Cu-61 production and purification


Cu-61 production and purification

Thieme, S.; Walther, M.; Pietzsch, H.-J.; Steinbach, J.

Cu-61 (T1/2=3.32 h, Eβ+=1.22 MeV 60%) is a positron emitter from the set of medically useful copper radioisotopes. Its nuclear properties and ease of production make it suitable for positron emission tomography imaging. The 64Zn (p,α)61Cu reaction with enriched Zn-64 as target material seems to be more convenient for the routine production of Cu-61 than the 61Ni(p,n)61Cu route, due to the higher costs of enriched Ni-61. As reported, the 64Zn(p,α)61Cu reaction delivers adequate yields of Cu-61 in an energy window of 19à10MeV with low contaminants like Cu-60/62 which occur at higher proton energies.
Cu-61 was generated using the 64Zn(p,α)61Cu reaction utilizing 16 MeV. For the purification of Cu-61, a system of cation- and anion-exchange columns was applied which allows recycling of the target material for uncomplicated electro deposition for the next irradiation cycle. The abandonment of heating and drying steps, applying pumps or any pressure to the columns makes this process suitable for remote handling in hot cells and causing fewer sources of contaminants and enables good/reasonable yields. An overview of the key data (yield at EOB and after processing, specific activity and radiochemical purity) will be presented.

  • Abstract in refereed journal
    Nuclear Medicine and Biology 37(2010)6, 719
    DOI: 10.1016/j.nucmedbio.2010.04.049
  • Contribution to external collection
    Ulderico Mazzi, William V. Eckelman, Wynn A. Volkert: Technetium and Other Radiometals in Chemistry and Medicine, Padova: SGEditoriali, 2010, 475-478
  • Lecture (Conference)
    International Symposium on Technetium and other Radiometals in Chemistry and Medicine, 08.-11.09.2010, Bressanone, Italy

Permalink: https://www.hzdr.de/publications/Publ-14761
Publ.-Id: 14761