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Molecular imaging in neuroendocrine tumors: Molecular uptake mechanisms and clinical results

Koopmans, K.; Neels, O.; Kema, I.; Elsinga, P.; Links, T.; de Vries, E.; Jager, P.
Neuroendocrine tumors can originate almost everywhere in the body and consist of a great variety of subtypes. This paper focuses on molecular imaging methods using nuclear medicine techniques in neuroendocrine tumors, coupling molecular uptake mechanisms ofradiotracers with clinical results. A non-systematic review is presented on receptor based and metabolic imaging methods. Receptor-based imaging covers the molecular backgrounds of somatostatin, vaso-intestinal peptide (VIP), bombesin and cholecystokinin (CCK) receptors and their link with nuclear imaging. Imaging methods based on specific metabolic properties include meta-iodo-benzylguanide (MIBG) and dimercapto-sulphuric acid (DMSA-V) scintigraphy as well as more modern positron emission tomography (PET)-based methods using radio-labeled analogues of amino acids, glucose, dihydroxyphenylalanine (DOPA), dopamine and tryptophan. Diagnostic sensitivities are presented for each imaging method and for each neuroendocrine tumor subtype. Finally, a Forest plot analysis of diagnostic performance is presented for each tumor type in order to provide a comprehensive overview for clinical use.
Keywords: Neuroendocrine tumors; Review; Diagnostic imaging; Radiopharmaceuticals/diagnostic use; Positron emission tomography; Gamma camera imaging

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Permalink: https://www.hzdr.de/publications/Publ-30998
Publ.-Id: 30998