Publications of Institute of Radiopharmaceutical Cancer Research

1320 Publications

2015

Bispecific antibody releasing-mesenchymal stromal cell machinery for retargeting T cells towards acute myeloid leukemia blasts

Aliperta, R.; Cartellieri, M.; Feldmann, A.; Arndt, C.; Koristka, S.; Michalk, I.; von Bonin, M.; Ehninger, A.; Bachmann, J.; Ehninger, G.; Bornhäuser, M.; Bachmann, M. P.

18F-Labeled 1,4-Dioxa-8-azaspiro[4.5]decane Derivative: Synthesis and Biological Evaluation of a σ1 Receptor Radioligand with Low Lipophilicity as Potent Tumor Imaging Agent

Xie, F.; Bergmann, R.; Kniess, T.; Deuther-Conrad, W.; Mamat, C.; Neuber, C.; Liu, B.; Steinbach, J.; Brust, P.; Pietzsch, J.; Jia, H.

Involved research facilities

  • PET-Center

Targeting lysyl oxidase for molecular imaging in breast cancer

Wuest, M.; Kuchar, M.; Sharma, S. K.; Richter, S.; Hamann, I.; Wang, M.; Vos, L.; Mackey, J. R.; Wuest, F.; Löser, R.

Involved research facilities

  • PET-Center

18F-FDG PET/MRI for therapy response assessment in sarcoma: Comparison of PET and MR imaging results

Schuler, M. K.; Platzek, I.; Beuthien-Baumann, B.; Fenchel, M.; Ehninger, G. E.; van den Hoff, J.

Involved research facilities

  • PET-Center

2-[18F]Fluoroethyl tosylate - a versatile tool for building 18F-based radiotracers for positron emission tomography

Knieß, T.; Laube, M.; Brust, P.; Steinbach, J.

Involved research facilities

  • PET-Center

Repeatability of tumor SUV quantification: the role of variable blood SUV

van den Hoff, J.; Hofheinz, F.

Involved research facilities

  • PET-Center

Novel (pyrazolyl)benzenesulfonamides with a nitric oxide-releasing moiety as selective cyclooxygenase-2 inhibitors

Bechmann, N.; Kniess, T.; Köckerling, M.; Pigorsch, A.; Steinbach, J.; Pietzsch, J.

Involved research facilities

  • PET-Center

Rational design of dual peptides targeting ghrelin and Y2 receptors to regulate food intake and body weight

Kilian, T. M.; Klöting, N.; Bergmann, R.; Els-Heindl, S.; Babilon, S.; Clément-Ziza, M.; Zhang, Y.; Beck-Sickinger, A. G.; Chollet, C.

Involved research facilities

  • PET-Center

On the relation between Kaiser-Bessel blob and tube of response based modelling of the system matrix in iterative PET image reconstruction

Lougovski, A.; Hofheinz, F.; Maus, J.; Schramm, G.; van den Hoff, J.

Involved research facilities

  • PET-Center

Methods to increase the metabolic stability of 18F-radiotracers

Kuchar, M.; Mamat, C.

Involved research facilities

  • PET-Center

In vivo Demonstration of an Active Tumor Pretargeting Approach with Peptide Nucleic Acid Bioconjugates as Complementary System

Leonidova, A.; Foerster, C.; Zarschler, K.; Schubert, M.; Pietzsch, H.-J.; Steinbach, J.; Bergmann, R.; Metzler-Nolte, N.; Stephan, H.; Gasser, G.

Involved research facilities

  • PET-Center

Synthesis and First Evaluation of [18F]Fluorocyano- and [18F]Fluoronitroquinoxalinedione as Putative AMPA Receptor Antagonists

Olma, S.; Ermert, J.; Sihver, W.; Coenen, H.-H.

Biodistribution, cellular localization, and in vivo tolerability of S-35-labeled antiinflammatory dendritic polyglycerol sulfate amine

Holzhausen, C.; Groger, D.; Mundhenk, L.; Donat, C. K.; Schnorr, J.; Haag, R.; Gruber, A. D.

Active Site Mapping of Human Cathepsin F with Dipeptide Nitrile Inhibitors

Schmitz, J.; Furtmann, N.; Ponert, M.; Frizler, M.; Löser, R.; Bartz, U.; Bajorath, J.; Gütschow, M.

Involved research facilities

  • PET-Center

Cysteine cathepsins: their role in tumor progression and recent trends in the development of imaging probes

Löser, R.; Pietzsch, J.

Involved research facilities

  • PET-Center

Copper(II) cyclam complexes with N-propionic acid pendant arms

Kubeil, M.; Zarschler, K.; Pietzsch, J.; Kraus, W.; Comba, P.; Stephan, H.

Involved research facilities

  • PET-Center

Novel indole-based sigma-2 receptor ligands: synthesis, structure–affinity relationship and antiproliferative activity

Xie, F.; Kniess, T.; Neuber, C.; Deuther-Conrad, W.; Mamat, C.; Liebermann, B. P.; Liu, B.; Mach, R. H.; Brust, P.; Steinbach, J.; Pietzsch, J.; Jia, H.

Involved research facilities

  • PET-Center

First-in-human PET quantification study of cerebral α4β2* nicotinic acetylcholine receptors using the novel specific radioligand (−)-[18F]Flubatine

Sabri, O.; Becker, G.-A.; Meyer, P. M.; Hesse, S.; Wilke, S.; Graef, S.; Patt, M.; Luthardt, J.; Wagenknecht, G.; Hoepping, A.; Smits, R.; Franke, A.; Sattler, B.; Habermann, B.; Neuhaus, P.; Fischer, S.; Tiepolt, S.; Deuther-Conrad, W.; Barthel, H.; Schönknecht, P.; Brust, P.

Combined PET/MR: The Real Work Has Just Started. Summary Report of the Third International Workshop on PET/MR Imaging; February 17-21, 2014, Tubingen, Germany

Bailey, D. L.; Antoch, G.; Bartenstein, P.; Barthel, H.; Beer, A. J.; Bisdas, S.; Bluemke, D. A.; Boellaard, R.; Claussen, C. D.; Franzius, C.; Hacker, M.; Hricak, H.; La Fougere, C.; Guckel, B.; Nekolla, S. G.; Pichler, B. J.; Purz, S.; Quick, H. H.; Sabri, O.; Sattler, B.; Schafer, J.; Schmidt, H.; van den Hoff, J.; Voss, S.; Weber, W.; Wehrl, H. F.; Beyer, T.

Involved research facilities

  • PET-Center

The association of tumor-to-background ratios and SUVmax deviations related to point spread function and time-of-flight F18-FDG-PET/CT reconstruction in colorectal liver metastases

Rogasch, J. M. M.; Steffen, I. G.; Hofheinz, F.; Großer, O. S.; Furth, C.; Mohnike, K.; Hass, P.; Walke, M.; Apostolova, I.; Amthauer, H.

Involved research facilities

  • PET-Center

Synthesis and Molecular Structure of 2-(Diphenylphosphano) phenyl Benzoate Borane Adduct

Mamat, C.; Köckerling, M.

DAP12-Based Activating Chimeric Antigen Receptor for NK Cell Tumor Immunotherapy

Toepfer, K.; Cartellieri, M.; Michen, S.; Wiedemuth, R.; Mueller, N.; Lindemann, D.; Bachmann, M.; Fuessel, M.; Schackert, G.; Temme, A.

A promising PET tracer for imaging of α7 nicotinic acetylcholine receptors in the brain: Design, synthesis, and in vivo evaluation of a dibenzothiophene-based radioligand

Teodoro, R.; Scheunemann, M.; Deuther-Conrad, W.; Wenzel, B.; Colombo, S.; Gotti, C.; Kranz, M.; Donat, C.; Patt, M.; Hillmer, A.; Zheng, M.; Peters, D.; Steinbach, J.; Sabri, O.; Huang, Y.; Brust, P.

CuII-selective bispidine–dye conjugates

Bronx, D.; Comba, P.; Herten, D.-P.; Kimmle, E.; Morgen, M.; Rühl, C. L.; Rybina, A.; Stephan, H.; Storch, G.; Wadepohl, H.

Improving external beam radiotherapy by combination with internal irradiation.

Dietrich, A.; Koi, L.; Zöphel, K.; Sihver, W.; Kotzerke, J.; Baumann, M.; Krause, M.

Synthesis and Biodistribution Studies of 3H- and 64Cu-labeled Dendritic Polyglycerol and Dendritic Polyglycerol Sulfate

Pant, K.; Gröger, D.; Bergmann, R.; Pietzsch, J.; Steinbach, J.; Graham, B.; Spiccia, L.; Berthon, F.; Czarny, B.; Devel, L.; Dive, V.; Stephan, H.; Haag, R.

Involved research facilities

  • PET-Center

Synthesis, 18F-radiolabelling and biological characterization of novel fluoroalkylated triazine derivatives for in vivo imaging of phosphodiesterase 2A in brain via positron emission tomography

Schröder, S.; Wenzel, B.; Deuther-Conrad, W.; Teodoro, R.; Egerland, U.; Kranz, M.; Scheunemann, M.; Höfgen, N.; Steinbach, J.; Brust, P.

Development of indazolylpyrimidine derivatives as high-affine EphB4 receptor ligands and potential PET-radiotracers

Ebert, K.; Wiemer, J.; Caballero, J.; Köckerling, M.; Steinbach, J.; Pietzsch, J.; Mamat, C.

Involved research facilities

  • PET-Center

Reduced pulmonary blood flow in regions of injury 2 hours after acid aspiration in rats

Richter, T.; Bergmann, R.; Musch, G.; Pietzsch, G.; Koch, T.

Involved research facilities

  • PET-Center

Accuracy of parenchymal cerebral blood flow measurements using pseudo-continuous arterial spin labeling in healthy volunteers

Ambarki, K.; Wåhlin, A.; Zarrinkoob, L.; Wirestam, R.; Petr, J.; Malm, J.; Eklund, A.

Involved research facilities

  • PET-Center

Tregs activated by bispecific antibodies: Killers or suppressors?

Koristka, S.; Cartellieri, M.; Arndt, C.; Feldmann, A.; Seliger, B.; Ehninger, G.; Bachmann, M. P.

Optical imaging of COX-2: Studies on an autofluorescent 2,3-diaryl-substituted indole-based cyclooxygenase-2 inhibitor.

Tondera, C.; Ullm, S.; Laube, M.; Meister, S.; Neuber, C.; Mosch, B.; Kniess, T.; Pietzsch, J.

Involved research facilities

  • PET-Center

Theranostic mercury: 197(m)Hg with high specific activity for imaging and therapy

Walther, M.; Preusche, S.; Bartel, S.; Wunderlich, G.; Freudenberg, R.; Steinbach, J.; Pietzsch, H.-J.

Involved research facilities

  • PET-Center

New systematically modified vesamicol analogs and their affinity and selectivity for the vesicular acetylcholine transporter – A critical examination of the lead structure.

Barthel, C.; Sorger, D.; Deuther-Conrad, W.; Scheunemann, M.; Schweiger, S.; Jäckel, P.; Roghani, A.; Steinbach, J.; Schüürmann, G.; Sabri, O.; Brust, P.; Wenzel, B.

Cyclopeptides containing the DEKS motif as conformationally restricted collagen telopeptide analogues: synthesis and conformational analysis

Wodtke, R.; Ruiz-Gómez, G.; Kuchar, M.; Pisabarro, M. T.; Novotná, P.; Urbanová, M.; Steinbach, J.; Pietzsch, J.; Löser, R.

Involved research facilities

  • PET-Center

Speciation of uranium in compartments of living cells

Geipel, G.; Viehweger, K.

Bifunctional Cyclam-Based Ligands with Phosphorus Acid Pendant Moieties for Radiocopper Separation – Thermodynamic and Kinetic Studies

Paúrová, M.; Havlíčková, J.; Pospíšilová, A.; Vetrík, M.; Císařová, I.; Stephan, H.; Pietzsch, H.-J.; Hrubý, M.; Hermann, P.; Kotek, J.

Diaryl-substituted (dihydro)pyrrolo[3,2,1-hi]indoles, a class of potent COX-2 inhibitors with tricyclic core structure

Laube, M.; Gassner, C.; Sharma, S. K.; Günther, R.; Pigorsch, A.; König, J.; Köckerling, M.; Wuest, F.; Pietzsch, J.; Kniess, T.

Involved research facilities

  • PET-Center

Polyoxometalates - potent and selective ecto-nucleotidase inhibitors

Lee, S.-Y.; Fiene, A.; Li, W.; Hank, T.; Brylev, K.; Fedovrov, V.; Lecka, J.; Haider, A.; Pietzsch, H.-J.; Zimmermann, H.; Sévigny, J.; Kortz, U.; Stephan, H.; Müller, C. E.

A high-yield automated radiosynthesis of the alpha-7 nicotinic receptor radioligand [18F]NS10743

Teodoro, R.; Wenzel, B.; Oh-Nishi, A.; Fischer, S.; Peters, D.; Suhara, T.; Deuther-Conrad, W.; Brust, P.

Effects of pulmonary acid aspiration on the regional pulmonary blood flow within the first hour after injury: an observational study in rats

Richter, T.; Bergmann, R.; Pietzsch, J.; Mueller, M. P.; Koch, T.

Involved research facilities

  • PET-Center

Convenient recycling and reuse of bombarded [18O]H2O for the production and the application of [18F]F‒

Rötering, S.; Franke, K.; Zessin, J.; Brust, P.; Füchtner, F.; Fischer, S.; Steinbach, J.

Evaluation of Novel Fluorescence Probes for Conjugation Purposes Using the Traceless Staudinger Ligation

Wodtke, R.; König, J.; Pigorsch, A.; Köckerling, M.; Mamat, C.

Involved research facilities

  • PET-Center

2014

Quantitative assessment of the asphericity of pretherapeutic FDG uptake as an independent predictor of outcome in NSCLC.

Apostolova, I.; Rogasch, J.; Buchert, R.; Wertzel, H.; Achenbach, H. J.; Schreiber, J.; Riedel, S.; Furth, C.; Lougovski, A.; Schramm, G.; Hofheinz, F.; Amthauer, H.; Steffen, I. G.

Involved research facilities

  • PET-Center

The influence of different signal-to-background ratios on spatial resolution and F18-FDG-PET quantification using point spread function and time-of-flight reconstruction

Rogasch, J. M. M.; Hofheinz, F.; Lougovski, A.; Furth, C.; Ruf, J.; Großer, O. S.; Mohnike, K.; Hass, P.; Walke, M.; Amthauer, H.; Steffen, I. G.

Involved research facilities

  • PET-Center

Dual Role of B7 Costimulation in Obesity-Related Nonalcoholic Steatohepatitis and Metabolic Dysregulation

Chatzigeorgiou, A.; Chung, K.-J.; Garcia-Martin, R.; Alexaki, V.-I.; Klotzsche-Von Ameln, A.; Phieler, J.; Sprott, D.; Kanczkowski, W.; Tzanavari, T.; Bdeir, M.; Bergmann, S.; Cartellieri, M.; Bachmann, M.; Nikolakopoulou, P.; Androutsellis-Theotokis, A.; Siegert, G.; Bornstein, S. R.; Muders, M. H.; Boon, L.; Karalis, K. P.; Lutgens, E.; Chavakis, T.

FDG PET/MR for the Assessment of Lymph Node Involvement in Lymphoma: Initial Results and Role of Diffusion-Weighted MR

Platzek, I.; Beuthien-Baumann, B.; Ordemann, R.; Maus, J.; Schramm, G.; Kitzler, H. H.; Laniado, M.; Kotzerke, J.; van den Hoff, J.

Involved research facilities

  • PET-Center

Preparation of 4-Halobenzoate Containing Phosphane Based Building Blocks for Labeling Reactions Using the Traceless Staudinger Ligation

Mamat, C.; Köckerling, M.

Involved research facilities

  • PET-Center

X-ray structure of 2-(diphenylphosphano)phenyl-4-(hydroxymethyl)benzoate

Mamat, C.; Flemming, A.; Köckerling, M.

Involved research facilities

  • PET-Center

Organotypical vascular model for characterization of radioprotective compounds: Studies on antioxidant 2,3-diaryl-substituted indole-based cyclooxygenase-2 inhibitors

Ullm, S.; Laube, M.; Bechmann, N.; Knieß, T.; Pietzsch, J.

Involved research facilities

  • PET-Center

Internal Dose Assessment of (-)-18F-Flubatine, Comparing Animal Model Datasets of Mice and Piglets with First-in-Human Results

Sattler, B.; Kranz, M.; Starke, A.; Wilke, S.; Donat, C. K.; Deuther-Conrad, W.; Patt, M.; Schildan, A.; Patt, J.; Smits, R.; Hoepping, A.; Schoenknecht, P.; Steinbach, J.; Brust, P.; Sabri, O.

Redirection of CD4+ and CD8+ T lymphocytes via a novel antibody-based modular targeting system triggers efficient killing of PSCA+ prostate tumor cells

Arndt, C.; Feldmann, A.; Töpfer, K.; Koristka, S.; Cartellieri, M.; Temme, A.; Ehninger, A.; Ehninger, G.; Bachmann, M.

Synthesis and evaluation of a 18F-labeled spirocyclic piperidine derivative as promising σ1 receptor imaging agent

Chen, Y.-Y.; Wang, X.; Zhang, J.-M.; Deuther-Conrad, W.; Zhang, X.-J.; Huang, Y.; Li, Y.; Ye, J.-J.; Cui, M.-C.; Steinbach, J.; Brust, P.; Liu, B.-L.

Novel Cyclopentadienyl Tricarbonyl 99mTc Complexes Containing 1‑Piperonylpiperazine Moiety: Potential Imaging Probes for Sigma‑1 Receptors

Wang, X.; Li, D.; Deuther-Conrad, W.; Lu, J.; Xie, Y.; Jia, B.; Cui, M.; Steinbach, J.; Brust, P.; Liu, B.; Jia, H.

Characterization of circulating microparticle-associated CD39 family ecto-nucleotidases in human plasma

Jiang, Z. G.; Wu, Y.; Csizmadia, E.; Feldbrügge, L.; Enjyoji, K.; Tigges, J.; Toxavidis, V.; Stephan, H.; Müller, C. E.; Mcknight, C. J.; Moss, A.; Robson, S. C.

The Ti7-Containing, Tetrahedral 36-Tungsto-4-Arsenate(III)[Ti6(TiO6)(AsW9O33)4]20-

Wang, K.-Y.; Bassil, B. S.; Lin, Z. G.; Haider, A.; Cao, J.; Stephan, H.; Viehweger, K.; Kortz, U.

Bispidines for dual imaging

Stephan, H.; Walther, M.; Fähnemann, S.; Ceroni, P.; Molloy, J.; Bergamini, G.; Heisig, F.; Müller, C. E.; Kraus, W.; Comba, P.

2,3-Diaryl-substituted indole based COX-2 inhibitors as leads for imaging tracer development

Laube, M.; Tondera, C.; Sharma, S. K.; Bechmann, N.; Pietzsch, F.-J.; Pigorsch, A.; Köckerling, M.; Wuest, F.; Pietzsch, J.; Kniess, T.

Involved research facilities

  • PET-Center

In Vivo Fluorescence Imaging and Urinary Monoamines as Surrogate Biomarkers of Disease Progression in a Mouse Model of Pheochromocytoma

Ullrich, M.; Bergmann, R.; Peitzsch, M.; Cartellieri, M.; Quin, N.; Erhart-Bornstein, M.; Block, N. L.; Schalley, A. V.; Pietzsch, J.; Eisenhofer, G.; Bornstein, S. R.; Ziegler, C. G.

Involved research facilities

  • PET-Center

Biocompatibility and inflammatory response in vitro and in vivo to gelatin-based biomaterials with tailorable elastic properties

Ullm, S.; Krüger, A.; Tondera, C.; Gebauer, T. P.; Neffe, A. T.; Lendlein, A.; Jung, F.; Pietzsch, J.

Involved research facilities

  • PET-Center

Adenosine activates brown adipose tissue and recruits beige adipocytes via A2A receptors

Gnad, T.; Scheibler, S.; von Kügelgen, I.; Scheele, C.; Kilic, A.; Glöde, A.; Hoffmann, L.; Reverte, L.; Horn, P.; Mutlu, S.; El-Tayeb, A.; Kranz, M.; Deuther-Conrad, W.; Brust, P.; Lidell, M.; Betz, M.; Enerbäck, S.; Schrader, J.; Yegutkin, G.; Mueller, C.; Pfeifer, A.

Asphericity of pretherapeutic tumour FDG uptake provides independent prognostic value in head-and-neck cancer

Apostolova, I.; Steffen, I. G.; Wedel, F.; Lougovski, A.; Marnitz, S.; Derlin, T.; Amthauer, H.; Buchert, R.; Hofheinz, F.; Brenner, W.

Involved research facilities

  • PET-Center

Periacetabular bone metabolism following hip revision surgery. PET-based evaluation of allograft osteointegration.

Bernstein, P.; Beuthien-Baumann, B.; Kotzerke, J.; Hofheinz, F.; Zessin, J.; Stiehler, M.; Günther, K.-P.

Involved research facilities

  • PET-Center

Zwitterionic-Coated "Stealth" Nanoparticles for Biomedical Applications: Recent Advances in Countering Biomolecular Corona Formation and Uptake by the Mononuclear Phagocyte System

Pombo Garcia, K.; Zarschler, K.; Barbaro, L.; Barreto, J. A.; O'Malley, W.; Spiccia, L.; Stephan, H.; Graham, B.

Evaluation of metabolism, plasma protein binding and other biological parameters after administration of (−)-[18 F]Flubatine in humans

Patt, M.; Becker, G. A.; Grossmann, U.; Habermann, B.; Schildan, A.; Wilke, S.; Deuther-Conrad, W.; Graefe, S.; Fischer, S.; Smits, R.; Wagenknecht, G.; Steinbach, J.; Gertze, H.-J.; Hesse, S.; Schönknecht, P.; Brust, P.; Sabri, O.

Assessment of the best N3− donors in preparation of [M(N)(PNP)]-based (M = 99mTc-; 188Re) target-specific radiopharmaceuticals: Comparison among succinic dihydrazide (SDH), N-methyl-S-methyl dithiocarbazate (HDTCZ) and PEGylated N-methyl-S-methyl dithiocarbazate (HO2C-PEG600-DTCZ)

Carta, D.; Jentschel, C.; Thieme, S.; Salvarese, N.; Morellato, N.; Refosco, F.; Ruzza, P.; Bergmann, R.; Pietzsch, H.-J.; Bolzati, C.

Involved research facilities

  • PET-Center

Imaging of α7 nicotinic acetylcholine receptors in brain and cerebral vasculature of juvenile pigs with [18F]NS14490

Rötering, S.; Deuther-Conrad, W.; Cumming, P.; Donat, C. K.; Scheunemann, M.; Fischer, S.; Xiong, G.; Steinbach, J.; Peters, D.; Sabri, O.; Bucerius, J.; Brust, P.

Bispidine dioxotetraaza macrocycles: a new class of bispidines for 64Cu PET imaging

Comba, P.; Kubeil, M.; Pietzsch, J.; Rudolf, H.; Stephan, H.; Zarschler, K.

Involved research facilities

  • PET-Center

Radiofluorination and first radiopharmacological characterization of a SWLAY peptide-based ligand targeting EphA2

Pretze, M.; Mosch, B.; Bergmann, R.; Steinbach, J.; Pietzsch, J.; Mamat, C.

Involved research facilities

  • PET-Center

Proinflammatory human 6-sulfo LacNAc-positive dendritic cells accumulate in intestinal acute graft-versus-host disease

Sommer, U.; Larsson, B.; Tuve, S.; Wehner, R.; Zimmermann, N.; Kramer, M.; Kloß, A.; Günther, C.; Babatz, J.; Schmelz, R.; Brückner, S.; Schetelig, J.; Bornhäuser, M.; Schäkel, K.; Bachmann, M. P.; Aust, D.; Baretton, G.; Schmitz, M.

Combined measurement of tumor perfusion and glucose metabolism for improved tumor characterization in advanced cervical carcinoma: A PET/CT pilot study using [15O]water and [18F]fluorodeoxyglucose

Apostolova, I.; Hofheinz, F.; Buchert, R.; Steffen, I. G.; Michel, R.; Rosner, C.; Prasad, V.; Köhler, C.; Derlin, T.; Brenner, W.; Marnitz, S.

Involved research facilities

  • PET-Center

Effect of [18F]FMISO stratified dose-escalation on local control in FaDu hSCC in nude mice

Schütze, C.; Bergmann, R.; Brüchner, K.; Mosch, B.; Yaromira, A.; Zips, D.; Hessel, F.; Krause, M.; Thames, H.; Kotzerke, J.; Steinbach, J.; Baumann, M.; Beuthien-Baumann, B.

Involved research facilities

  • PET-Center

Potential of a Cetuximab-based radioimmunotherapy combined with external irradiation manifests in a 3-D cell assay

Ingargiola, M.; Runge, R.; Heldt, J.-M.; Freudenberg, R.; Steinbach, J.; Cordes, N.; Baumann, M.; Kotzerke, J.; Brockhoff, G.; Kunz-Schughart, L. A.

Evaluation and automatic correction of metal-implant-induced artifacts in MR-based attenuation correction in whole-body PET/MR imaging

Schramm, G.; Maus, J.; Hofheinz, F.; Petr, J.; Lougovski, A.; Beuthien-Baumann, B.; Platzek, I.; van den Hoff, J.

Involved research facilities

  • PET-Center

EGF receptor-targeting peptide conjugate incorporating a near-IR fluorescent dye and a novel 1,4,7-triazacyclononane-based 64Cu(II) chelator assembled via click chemistry

Viehweger, K.; Barbaro, L.; Pombo García, K.; Joshi, T.; Geipel, G.; Steinbach, J.; Stephan, H.; Spiccia, L.; Graham, B.

Diagnostic nanoparticle targeting of the EGF-receptor in complex biological conditions using single-domain antibodies

Zarschler, K.; Prapainop, K.; Mahon, E.; Rocks, L.; Bramini, M.; Kelly, P.; Stephan, H.; Dawson, K. A.

Early increase of cannabinoid receptor density after experimental traumatic brain injury in the newborn piglet

Donat, C. K.; Fischer, F.; Walter, B.; Deuther-Conrad, W.; Brodhun, M.; Bauer, R.; Brust, P.

  • Open Access Logo Acta Neurobiologiae Experimentalis 74(2014), 197-210
    ISSN: 0365-0820

Cytotoxic properties of radionuclide-conjugated Cetuximab without and in combination with external irradiation in head and neck cancer cells in vitro

Eke, I.; Ingargiola, M.; Förster, C.; Kunz-Schughart, L.; Baumann, M.; Runge, R.; Freudenberg, R.; Kotzerke, J.; Heldt, J.; Pietzsch, H.; Steinbach, J.; Cordes, N.

FDG PET/MR for lymph node staging in head and neck cancer

Platzek, I.; Beuthien-Baumann, B.; Schneider, M.; Gudziol, V.; Kitzler, H. H.; Maus, J.; Schramm, G.; Popp, M.; Laniado, M.; Kotzerke, J.; van den Hoff, J.

Involved research facilities

  • PET-Center

Distinctive In Vivo Kinetics of the New Sigma1 Receptor Ligands (R)-(+) and (S)-(-)- 18F-Fluspidine in Porcine Brain

Brust, P.; Deuther-Conrad, W.; Becker, G.; Patt, M.; Dont, C. K.; Stittsworth, S.; Fischer, S.; Hiller, A.; Wenzel, B.; Dukic-Stefanovic, S.; Hesse, S.; Steinbach, J.; Wünsch, B.; Lever, S. Z.; Sabri, O.

Correction of scan time dependence of standard uptake values in oncological PET

van den Hoff, J.; Lougovski, A.; Schramm, G.; Maus, J.; Oehme, L.; Petr, J.; Beuthien-Baumann, B.; Kotzerke, J.; Hofheinz, F.

Involved research facilities

  • PET-Center

Combined PET/MR: Where Are We Now? Summary Report of the Second International Workshop on PET/MR Imaging April 8–12, 2013, Tubingen, Germany

Bailey, D. L.; Barthel, H.; Beuthien-Baumann, B.; Beyer, T.; Bisdas, S.; Boellaard, R.; Czernin, J.; Drzezga, A.; Ernemann, U.; Franzius, C.; Gückel, B.; Handgretinger, R.; Hartenbach, M.; Hellwig, D.; Nadel, H.; Nekolla, S. G.; Pfluger, T.; Pichler, B. J.; Quick, H. H.; Sabri, O.; Sattler, B.; Schäfer, J.; Schick, F.; Siegel, B. A.; Schlemmer, H. P.; Schwenzer, N. F.; van den Hoff, J.; Veit-Haibach, P.; Wehrl, H. F.

Involved research facilities

  • PET-Center

Metastatic potential of B16-F10 melanoma cells is enhanced by extracellular S100A4 derived from RAW264.7 macrophages

Haase-Kohn, C.; Wolf, S.; Herwig, N.; Mosch, B.; Pietzsch, J.

Involved research facilities

  • PET-Center

Simultaneous Targeting of Prostate Stem Cell Antigen and Prostate-Specific Membrane Antigen Improves the Killing of Prostate Cancer Cells Using a Novel Modular T Cell-Retargeting System

Arndt, C.; Feldmann, A.; Koristka, S.; Cartellieri, M.; Dimmel, M.; Ehninger, A.; Ehninger, G.; Bachmann, M.

A novel ex vivo Isolation and Expansion Procedure for Chimeric Antigen Receptor Engrafted Human T Cells

Cartellieri, M.; Koristka, S.; Arndt, C.; Feldmann, A.; Stamova, S.; von Bonin, M.; Töpfer, K.; Krüger, T.; Geib, M.; Michalk, I.; Temme, A.; Bornhäuser, M.; Lindemann, D.; Ehninger, G.; Bachmann, M. P.

Characterization of a novel single-chain bispecific antibody for retargeting of T cells to tumor cells via the TCR co-receptor CD8

Michalk, I.; Feldmann, A.; Koristka, S.; Arndt, C.; Cartellieri, M.; Ehninger, A.; Ehninger, G.; Bachmann, M. P.

Letter to the editor: Cytotoxic response of human regulatory 1 T cells upon T cell receptor-mediated activation – a 2 matter of purity

Koristka, S.; Cartellieri, M.; Arndt, C.; Feldmann, A.; Töpfer, K.; Michalk, I.; Temme, A.; Ehninger, G.; Bachmann, M.

Visualizing inflammation activity in rheumatoid arthritis with Tc-99 m Anti-CD4-mAb fragment scintigraphy

Steinhoff, K.; Pierer, M.; Siegert, J.; Pigla, U.; Laub, R.; Hesse, S.; Seidel, W.; Sorger, D.; Seese, A.; Künstler, J.-U.; Pietzsch, H.-J.; Lincke, T.; Rullmann, M.; Emmrich, F.; Sabri, O.

Influence of different chelators on the radiochemical properties of a 68-Gallium labelled bombesin analogue.

Asti, M.; Iori, M.; Capponi, P. C.; Atti, G.; Rubagotti, S.; Martin, R.; Brennauer, A.; Müller, M.; Bergmann, R.; Erba, P. A.; Versari, A.

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Radiolabeled anti-EGFR-antibody improves local tumor control after external beam radiotherapy and offers theragnostic potential

Koi, L.; Bergmann, R.; Brüchner, K.; Pietzsch, J.; Pietzsch, H.-J.; Krause, M.; Steinbach, J.; Zips, D.; Baumann, M.

Involved research facilities

  • PET-Center

Establishment of two complementary in vitro assays for radiocopper complexes achieving reliable and comparable evaluation of in vivo stability

Zarschler, K.; Kubeil, M.; Stephan, H.

Involved research facilities

  • PET-Center

TCR/CD3 activation and co-stimulation combined in one T cell retargeting system improve anti-tumor immunity

Cartellieri, M.; Arndt, C.; Feldmann, A.; von Bonin, M.; Ewen, E.-M.; Koristka, S.; Michalk, I.; Stamova, S.; Berndt, N.; Gocht, A.; Bornhäuser, M.; Ehninger, G.; Schmitz, M.; Bachmann, M.

Evaluation of PET quantification accuracy in vivo - Comparison of measured FDG concentration in the bladder with urine samples / In-vivo-Evaluation der Quantifizierungsgenauigkeit der PET - Vergleich der gemessenen FDG-Konzentration in der Blase mit Urinproben

Maus, J.; Hofheinz, F.; Schramm, G.; Oehme, L.; Beuthien-Baumann, B.; Lukas, M.; Buchert, R.; Steinbach, J.; Kotzerke, J.; van den Hoff, J.

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Costimulation improves the killing capability of T cells redirected to tumor cells expressing low levels of CD33: Description of a novel modular targeting system

Arndt, C.; Feldmann, A.; von Bonin, M.; Cartellieri, M.; Ewen, E.-M.; Koristka, S.; Michalk, I.; Stamova, S.; Berndt, N.; Gocht, A.; Bornhäuser, M.; Ehninger, G.; Schmitz, M.; Bachmann, M.

Asymmetric Synthesis of Spirocyclic 2-Benzopyrans for Positron Emission Tomography of σ1 Receptors in the Brain

Holl, K.; Schepmann, D.; Fischer, S.; Ludwig, F. A.; Hiller, A.; Donat, C. K.; Deuther-Conrad, W.; Brust, P.; Wünsch, B.

A volume of intersection approach for on-the-fly system matrix calculation in 3D PET image reconstruction

Lougovski, A.; Hofheinz, F.; Langner, J.; Schramm, G.; Will, E.; van den Hoff, J.

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Synthesis and biological evaluation of both enantiomers of [18F]flubatine, promising radiotracers with fas kinetics for the imaging of α4β2-nicotinic acetylcholine receptors

Smits, R.; Fischer, S.; Hiller, A.; Deuther-Conrad, W.; Wenzel, B.; Patt, M.; Cumming, P.; Steinbach, J.; Sabri, O.; Brust, P.; Hoepping, A.

Development of 18F-labeled radiotracers for neuroreceptor imaging with positron emission tomography

Brust, P.; van den Hoff, J.; Steinbach, J.

Radiolabeled cetuximab conjugates for EGFR targeted cancer diagnostics and therapy

Sihver, W.; Pietzsch, J.; Krause, M.; Baumann, M.; Steinbach, J.; Pietzsch, H. J.

Performance Evaluation of Stationary and Semi-Stationary Acquisition with a Non-Stationary Small Animal Multi-Pinhole SPECT System

Lange, C.; Apostolova, I.; Lukas, M.; Huang, K. P.; Hofheinz, F.; Gregor-Mamoudou, B.; Brenner, W.; Buchert, R.

Involved research facilities

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