Poster
    THz-Bridge Workshop, 29.09.-01.10.2002, Capri, Italy

2002

FTIR- and Fluorescence-Spectroscopic Analyses of Receptor G-Protein Coupling in Photoreception Curr. Org. Chem. 2002, 6, 1259-1284.
Fahmy, K.
  • Curr. Org. Chem. 2002, 6, 1259-1284.