Publications Repository - Helmholtz-Zentrum Dresden-Rossendorf

1 Publication
Efficient synthesis of the 18F-labelled amino acid 3-O-methyl-6-[18F]fluoro-L-DOPA
Füchtner, F.; Steinbach, J.;
The 18F-labelled amino acid derivative 3-O-methyl-6-[18F]fluoro-L-DOPA ([18F]OMFD) is a potential radiotracer to image tumour tissue using positron emission tomography. The precursor N-formyl-3-O-methyl-4-O-boc-6-trimethyl-stannyl-L-DOPA--ethyl ester enables the direct electrophilic radiofluorination by stereoselective destannylation. After partial hydrolysis, an optimized HPLC purification and sterile filtration the [18F]OMFD obtained with high radiochemical purity is ready for use. The total synthesis time is about 50 minutes and the radiochemical yield achieved is 20-25% (decay corrected, related to [18F]F2). It was demonstrated that [18F]OMFD can be produced routinely and reliably for clinical use. [18F]FDOPA - preparation devices can be used with minor modifications.
Keywords: 3-O-methyl-6-[18F]fluoro-L-DOPA, radiolabelled amino acid, electrophilic 18F-fluorination, PET-radiotracer
  • Applied Radiation and Isotopes 58 (2003) 575-578

Publ.-Id: 5250 - Permalink