Imaging and Radiooncology
Health > Cancer Research - All Topics
In Germany, 500,000 people are diagnosed with cancer every year. New, faster, and primarily more gentle diagnostic and therapeutic procedures can help to fight the disease and to save lifes.
Cancer research at the HZDR addresses the following topics: The scientists conduct research, for example, on new radiopharmaceuticals for the diagnosis of cancer and for the characterization of cancer tissue and, as a further development, also investigate substances for the cancer therapy of tomorrow. Our research has already resulted in the development of new substances. Two radiopharmaceuticals are officially approved and registered pursuant to the pharmaceutical law. These substances, which are produced at the HZDR and subsequently distributed on the market, are needed for the detection of tumors and metastases with a PET camera (PET = Positron Emission Tomography). That is also possible in Dresden – patients can be examined utilizing a full-body scan PET/MRI system which is the first of its kind to have been approved for patients in Germany. HZDR scientists are further developing and improving these innovative imaging procedures which are used in oncology.
They are also investigating particle acceleration with the help of innovative laser technologies. The objective: Making proton-therapy centers smaller while, at the same time, lowering the costs through more powerful lasers and with pulsed magnetic fields. Researchers are also aiming on monitoring irradiation of patients with proton beams in real time.
The HZDR is part of the Competence Network for Radiation Research (KVSF, promoted by the BMBF). This alliance promotes the sustainability of competences in the field of radiation research, in particular, by fostering young scientists.
Important partners are the TU Dresden (Dresden University of Technology) and the University Hospital Carl Gustav Carus Dresden. We jointly operate the OncoRay Center. More information on collaborations with Dresden and Heidelberg partners
Objectives
- Development and application of new technologies for the diagnosis and therapy of cancer
- Establishment of laser-accelerated ions in radiation oncology
- Monitoring and controlling tumor radiation in real time
- Continued development of individualized and tolerable therapy forms
Press Releases
- Kopf-Hals-Tumoren: Zeit für neue Einblicke in die individualisierte Krebstherapie
- Neubau bietet Wissenschaftlern und Ärzten optimale Infrastruktur für innovative Krebsforschung
- Bestrahlungserfolg bei Hirntumoren lässt sich mit kombinierter PET/MRT vorhersagen
- Forscher packen Alpha-Strahler in Käfig
- Stealth-cap technology for light-emitting nanoparticles
- High-contrast imaging for cancer therapy with protons
- New approach for range prediction improves accuracy of proton therapy
- Die Teilchenjägerin
- Der Spurenleger zum Tumor
- Directing nanoparticles straight to tumors
- Innovative ways to battle Parkinson’s disease
- Synthesis against the clock
- Vielversprechende Laborforschung
- Mit dem Lego-Prinzip gegen das Virus: HZDR-Wissenschaftler*innen erhalten millionenschwere Förderung für Corona-Forschung
- Staatsminister Christian Piwarz besuchte das HZDR
- NCT/UCC Dresden: Neubau für innovative Krebsforschung eröffnet
- Strahlender Helfer: HZDR und ROTOP stellen Radionuklid für Medikament zur Parkinson-Diagnostik her
- An important step towards live imaging in proton therapy
- HZDR und Monash University bauen gemeinsames Labor auf
- Strahlender Sieger dank strahlender Idee
- HZDR-Institut für Radiopharmazeutische Krebsforschung erhält Fördermittel für neues Forschungsgerät
- Glocker-Medaille für Dresdner Medizinphysiker
- Zelluläre Immuntherapien – Präzisionsmedizin gegen Krebs
- ProtOnART – a new consortium for proton online adaptive radiation therapy
- Radioactive Substances Fight Cancer in the Mini-lab
- Vision: Radiopharmaceutical Valley
- Mission to beat rare cancers: More targets on tumor cell surface for optimized radionuclide therapy
- Internationale Partnerschaft mit Monash University: Gemeinsames MHELTHERA-Labor gestartet
- Blockieren eines Eiweißmoleküls macht aggressive Hirntumoren sensibler für Strahlen- und Chemotherapie
- Smart Keys for cancer therapy: Research team develops new system for imaging and treating tumors
- A light in the dark: How the trajectory of protons is made visible
- Wegweisende CAR-T-Zelltherapie für Blutkrebs-Erkrankungen
- The world’s first Prototype for High-Contrast Live Imaging in Proton Therapy
- Neuer Ansatz bei schweren Verläufen von Prostatakrebs
- Krebs von innen bestrahlen: HZDR und DKFZ gründen Helmholtz-Verbund für Radiopharmazeutische Wissenschaften
- Radioaktivität rettet Leben
Involved HZDR institutes
- Institute of Radiopharmaceutical Cancer Research
- Institute of Radiation Physics
- Institute of Radiooncology - OncoRay
- Dresden High Magnetic Field Laboratory
Collaborations
- OncoRay Center
- Nuclear Medicine Clinic at the University Hospital
- Deutsches Krebsforschungszentrum
- National Center for Tumor Diseases Dresden
Contacts
Publications
- Padrela, B.; Mahroo, A.; Tee, M. et al.
Developing blood-brain barrier arterial spin labelling as a non-invasive early biomarker of Alzheimer’s disease (DEBBIE-AD): a prospective observational multicohort study protocol
BMJ Open 14(2024)3, e081635 (10.1136/bmjopen-2023-081635) - Paschoal, A. M.; Woods, J. G.; Pinto, J. et al.
Reproducibility of Arterial Spin Labeling Cerebral Blood Flow image processing: A Report of The ISMRM Open Science Initiative for Perfusion Imaging and the ASL MRI Challenge
Magnetic Resonance in Medicine (2024) (10.1002/mrm.30081) - Cegla, P.; Hofheinz, F.; Czepczyński, R. et al.
Value of [18F] FDG PET/CT parameters of the primary tumor in assessing overall survival in NSCLC patients with cN1-cN3 lymph nodes involvement
Reports of Practical Oncology and Radiotherapy (2024) (10.5603/rpor.99360) - Bigos, K.; Quiles, C.; Lunj, S. et al.
Tumour response to hypoxia: understanding the hypoxic tumour microenvironment to improve treatment outcome in solid tumours
Frontiers in Oncology 14(2024), 1331355 - Maisonial-Besset, A.; Kryza, D.; Kopka, K. et al.
Improved automated one-pot two-step radiosynthesis of (S)-[18F]FETrp, a radiotracer for PET imaging of indoleamine 2,3-dioxygenase 1 (IDO1)
European Journal of Nuclear Medicine and Molecular Imaging 9(2024), 28 (10.1186/s41181-024-00256-0) - Peng, X.; Janićijević, Ž.; Lemm, S. et al.
Impact of Viscosity on Human Hepatoma Spheroids in Soft Core-Shell Microcapsules
Advanced Healthcare Materials (2024), 2302609 (10.1002/adhm.202302609) - Zhang, Y.; Trnkova, P.; Toshito, T. et al.
A survey of practice patterns for real-time intrafractional motion-management in particle therapy
Physics and Imaging in Radiation Oncology 26(2023), 100439 (10.1016/j.phro.2023.100439) - Trnkova, P.; Zhang, Y.; Toshito, T. et al.
A survey of practice patterns for adaptive particle therapy for interfractional changes
Physics and Imaging in Radiation Oncology 26(2023), 100442 (10.1016/j.phro.2023.100442) - Tawk, B.; Rein, K.; Schwager, C. et al.
DNA-Methylome–Based Tumor Hypoxia Classifier Identifies HPV-Negative Head and Neck Cancer Patients at Risk for Locoregional Recurrence after Primary Radiochemotherapy
Clinical Cancer Research 29(2023)16, 3051-3064 (10.1158/1078-0432.CCR-22-3790) - Peters, N.; Trier Taasti, V.; Ackermann, B. et al.
Consensus guide on CT-based prediction of stopping-power ratio using a Hounsfield look-up table for proton therapy
Radiotherapy and Oncology 184(2023), 109675 (10.1016/j.radonc.2023.109675) - Vrou Offersen, B.; Aznar, M. C.; Bacchus, C. et al.
The role of ESTRO guidelines in achieving consistency and quality in clinical radiation oncology practice
Radiotherapy and Oncology 179(2023), 109446 (10.1016/j.radonc.2022.109446) - Leichtle, F.; Betzler, A. C.; Eizenberger, C. et al.
Influence of Bruton’s Tyrosine Kinase (BTK) on Epithelial–Mesenchymal Transition (EMT) Processes and Cancer Stem Cell (CSC) Enrichment in Head and Neck Squamous Cell Carcinoma (HNSCC)
International Journal of Molecular Sciences 24(2023)17, 13133 (10.3390/ijms241713133) - Koi, L.; Bitto, V.; Weise, C. et al.
Prognostic biomarkers for the response to the radiosensitizer nimorazole combined with RCTx: a pre-clinical trial in HNSCC xenografts
Journal of Translational Medicine 21(2023), 576 (10.1186/s12967-023-04439-2) - Klusa, D.; Lohaus, F.; Franken, A. et al.
Dynamics of CXCR4 positive circulating tumor cells in prostate cancer patients during radiotherapy
International Journal of Cancer 152(2023), 2639-2654 (10.1002/ijc.34457) - Gantz, S.; Karsch, L.; Pawelke, J. et al.
Direct visualization of proton beam irradiation effects in liquids by MRI
Proceedings of the National Academy of Sciences of the United States of America 120(2023)23, e2301160120 (10.1073/pnas.2301160120) - Franke, F.; Michlikova, S.; Aland, S. et al.
Efficient Radial-Shell Model for 3D Tumor Spheroid Dynamics with Radiotherapy
Cancers 15(2023), 5645 (10.3390/cancers15235645) - Corti, C.; Cobanaj, M.; Dee, E. C. et al.
Artificial intelligence in cancer research and precision medicine: Applications, limitations and priorities to drive transformation in the delivery of equitable and unbiased care
Cancer Treatment Reviews 112(2023), 102498 (10.1016/j.ctrv.2022.102498) - Baumann, M.; Bacchus, C.; Aznar, M. C. et al.
Are hybrid conferences the new standard?
Radiotherapy and Oncology 128(2023), 109695 (10.1016/j.radonc.2023.109695) - Runge, R.; Reissig, F.; Herzog, N. et al.
Combining Cisplatin with Different Radiation Qualities—Interpretation of Cytotoxic Effects In Vitro by Isobolographic Analysis
Pharmaceuticals 16(2023)12, 1720 (10.3390/ph16121720) - Towers, R.; Trombello, L.; Fusenig, M. et al.
Bone marrow-derived mesenchymal stromal cells obstruct AML-targeting CD8+ clonal effector and CAR T cell function while promoting a senescence-associated phenotype
Cancer Immunology, Immunotherapy 73(2024), 8 (10.1007/s00262-023-03594-1) - Miederer, M.; Benešová-Schäfer, M.; Mamat, C. et al.
Alpha-emitting Radionuclides: Current Status and Future Perspectives
Pharmaceuticals 17(2024), 76 (10.3390/ph17010076) - Janićijević, Ž.; Huang, T.; Sandoval Bojorquez, D. I. et al.
Design and Development of Transient Sensing Devices for Healthcare Applications
Advanced Science (2024), 2307232 (10.1002/advs.202307232) - Ludwig, F.-A.; Laurini, E.; Schmidt, J. et al.
[¹⁸F]Fluspidine – a PET tracer for imaging of σ1 receptors in the central nervous system
Pharmaceuticals 17(2024)166, 1-21 (10.3390/ph17020166) - Weiß, A.; Löck, S.; Xu, T. et al.
Prediction of radiation pneumonitis using the effective α/β of lungs and heart in NSCLC patients treated with proton beam therapy
Radiotherapy and Oncology 190(2024), 110013 (10.1016/j.radonc.2023.110013) - Samuels, M.; Falkenius, J.; Bar-Ad, V. et al.
A Phase I Study of the DNA-PK Inhibitor Peposertib in Combination with Radiotherapy with or without Cisplatin in Patients with Advanced Head and Neck Tumors
International Journal of Radiation Oncology Biology Physics 118(2024)3, 743-756 (10.1016/j.ijrobp.2023.09.024) - Mazzola, G. C.; Bergamaschi, L.; Vincini, M. et al.
Patients’ needs in Proton Therapy: a survey among 10 European Facilities
Clinical and Translational Radiation Oncology 43(2023), 100670 (10.1016/j.ctro.2023.100670) - Lococo, F.; Boldrini, L.; Diepriye, C.-D. et al.
Lung cancer multi-omics digital human avatars for integrating precision medicine into clinical practice: the LANTERN study
BMC Cancer 23(2023), 540 (10.1186/s12885-023-10997-x) - Elkhamisy, S. A.; Valentini, C.; Lattermann, A. et al.
Normo-or hypo-fractionated photon or proton radiotherapy in the management of locally advanced unresectable pancreatic cancer: a systematic review
Cancers 15(2023), 3771 (10.3390/cancers15153771) - Kreller, M.; Walther, M.; Brühlmann, S. A. et al.
Production of medical radionuclides in the Center for Radiopharmaceutical Tumor Research – a status report
Instruments 8(2024)1, 10 (10.3390/instruments8010010) - Zhao, X.; Kolbinger, F. R.; Distler, M. et al.
Portable Droplet-Based Real-Time Monitoring of Pancreatic α-Amylase in Postoperative Patients
Biosensors and Bioelectronics 251(2024), 116034 (10.1016/j.bios.2024.116034) - Szöllősi, D.; Hajdrik, P.; Tordai, H. et al.
Molecular imaging of bacterial outer membrane vesicles based on bacterial surface display
Scientific Reports 13(2023), 18752 (10.1038/s41598-023-45628-9) - Gorodetska, I.; Offerman, A.; Püschel, J. et al.
ALDH1A1 drives prostate cancer metastases and radioresistance by interplay with AR- and RAR-dependent transcription
Theranostics 14(2024)2, 714-737 (10.7150/thno.88057) - Drewitz, L.; Kegler, A.; Arndt, C. et al.
Development Of A Novel ACE2 Decoy For Both SARS-CoV-2 Variant Neutralization And Infected Cell Elimination Via Unmodified Or CAR Modified Immune Cells
Human Gene Therapy 34(2023), 92 (10.1089/hum.2023.29252.abstracts) - Brühlmann, S. A.; Walther, M.; Kopka, K. et al.
Production of the PET radionuclide 61Cu via the 62Ni(p,2n)61Cu Nuclear Reaction
EJNMMI Radiopharmacy and Chemistry 9(2024)1, 3 (10.1186/s41181-023-00233-z) - Misko, V. R.; Baraban, L.; Makarov, D. et al.
Selecting active matter according to motility in an acoustofluidic setup: Self-propelled particles and sperm cells
Soft Matter 19(2023), 8635 (10.1039/D3SM01214J) - Horst, F. E.
Calorimetry as a tool to improve the dosimetric accuracy in novel radiotherapy modalities
Physics and Imaging in Radiation Oncology 28(2023), 100516 (10.1016/j.phro.2023.100516) - Horst, F. E.; Bodenstein, E.; Brand, M. et al.
Dose and dose rate dependence of the tissue sparing effect at ultra-high dose rate studied for proton and electron beams using the zebrafish embryo model.
Radiotherapy and Oncology 194(2024), 110197 (10.1016/j.radonc.2024.110197) - Janićijević, Ž.; Nguyen Le, T. A.; Baraban, L.
Extended-gate field-effect transistor chemo- and biosensors: State of the art and perspectives
Next Nanotechnology 3–4(2023), 100025 (10.1016/j.nxnano.2023.100025) - Wodtke, R.; Laube, M.; Hauser, S. et al.
Preclinical evaluation of an ¹⁸F-labeled Nε-acryloyllysine piperazide for covalent targeting of transglutaminase 2
EJNMMI Radiopharmacy and Chemistry 9(2024)1, 1 (10.1186/s41181‑023‑00231‑1) - Novgorodova, O.; Glatte, A.; Hentges, R. et al.
Characterisation of a high granularity multi-channel prompt γ-ray detection system prototype for proton range verification based on the PETsys TOFPET2 ASIC
Journal of Instrumentation 19(2024), P02030 (10.1088/1748-0221/19/02/P02030) - Craig, A.; Kogler, J.; Laube, M. et al.
Preparation of 18F-Labeled Tracers Targeting Fibroblast Activation Protein via Sulfur [18F]Fluoride Exchange Reaction
Pharmaceutics 15(2023)12, 2749 (10.3390/pharmaceutics15122749) - Patt, M.; Decristoforo, C.; de Martini, A. et al.
The revision of the pharmaceutical legislation – it is time to act for nuclear medicine in Europe
European Journal of Nuclear Medicine and Molecular Imaging 51(2023), 20-24 (10.1007/s00259-023-06472-1) - Broghammer, F.; Gouda, M.; Korovina, I. et al.
Resistance of HNSCC cell models to pan-FGFR inhibition depends on the EMT phenotype associating with clinical outcome
Molecular Cancer 23(2024), 39 (10.1186/s12943-024-01954-8) - González Soto, K. E.; Rodrigues Loureiro, L. R.; Bartsch, T. et al.
Targeting colorectal cancer cells using AND-gated Adaptor RevCAR T-cells
Frontiers in Immunology 14(2023), 1302354 (10.3389/fimmu.2023.1302354) - Krutzek, F.; Donat, C.; Stadlbauer, S.
Chelator Impact: Investigating the Pharmacokinetic Behavior of Copper-64 Labeled PD-L1 Radioligands
EJNMMI Radiopharmacy and Chemistry 9(2024), 14 (10.1186/s41181-024-00243-5) - Janićijević, Ž.; Nguyen Le, T. A.; Alsadig, A. et al.
Methods gold standard in clinic millifluidics multiplexed extended gate field-effect transistor biosensor with gold nanoantennae as signal amplifiers
Biosensors and Bioelectronics 241(2023), 115701 (10.1016/j.bios.2023.115701) - Rodrigues Loureiro, L. R.; Hoffmann, L.; Neuber, C. et al.
Immunotheranostic target modules for imaging and navigation of UniCAR T-cells to strike FAP-expressing cells and the tumor microenvironment
Journal of Experimental & Clinical Cancer Research 42(2023), 341 (10.1186/s13046-023-02912-w) - Zhao, X.; Ruelens, P.; Farr, A. D. et al.
Bacterial filamentation mediates cross-protection against β-lactam antibiotics in droplet microreactors
Frontiers in Microbiology 14(2023), 1294790 (10.3389/fmicb.2023.1294790) - Zschaeck, S.; Klinger, B.; van den Hoff, J. et al.
Combination of tumor asphericity and an extracellular matrix-related prognostic gene signature in non-small cell lung cancer patients
Scientific Reports 13(2023), 20840 (10.1038/s41598-023-46405-4) - Korde, A.; Patt, M.; Selivanova, S. et al.
Position Paper to facilitate patient access to radiopharmaceuticals - considerations for a suitable pharmaceutical regulatory framework
EJNMMI Radiopharmacy and Chemistry 9(2024)1, 2 (10.1186/s41181-023-00230-2) - Klotz, D. M.; Schwarz, F.; Dubrovska, A. et al.
Establishment and Molecular Characterization of an In Vitro Model for PARPi-Resistant Ovarian Cancer.
Cancers 15(2023)15, 3774 (10.3390/cancers15153774) - Kubeil, M.; Suzuki, Y.; Casulli, M. A. et al.
Exploring the Potential of Nanogels: From Drug Carriers to Radiopharmaceutical Agents
Advanced Healthcare Materials 13(2023)1, 2301404 (10.1002/adhm.202301404) - Poldrack, R. A.; Markiewicz, C. J.; Appelhoff, S. et al.
The Past, Present, and Future of the Brain Imaging Data Structure (BIDS)
Imaging Neuroscience 2(2024), 1-19 (10.1162/imag_a_00103) - Korovina, I.; Elser, M.; Borodins, O. et al.
β1 integrin mediates unresponsiveness to PI3Kα inhibition for radiochemosensitization of 3D HNSCC models
Biomedicine and Pharmacotherapy 171(2024), 116217 (10.1016/j.biopha.2024.116217) - Kopp, I.; Cieslik, P.; Anger, K. et al.
Bispidine Chelators for Radiopharmaceutical Applications with Lanthanide, Actinide and Main Group Metal Ions
Inorganic Chemistry 62(2023)50, 20754-20768 (10.1021/acs.inorgchem.3c02340) - Pasternak, M.; Mirza, S.; Luciw, N. et al.
Longitudinal cerebral perfusion in presymptomatic genetic frontotemporal dementia: GENFI results
Alzheimer's & Dementia (2024) (10.1002/alz.13750) - Krutzek, F.; Donat, C.; Stadlbauer, S.
Exploring Hydrophilic PD-L1 Radiotracers Utilizing Phosphonic Acids: Insights Into Unforeseen Pharmacokinetics
International Journal of Molecular Sciences 24(2023)20, 15088 (10.3390/ijms242015088) - Nenoff, L.; Amstutz, F.; Murr, M. et al.
Review and recommendations on deformable image registration uncertainties for radiotherapy applications
Physics in Medicine and Biology 68(2023), 24TR01 (10.1088/1361-6560/ad0d8a) - Wang, T.; Wang, J.; Chen, L. et al.
Development of a Highly Specific 18F-labeled Radioligand for Imaging of Sigma-2 Receptor in Brain Tumor
Journal of Medicinal Chemistry 66(2023)18, 12840-12857 (10.1021/acs.jmedchem.3c00735) - Cegla, P.; Hofheinz, F.; Burchardt, E. et al.
Asphericity derived from [18F]FDG PET as a new prognostic parameter in cervical cancer patients
Scientific Reports 13(2023)1, 8423 (10.1038/s41598-023-35191-8) - Maria Sag, S. J.; Menhart, K.; Hitzenbichler, F. et al.
18F-FDG PET/CT-derived total lesion glycolysis predicts abscess formation in patients with surgically confirmed infective endocarditis: Results of a retrospective study at a tertiary center
Journal of Nuclear Cardiology 30(2023), 2400-2414 (10.1007/s12350-023-03285-5) - Starke, S.; Zwanenburg, A.; Leger, K. et al.
Multitask Learning with Convolutional Neural Networks and Vision Transformers Can Improve Outcome Prediction for Head and Neck Cancer Patients
Cancers 15(2023)19, 4897 (10.3390/cancers15194897) - Elser, M.; Vehlow, A.; Juratli, T. et al.
Simultaneous inhibition of discoidin domain receptor 1 and integrin αVβ3 radiosensitizes human glioblastoma cells
American Journal of Cancer Research 13(2023)10, 4597-4612 - Samimi, R.; Shiri, I.; Ahmadyar, Y. et al.
Radiomics predictive modeling from dual-time-point FDG PET Ki parametric maps: application to chemotherapy response in lymphoma
EJNMMI Research 13(2023)1, 70 (10.1186/s13550-023-01022-0) - Krutzek, F.; Donat, C.; Ullrich, M. et al.
Design, Synthesis, and Biological Evaluation of Small Molecule Based Radioligands with Improved Pharmacokinetic Properties for Imaging of Programmed Death Ligand 1
Journal of Medicinal Chemistry 66(2023)23, 15894-15915 (10.1021/acs.jmedchem.3c01355) - Yaromina, A.; Koi, L.; Schuitmaker, L. et al.
Overcoming radioresistance with the hypoxia-activated prodrug CP-506: A pre-clinical study of local tumour control probability
Radiotherapy and Oncology 186(2023), 109738 (10.1016/j.radonc.2023.109738) - Lai, T. H.; Wenzel, B.; Dukic-Stefanovic, S. et al.
Radiosynthesis and biological evaluation of [¹⁸F]AG-120 for PET imaging of the mutant isocitrate dehydrogenase 1 in gliomas
European Journal of Nuclear Medicine and Molecular Imaging (2023) (10.1007/s00259-023-06515-7) - Schellhammer, S.; Meric, I.; Löck, S. et al.
Hybrid treatment verification based on prompt gamma-rays and fast neutrons: Multivariate modelling for proton range determination
Frontiers in Physics 11(2023), 1295157 (10.3389/fphy.2023.1295157) - Xia, P.; Dubrovska, A.
CD98 heavy chain as a prognostic biomarker and target for cancer treatment
Frontiers in Oncology 13(2023), 1251100 (10.3389/fonc.2023.1251100) - Blei, M. K.; Drobot, B.; Kretzschmar, J. et al.
Bestimmung von logK-Werten macropa-basierter Chelatoren für die stabile Komplexierung von 131Ba, 223/224Ra und 133La
Nuklearmedizin 62(2023), 149 - Reissig, F.; Zarschler, K.; Novy, Z. et al.
Entwicklung alternativer Verbindungen für die PSMA-Therapie mit Actinium-225
Nuklearmedizin 62(2023), 147 - Blei, M. K.; Waurick, L.; Reissig, F. et al.
Equilibrium Thermodynamics of Macropa Complexes with Selected Metal Isotopes of Radiopharmaceutical Interest
Inorganic Chemistry 62(2023)50, 20699-20709 (10.1021/acs.inorgchem.3c01983) - Löser, R.; Kuchar, M.; Wodtke, R. et al.
Lysyl oxidases as targets for cancer therapy and diagnostic imaging
ChemMedChem 18(2023)18, e202300331 (10.1002/cmdc.202300331) - Crespo, E.; Rodrigues Loureiro, L. R.; Arndt, C. et al.
Turning an Immunosuppressive Marker Into a T-Cell Activating Signal: Using the RevCAR System to Target Immune Checkpoints
Human Gene Therapy 54(2023) (10.1089/hum.2023.29252.abstracts) - Jósza, T.; Petr, J.; Payne, S. J. et al.
MRI-based parameter inference for cerebral perfusion modelling in health and ischaemic stroke
Computers in Biology and Medicine 166(2023), 107543 (10.1016/j.compbiomed.2023.107543) - Richter, S.; Steenblock, C.; Lemm, S. et al.
Improving susceptibility of neuroendocrine tumors to radionuclide therapies: personalized approaches towards complementary treatments
Theranostics 14(2024)1, 17-32 (10.7150/thno.87345) - Kegler, A.; Drewitz, L.; Arndt, C. et al.
A novel ACE2 decoy for both neutralization of SARS-CoV-2 variants and killing of infected cells
Frontiers in Immunology 14(2023), 1204543 (10.3389/fimmu.2023.1204543) - Gerlach, S.; Balling, F.; Schmidt, A. K. et al.
Three-dimensional acoustic monitoring of laser-accelerated protons in the focus of a pulsed-power solenoid lens
High Power Laser Science and Engineering 11(2023), e38 (10.1017/hpl.2023.16) - Braun, S.; Jelača, S.; Laube, M. et al.
Synthesis and In Vitro Biological Evaluation of p-Carborane-based Di-tert-butylphenol Analogs
Molecules 28(2023), 4547 (10.3390/molecules28114547) - Peschke, J.; Bergmann, R.; Mehnert, M. et al.
FLT3-directed UniCAR T-cell therapy of Acute Myeloid Leukaemia
British Journal of Haematology 202(2023)6, 1137-1150 (10.1111/bjh.18971) - Krutzek, F.; Donat, C.; Ullrich, M. et al.
Design and Biological Evaluation of Small-Molecule PET-Tracers for Imaging of Programmed Death Ligand 1
Cancers 15(2023), 2638 (10.3390/cancers15092638) - Ueberham, L.; Gündel, D.; Kellert, M. et al.
Development of the High-Affinity Carborane-Based Cannabinoid Receptor Type 2 PET Ligand [18F]LUZ5-d8
Journal of Medicinal Chemistry 66(2023), 5242-5260 (10.1021/acs.jmedchem.3c00195) - Wenzel, B.; Schmid, M.; Teodoro, R. et al.
Radiofluorination of an anionic, azide-functionalized teroligomer by copper-catalyzed azide-alkyne cycloaddition
Nanomaterials 13(2023)14, 2095 (10.3390/nano13142095) - Valentini, C.; Ebert, N.; Koi, L. et al.
Preclinical trial comparing radiotherapy alone versus standard radiochemotherapy in three human papilloma virus (HPV) negative and three HPV-positive head and neck squamous cell carcinoma (HNSCC) xenograft tumour models.
Radiotherapy and Oncology 183(2023), 109546 (10.1016/j.radonc.2023.109546) - Koevoets, E. W.; Petr, J.; Monninkhof, E. M. et al.
Effect of physical exercise on brain perfusion in chemotherapy-treated breast cancer patients: a randomized controlled trial (PAM study)
Journal of Magnetic Resonance Imaging 59(2024)5, 1667-1680 (10.1002/jmri.28967) - Wamelink, I. J. H. G.; Azizova, A.; Booth, T. C. et al.
Brain tumor imaging without gadolinium-based contrast agents: Feasible or Fantasy?
Radiology 310(2024)2 (10.1148/radiol.230793) - Striese, F.; Neuber, C.; Gräßel, S. et al.
Preclinical Characterization of the 177Lu-Labeled Prostate Stem Cell Antigen (PSCA)-Specific Monoclonal Antibody 7F5
International Journal of Molecular Sciences 24(2023)11, 9420 (10.3390/ijms24119420) - Pfeifer Serrahima, J.; Zhang, C.; Oberoi, P. et al.
Multivalent adaptor proteins specifically target NK cells carrying a universal chimeric antigen receptor to ErbB2 (HER2)-expressing cancers
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The Chemotype of Chromanones as a Privileged Scaffold for Multineurotarget Anti-Alzheimer Agents
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Combined Systemic Drug Treatment with Proton Therapy: Investigations on Patient-Derived Organoids
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Integration of p16/HPV DNA Status with a 24-miRNA-Defined Molecular Phenotype Improves Clinically Relevant Stratification of Head and Neck Cancer Patients
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Targeting of p21-Activated Kinase 4 Radiosensitizes Glioblastoma Cells via Impaired DNA Repair
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Efficient Production of the PET radionuclide 133La for Theranostic Purposes in Targeted Alpha Therapy using the 134Ba(p,2n)133La Reaction
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Exploring nitric oxide (NO)- releasing celecoxib derivatives as modulators of radioresponse in pheochromocytoma cells
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Changes in Radical Levels as a Cause for the FLASH effect: Impact of beam structure parameters at ultra-high dose rates on oxygen depletion in water
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Development of Radiotracers for Imaging of the PD-1/PD-L1 Axis
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Development of a neurotensin-derived 68Ga-labeled PET ligand with high in vivo stability for imaging of NTS1 receptor-expressing tumors
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Prompt-gamma imaging for prostate cancer proton therapy: CNN-based detection of anatomical changes
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Solid-phase synthesis of selectively mono-fluorobenz(o)ylated polyamines as a basis for for the Development of 18F-Labeled Radiotracers
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18F-Fluorodeoxyglucose Positron Emission Tomography of Head and Neck Cancer: Location and HPV Specific Parameters for Potential Treatment Individualization
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Strategic Evaluation of the Traceless Staudinger Ligation for Radiolabeling with the Tricarbonyl Core
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Targeting glutamine metabolism and autophagy: the combination for prostate cancer radiosensitization
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Highlight selection of radiochemistry and radiopharmacy developments by editorial board
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Experimental validation of 4D log file-based proton dose reconstruction for interplay assessment considering amplitude-sorted 4DCTs
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Pharmacokinetic studies of [⁶⁸Ga]Ga‑PSMA‑11 in patients with biochemical recurrence of prostate cancer: detection, differences in temporal distribution and kinetic modelling by tissue type
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Does the uncertainty in relative biological effectiveness affect patient treatment in proton therapy?
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Final Results of the Prospective Biomarker Trial PETra: [11C]-MET-Accumulation in Postoperative PET/MRI Predicts Outcome after Radiochemotherapy in Glioblastoma
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Role of TRPC6 in Kidney Damage after Acute Ischemic Kidney Injury
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Aktuelle Entwicklungen aus den Radiopharmazeutischen Wissenschaften für theranostische Anwendungen - Editorial
Der Nuklearmediziner 44(2021), 100 (10.1055/a-1463-6602) - Mukha, A.; Kahya, U.; Linge, A. et al.
GLS-driven glutamine catabolism contributes to prostate cancer radiosensitivity by regulating the redox state, stemness and ATG5-mediated autophagy
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Tyrosine kinase C-MET as therapeutic target for radiosensitization of head and neck squamous cell carcinomas
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Epileptogenic zone detection in MRI negative epilepsy using adaptive thresholding of arterial spin labeling data
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131Ba as a promising SPECT-diagnostic match for 223/224Radium
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H2pyhox - Octadentate Bis(pyridyloxine)
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Pathophysiological Changes in the Enteric Nervous System of Rotenone-Exposed Mice as Early Radiological Markers for Parkinson's Disease
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Discovery and development of brain-penetrant 18F-labeled radioligands for neuroimaging of the sigma-2 receptors
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Modulation of γ-secretase activity by a carborane-based flurbiprofen analogue
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Development of [18F]LU14 for PET Imaging of Cannabinoid Receptor Type 2 in the Brain
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Development of fluorinated and methoxylated benzothiazole derivatives as highly potent and selective cannabinoid CB2 receptor ligands
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Synthesis of novel fluorinated xanthine derivatives with high adenosine A2B receptor binding affinity
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Cisplatin - A more Efficient Drug in Combination with Radionuclides?
Nuklearmedizin 61(2022)04, 325-332 (10.1055/a-1759-1749) - Witzmann, K.; Raschke, F.; Troost, E. G. C.
Review mr image changes of normal-appearing brain tissue after radiotherapy
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Design, radiosynthesis and preliminary biological evaluation in mice of a brain-penetrant 18F-labelled σ2 receptor ligand
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Aktuelle radiopharmazeutische Entwicklungen für die theranostische Anwendung
Der Nuklearmediziner 44(2021)02, 135-1521 (10.1055/a-1474-8976) - Neels, O.; Kratochwil, C.; Patt, M.
Aktuelle radiopharmazeutische Entwicklungen für die theranostische Anwendung
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Predicting the Risk of Metastases by PSMA-PET/CT—Evaluation of 335 Men with Treatment-Naïve Prostate Carcinoma.
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Conductive hydrogels with dynamic reversible networks for biomedical applications
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Two Be or Not Two Be: The Nuclear Autoantigen La/SS-B Is able to form Dimers and Oligomers in a Redox Dependent Manner
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Overestimation of grey matter atrophy in glioblastoma patients following radio(chemo)therapy
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Experimental assessment of inter-centre variation in stopping-power and range prediction in particle therapy
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Slice2Volume: Fusion of multimodal medical imaging and light microscopy data of irradiation-injured brain tissue in 3D
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Patterns Of Practice in Adaptive and Real-Time Particle Therapy (POP-ART PT), Part I: intrafractional respiratory motion
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Patterns Of Practice in Adaptive and Real Time Particle Therapy part II: interfractional changes
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Reduzierung von respirationsbedingter Pankreasbewegung mittels eines MRT- und Partikeltherapie-kompatiblen abdominellen Korsetts
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Development and Validation of a GMP-Compliant High-Pressure Liquid Chromatography Method for the Determination of the Chemical and Radiochemical Purity of [18F]PSMA-1007, a PET Tracer for the Imaging of Prostate Cancer
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Synthesis and application of a thiol-reactive HBED-type chelator for development of easy-toproduce Ga-radiopharmaceutical kits and imaging probes
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Benefit of 4D robustly optimized proton plans for NSCLC patients with intrafractional motion > 5mm
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Development of an 18F-labelled irreversible inhibitor of transglutaminase 2 as radiometric tool for quantitative expression profiling in cells and tissues
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Highlight selection of radiochemistry and radiopharmacy developments by editorial board
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