Publications Repository - Helmholtz-Zentrum Dresden-Rossendorf

Dendritic encapsulation of 99mTc and 188Re species

Stephan, H.; Drews, A.; Pietzsch, H.-J.; Schiller, E.; Spies, H.; Johannsen, B.; Gloe, K.; Stute, S.; Appelhans, D.; Müller, H.; Voit, B.; Osswald, F.; Vögtle, F.

A series of different dendrons for the encapsulation of 99mTc and 188Re have been synthesised, "3+1" mixed ligand 99mTc complexes with dendritic polyether thiols as monodendate ligands have been prepared. Challenge experiments with glutathione showed a remarkable enhancement of stability with increasing number of dendron generation. To achieve better solubility behaviour oligoethyleneoxy- and sugar-substituted dendrons are developed. In this case 2-aminobenzenethiol is introduced as chelating unit. Molecular modeling calculations point to an almost complete shielding of the radionuclide by use of second generation dendrons.

Keywords: 2-aminobenzenethiole; dendrimers; dendrons; encapsulation; rhenium

  • Poster
    6th International Symposium on Technetium in Chemistry and Nuclear Medicine, Bressanone/I, 04.-07.09.2002
  • Contribution to external collection
    In: Technetium, Rhenium and Other Metals in Chemistry and Nuclear Medicine (Edited by Nicolini M., Mazzi U.) SGEditoriali Padova 2002, 267-269

Publ.-Id: 4936