MHELTHERA Publications

2024

H. A. Saleh, N. Mitwasi, L. R. Loureiro, A. Kegler, K. E. G. Soto, L. Hoffmann, E. Crespo, C. Arndt, R. Bergmann, M. Bachmann, A. Feldmann

RevCAR-expressing immune effector cells for targeting of Fn14-positive glioblastoma

Cancer Gene Ther. 2024. https://doi.org/10.1038/s41417-024-00766-8
M. Kubeil, C. Neuber, M. Starke, C. Arndt, L. R. Loureiro, L. Hoffmann, A. Feldmann, M. Bachmann, J. Pietzsch, P. Comba, H. Stephan

⁶⁴Cu tumor labeling with hexadentate picolinic acid-based bispidine immunoconjugates

Chem. Eur. J. 2024, e202400366. https://doi.org/10.1002/chem.202400366

X. Zhao, F. R. Kolbinger, M. Diestler, J. Weitz, D. Makarov, M. Bachmann, L. Baraban

Portable droplet-based real-time monitoring of pancreatic α-amylase in postoperative patients

Biosens. Bioelectron. 2024, 116034. https://doi.org/10.1016/j.bios.2024.116034
X. Peng, Ž. Janićijević, S. Lemm, S. Hauser, M. Knobel, J. Pietzsch, M. Bachmann, L. Baraban

Impact of Viscosity on Human Hepatoma Spheroids in Soft Core-Shell Microcapsules

Adv. Healthcare Mater. 2024, 2302609. https://doi.org/10.1002/adhm.202302609
M. Kubeil, Y. Suzuki, M. A. Casulli, R. Kamal, T. Hashimoto, M. Bachmann, T. Hayashita, H. Stephan

Exploring the Potential of Nanogels: From Drug Carriers to Radiopharmaceutical Agents (Cover)

Adv. Healthcare Mater. 2024, 13, 2301404. https://doi.org/10.1002/adhm.202301404

2023

L. R. Loureiro, L. Hoffmann, C. Neuber, L. Rupp, C. Arndt, A. Kegler, M. Kubeil, C. E. Hagemeyer, H. Stephan, M. Schmitz, A. Feldmann, M. Bachmann

Immunotheranostic target modules for imaging and navigation of UniCAR T-cells to strike FAP-expressing cells and the tumor microenviroment

J. Exp. Clin. Cancer Res. 2023, 42, 341. https://jeccr.biomedcentral.com/articles/10.1186/s13046-023-02912-w
K. E. González Soto, L. R. Loureiro, T. Bartsch, C. Arndt, A. Kegler, N. Mitwasi, L. Drewitz, L. Hoffmann, H. A. Saleh, E. Crespo, M. Mehnert, C Daglar, F. Momburg, H. Abken, M. Bachmann, A. Feldmann

Targeting of colorectal cancer using AND-gated Adaptor RevCAR T-cells

Front. Immunol. 2023, 14,1302354. https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1302354/full
I. Kopp, P. A. Cieslik, K. Anger, T. Josephy, L. Neupert, G. Velmurugan, M. Gast, H. Wadepohl, S. A. Brühlmann, M. Walther, K. Kopka, M. Bachmann, H. Stephan, M. Kubeil, P. Comba

Bispidine Chelators for Radiopharmaceutical Applications with Lanthanide, Actinide, and Main Group Metal Ions (Cover)

Inorg. Chem. 2023, 62, 20754. https://pubs.acs.org/doi/full/10.1021/acs.inorgchem.3c02340

Ž. Janićijević, T. A. Nguyen-Le, A. Alsadig, I. Cela, R. Zilénaite, T. Hossain Tonmoy, M. Kubeil, M. Bachmann, L. Baraban
Methods gold standard in clinic millifluidics multiplexed extended gate field-effect transistor biosensor with gold nanoantennae as signal amplifiers

Biosens. Bioelectron. 2023, 241, 115701. https://doi.org/10.1016/j.bios.2023.115701
A. Kegler, L. Drewitz, C. Arndt, C. Daglar, L. R. Loureiro, N. Mitwasi, C. Neuber, K. E. González Soto, T. Bartsch, L. Baraban, H. Ziehr, M. Heine, A. Nieter, A. Moreira-Soto, A. Kühne, J. F. Drexler, B. Seliger, M. Laube, D. Máthé, B. Pályi, P. Hajdrik, L. Forgách, Z. Kis, K. Szigeti, R. Bergmann, A. Feldmann, M. Bachmann

A novel ACE2 decoy for both neutralization of SARS-CoV-2 variants and killing of infected cells

Front. Immunol. 2023, 14, 1204543. https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1302354/full
F. Striese, S. Weißflog, C. Neuber, C. Arndt, M. Ullrich, J. Steinbach, J. Pietzsch, R. Bergmann, H. J. Pietzsch, W. Sihver, M. Frenz, A. Feldmann, M. P. Bachmann

Preclinical characterization of the 177Lu-labeled prostate stem cell antigen (PSCA)-specific monoclonal antibody 7F5 as a potential immunotheranostic agent for prostate cancer

Int. J. Mol. Sci. 2023, 24, 9420. https://www.mdpi.com/1422-0067/24/11/9420
X. Peng, Ž. Janićijević, S. Lemm, M. Laube, J. Pietzsch, M. Bachmann, L. Baraban

Shell engineering in soft alginate-based capsules for culturing liver spheroids
Biotechnol. J. 2023, 2200365. https://doi.org/10.1002/biot.202200365
T. A. Nguyen-Le, X. Zhao, M. Bachmann, P. Ruelens, J. A. G. M. d Visser, L. Baraban

High-Throughput Gel Microbeads as Incubators for Bacterial Competition Study
Micromachines 2023, 14, 645. https://doi.org/10.3390/mi14030645
A. S. Köseer, S. Di Gaetano, C. Arndt, M. Bachmann, A. Dubrovska

Immunotargeting of cancer stem cells
Cancers 2023, 5, 1608. https://doi.org/10.3390/mi14030645

2022

P. Cieslik, M. Kubeil, K. Zarschler, M. Ullrich, F. Brandt, K. Anger, H. Wadepohl, K. Kopka, M. Bachmann, J. Pietzsch, H. Stephan, P. Comba
Toward Personalized Medicine: One Chelator for Imaging and Therapy with Lutetium-177 and Actinium-225

J. Am. Chem. Soc. 2022, 144, 21555. https://doi.org/10.1021/jacs.2c08438
V. Sessi, B. Ibarlucea, F. Seichepine, S. Klinghammer, I. Ibrahim, A. Heinzig, N. Szabo, T. Mikolajick, A. Hierlemann, U. Frey, W. M. Weber, L. Baraban, G. Cuniberti

Multisite Dopamine Sensing With Femtomolar Resolution Using a CMOS Enabled Aptasensor Chip

Front. Neurosci. 2022, 16, 875656.
D. Lindner, C. Arndt, L. R. Loureiro, A. Feldmann, S. Koristka, N. Berndt, R. Bergmann, M. Frenz, M. Bachmann

Combining radiation- with immunotherapy: Influence of radiation on T cells

Int. J. Mol. Sci. 2022 23, 7922. https://doi.org/10.3390/ijms23094920
N. Mitwasi, C. Arndt, L. R. Loureiro, A. Kegler, F. Fasslrinner, N. Berndt, R. Bergmann, V. Hořejší, C. Rössig, M. Bachmann, A. Feldmann

Targeting CD10 on B-Cell Leukemia Using the Universal CAR T-Cell Platform (UniCAR)

Int. J. Mol. Sci. 2022, 23, 4920. https://doi.org/10.3390/ijms23094920
C. Arndt, R. Bergmann, F. Striese , K. Merkel, D. Máthé, L. R. Loureiro , N. Mitwasi, A. Kegler, F. Fasslrinner, K. E. González Soto, C. Neuber, N. Berndt, N. Kovács, D. Szöllősi, N. Hegedűs, G. Tóth, J.-P. Emmermann, K. B. Harikumar, T. Kovacs, M. Bachmann, A. Feldmann
Development and Functional Characterization of a Versatile Radio-/Immuno-theranostic Tool for Prostate Cancer Management
Cancers 2022, 14, 1996. https://doi.org/10.3390/cancers14081996
A. S. Köseer, L. R. Loureiro, J. Jureczek, N. Mitwasi, K. E. González Soto, J. Aepler, T. Bartsch, A. Feldmann, L. A. Kunz-Schughart, A. Linge, M. Krause, M. Bachmann, C. Arndt, A. Dubrovska
Validation of CD98hc as a Therapeutic Target for a Combination of Radiation and Immunotherapies in Head and Neck Squamous Cell Carcinoma
Cancers 2022, 14, 1677. https://doi.org/10.3390/cancers14071677
M. Kubeil, I. I. Santana Martinez, M. Bachmann, K. Kopka, K. L. Tuck, H. Stephan
Dual-Labelling Strategies for Nuclear and Fluorescence Molecular Imaging: Current Status and Future Perspectives
Pharmaceuticals 2022, 15, 432. https://doi.org/10.3390/ph15040432
T. A. Nguyen-Le, T. Bartsch, R. Wodtke, F. Brandt, C. Arndt, A. Feldmann, D. I. Sandoval Bojorquez, A. Perez Roig, B. Ibarlucea, S. Lee, C.-K. Baek, G. Cuniberti, R. Bergmann, E. Puentes-Cala, J. Andrés Soto, B. T. Kurien, M. Bachmann, L. Baraban
Nanosensors in clinical development of CAR-T cell immunotherapy
Biosens. Bioelectron. 2022, 114124. . https://doi.org/10.1016/j.bios.2022.114124

Previous Joint Publications

2011-2021

C. Arndt, L. R. Loureiro, A. Feldmann, J. Jureczek, R. Bergmann, D. Máthé, N. Hegedüs, N. Berndt, S. Koristka, N. Mitwasi, F. Fasslrinner, C. Lamprecht, A. Kegler, A. Hoffmann, T. Bartsch, A. S. Köseer, G. Egan, M. Schmitz, V. Hořejší, M. Krause, A. Dubrovska, M. Bachmann
UniCAR T cell immunotherapy enables efficient elimination of radioresistant cancer cells
Oncoimmunology 2020, 9, (doi: 10.1080/2162402X.2020.1743036).
D. C. Senevirathna, M. V. Werrett, M. Kubeil, H. Stephan, P. C. Andrews
Synthesis, Structural Characterisation, and Cytotoxicity Studies of Bi, W, and Mo containing Homo- and Hetero-bimetallic Polyoxometalates
Dalton Trans. 2019, 48, 15962-15969.
A. Nsubuga, K. Zarschler, M. Sgarzi, B. Graham, H. Stephan, T. Joshi

Utilizing Photocrosslinking of Polydiacetylenes (PDAs) for the Preparation of “Stealth” Upconverting Nanoparticles (UCNPs)
Angew. Chem. Int. Ed. 2018, 57, 16036-16040; Angew. Chem. 2018, 130, 16268-16272.

A. Nsubuga, M. Sgarzi, K. Zarschler, M. Kubeil, R. Hübner, R. Steudtner, B. Graham, T. Joshi, H. Stephan (Back Cover)

Facile Preparation of Multifunctionalisable ‘Stealth’ Upconverting Nanoparticles for Biomedical Applications
Dalton Trans. 2018, 47, 8595-8604.

M. Kubeil, R. R. Vernooij, C. Kubeil, B. Wood, B. Graham, H. Stephan, L. Spiccia
Studies of carbon monoxide release from ruthenium(II) bipyridine carbonyl complexes upon UV light exposure
Inorg. Chem. 2017, 56, 5941-5952.
R. Bergmann, M. Kubeil, K. Zarschler, S. Chhabra, R. B. Tajhya, M. Bachmann, C. Beeton, M. W. Pennington, R. S. Norton, H. Stephan
Distribution and dynamics of the Kv1.3-blocking peptide HsTX1[R14A] in experimental rats
Sci. Reports 2017, 7, article 3756.
K. Pombo-Garcia, C. Rühl, T. Joshi, R. Lam, C.-S. Ang, P. J. Scammells, P. Comba, L. Spiccia, B. Graham, H. Stephan
Zwitterionic Modifications of Ultrasmall Iron Oxide Nanoparticles for Reduced Corona Formation
ChemPlusChem 2017, 82, 638-646.
K. Pombo-García, S. Weiss, K. Zarschler, C.-S. Ang, R. Hübner, J. Pufe, S. Meister, J. Seidel, J. Pietzsch, L. Spiccia, H. Stephan, B. Graham
Zwitterionic polymer-coated ultrasmall superparamagnetic iron oxide nanoparticles with low protein interaction and high biocompatibility
ChemNanoMat 2016, 2, 959-971.
K. Viehweger, L. Barbaro, K. Pombo García, T. Joshi, G. Geipel, J. Steinbach, H. Stephan, L. Spiccia, B. Graham
EGF receptor-targeting peptide conjugate incorporating a near-IR fluorescent dye and a novel 1,4,7-triazacyclononane-based ⁶⁴Cu(II) chelator assembled via click chemistry
Bioconjugate Chem. 2014, 25, 1011-1022.
K. Pombo-García, K. Zarschler, L. Barbaro, J. A. Barreto, W. O’ Malley, L. Spiccia, H. Stephan, B. Graham

Zwitterionic-coated „stealth“ nanoparticles for biomedical applications: recent advances in countering biomolecular corona formation and

uptake by the monomolecular phagocyte system
Small 2014, 10, 2516-2529.

R. Bergmann, A. Ruffani, B. Graham, L. Spiccia, J. Steinbach, J. Pietzsch, H. Stephan
Synthesis and radiopharmacological evaluation of 64Cu-labeled bombesin analogs featuring a bis(2-pyridylmethyl)-1,4,7-triazacyclononane chelator
Eur. J. Med. Chem. 2013, 70, 434-446.
K. Pombo-García, K. Zarschler, J. A. Barreto, J. Hesse, L. Spiccia, B. Graham, H. Stephan
Design, synthesis, characterisation and in vitro studies of hydrophilic, colloidally-stable, ⁶⁴Cu(II)-labelled, ultra-small iron oxide nanoparticles in a range of human cell lines
RSC Adv. 2013, 3, 22443-22454.
J. A. Barreto, M. Matterna, B. Graham, H. Stephan, L. Spiccia
Synthesis, Colloidal Stability and ⁶⁴Cu Labelling of Iron Oxide Nanoparticles Bearing Different Macrocyclic Ligands
New J. Chem. 2011, 35, 2705-2712.
J. A. Barreto, W. O’Malley, M. Kubeil, B. Graham, H. Stephan, L. Spiccia

Nanomaterials: applications in cancer imaging and therapy
Adv. Mater. 2011, 23, H18-H40.