Publications Repository - Helmholtz-Zentrum Dresden-Rossendorf
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Is reducing irradiated margins key to improving outcomes for radiotherapy
Radiotherapy is a four-dimensional geometrical challenge. For modern radiotherapy planning, gross tumour volume (GTV) is pictured before treatment using CT scanning fused with anatomical and functional imaging. To account for microscopic tumour spread, a safety margin is added to the GTV and corrected for anatomical boundaries to determine the clinical target volume (CTV). Finally, systematic and random errors occurring during the fractionated course of radiotherapy are corrected for by adding another safety margin.
- Lancet Oncology 20(2019)9, 1208-1210