Publications of Institute of Radiopharmaceutical Cancer Research

261 Publications

2009

Fluorine-18-radiolabeled S100A12: a potential probe for functional characterization of inflammatory processes in vivo

Hoppmann, S.; Richter, S.; Steinbach, J.; Pietzsch, J.

  • Poster
    9th World Congress on Inflammation, 06.-10.07.2009, Tokyo, Japan
  • Inflammation Research 58(2009)Suppl. 2, S145-S146
    ISSN: 1023-3830

Synthesis and cyclooxygenase inhibition of various (aryl-1,2,3-triazole-1-yl)-methanesulfonylphenyl derivatives

Wuest, F.; Tang, X.; Knieß, T.; Pietzsch, J.; Suresh, M.


Radiosynthesis and radiopharmacological evaluation of [N-methyl-11C]Org 34850 as a glucocorticoid receptor (GR)-binding radiotracer

Wüst, F.; Knieß, T.; Henry, B.; Peeters, B. W. M. M.; Wiegerinck, P. H. G.; Pietzsch, J.; Bergmann, R.


Prediabetic and diabetic in vivo modification of circulating low density lipoprotein attenuates its stimulatory effect on adrenal mineralocorticoid secretion

Kopprasch, S.; Pietzsch, J.; Ansurudeen, I.; Graessler, J.; Krug, A. W.; Erhart-Bornstein, M.; Bornstein, S. R.


Validation of 99mTc-labeled "4+1" fatty acids for myocardial metabolism and flow imaging Part 2: Subcellular distribution

Mirtschink, P.; Stehr, S. N.; Walther, M.; Pietzsch, J.; Bergmann, R.; Pietzsch, H.-J.; Weichsel, J.; Pexa, A.; Dieterich, P.; Wunderlich, G.; Binas, B.; Kropp, J.; Deussen, A.


Validation of 99mTc-labeled "4+1" fatty acids for myocardial metabolism and flow imaging Part 1: Myocardial extraction and biodistribution

Mirtschink, P.; Stehr, S. N.; Walther, M.; Pietzsch, J.; Bergmann, R.; Pietzsch, H.-J.; Weichsel, J.; Pexa, A.; Dieterich, P.; Wunderlich, G.; Binas, B.; Kropp, J.; Deussen, A.


Cell cycle regulating kinase Cdk4 as a potential target for tumor cell treatment and tumor imaging

Graf, F.; Köhler, L.; Knieß, T.; Wüst, F.; Mosch, B.; Pietzsch, J.


Human S100A12: a novel key player in inflammation?

Pietzsch, J.; Hoppmann, S.


Systematic comparison of two novel thiol-reactive prosthetic groups for 18F labeling of peptides and proteins with the acylation agent succinimidyl-4-[18F]fluorobenzoate [18F]SFB

Wüst, F.; Köhler, L.; Berndt, M.; Pietzsch, J.

  • Amino Acids 36(2009), 283-295
    ISSN: 0939-4451

2008

Effects of pioglitazone and/or simvastatin on low density lipoprotein subfractions in non-diabetic patients with high cardiovascular risk: A sub-analysis from the PIOSTAT study

Leonhardt, W.; Pfützner, A.; Müller, J.; Pietzsch, J.; Forst, T.; Karagiannis, E.; Lübben, G.; Hanefeld, M.


Synthesis and evaluation in vitro and in vivo of a 11C-labeled cyclooxygenase-2 (COX-2) inhibitor

Wüst, F.; Knieß, T.; Bergmann, R.; Pietzsch, J.


Factfile: S100A12

Pietzsch, J.

  • Open Access Logo Calcium Binding Proteins 3(2008), 18-21

Yttrium-86-labelled human serum albumin microspheres: relation of surface structure with in vivo stability

Schiller, E.; Bergmann, R.; Pietzsch, J.; Noll, B.; Sterger, A.; Johannsen, B.; Wunderlich, G.; Pietzsch, H.-J.


Synthesis and Application of [18F]FDG-maleimidehexyloxime ([18F]FDG-MHO): A [18F]FDG-based Prosthetic Group for the Chemoselective 18F-Labeling of Peptides and Proteins

Wüst, F.; Berndt, M.; Bergmann, R.; van den Hoff, J.; Pietzsch, J.

  • Bioconjugate Chemistry 19(2008)6, 1202-1210

Radiolabeled glucocorticoids as molecular probes for imaging brain glucocorticoid receptors by means of positron-emission-tomography (PET)

Steiniger, B.; Knieß, T.; Bergmann, R.; Pietzsch, J.; Wüst, F.

  • Mini-Reviews in Medicinal Chemistry 8(2008)7, 728-739
    ISSN: 1389-5575

Radiosynthesis of n.c.a. sodium [18F]fluoroacetate and radiopharmacological characterization in rats and tumour-xenografted mice

Richter, S.; Bergmann, R.; Pietzsch, J.; Beuthien-Baumann, B.; Wüst, F.

  • Current Radiopharmaceuticals 1(2008)2, 103-109
    ISSN: 1874-4710

Expression, purification and fluorine-18 radiolabeling of recombinant S100 proteins - potential probes for molecular imaging of receptor for advanced glycation endproducts (RAGE) in vivo

Hoppmann, S.; Haase, C.; Richter, S.; Pietzsch, J.


Glycoxidation of low-density lipoprotein in impaired glucose tolerance: implications for the pathogenesis of diabetic vascular disease

Kopprasch, S.; Graessler, J.; Bornstein, S. R.; Pietzsch, J.

  • Vascular Disease Prevention 5(2008), 24-28
    ISSN: 1567-2700

Localized proton magnetic resonance spectroscopy of lipids in adipose tissue at high spatial resolution in mice in vivo

Strobel, K.; van den Hoff, J.; Pietzsch, J.


Modified “4+1” Mixed Ligand Technetium Labeled Fatty Acids for Myocardial Imaging: Evaluation of Myocardial Uptake and Biodistribution

Mirtschink, P.; Stehr, S. N.; Pietzsch, H.-J.; Bergmann, R.; Pietzsch, J.; Wunderlich, G.; Heintz, A. C.; Kropp, J.; Spies, H.; Kraus, W.; Deussen, A.; Walther, M.


2007

Factors influencing the formation of small dense low-density lipoprotein particles in dependence on the presence of the metabolic syndrome and on the degree of glucose intolerance

Julius, U.; Dittrich, M.; Pietzsch, J.


Myocardial uptake and biodistribution of newly designed technetium-labelled fatty acid analogues

Heintz, A. C.; Jung, C. M.; Stehr, S. N.; Mirtschink, P.; Walther, M.; Pietzsch, J.; Bergmann, R.; Pietzsch, H.-J.; Spies, H.; Wunderlich, G.; Kropp, J.; Deussen, A.

  • Nuclear Medicine Communications 28(2007)8, 637-647
    ISSN: 0143-3636

Experimental hypoxia is a potent stimulus for radiotracer uptake in vitro: Comparison of different tumor cells and primary endothelial cells

Oswald, J.; Treite, F.; Haase, C.; Kampfrath, T.; Mäding, P.; Schwenzer, B.; Bergmann, R.; Pietzsch, J.


[18F]FBAM and [18F]FBOM: Novel Thiol-reactive prosthetic groups derived from 4-[18F]fluorobenzaldehyde

Vogler, L.; Berndt, M.; Pietzsch, J.; Wüst, F.

  • Lecture (Conference)
    14th Workshop der International Isotope Society, 21.-22.06.2007, Bad Soden, Germany
  • Journal of Labelled Compounds and Radiopharmaceuticals 50(2007), 1276-1286

L-Type Amino Acid Transporters LAT1 and LAT4 in Cancer: Uptake of 3-O- Methyl-6-18F-Fluoro-L-Dopa (18F-OMFD) in Human Adenocarcinoma and Squamous Cell Carcinoma in vitro and in vivo

Haase, C.; Bergmann, R.; Füchtner, F.; Hoepping, A.; Pietzsch, J.


Glycoxidised LDL isolated from subjects with impaired glucose tolerance increases CD36 and peroxisome proliferator-activator receptor gamma gene expression in macrophages

Graessler, J.; Pietzsch, J.; Westendorf, T.; Julius, U.; Bornstein, S. R.; Kopprasch, S.


Lipid transfer protein activities in subjects with impaired glucose tolerance

Julius, U.; Jauhiainen, M.; Ehnholm, C.; Pietzsch, J.

  • Clinical Chemistry and Laboratory Medicine 45(2007)2, 237-243
    ISSN: 1434-6621

Labeling of low-density lipoproteins using the 18F-labeled thiol-reactive reagent N-[6-(4-[18F]fluorobenzylidene)aminooxyhexyl]maleimide [18F]FBAM

Berndt, M.; Pietzsch, J.; Wüst, F.


Synthesis of 18F-labelled stilbenes from 4-[18F]fluorobenzaldehyde using the Horner-Wadsworth-Emmons reaction

Gester, S.; Pietzsch, J.; Wüst, F.


Synthesis and radiopharmacological characterization of [11C]AL-438 as a nonsteroidal ligand for imaging brain glucocorticoid receptors

Wüst, F.; Knieß, T.; Bergmann, R.; Henry, B.; Pietzsch, J.

  • Bioorganic & Medicinal Chemistry Letters 17(2007), 4035-4039

Synthesis and biological evaluation of a new type of 99mTechnetium-labeled fatty acid for myocardial metabolism imaging

Walther, M.; Jung, C.; Bergmann, R.; Pietzsch, J.; Rode, K.; Fahmy, K.; Mirtschink, P.; Stehr, S.; Heintz, A.; Wunderlich, G.; Kraus, W.; Pietzsch, H.-J.; Kropp, J.; Deussen, A.; Spies, H.

  • Bioconjugate Chemistry 18(2007), 216-230
    ISSN: 10.1021/bc0601222

2006

Neurotensin Receptors in Adeno- and Squamous Cell Carcinoma

Haase, C.; Bergmann, R.; Oswald, J.; Zips, D.; Pietzsch, J.

  • Open Access Logo Anticancer Research 26(2006), 3527-3534

Biodistribution and catabolism of 18F-labeled N-epsilon-fructoselysine as a model of Amadori products

Hultsch, C.; Hellwig, M.; Pawelke, B.; Bergmann, R.; Rode, K.; Pietzsch, J.; Krause, R.; Henle, T.


2005

Positron emission tomography in food sciences

Pietzsch, J.; van den Hoff, J.


Small animal positron emission tomography in food sciences

Bergmann, R.; Pietzsch, J.


Biodistribution and catabolism of 18F-labelled isopeptide N (varepsilon)-(gamma-glutamyl)-L-lysine

Hultsch, C.; Bergmann, R.; Pawelke, B.; Pietzsch, J.; Wüst, F.; Johannsen, B.; Henle, T.


Catabolism of native and oxidized low density lipoproteins (LDL): in vivo insights from small animal positron emission tomography studies

Pietzsch, J.; Bergmann, R.; Wüst, F.; Pawelke, B.; Hultsch, C.; van den Hoff, J.


Glucose-Induced Enhancement of Hemin-Catalyzed LDL Oxidation In Vitro and In Vivo

Julius, U.; Pietzsch, J.

  • Antioxidants and Redox Signaling 7(2005)11-12, 1507-1512

Pathological consequenses of systemic oxidative stress and dyslipidemia in impaired glucose tolerance and diabetes mellitus

Kopprasch, S.; Grässler, J.; Pietzsch, J.

  • Trends in Cell & Molecular Biology 1(2005), 1-14

In vivo metabolism of oxidized low density lipoproteins: Insights from small animal positron emission tomography (PET) studies

Pietzsch, J.; Bergmann, R.; Wüst, F.; van den Hoff, J.

  • Recent Research Developments in Molecular & Cellular Biochemistry 2(2005), 153-177

Synthesis and biodistribution of an 18F-labelled resveratrol derivative for small animal positron emission tomography (PET)

Gester, S.; Wüst, F.; Pawelke, B.; Bergmann, R.; Pietzsch, J.


2004

Fluorine-18 radiolabeling of low-density lipoproteins: a potential approach for characterization and differentiation of metabolism of native and oxidized low-density lipoproteins in vivo.

Pietzsch, J.; Bergmann, R.; Rode, K.; Hultsch, C.; Pawelke, B.; Wüst, F.; van den Hoff, J.

  • Nuclear Medicine and Biology 31(2004), 1043-1050

3-O-Methyl-6-18F-Fluoro-L-Dopa, a New Tumor Imaging Agent: Investigation of Transport Mechanism In Vitro

Bergmann, R.; Pietzsch, J.; Füchtner, F.; Pawelke, B.; Beuthien-Baumann, B.; Johannsen, B.; Kotzerke, J.

  • Journal of Nuclear Medicine 45(2004), 2116-2122

The effect of garlic on arteriosclerotic nanoplaque formation and size

Siegel, G.; Malmsten, M.; Pietzsch, J.; Schmidt, A.; Buddecke, E.; Michel, F.; Ploch, M.; Schneider, W.

  • Phytomedicine 11(2004), 24-35

Oxidativ modifizierte Lipoproteine und deren Antikörper bei Patienten mit Antiphospholipid-Syndrom

Roch, B.; Kopprasch, S.; Pietzsch, J.; Schröder, H.


The pivotal role of scavenger receptor CD36 and phagocyte-derived oxidants in oxidized low density lipoprotein-induced adhesion to endothelial cells

Kopprasch, S.; Pietzsch, J.; Westendorf, T.; Kruse, H.-J.; Graessler, J.

  • International Journal of Biochemistry and Cell Biology 36(2004)3, 460-471

The protective effects of HDL and its constituents against neutrophil respiratory bust activation by hypochlirite-oxidized LDL

Kopprasch, S.; Pietzsch, J.; Graessler, J.

  • Molecular and Cellular Biochemistry 258(2004), 121-127

Analysis of non-protein amino acids as specific markers of low density lipoprotein apolipoprotein B-100 oxidation in human atherosclerotic lesions: the use of N(O,S)-ethoxycarbonyl trifluoroethyl ester derivatives and GC-MS

Pietzsch, J.; Bergmann, R.; Kopprasch, S.

  • Spectroscopy 18(2004),177-183

Analysis of 6-hydroxy-2-aminocaproic acid (HACA) as a specific marker of protein oxidation: The use of N(O,S)-ethoxycarbonyl trifluoroethyl ester derivatives and gas chromatography/mass spectrometry

Pietzsch, J.; Bergmann, R.

  • Amino Acids 26(2004), 45-51

2003

Validation of different chemilumigenic substrates for detecting extracellular generation of reactive oxygen species by phagocytes and endothelial cells

Kopprasch, S.; Pietzsch, J.; Graessler, J.

  • Luminescence (2003) 18: 268-273

Fortschritte in der Aminosäureanalytik: N(O,S)-Ethoxycarbonyl-(trifluoro)ethylester-Derivate

Pietzsch, J.

  • Bioforum 10/2003, 643-645

Measurement of 5-hydroxy-2-aminovaleric acid as a specific marker of iron-mediated oxidation of proline and arginine residues of low density lipoprotein aplipoprotein B-100 in human atherosclerotic lesions

Pietzsch, J.; Bergmann, R.

  • J Clin Pathol (2003) 56: 622-623

Flavonoide: Wirkmechanismen und neue Anwendungsmöglichkeiten (Teil 2)

Pietzsch, J.; Bergmann, R.; Wüst, F.

  • Bioforum (2003) 6:384-385

Flavonoide: Wirkmechanismen und neue Anwendungsmöglichkeiten (Teil 1)

Pietzsch, J.; Bergmann, R.; Wüst, F.

  • Bioforum (2003) 5: 289-291

Increased cholesteryl ester transfer protein (CETP) activity in impaired glucose tolerance: relationship to high density lipoprotein metabolism

Pietzsch, J.; Fücker, K.

  • Croatian Medical Journal 44 (2): 171-177, 2003

Lack of association between serum paraoxonase (PON1) activities and increased oxidized LDL levels in impaired glucose tolerance and newly diagnosed diabetes mellitus

Kopprasch, S.; Pietzsch, J.; Kuhlisch, E.; Gräßler, J.

  • Journal of Clinical Endocrinology & Metabolism 2003; 88: 1711-1716

Analysis of 3-chlorotyrosine as a specific marker of protein oxidation: The use of N(O,S)-ethoxycarbonyl trifluoroethyl ester derivatives and gas chromatography/mass spectrometry

Pietzsch, J.; Kopprasch, S.; Bergmann, R.

  • Rapid Commun. Mass Spectrom 17 (2003):767-770

2002

Intraindividual comparison of two extracorporeal LDL apheresis methods: lipidfiltration and HELP

Julius, U.; Metzler, W.; Pietzsch, J.; Fassbender, T.; Klingel, R.

  • Int J Artif Organs 25 (2002): 1180-1188

Homocystein: Von der Spezialanalyse zum Routineparameter

Pietzsch, J.

  • Bioforum 9 (2002) 577-580

In vivo evidence for increased oxidation of circulating LDL in impaired glucose tolerance

Kopprasch, S.; Pietzsch, J.; Kuhlisch, E.; Fuecker, K.; Temelkova-Kurktschiev, T.; Hanefeld, M.; Kühne, H.; Julius, U.; Graessler, J.

  • Diabetes 51 (2002) 3102-3106

Impaired glucose tolerance is not associated with lipid intolerance

Henkel, E.; Temelkova-Kurtschiev, T.; Köhler, C.; Pietzsch, J.; Leonhardt, W.; Hanefeld, M.

  • Diab Nutr Metab 15 (2002) 84-90

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