Publications Repository - Helmholtz-Zentrum Dresden-Rossendorf

1 Publication
Relative biological effectiveness in proton beam therapy – current knowledge and future challenges
Lühr, A.; von Neubeck, C.; Krause, M.; Troost, E. G. C.;
This review summarizes recent abstracts to international meetings and international peer-reviewed publications on the potential variation of the RBE and its possible side-effects, and compares these with past publication on photon beam irradiation. Moreover, recent literature on how to deal with potential RBE variations and the resulting uncertainty during treatment planning as well as solutions to correlate dose and LET distributions to subsequent (magnetic resonance) imaging changes are presented. Finally, the current status on RBE measured in vitro and in vivo is reviewed and input given on how to bridge the existing gap between lab and clinic.
Keywords: RBE, relative biological effectiveness, clinical side-effects, in vitro and in vivo models, MRI, dose recalculation

Publ.-Id: 26658 - Permalink