Publications of the Nanoscalic Systems Group

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2020

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• V. Lopez, S.-Y. Lee, H. Stephan, and C. E. Müller. Recombinant expression of ecto-nucleotide pyrophosphatase/phosphodiesterase 4 (NPP4) and development of a luminescence-based assay to identify inhibitors. Anal. Biochem. 2020, 603, 113774.

• T. Joshi, C. Mamat, and H. Stephan. Contemporary Synthesis of Ultrasmall (sub‑10 nm) Upconverting Nanomaterials (Invited Minireview). ChemistryOpen. 2020, 9 (6), 703-712.

• T. Avellini, N. Soni, N. Silvestri, S. Fiorito, F. De Donato, C. De Mei, M. Cassani, S. Ghosh, M. Walther, L. Manna, H. Stephan, and T. Pellegrino. Cation exchange protocols to radiolabel aqueous stabilized ZnS, ZnSe and CuFeS₂ nanocrystals with ⁶⁴Cu for dual radio- and photo-thermal therapy. Adv. Funct. Mat. 2020, 30 (28), 2002362.

• S. Geri, T. Krunclova, O. Janouskova, J. Panek, M. Hruby, D. Hernandez, B. Probst, R. A. Alberto, C. Mamat, M. Kubeil, and H. Stephan. Light-Activated Carbon Monoxide Prodrugs Based on Bipyridyl Dicarbonyl Ruthenium(II) Complexes. Chem. Eur. J. 2020, 26 (48), 10992 –11006.

• F. Reissig, K. Zarschler, R. Hübner, H.‐J. Pietzsch, K. Kopka, and C. Mamat. Sub‐10 nm Radiolabeled Barium Sulfate Nanoparticles as Carriers for Theranostic Applications and Targeted Alpha Therapy. ChemistryOpen. 2020, 9 (8), 797-805.

• T. I. Kostelnik, X. Wang, L. Southcott, H. K. Wagner, M. Kubeil, H. Stephan, M. de Guadalupe Jaraquemada-Peláez, and C. Orvig. Rapid Thermodynamically Stable Complex Formation of [^nat/111In]In³⁺, [^nat/90Y]Y³⁺, and [^nat/177Lu]Lu³⁺ with H₆dappa. Inorg. Chem. 2020, 59 (10), 7238-7251.

• G. Singh, J. L. Z. Ddungu, N. Licciardello, R. Bergmann, L. De Cola, and H. Stephan. Ultrasmall silicon nanoparticles as a promising platform for multimodal imaging. Faraday Discuss. 2020, 222, 362-383.

• N. Choudhary, M. de Guadalupe Jaraquemada-Peláez, K. Zarschler, X. Wang, V. Radchenko, M. Kubeil, H. Stephan, and C. Orvig. Chelation in One Fell Swoop: Optimizing Ligands for Smaller Radiometal Ions. Inorg Chem. 2020, 59 (8), 5728-5741.

• K. Pant, C. Neuber, K. Zarschler, J. Wodtke, S. Meister, R. Haag, J. Pietzsch, and H. Stephan. Active Targeting of Dendritic Polyglycerols for Diagnostic Cancer Imaging. Small 2020, 16 (7), 1905013.

• G. Singh, K. Zarschler, S. Hunoldt, I.I. Santana Martínez, C.L. Ruehl, M. Matterna, R. Bergmann, D. Máthé, N. Hegedüs, M. Bachmann, P. Comba, and H. Stephan. Versatile Bispidine-based Bifunctional Chelators for ⁶⁴Cu^II-Labelling of Biomolecules. Chem. Eur. J. 2020, 26 (9), 1989-2001.

• J. Karges, M. Jakubaszek, C. Mari, K. Zarschler, B. Goud, H. Stephan, and Gilles Gasser. Synthesis and Characterization of an Epidermal Growth Factor Receptor selective Ru(II) Polypyridyl-Nanobody Conjugate as a Photosensitizer for Photodynamic Therapy. ChemBioChem. 2020, 21 (4), 531-542.

• C. van Heusden, B. Button, W. H. Anderson, A. Ceppe, L. C. Morton, W. K. O’Neal, H. Dang, N. E. Alexis, S. Donaldson, H. Stephan, R. C. Boucher, and E. R. Lazarowski. Inhibition of ATP hydrolysis restores airway surface liquid production in cystic fibrosis airway epithelia. Am J Physiol Lung Cell Mol Physiol. 2020, 318 (2), L356-L365.

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2019

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• D.C. Senevirathna, M.V. Werrett, M. Kubeil, H. Stephan, and P.C. Andrews. Synthesis, structural characterisation, and cytotoxicity studies of Bi, W, and Mo containing homo- and hetero-bimetallic polyoxometalates. Dalton Trans. 2019, 48 (42), 15962-15969.

• M. Gott, P. Yang, U. Kortz, H. Stephan, H.J. Pietzsch, and C. Mamat. A ²²⁴Ra-labeled polyoxopalladate as a putative radiopharmaceutical. Chem Commun (Camb). 2019, 55 (53), 7631-7634.

• F. Gao, W. Sihver, R. Bergmann, M. Walther, H. Stephan, B. Belter, C. Neuber, C. Haase-Kohn, C. Bolzati, J. Pietzsch, and H.J. Pietzsch. Radiochemical and radiopharmacological characterization of a ⁶⁴Cu-labeled α-MSH analog conjugated with different chelators. J Labelled Comp Radiopharm. 2019, 62 (8), 495-509.

• K. Peewasan, M. P. Merkel, K. Zarschler, H. Stephan, C. E. Ansona, and A. K. Powell. Tetranuclear Cu(II)-chiral complexes: synthesis, characterization and biological activity. RSC Adv. 2019, 9 (42), 24087-24091.

• M. Rahbari, M. Pecqueux, D. Aust, H. Stephan, O. Tiebel, A. Chatzigeorgiou, T. Tonn, F. Baenke, V. Rao, N. Ziegler, H. Greif, K. Lin, J. Weitz, N. N. Rahbari, and C. Kahlert. Expression of Glypican 3 is an Independent Prognostic Biomarker in Primary Gastro-Esophageal Adenocarcinoma and Corresponding Serum Exosomes. J Clin Med. 2019, 8 (5), pii: E696.

• M. Kubeil, T. Joshi, B. R. Wood, and H. Stephan. Synthesis, Structural Characterization and Photodecarbonylation Study of a Dicarbonyl Ruthenium(II)-Bisquinoline Complex. ChemistryOpen. 2019, 8 (5), 637-642.

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2018

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• A. Nsubuga, K. Zarschler, M. Sgarzi, B. Graham, H. Stephan, and T. Joshi. Towards Utilising Photocrosslinking of Polydiacetylenes for the Preparation of “Stealth” Upconverting Nanoparticles. Angew. Chem. Int. Ed. 2018, 57 (49), 16036-16040.

• A. Haider, K. Zarschler, S. A. Joshi, R. M. Smith, Z. Lin, A. S. Mougharbel, U. Herzog, C. E. Müller, H. Stephan, and Ulrich Kortz. Preyssler‐Pope‐Jeannin Polyanions [NaP₅W₃₀O₁₁₀]^14– and [AgP₅W₃₀O₁₁₀]^14–: Microwave‐Assisted Synthesis, Structure, and Biological Activity. Z. anorg. allg. Chem. 2018, 644 (14), 752-758.

• T. Joshi, M. Kubeil, A. Nsubuga, G. Singh, G. Gasser, and H. Stephan. Harnessing the Coordination Chemistry of 1,4,7‐Triazacyclononane for Biomimicry and Radiopharmaceutical Applications. ChemPlusChem. 2018, 83 (7), 554-564.

• A. Nsubuga, M. Sgarzi, K. Zarschler, M. Kubeil, R. Hübner, R. Steudtner, B. Graham, T. Joshi, and H. Stephan. Facile preparation of multifunctionalisable 'stealth' upconverting nanoparticles for biomedical applications. Dalton Trans. 2018, 47 (26), 8595-8604.

• N. Licciardello, S. Hunoldt, R. Bergmann, G. Singh, C. Mamat, A. Faramus, J.L.Z. Ddungu, S. Silvestrini, M. Maggini, L. De Cola, and H. Stephan. Biodistribution studies of ultrasmall silicon nanoparticles and carbon dots in experimental ratsand tumor mice. Nanoscale. 2018, 10 (21), 9880-9891.

• J. Hesse, D. T. Klier, M. Sgarzi, A. Nsubuga, C. Bauer, J. Grenzer, R. Hübner, M. Wislicenus, T. Joshi, M. U. Kumke, and H. Stephan. Rapid Synthesis of Sub-10 nm Hexagonal NaYF₄-Based Upconverting Nanoparticles using Therminol® 66. ChemistryOpen 2018, 7 (2), 159-168.

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2017

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• L. Feldbrügge, A. C. Moss, E. U. Yee, E. Csizmadia, S. Mitsuhashi, M. S. Longhi, H. Stephan, Y. Wu, A. S. Cheifetz, C. E. Müller, J. Sevigny, S. C. Robson, and Z. G. Jiang
  Expression of ecto-nucleoside triphosphate diphosphohydrolases-2 and -3 in the enteric nervous system impacts inflammation in experimental colitis and Crohn's disease
  J Crohns Colitis. 2017, 11 (9), 1113-1123.

• M. Kubeil, R. R. Vernooij, C. Kubeil, B. R. Wood, B. Graham, H. Stephan, and L. Spiccia
  Studies of Carbon Monoxide Release from Ruthenium(II) Bipyridine Carbonyl Complexes upon UV-Light Exposure
  Inorg Chem. 2017, 56 (10), 5941-5952.

• R. Bergmann, M. Kubeil, K. Zarschler, S. Chhabra, R. B. Tajhya, C. Beeton, M. W. Pennington, M. Bachmann, R. S. Norton, and H. Stephan
  Distribution and kinetics of the Kv1.3-blocking peptide HsTX1[R14A] in experimental rats
  Sci. Rep. 2017, 7, 3756.

• K. Pant, J. Pufe, K. Zarschler, R. Bergmann, J. Steinbach, S. Reimann, R. Haag, J. Pietzsch, and H. Stephan
  Surface charge and particle size determine the metabolic fate of dendritic polyglycerols
  Nanoscale 2017, 9 (25), 8723-8739.

• K. Pombo-García, C. Rühl, R. Lam, J. A. Barreto, C.-S. Ang, P. J. Scammells, P. Comba, L. Spiccia, B. Graham, T. Joshi and H. Stephan
  Zwitterionic Modification of Ultra-Small Iron Oxide Nanoparticles for Reduced Protein Corona Formation
  ChemPlusChem. 2017, 82 (4), 638-646.

• K. Pant, O. Sedláček, R. A. Nadar, M. Hrubý, and H. Stephan
  Radiolabelled Polymeric Materials for Imaging and Treatment of Cancer: Quo Vadis?
  Adv. Healthc. Mater. 2017, 6 (6).

• S.-Y. Lee, S. Sarkar, S. Bhattarai, V. Namasivayam, S. De Jonghe, H. Stephan, P. Herdewijn, A. El-Tayeb and C. E. Müller
  Substrate-Dependence of Competitive Nucleotide Pyrophosphatase/Phosphodiesterase1 (NPP1) Inhibitors
  Front. Pharmacol. 2017, 8:54.

• L. A. Kunz-Schughart, A.Dubrovska, C. Peitzsch, A. Ewe, A. Aigner, S. Schellenburg, M. H. Muders, S. Hampel, G. Cirillo, F. Iemma, R. Tietze, C. Alexiou, H. Stephan, K. Zarschler, O. Vittorio, M. Kavallaris, W. J. Parak, L. Mädler, and S. Pokhrel
  Nanoparticles for Radiooncology: Mission, Vision, Challenges
  Biomaterials 2017, 120, 155-184.

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2016

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• M. Patra, K. Zarschler, H.-J. Pietzsch, H. Stephan, and G. Gasser
  

  New insights into the pretargeting approach to image and treat tumours

  Chem Soc Rev. 2016, 45 (23), 6415-6431.

• K. Pombo-García, S. Weiss, K. Zarschler, C.-S. Ang, R. Hübner, J. Pufe, S. Meister, J. Seidel, J. Pietzsch, L. Spiccia, H. Stephan, and B. Graham

  Zwitterionic polymer-coated ultrasmall superparamagnetic iron oxide nanoparticles with low protein interaction and high biocompatibility

  ChemNanoMat 2016, 2 (10), 959-971.

• G. Singh, M. D. Gott, H.-J. Pietzsch, and H. Stephan

  Nuclear and optical dual-labelled imaging agents. Design and challenges

  Nuklearmedizin 2016, 55 (2), 41-50.

• R. Albrecht, S. Fehse, K. Pant, S. Nowag, H. Stephan, R. Haag, and C. C. Tzschucke

  Polyglycerol-Based Copper Chelators for the Transport and Release of Copper Ions in Biological Environments

  Macromol Biosci. 2016, 16 (3), 412-419.

• K. Zarschler, L. Rocks, N. Licciardello, L. Boselli, E. Polo, K. Pombo Garcia, L. De Cola, H. Stephan, and K. A. Dawson

  Ultrasmall inorganic nanoparticles: state-of-the-art and perspectives for biomedical applications

  Nanomedicine 2016, 12 (6), 1663-1701. Highly Cited Paper

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2015

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• M. Kubeil, K.Zarschler, J. Pietzsch, W. Kraus, P. Comba, and H. Stephan

  Copper(II) cyclam complexes with N-propionic acid pendant arms

  Eur. J. Inorg. Chem. 2015, 24, 4013-4023.

• M. Paúrová, J. Havlíčková, A. Pospíšilová, M. Vetrík, I. Císařová, H. Stephan, H.J. Pietzsch, M. Hrubý, P. Hermann, and J. Kotek
  Bifunctional Cyclam-Based Ligands with Phosphorus Acid Pendant Moieties for Radiocopper Separation – Thermodynamic and Kinetic Studies
  Chem. Eur. J. 2015, 21, 4671-4687.

• A. Leonidova, C. Foerster, K. Zarschler, M. Schubert, H.-J. Pietzsch, J. Steinbach, R. Bermann, N. Metzler-Nolte, H. Stephan, and G. Gasser 
  In vivo Demonstration of an Active Tumor Pretargeting Approach with Peptide Nucleic Acid Bioconjugates as Complementary System
  Chem. Sci. 2015, 6, 5601-5616.

• D. Bronx, P. Comba, D.-P. Herten, E. Kimmle, M. Morgen, C. Rühl, A. Rybina, H. Stephan, G. Storch, and H. Wadepohl

  Cu^II-selective bispidine-dye conjugates
  J. Inorg. Biochem. 2015, 148, 78-83.

• K. Pant, D. Gröger, R. Bergmann, J. Pietzsch, J. Steinbach, B. Graham, L. Spiccia, F. Berthon, B. Czarny, L. Devel, V. Dive, H. Stephan, and R. Haag
  Synthesis and Biodistribution Studies of ³H- and ⁶⁴Cu-labeled Dendritic Polyglycerol and Dendritic Polyglycerol Sulfate
  Bioconjugate Chem. 2015, 26 (5), 906-18.

• S.-Y. Lee, A. Fiene, W. Li, T. Hank, K. Brylev, V. Fedovrov, J. Lecka, A. Haider, H.-J. Pietzsch, H. Zimmermann, J. Sévigny, U. Kortz, H. Stephan, and C. E. Müller
  Polyoxometalates - potent and selective ecto-nucleotidase inhibitors
  Biochem. Pharmacol. 2015, 93, 171-181.

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2014

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• H. Stephan, C. Förster and G. Gasser
  Synthesis, Characterization and Evaluation of Radiometal-Containing Peptide Nucleic Acids
  in Peptide Nucleic Acids, Methods and Protocols, 2^nd ed., Series: Methods in Molecular Biology, Vol. 1050, (Nielsen, P. E. and Appella, D., Eds.), Springer, Humana Press 2014, pp 37-54.

• H. Stephan, M. Walther, S. Fähnemann, P. Ceroni, J. Molloy, G. Bergamini, F. Heisig, C. E. Müller, W. Kraus, and P. Comba
  Bispidines for dual imaging
  Chem. Eur. J. 2014, 20, 17011-8.
  

• K.-Y. Wang, Z. Lin, B. B. Bassil, J. Cao, H. Stephan, K. Viehweger, and U. Kortz
  The Ti₇-Containing, Tetrahedral 36-Tungsto-4-Arsenate(III) [Ti₆(TiO₆)(AsW₉O₃₃)₄]^20-
  Dalton Trans. 2014, 43, 16143-16146.

• P. Comba, M. Kubeil, J. Pietzsch, H. Rudolf, H. Stephan, and K. Zarschler
  Bispidine Dioxotetraaza Macrocycles: A New Class of Bispidines for ⁶⁴Cu PET Imaging
  Inorg. Chem. 2014, 53, 6698-707.

• K. Viehweger, L. Barbaro, K. Pombo García, T. Joshi, G. Geipel, J. Steinbach, H. Stephan, L. Spiccia, and B. Graham
  EGF receptor-targeting peptide conjugate incorporating a near-IR fluorescent dye and a novel 1,4,7-triazacyclononane-based ⁶⁴Cu(II) chelator assembled via click chemistry
  Bioconjugate Chem. 2014, 25, 1011-22.

• K. Zarschler, K. Prapainop, E. Mahon, L. Rocks, P. M. Kelly, M. Bramini, H. Stephan, and K. A. Dawson
  Diagnostic nanoparticle targeting of the EGF-receptor in complex biological conditions using single-domain antibodies
  Nanoscale 2014, 6, 6046-6056.

• K. Pombo García, K. Zarschler, L. Barbaro, J. A. Barreto, W. O'Malley, L. Spiccia, H. Stephan, and B. Graham
  Zwitterionic-Coated “Stealth” Nanoparticles for Biomedical Applications: Recent Advances in Countering Biomolecular Corona Formation and Uptake by the Mononuclear Phagocyte System
  Small 2014, 10(13), 2516-29. Highly Cited Paper

• K. Zarschler, M. Kubeil and H. Stephan
  Establishment of two complementary in vitro assays for radiocopper complexes achieving reliable and comparable evaluation of in vivo stability
  RSC Adv. 2014, 4, 10157-10164.

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2013

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• K. Zarschler, S. Witecy, F. Kapplusch, C. Foerster, and H. Stephan
  High-yield production of functional soluble single-domain antibodies in the cytoplasm of Escherichia coli
  Microb. Cell Fact. 2013, 12:97.

• H. Stephan, M. Kubeil, F. Emmerling, and C. E. Müller
  Polyoxometalates as versatile enzyme inhibitors
  Eur. J. Inorg. Chem. 2013, 1585-1594.

• P. Comba, F. Emmerling, M. Jakob, W. Kraus, M. Kubeil, M. Morgen, J. Pietzsch, and H. Stephan
  Copper(II) chemistry of the functionalized macrocycle cyclam tetraproprionic acid
  Dalton Trans. 2013, 42, 6142-6148.

• R. Bergmann, A. Ruffani, B. Graham, L. Spiccia, J. Steinbach, J. Pietzsch, and H. Stephan
  Synthesis and radiopharmacological evaluation of ⁶⁴Cu-labeled bombesin analogs featuring a bis(2-pyridylmethyl)-1,4,7-triazacyclononane chelator
  Eur. J. Med. Chem. 2013, 70, 434-446.

• K. Pombo-García, K. Zarschler, J. A. Barreto, J. Hesse, L. Spiccia, B. Graham, and H. Stephan
  Design, synthesis, characterisation and in vitro studies of hydrophilic, colloidally stable, ⁶⁴Cu(II)-labelled, ultra-small iron oxide nanoparticles in a range of human cell lines
  RSC Adv. 2013, 3, 22443-22454.

• Z. S. Pillai, P. Ceroni, M. Kubeil, J.-M. Heldt, H. Stephan, and G. Bergamini
  Dendrimers as Nb³⁺ ligands: effect of generation on the efficiency of the sensitized lanthanide emission
  Chem. Asian J. 2013, 8, 771-777.

• P. Comba, B. Martin, A. Sanyal, and H. Stephan
  The computation of lipophilicities of ⁶⁴Cu PET systems based on a novel approach for fluctuating charges
  Dalton Trans. 2013, 42(31), 11066-11073.

• P. Comba, S. Hunoldt, M. Morgen, J. Pietzsch, H. Stephan, and H. Wadepohl
  Optimization of pentadentate bispidines as bifunctional chelators for ⁶⁴Cu positron emission tomography (PET)
  Inorg. Chem. 2013, 52, 8131-8143.

• K. Yoshizuka, H.-J. Pietzsch, S. Seifert, and H. Stephan
  Quantitative Structure Property Relationship of logP for Radiopharmaceutical Technetium and Rhenium Complexes by using Molecular Dynamics Calculations
  Solv. Extr. Res. Devel. (Japan) 2013, 20, 15-27.

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2012

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• A. Melani, F. Corti, H. Stephan, C. E. Müller, C. Donati, P. Bruni, M. G. Vannucchi, and F. Pedata
  Ecto-ATPase Inhibition: ATP and Adenosine Release under Physiological and Ischemic In Vivo Conditions in the Rat Striatum
  Exp. Neurol. 2012, 233, 193-204.

• H. Stephan, M. Kubeil, K. Gloe, and K. Gloe
  Extraction Methods
  in Analytical Methods in Supramolecular Chemistry, C. A. Schalley (Ed.), 2^nd, completely revised and enlarged edition, Wiley-VCH, Weinheim, 2012, 105-125.

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2011

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• J. A. Barreto, W. O’Malley, M. Kubeil, B. Graham, H. Stephan, and L. Spiccia
  Nanomaterials: Applications in Cancer Imaging and Therapy
  Adv Mater. 2011, 23, H18-40. Highly Cited Paper

• A. Röhrich, R. Bergmann, A. Kretzschmann, S. Noll, J. Pietzsch, J. Steinbach, and H. Stephan
  A Novel Tetrabranched Neurotensin(8-13) Cyclam Derivative: Synthesis, ⁶⁴Cu-Labeling and Biological Evaluation
  J. Inorg. Biochem. 2011, 105, 821-832.

• M. Walther, M. Matterna, S. Juran, S. Fähnemann, H. Stephan, W. Kraus, and F. Emmerling
  Imidazole Containing Bispidine Ligands: Synthesis, Structure and Cu(II) Complexation
  Z. Naturforsch. 2011, 66b, 721-728.

• J. A. Barreto, M. Matterna, B. Graham, H. Stephan, and L. Spiccia
  Synthesis, Colloidal Stability and ⁶⁴Cu Labeling of Iron Oxide Nanoparticles Bearing Different Macrocyclic Ligands
  New J. Chem. 2011, 35, 2705-2712.

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• Publications 2006-2010
• Publications 2000-2005
• Publications 1990-1999