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Light-activated ruthenium(II) carbonyl complexesKubeil, M.ORC; Stephan, H.; Johnston, A.; Graham, B.; Spiccia, L.
The development of photo-activated carbon monoxide releasing molecules (photoCORMs) has received considerable attention as a new prodrug approach, since the CO is released only upon exposure to electromagnetic radiation . Carbon monoxide itself has been demonstrated to exhibit several beneficial effects on biological targets such as anti-inflammation, anti-proliferation, anti-apoptosis, anti-oxidation and vasodilatory effects . However, despite a large number of photoCORMs reported, relatively little information is available on the precise mechanism of CO release from most photoCORMs and even less compounds have been tested as anti-cancer agents in cells so far. Overall, a fundamental understanding of the mechanism of CO release from photoCORMs is essential for their exploitation as therapeutics.
Herein, we report the synthesis of ruthenium(II) carbonyl complexes functionalized with bidentate pyridyl (1) and tridentate diquinolyl ligands (2) and investigate the mechanism of CO release in aqueous media (before and after light-activation). The photo-induced CO release kinetics of the Ru(II) photoCORMs, as well as the identity of the intermediates and photo-activated products, will be presented . Moreover, the complexes have been tested in cancer cell lines showing a reduced viability after CO release.
 U. Schatzschneider, Br. J. Pharmacol. 2015, 172, 1638.  R. Motterlini, L. E. Otterbein, Nat. Rev. Drug Discov. 2010. 9, 728-743.  M. Kubeil, R. R. Vernooij, C. Kubeil, B. R. Wood, B. Graham, H. Stephan, L. Spiccia, Inorg. Chem. 2017, 56, 5941−5952.
Keywords: ruthenium carbonyl complexes, kinetics, in vitro studies
Wissenschaftsforum, 10.-14.09.2017, Berlin, Deutschland
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