Imaging and Radiooncology
Health > Cancer Research - All Topics
In Germany, 500,000 people are diagnosed with cancer every year. New, faster, and primarily more gentle diagnostic and therapeutic procedures can help to fight the disease and to save lifes.
Cancer research at the HZDR addresses the following topics: The scientists conduct research, for example, on new radiopharmaceuticals for the diagnosis of cancer and for the characterization of cancer tissue and, as a further development, also investigate substances for the cancer therapy of tomorrow. Our research has already resulted in the development of new substances. Two radiopharmaceuticals are officially approved and registered pursuant to the pharmaceutical law. These substances, which are produced at the HZDR and subsequently distributed on the market, are needed for the detection of tumors and metastases with a PET camera (PET = Positron Emission Tomography). That is also possible in Dresden – patients can be examined utilizing a full-body scan PET/MRI system which is the first of its kind to have been approved for patients in Germany. HZDR scientists are further developing and improving these innovative imaging procedures which are used in oncology.
They are also investigating particle acceleration with the help of innovative laser technologies. The objective: Making proton-therapy centers smaller while, at the same time, lowering the costs through more powerful lasers and with pulsed magnetic fields. Researchers are also aiming on monitoring irradiation of patients with proton beams in real time.
The HZDR is part of the Competence Network for Radiation Research (KVSF, promoted by the BMBF). This alliance promotes the sustainability of competences in the field of radiation research, in particular, by fostering young scientists.
Important partners are the TU Dresden (Dresden University of Technology) and the University Hospital Carl Gustav Carus Dresden. We jointly operate the OncoRay Center. More information on collaborations with Dresden and Heidelberg partners
Objectives
- Development and application of new technologies for the diagnosis and therapy of cancer
- Establishment of laser-accelerated ions in radiation oncology
- Monitoring and controlling tumor radiation in real time
- Continued development of individualized and tolerable therapy forms
Press Releases
- Kopf-Hals-Tumoren: Zeit für neue Einblicke in die individualisierte Krebstherapie
- Neubau bietet Wissenschaftlern und Ärzten optimale Infrastruktur für innovative Krebsforschung
- Bestrahlungserfolg bei Hirntumoren lässt sich mit kombinierter PET/MRT vorhersagen
- Forscher packen Alpha-Strahler in Käfig
- Stealth-cap technology for light-emitting nanoparticles
- High-contrast imaging for cancer therapy with protons
- New approach for range prediction improves accuracy of proton therapy
- Die Teilchenjägerin
- Der Spurenleger zum Tumor
- Directing nanoparticles straight to tumors
- Innovative ways to battle Parkinson’s disease
- Synthesis against the clock
- Vielversprechende Laborforschung
- Mit dem Lego-Prinzip gegen das Virus: HZDR-Wissenschaftler*innen erhalten millionenschwere Förderung für Corona-Forschung
- Staatsminister Christian Piwarz besuchte das HZDR
- NCT/UCC Dresden: Neubau für innovative Krebsforschung eröffnet
- Strahlender Helfer: HZDR und ROTOP stellen Radionuklid für Medikament zur Parkinson-Diagnostik her
- An important step towards live imaging in proton therapy
- HZDR und Monash University bauen gemeinsames Labor auf
- Strahlender Sieger dank strahlender Idee
- HZDR-Institut für Radiopharmazeutische Krebsforschung erhält Fördermittel für neues Forschungsgerät
- Glocker-Medaille für Dresdner Medizinphysiker
- Zelluläre Immuntherapien – Präzisionsmedizin gegen Krebs
- ProtOnART – a new consortium for proton online adaptive radiation therapy
- Radioactive Substances Fight Cancer in the Mini-lab
- Vision: Radiopharmaceutical Valley
- Mission to beat rare cancers: More targets on tumor cell surface for optimized radionuclide therapy
- Internationale Partnerschaft mit Monash University: Gemeinsames MHELTHERA-Labor gestartet
- Blockieren eines Eiweißmoleküls macht aggressive Hirntumoren sensibler für Strahlen- und Chemotherapie
- Smart Keys for cancer therapy: Research team develops new system for imaging and treating tumors
- A light in the dark: How the trajectory of protons is made visible
- Wegweisende CAR-T-Zelltherapie für Blutkrebs-Erkrankungen
- The world’s first Prototype for High-Contrast Live Imaging in Proton Therapy
- Neuer Ansatz bei schweren Verläufen von Prostatakrebs
- Krebs von innen bestrahlen: HZDR und DKFZ gründen Helmholtz-Verbund für Radiopharmazeutische Wissenschaften
- Radioaktivität rettet Leben
- HZDR trauert um Pius August Schubiger
- Innovative Immuntherapie gegen malignes Melanom: Neues Projekt soll mit KI-Hilfe die Hautkrebs-Behandlung verbessern
- Meilenstein für präklinische Bewertung neuer Radiopharmaka: HZDR erhält am Standort Leipzig hochauflösenden PET/MRT-Scanner
- Better understanding and treatment of brain tumors with the help of imaging: Andreas Maurer moves to the HZDR
- Multi-million funding for revolutionary radiation treatment for cancer: HZDR participates in research project UPLIFT
- Radiopharmazie: Strahlkraft made in Saxony
- New method for interactive 3D microscopy
- Radioaktivität rettet Leben: Forschungsmagazin „entdeckt“ gibt Einblicke in die moderne radiopharmazeutische Krebsforschung
- New talents for radiation research: Anna Dubrovska appointed as a Henriette Herz Scout for the Alexander von Humboldt Foundation
- HZDR-Doktorand gewinnt Dresdner Vorentscheid von FameLab Germany
- Protonentherapie: Mehr Sicherheit durch smarte Planung
- The world’s first single-source photon-counting CT system for radiotherapy has been installed in Dresden
- HZDR joins €8 M European consortium to decentralize CAR-T cell therapy and improve hospital workflows
- Three questions for biologist Magali Toussaint
- Radiopharmazie: Sachsen setzt auf stärkere Vernetzung im Ökosystem
- Precision diagnostics using peptides: Radiotracers could improve choice of bladder cancer therapies
- New blood marker opens up new perspectives for cancer diagnostics: Research team at OncoRay identifies MMP11 as a promising biomarker for liquid biopsy
- Meilenstein für radiopharmazeutische Krebsforschung und Präzisionsmedizin: HZDR erhält Fördermittel in Millionenhöhe für Ganzkörper-PET
- MEDABIS-PRO: Biophysical research on MRI-guided proton therapy
Involved HZDR institutes
- Institute of Radiopharmaceutical Cancer Research
- Institute of Radiation Physics
- Institute of Radiooncology - OncoRay
- Dresden High Magnetic Field Laboratory
Collaborations
- OncoRay Center
- Nuclear Medicine Clinic at the University Hospital
- Deutsches Krebsforschungszentrum
- National Center for Tumor Diseases Dresden
Contacts
Publications
- Hadova, K.; Gündel, D.; Knieß, T. et al.
Protein phosphatase 2A impairs cardiac uptake of glucose in the mammalian heart
Naunyn-Schmiedeberg's Archives of Pharmacology (2026) (10.1007/s00210-026-05617-x) - Simbirova, A.; Thomas, E.; Hessel, F. et al.
Radiation Therapy in Adolescents and Young Adults (AYA): Contemporary Evidence on Utilization, Outcomes, Late Toxicities, and Second Malignant Neoplasms – A Comprehensive Systematic Review and Synthesis
Radiotherapy and Oncology 221(2026), 111638 (10.1016/j.radonc.2026.111638) - Ferreira Machado, J. d. M.; Zarschler, K.; Knieß, T. et al.
A translational journey in Germany: From literature to local implementation of [89Zr]Zr-DFO-trastuzumab
Nuklearmedizin (2026) (10.1055/a-2883-7600) - Linge, A.; Lohaus, F.; Appold, S. et al.
De-escalation of adjuvant radio(chemo)therapy for patients with HPV-positive head and neck squamous cell carcinoma: study protocol for a phase I trial to reduce late toxicity (DELPHI)
BMC Cancer 26(2026), 542 (10.1186/s12885-026-16050-x) - Jacobs, J.; van Weerd, E.; Moerman, A. et al.
Identifying Best Practices for RTTs and Dosimetrists: A Delphi Consensus Study on Standardizing Workflows in Proton Therapy
Technical Innovations & Patient Support in Radiation Oncology 38(2026), 100411 (10.1016/j.tipsro.2026.100411) - Dalfovo, D.; Sassorossi, C.; de Paolis, E. et al.
LANTERN-XGB: An Interpretable Multi-Modal Machine Learning for Improving Clinical Decision-Making in Lung Cancer
International Journal of Molecular Sciences 27(2026), 3128 (10.3390/ijms27073128) - Lebbink, F.; Alvares Michael, E.; Kornek, A. et al.
Comparison of gantry-less magnetic resonance guided proton therapy with photon therapy for hepatocellular carcinoma patients
Physics and Imaging in Radiation Oncology 39(2026), 100967 (10.1016/j.phro.2026.100967) - Aulsebrook, M. L.; Pascali, G.; Tuck, K. L. et al.
Next-Gen 18F-Relay Reagent: Optimising [18F]Ethanesulfonyl Fluoride
International Journal of Molecular Sciences 27(2026)9, 3982 (10.3390/ijms27093982) - Mari, M.; Patinec, V.; Alvarado, R. et al.
Neutralizing copper(II) complex charge through sulfonation: a new chelator for 64Cu radiopharmaceuticals
Inorganic Chemistry Communications 189(2026), 116782 (10.1016/j.inoche.2026.116782) - Karpinski, M. J.; Civan, C.; Rauscher, I. et al.
New prostate cancer risk groups by PSMA-PET (PPP3): an international, retrospective, registry-based cohort study
Lancet Oncology 27(2026)4, 480-490 (10.1016/S1470-2045(26)00016-1) - Benčurová, K.; Gündel, D.; Kieler, M. et al.
PET/MRI with 89Zr-labelled antibodies provides insights into altered antibody pharmacokinetics in the chick embryo model
European Journal of Pharmaceutical Sciences 221(2026), 107520 (10.1016/j.ejps.2026.107520) - Schädlich, J.; Selg, C.; Haase-Kohn, C. et al.
An approach toward radioiodination and radiopharmacological evaluation of a carborane-containing analog of indomethacin
Molecules 31(2026), 1944 (10.3390/molecules31111944) - Kaufmann, J.; Trommer, M.; Rühle, A. et al.
Radiotherapy in patients with NSCLC developing progressive disease during immune checkpoint inhibition: Abscopal responses and survival
Clinical and Translational Radiation Oncology 58(2026), 101125 (10.1016/j.ctro.2026.101125) - Grey, A.; Thiem, J.; Wahl, H. et al.
Incidence and time course of new contrast-enhancing lesions on MRI after proton versus photon radiotherapy in glioma patients
Neuroradiology 68(2026), 517-531 (10.1007/s00234-025-03829-1) - Curvello, R.; Hauser, S.; Seifert, M. et al.
GOT1 inhibition induces extracellular matrix remodelling in pancreatic cancer
Advanced Science 13(2026)13, e16578 (10.1002/advs.202516578) - Turhan, G.; Irem Cetin, A.; Padrela, B. E. et al.
Cerebral Blood Flow and Time of Exchange Measurements Using Multi-TE Blood-Brain Barrier Arterial Spin Labeling MRI in IDH Mutational Subgroups of Gliomas
Magnetic Resonance Materials in Physics, Biology and Medicine (2026) (10.1007/s10334-026-01348-5) - Essed, R. A.; Wamelink, I. J. H. G.; Petr, J. et al.
Amide Proton Transfer and Arterial Spin Labeling for Non-Invasive Molecular Stratification of Glioma: A Multi-Dataset Imaging Biomarker Study
Neuroradiology 68(2026), 1387-1401 (10.1007/s00234-026-04006-8) - Sonam, S.; Mojić, M.; Laube, M. et al.
nido-carborane conjugates with ibuprofen, flurbiprofen and fenoprofen: synthesis, characterization, COX inhibition potential and anticancer activity
Journal of Inorganic Biochemistry 280(2026), 113282 (10.1016/j.jinorgbio.2026.113282) - Paul, S.; Bera, A.
Enriching BODIPY Triplet States via Ruthenium(II) Conjugation for Improved Photodynamic Therapy
Journal of Medicinal Chemistry 69(2026)2, 721-743 (10.1021/acs.jmedchem.5c02024) - Yoshizuka, K.; Kubeil, M.; Stephan, H.
Characterization of macrocyclic host-guest systems by liquid-liquid extraction
Journal of Inclusion Phenomena and Macrocyclic Chemistry 106(2026), 265-278 (10.1007/s10847-026-01341-4) - Kuchar, M.; Zessin, J.; Kopka, K. et al.
Bestimmung von Kupfer in der Qualitätskontrolle von Radiopharmaka bei kupfergestützten Radiofluorierungen
Nuklearmedizin 65(2026)2, L27 - Lai, T. H.; Dukic-Stefanovic, S.; Deuther-Conrad, W. et al.
Fluorinated derivatives of AG-881 for Positron Emission Tomography detection of mutated Isocitrate Dehydrogenase 1
Pharmaceuticals 19(2026)5 (10.3390/ph19050660) - Busch-Casler, J.; Teichert, A.; Bach, F. et al.
RWD120 Making Health Data Trustees Sustainable: An Overview of Potential Business and Financing Models
Value in Health 28(2026)12, S628 (10.1016/j.jval.2025.09.2870) - Kiß, O.; Penuelas, I.; Rey, A. et al.
Highlight selection of radiochemistry and radiopharmacy developments by editorial board
EJNMMI Radiopharmacy and Chemistry 11(2026), 26 (10.1186/s41181-026-00443-1) - Tanderup, K.; Kirby, A.; Eriksen, J. et al.
ESTRO’s principles for environmental sustainability in the radiation oncology community
Radiotherapy and Oncology 217(2026), 111384 (10.1016/j.radonc.2026.111384) - Trommer, M.; Rühle, A.; Ehret, F. et al.
Sex-specific differences in abscopal responses to combined radiotherapy and immune checkpoint inhibition–insights from a multicenter study
Frontiers in Immunology 16(2026), 1699362 (10.3389/fimmu.2025.1699362) - Brühlmann, S. A.; Walther, M.; Kopka, K. et al.
CopperNostics – here we are now, entertain us!
Pharmaceuticals 19(2026)2, 321 (10.3390/ph19020321) - Brühlmann, S. A.; Brandt, F.; Walther, M. et al.
Cyclotron production of 67Ga using electroplated 68Zn targets on gold and gold-coated aluminum backings
Applied Radiation and Isotopes 233(2026), 112607 (10.1016/j.apradiso.2026.112607) - Chen, O.; Vovk, O.; Polishchuk, N. et al.
Adaptation to Arginine Deprivation Leads to a More Aggressive, Therapy-Resistant Phenotype in HNSCC Cells
Biomolecules 15(2025)6, 900 (10.3390/biom15060900) - Valentini, C.; Perwein, T.; Bison, B. et al.
Haematotoxicity of Craniospinal Radiochemotherapy for Metastatic Paediatric High-Grade Glioma
Clinical Oncology 48(2025), 103956 (10.1016/j.clon.2025.103956) - Sagerer, A.; Eyüpoglu, I. Y.; Juratli, T. A. et al.
Context-specifi c targeting of focal adhesion kinase in brain tumors: lessons from glioblastoma and neurofi bromatosis type 2-mutant meningioma
Frontiers in Oncology 15(2025), 1724278 (10.3389/fonc.2025.1724278) - Ramirez Parra, M.; Dietrich, A.; Pfeifer, M. et al.
Comparative analysis of molecular targeted radiosensitizers in 2D and 3D cancer cell line models
Acta Oncologica 64(2025), 1631 (10.2340/1651-226X.2025.43916) - Metzner, M.; Longarino, F. K.; Ackermann, B. et al.
Accuracy of a helium-beam radiography system based on thin pixel detectors for an anthropomorphic head phantom
Medical Physics 52(2025), 4757 (10.1002/mp.17786) - Rabasco Meneghetti, A.; Ligero Hernández, M.; Kühn, J.-P. et al.
End-to-end prediction of clinical outcomes in head and neck squamous cell carcinoma with foundation model-based multiple instance learning
BMC Artificial Intelligence 1(2025)1, 3 (10.1186/s44398-025-00003-8) - Löck, S.; Koi, L.; Gurtner, K. et al.
Application of a preclinical 18-gene classifier to patients with locally advanced HNSCC
Clinical and Translational Radiation Oncology 56(2025), 101067 (10.1016/j.ctro.2025.101067) - Bütof, R.; Koi, L.; Löck, S. et al.
Accelerated vs. conventionally fractionated postoperative radiotherapy of non-small cell lung cancer – final results of the prematurely terminated PORTAF trial
Strahlentherapie und Onkologie 202(2026), 299-306 (10.1007/s00066-025-02422-y) - Trommer, M.; Rühle, A.; Lamrani, A. et al.
Radiotherapy-induced abscopal effects in immune checkpoint inhibitor-refractory metastatic disease: results from a large multicenter real-world cohort study
OncoImmunology 15(2026)1, 2610529 (10.1080/2162402X.2025.2610529) - Vipin, A.; Xiao Yuan Chen, J.; Tee, M. et al.
Cerebral haemodynamics and white matter hyperintensities: findings using non-invasive brain imaging
The Journal of Prevention of Alzheimer's Disease 13(2026)1 (10.1016/j.tjpad.2026.100479) - Schädlich, J.; Ullrich, M.; Haase-Kohn, C. et al.
Radioiodination of two carborane-based dual cyclooxygenase 2/5-lipoxygenase inhibitors and their in vitro and in vivo evaluation
ChemBioChem 27(2026)7, e202600004 (10.1002/cbic.202600004) - Populaire, P.; Simoes, R.; Nenoff, L. et al.
Terminology Proposal for Adaptive Particle Therapy Classification and Strategies
International Journal of Particle Therapy 19(2026), 101293 (10.1016/j.ijpt.2025.101293) - Tonmoy, T. H.; Seçkin, S.; Hoffmann, M. et al.
Enhanced Refractive Index Sensitivity of Linearly Assembled Gold Nanoantennae for Biosensing Applications
Small 22(2026)9, e10159 (10.1002/smll.202510159) - Nieder, D.; Cela, I.; Zhao, X. et al.
Dual‐function, Reusable, and Flexible Thermal Interface for Kinetic Monitoring of In Vitro Bioassays
Small Methods 10(2026)3, e01243 (10.1002/smtd.202501243) - Maus, J.; Nitschke, J.; Nikulin, P. et al.
Automatic Delineation of Tumor Spheroids in Microscopic Images Using Deep-Learning
ACS Measurement Science Au 6(2026)2, 411-420 (10.1021/acsmeasuresciau.5c00172) - Padrela, B. E.; Tecelão, S.; Kirsebomd, B.-E. et al.
Blood-brain barrier water exchange in relation to amyloid, cognition and cerebrovascular burden
NeuroImage Clinical 49(2026), 103926 (10.1016/j.nicl.2025.103926) - Schönberg, P. Y.; Muñoz-Ovalle, Á.; Paszkowski-Rogacz, M. et al.
A pooled CRISPR screen identifies the Tα2 enhancer element as a driver of TRA expression in a subset of mature human T lymphocytes
Frontiers in Immunology 16(2025), 1536003 (10.3389/fimmu.2025.1536003) - Nakao, M.; Schwengfelder, J.; Richter, C. et al.
Comparison of two established approaches for generating Hounsfield look-up tables for CT-based SPR prediction
Medical Physics 53(2025)1, e70236 (10.1002/mp.70236) - Palkowitsch, M.; LS, K.; Hennings, F. et al.
Model validation confirms variable relative biological effectiveness and elevated periventricular sensitivity after proton therapy of brain tumors
Radiotherapy and Oncology 214(2026), 111271 (10.1016/j.radonc.2025.111271) - von der Grün, J.; Regnery, S.; Hörner-Rieber, J. et al.
Multicenter analysis of MRI-guided, stereotactic body radiotherapy as ablative treatment for lymph nodal metastases of the abdomen and pelvis
Radiotherapy and Oncology 214(2026), 111237 (10.1016/j.radonc.2025.111237) - Ferdinandus, S.; Rühle, A.; Lamrani, A. et al.
Abscopal effects in malignant melanoma patients treated with radiotherapy and immune checkpoint inhibition: analysis of a large observational multicenter study
Journal for ImmunoTherapy of Cancer 13(2025)10, e012717 (10.1136/jitc-2025-012717) - Bozorgmehr, F.; Chung, I.; Fischer, J. et al.
Reconsidering palliative radiotherapy in addition to PD-1 blockade for non-small cell lung cancer: results from the FORCE phase II trial (AIO/YMO-TRK-0415)
Clinical & Experimental Metastasis 42(2025)5, 42 (10.1007/s10585-025-10358-x) - Meattini, I.; Aznar, M.; Boldrini, L. et al.
Repositioning Radiation Oncology at the centre of integrated oncology care: a manifesto of the European Society for Radiotherapy and Oncology (ESTRO)
Radiotherapy and Oncology 210(2025), 111035 (10.1016/j.radonc.2025.111035) - Wittenstein, J.; Apolle, R.; Scharffenberg, M. et al.
Dual-energy computed tomography derived pulmonary blood volume: association with pulmonary blood flow
Respiratory Research 26(2025), 293 (10.1186/s12931-025-03374-8) - Boutier, H.; Kogler, J.; Rodrigues Loureiro, L. R. et al.
Novel Immunotheranostic FAP-Inhibitor Target Modules for Imaging and Elimination of FAP-positive Cells by UniCAR T-cells
OncoImmunology 14(2025)1, 2598908 (10.1080/2162402X.2025.2598908) - Horst, F. E.; Schüller, A.; Kapsch, R.-P. et al.
Study of the over-response of radiochromic films in ultra-high dose rate and dose per pulse electron beams
Physics in Medicine and Biology 71(2026), 045020 (10.1088/1361-6560/ae47b6) - Arndt, P.; Morton, L.; Briese, M. et al.
Vascular and Neural Transcriptomics Reveal Stage‐Dependent Pathways to Inflammation and Cognitive Dysfunction in a Rat Model of Hypertension
Journal of the American Heart Association 14(2025), e040710 (10.1161/JAHA.125.040710) - Blei, M. K.; Waurick, L.; Drobot, B. et al.
Development of four new diaza macrocycles with regioisomeric diazine carboxylic acid sidearms for stable complexation of lanthanum-133, actinium-225 and lead-203/-212 with focus on barium-131 and radium-223/-224
Nuclear Medicine and Biology 150-151(2025), 109122 (10.1016/j.nucmedbio.2025.109122) - Blei, M. K.; Hajduová, K.; Novy, Z. et al.
Preclinical Evaluation of 203Pb- and 212Pb-Labeled mcp-PSMA Ligands for Radionuclide Theranostics of Prostate Cancer
Nuclear Medicine and Biology 150-151(2025), 109097 (10.1016/j.nucmedbio.2025.109097) - Franchi, S.; Tosato, M.; Pozzo, S. et al.
Large Chelators for Large Radiometals: Endeavors to Complex Radium-223 and Barium-131 to Advance Targeted Alpha Therapy and Theranostics of Cancer
Nuclear Medicine and Biology 150-151(2025), 109123 (10.1016/j.nucmedbio.2025.109123) - Giesel, F.; Körber, S.; Hadaschik, B. et al.
The German Cancer Consortium (DKTK) multi-center prospective phase 1/2 68Ga-PSMA-11 PET-imaging trial in newly-diagnosed high-risk prostate cancer: Safety and diagnostic accuracy compared to histopathology and their impact on patient management
European Journal of Nuclear Medicine and Molecular Imaging 53(2025), 2994-3006 (10.1007/s00259-025-07540-4) - Berthold, J.; Nenoff, L.; Bertschi, S. et al.
Feasibility of in-vivo 4D prompt-gamma treatment verification in proton therapy for pancreatic cancer
Physics and Imaging in Radiation Oncology (2026) (10.1016/j.phro.2026.101027) - Nikulin, P.; Hoberück, S.; Apostolova, I. et al.
A convolutional neural network for fully automated total metabolic tumor volume delineation in patients with aggressive Non-Hodgkin lymphoma
European Journal of Nuclear Medicine and Molecular Imaging 53(2026), 5074-5087 (10.1007/s00259-026-07810-9) - Kuhne, K.; Strohbach, L.; Neuber, C. et al.
Development of cathepsin B-activatable cell-penetrating peptides for tumor targeting
ACS Pharmacology & Translational Science 9(2026)4, 966-996 (10.1021/acsptsci.5c00746) - Bertschi, S.; Perotti Bernardini, G.; Berthold, J. et al.
Prompt gamma imaging vs. range probing: Experimental comparison of two range verification approaches for proton therapy
Medical Physics 52(2025)12, e70142 (10.1002/mp.70142) - Krönke, T.; Blei, M. K.; Ullrich, M. et al.
Lanthanum-133 and iodine-123 as diagnostic counterparts to actinium-225 radioconjugates in a small animal PET/SPECT study with mcp-PSMA-ligands
Nuclear Medicine and Biology 150-151(2025)Suppl., 109291 (10.1016/j.nucmedbio.2025.109291) - Mastropasqua, F.; Teresa Lisi, A.; Crouzier, L. et al.
Development of Second-Generation Phenoxyethylpiperidines as Potent Sigma-1 Receptor Agonists with Neuroprotective Potential for Alzheimer’s Disease
Journal of Medicinal Chemistry 69(2026)4, 4613-4628 (10.1021/acs.jmedchem.5c03240) - Mastropasqua, F.; Ludwig, F.-A.; Abate, C.
A Full-Spectrum Evaluation of Sigma-1 Receptor (S1R) Positron Emission Tomography (PET) Radioligands from Binding Affinity to Clinical Imaging
Molecules 30(2025)21, 4296 (10.3390/molecules30214296) - Kogler, J.; Donat, C.; Trommer, J. et al.
Synthesis and preclinical evaluation of FAP-targeting radiotracers for PET and optical imaging
EJNMMI Radiopharmacy and Chemistry 10(2025), 77 (10.1186/s41181-025-00398-9) - Craig, A.; Sachse, F.; Laube, M. et al.
PET and SPECT Tracer Development via Copper-Mediated Radiohalogenation of Divergent and Stable Aryl-Boronic Esters
Pharmaceutics 17(2025)7, 837 (10.3390/pharmaceutics17070837) - Krönke, T.; Ullrich, M.; Blei, M. K. et al.
Diagnostic Twins: Exploring the Radiohybrid Concept with Iodine−123 and Lanthanum−133 for PSMA-Targeted SPECT and PET Imaging
Journal of Medicinal Chemistry 69(2026) (10.1021/acs.jmedchem.6c00161) - Azizova, A.; Prysiazhniuk, Y.; Cakmak, M. et al.
Visual versus Region-of-Interest Based Diffusion Evaluation and their Diagnostic Impact in Adult-Type Diffuse Gliomas
Neuroradiology 68(2026), 503-515 (10.1007/s00234-025-03832-6) - Burger, E.-M.; Hill, C.; Wodtke, R. et al.
In vitro characterization of the published glypican 3 targeting peptide TJ12P2 reveals a lack of specificity and potency
Pharmaceuticals 18(2025)11, 1656 (10.3390/ph18111656) - Laube, M.; Roscales, S.; Pietzsch, J. et al.
Nitrosoarenes as versatile precursors for 18F-fluorination
ACS Omega 11(2026), 32905-32911 (10.1021/acsomega.6c02349) - Arlt, E.; Bley, N.; Rausch, A. et al.
Sex determines the Natural Killer cell-mediated immunity against Pancreatic Cancer
OncoImmunology 15(2026)1, 2645298 (10.1080/2162402X.2026.2645298) - Sonam, S.; Mojić, M.; Gordić, V. et al.
Novel Ruthenacarborane−NSAID Conjugates
Molecules 30(2025)21, 4153 (10.3390/molecules30214153) - Lakshmi, K.; Jutrzenka-Trzebiatowski, A.; Rodrigues Loureiro, L. R. et al.
Automated GMP-Compatible Production of Universal CAR Tregs for Organ-Targeted Tolerance Induction
Journal of Translational Medicine 23(2025)1, 1399 (10.1186/s12967-025-07431-0) - Kubeil, M.; Stephan, H.
Cytotoxicity of Metal-containing Carbon Monoxide-Releasing Molecules: A Current Assessment
Journal of Inorganic Biochemistry 277(2026), 113235 (10.1016/j.jinorgbio.2026.113235) - Toyohara, J.; Elsinga, P.; Todde, S. et al.
Highlight selection of radiochemistry and radiopharmacy developments by editorial board
EJNMMI Radiopharmacy and Chemistry 10(2025), 65 (10.1186/s41181-025-00387-y) - Maqbool, M.; Gündel, D.; Liow, J.-S. et al.
Evaluation of deuterated [¹⁸F]JHU94620 for imaging cannabinoid type 2 receptors in rodent and monkey brain
Journal of Cerebral Blood Flow and Metabolism 45(2025)12, 2417-2427 (10.1177/0271678X251371377) - Gabriel, A.; Moeckli, R.; Beyreuther, E. et al.
New modalities for ultra-high dose rate irradiation and FLASH experiments
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Partial adaptation for online-adaptive proton therapy triggered by during-delivery treatment verification: Feasibility study on prostate cancer treatments
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Feasibility of prompt gamma verification for cone-beam CT-based online adaptive proton therapy
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Interfacing with the Brain: How Nanotechnology Can Contribute
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The UniCAR system – From Target Module Engineering to Diagnosis & Treatment of FAP+ tumours
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Cytotoxic and Radiosensitizing Effects of European and African Propolis in 3D Lung Carcinoma Cell Cultures
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Transcriptomic and epigenetic landscape of nimorazole-enhanced radiochemotherapy in head and neck cancer
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Development and Evaluation of Deuterated [18F]JHU94620 Isotopologues for the Non-invasive Assessment of the Cannabinoid type 2 Receptor in Brain
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Simulation and experimental benchmarking of a proton pencil beam scanning nozzle for development of MRI-guided proton therapy
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Carborane Conjugates with Ibuprofen, Fenoprofen and Flurbiprofen: Synthesis, Characterization, COX Inhibition Potential and In Vitro Activity
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SAPPHIRE - Establishment of Small Animal Proton and PHoton Image-guided Radiation Experiments
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MR imaging of proton beam-induced oxygen depletion
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Inter-center comparison of proton range verification prototypes with an anthropomorphic head phantom
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UniCAR T-cell potency – A matter of affinity between Adaptor Molecules and Adaptor CAR T-cells?
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Towards the Stable Binding of Mercury: Synthesis and Functionalization of Dibenzyldiazabicyclononane Scaffolds
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The crystal structure of (2-diphenylphosphanylphenyl) 2-[7-(dimethylamino)-2-oxochromen-4-yl]acetate, C31H26NO4P
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Improved automated one-pot two-step radiosynthesis of (S)-[18F]FETrp, a radiotracer for PET imaging of indoleamine 2,3-dioxygenase 1 (IDO1)
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A survey of practice patterns for real-time intrafractional motion-management in particle therapy
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A survey of practice patterns for adaptive particle therapy for interfractional changes
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Prognostic biomarkers for the response to the radiosensitizer nimorazole combined with RCTx: a pre-clinical trial in HNSCC xenografts
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Direct visualization of proton beam irradiation effects in liquids by MRI
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Artificial intelligence in cancer research and precision medicine: Applications, limitations and priorities to drive transformation in the delivery of equitable and unbiased care
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Combining Cisplatin with Different Radiation Qualities—Interpretation of Cytotoxic Effects In Vitro by Isobolographic Analysis
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Prediction of radiation pneumonitis using the effective α/β of lungs and heart in NSCLC patients treated with proton beam therapy
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A Phase I Study of the DNA-PK Inhibitor Peposertib in Combination with Radiotherapy with or without Cisplatin in Patients with Advanced Head and Neck Tumors
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Patients’ needs in Proton Therapy: a survey among 10 European Facilities
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Chelator Impact: Investigating the Pharmacokinetic Behavior of Copper-64 Labeled PD-L1 Radioligands
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Exploring Hydrophilic PD-L1 Radiotracers Utilizing Phosphonic Acids: Insights Into Unforeseen Pharmacokinetics
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Development of a Highly Specific 18F-labeled Radioligand for Imaging of Sigma-2 Receptor in Brain Tumor
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STereotactic Arrhythmia Radioablation (STAR): the Standardized Treatment and Outcome Platform for Stereotactic Therapy Of Re-entrant tachycardia by a Multidisciplinary consortium (STOPSTORM.eu) and review of current patterns of STAR practice in Europe
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High-Throughput Gel Microbeads as Incubators for Bacterial Competition Study
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Proton dosimetry in a magnetic field: measurement and calculation of correction factors for a plane-parallel ionization chamber
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Meta-analysis of expression and targeting of cell adhesion associated genes in nine cancer types – a one research lab re-evaluation
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Impedimetric Nanobiosensor for the Detection of SARS-CoV-2 Antigens and Antibodies
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Synthesis, Dynamic NMR Characterization, and XRD Study of 2,4-Difluorobenzoyl-Substituted Piperazines
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Strahlenschutzmaßnahmen bei der Anwendung von PET-Nukliden in der Krebsforschung
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Advanced MR Techniques for preoperative Glioma Characterization - Part 2
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Nemacol is a Small Molecule Inhibitor of C. elegans Vesicular Acetylcholine Transporter with Anthelmintic Potential
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Cyclotron-based Production of 67Cu for Radionuclide Theranostics Via the 70Zn(p,α)67Cu Reaction
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Out-of-field measurements and simulations of a proton pencil beam in a wide range of dose rates using a Timepix3 detector: Dose rate, flux and LET
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A convolutional neural network with self-attention for fully automated metabolic tumor volume delineation of head and neck cancer in [18F]FDG PET/CT
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