Publications Repository - Helmholtz-Zentrum Dresden-Rossendorf

2 Publications
Expression of Neurotensin Receptors in Human Adeno- and Squamous Cell Carcinoma
Haase, C.; Bergmann, R.; Pietzsch, J.;
There is increasing interest in targeting peptide receptors and their ligands for tumor diagnostics and therapy since there is evidence that some of these receptors are overexpressed in tumors compared to normal tissues. Among these receptors playing a key role in tumor progression is the neurotensin receptor (NTR) family. The present study investigated both mRNA and protein expression of NTR in human adeno- (HT-29) and squamous (FaDu) cell carcinoma cell lines and in corresponding mouse xenograft models. mRNA analysis revealed a higher expression of NTR3 compared to NTR1 and NTR2. Protein analysis revealed enhanced signals for NTR1 followed by NTR2 both in tumor cells and xenografts. In contrast, no NTR3 protein expression was detected. Autoradiography with [3H]neurotensin showed higher receptor binding activity on HT-29 compared to FaDu.
  • Poster
    4th International Conference on Tumor Microenvironment: Progression, Therapy & Prevention, 06.-10.03.2007, Florence, Italy
  • Contribution to proceedings
    4th International Conference on Tumor Microenvironment: Progression, Therapy and Prevention, 06.-10.03.2007, Florence, Italy
    Current Contents

Publ.-Id: 10096 - Permalink