Selected publications

A metabolic switch regulates the transition between growth and diapause in C. elegans Penkov S, Raghuraman BK, Erkut C, Oertel J, Galli R, Ackerman EJM, Vorkel D, Verbavatz JM, Koch E, Fahmy K, Shevchenko A, Kurzchalia TV. BMC BIOLOGY 18(2020) DOI: 10.1186/s12915-020-0760-3

Calcium binding to a disordered domain of a type III-secreted protein from a coral pathogen promotes secondary structure formation and catalytic activity Hoyer E, Knöppel J, Liebmann M, Steppert M, Raiwa M, Herczynski O, Hanspach E, Zehner S, Göttfert M, Tsushima S, Fahmy K, Oertel J

DNA-encircled lipid bilayers Iric K, Subramanian M, Oertel J, Agarwal N, Matthies M, Periole X, Sakmar TP, Huber T, Fahmy K, Schmidt TL. Nanoscale 39(2018): 18463-18467. DOI: 10.1039/c8nr06505e

Body size-dependent energy storage causes Kleiber's law scaling of the metabolic rate in planarians Thommen A, Werner S, Frank O, Philipp J, Knittelfelder O, Quek Y, Fahmy K, Shevchenko A, Friedrich BM, Jülicher F, Rink JC. eLife 2019;8:e38187 doi: 10.7554/eLife.38187

Layer-by-Layer Assembly of Heparin and Peptide-Polyethylene Glycol Conjugates to Form Hybrid Nanothin Films of Biomatrices Thomas AK, Wieduwild R, Zimmermann R, Lin W, Friedrichs J, Bickle M, Fahmy K, Werner C, Zhang Y. ACS Appl Mater Interfaces 10(2018):14264-14270

Uranium(VI) Complexes with a Calix[4]arene-Based 8-Hydroxyquinoline Ligand: Thermodynamic and Structural Characterization Based on Calorimetry, Spectroscopy, and Liquid-Liquid Extraction Bauer A, Jäschke A, Schöne S, Barthen R, März J, Schmeide K, Patzschke M, Kersting B, Fahmy K, Oertel J, Brendler V, Stumpf T. ChemistryOpen. 7(2018):467-474

Calorimetrically Determined U(VI) Toxicity in Brassica napus Correlates with Oxidoreductase Activity and U(VI) Speciation Sachs S, Geipel G, Bok F, Oertel J, Fahmy K. Environmental Science & Technology 51(2017):10843-10849

Dipolar Relaxation Dynamics at the Active Site of an ATPase Regulated by Membrane Lateral Pressure Fischermeier, E, Pospíšil, P, Sayed, A, Hof, M, Solioz, M, Fahmy, K. Angewandte Chemie International Edition 56(2017):1269-1272

The Molecular Switching Mechanism at the Conserved D(E)RY Motif in Class-A GPCRs Sandoval A, Eichler S, Madathil S, Reeves PJ, Fahmy K, Böckmann RA. Biophys J. 2016 Jul 12;111(1):79-89. doi: 10.1016/j.bpj.2016.06.004.

 Analysis of self-assembly of S-layer protein slp-B53 from Lysinibacillus sphaericus Liu J, Falke S, Drobot B, Oberthuer D, Kikhney A, Guenther T, Fahmy K, Svergun D, Betzel C, Raff J. Eur Biophys J. 46(2017):77-89.

Anisotropic metal growth on phospholipid nanodiscs via lipid bilayer expansion Oertel J, Keller A, Prinz J, Schreiber B, Hübner , Kerbusch J, Bald I, Fahmy K. Scientific Reports 6, Article number: 26718 (2016) doi:10.1038/srep26718

Mechanism of attenuation of uranyl toxicity by glutathione in Lactococcus lactis Obeid MH, Oertel J, Solioz M, Fahmy K. Appl Environ Microbiol. 82(2016):3563-3571

Rational Structure-Based Rescaffolding Approach to De Novo Design of Interleukin 10 (IL-10) Receptor-1 Mimetics Ruiz-Gómez G, Hawkins JC, Philipp J, Künze G, Wodtke R, Löser R, Fahmy K, Pisabarro MT. PLoS One. 2016 Apr 28;11(4):e0154046. doi: 10.1371/journal.pone.0154046

The role of phospholipid headgroup composition and trehalose in the desiccation tolerance of Caenorhabditis elegans Abusharkh SE, Erkut C, Oertel J, Kurzchalia TV, Fahmy K. Langmuir. 2014 Nov 4;30(43):12897-906. doi: 10.1021/la502654j. Epub 2014 Oct 22.

Filament formation by metabolic enzymes is a specific adaptation to an advanced state of cellular starvation Petrovska I, Nüske E, Munder MC, Kulasegaran G, Malinovska L, Kroschwald S, Richter D, Fahmy K, Gibson K, Verbavatz JM, Alberti S. Elife. 2014 Apr 25. doi: 10.7554/eLife.02409. [Epub ahead of print]

Paramagnetic decoration of DNA origami nanostructures by Eu³⁺ coordination Opherden L, Oertel J, Barkleit A, Fahmy K, Keller A.Langmuir. 2014 Jul 15;30(27):8152-9. doi: 10.1021/la501112a. Epub 2014 Jul 2.

Formic acid interaction with the uranyl(VI) ion: structural and photochemical characterization Lucks C, Rossberg A, Tsushima S, Foerstendorf H, Fahmy K, Bernhard G. Dalton Trans. 42(2013):13584-13589

3D Profile-Based Approach to Proteome-Wide Discovery of Novel Human Chemokines Tomczak A, Sontheimer J, Drechsel D, Hausdorf R, Gentzel M, Shevchenko A, Eichler S, Fahmy K, Buchholz F, Pisabarro MT. PLoS ONE 7(2012): e36151. doi:10.1371/journal.pone.0036151

"yl"-Oxygen Exchange in Uranyl(VI) Ion: A Mechanism Involving (UO2)(2)(mu-OH)(2)(2+) via U-O-yl-U Bridge Formation Tsushima S. Inorg Chem 51(2012):1434-1439

How worms survive desiccation: Trehalose pro water Erkut C, Penkov S, Fahmy K, Kurzchalia T. Worm 1(2012):1-4

Trehalose Renders the Dauer Larva of Caenorhabditis elegans Resistant to Extreme Desiccation Erkut C, Penkov S, Khesbak H, Vorkel D, Verbavatz JM, Fahmy K, Kurzchalia TV. Curr Biol. 21(2011):1331-6

On the "yl" bond weakening in uranyl(VI) coordination complexes Tsushima S. Dalton Transactions 40 (2011):6732-6737

The Role of Water H-Bond Imbalances in B-DNA Substate Transitions and Peptide Recognition Revealed by Time-Resolved FTIR Spectroscopy Khesbak H, Savchuk O, Tsushima S, Fahmy K. J Am Chem Soc 133(2011):5834-42

Eu(3+)-Mediated Polymerization of Benzenetetracarboxylic Acid Studied by Spectroscopy, Temperature-Dependent Calorimetry, and Density Functional Theory Barkleit A, Tsushima S, Savchuk O, Philipp J, Heim K, Acker M, Taut S, Fahmy K. Inorg Chem 50(2011):5451-9

Aqueous coordination chemistry and photochemistry of uranyl(VI) oxalate revisited: a density functional theory study Tsushima, S.; Brendler, V.; Fahmy, K. Dalton Transactions 39(2010): 10953-8

Photoluminescence of uranium(VI): quenching mechanism and role of uranium(V) Tsushima, S.; Götz, C.; Fahmy, K. Chemistry - A European Journal 16(2010)27, 8029-33

Heterologous expression of the surface-layer-like protein SllB induces the formation of long filaments of Escherichia coli consisting of protein-stabilized outer membrane Lederer FL, Günther TJ, Flemming K, Raff J, Fahmy K, Springer A, Pollmann K. Microbiology. 156 (2010):3584-95

Lipid protein interactions couple protonation to conformation in a conserved cytosolic domain of G-protein-coupled receptors Madathil S, Fahmy K. J Biol Chem 284(2009):28801-9

Secondary structure and compliance of a predicted flexible domain in kinesin-1 necessary for cooperation of motors Crevenna AH, Madathil S, Cohen DN, Wagenbach M, Fahmy K, Howard J. Biophys J. 2008 Dec;95(11):5216-27

Flavonoids affect actin functions in cytoplasm and nucleus Böhl M, Tietze S, Sokoll A, Madathil S, Pfennig F, Apostolakis J, Fahmy K, Gutzeit HO. Biophys J (2007) 93:2767-80

Synthesis and biological evaluation of a new type of 99mtechnetium-labeled Fatty Acid for myocardial metabolism imaging Walther M, Jung CM, Bergmann R, Pietzsch J, Rode K, Fahmy K, Mirtschink P, Stehr S, Heintz A, Wunderlich G, Kraus W, Pietzsch HJ, Kropp J, Deussen A, Spies H. Bioconjug Chem (2007) 18:216-30

Secondary structure and Pd(II) coordination in S-layer proteins from Bacillus sphaericus studied by infrared and X-ray absorption spectroscopy Fahmy K, Merroun M, Pollmann K, Raff J, Savchuk O, Hennig C, Selenska-Pobell S. Biophys J (2006) 91:996-1007

Structure and pH sensitivity of the transmembrane segment 3 of rhodopsin Madathil S, Furlinski G, Fahmy K. Biopolymers (2006) 82:329-33

Metal binding by bacteria from uranium mining waste piles and its technological applications Pollmann K, Raff J, Merroun M, Fahmy K, Selenska-Pobell S. Biotechnol Adv (2006) 24:58-68

Conserved high affinity ligand binding and membrane association in the native and refolded extracellular domain of the human glycine receptor alpha1-subunit Breitinger U, Breitinger HG, Bauer F, Fahmy K, Glockenhammer D, Becker CM. J Biol Chem (2004) 279:1627-36

FTIR- and fluorescence-spectroscopic analyses of receptor G-protein coupling in photoreception Fahmy, K. Cur Org Chem (2002) 6:1259-1284. Review.

FT-IR-ATR-spectroscopy: Characterisation of the association / dissociation of a G-protein-receptor complex. Fahmy, K. Boese, M. BRUKER Report 148/2000, ISSN 0724-0185

Suramin affects coupling of rhodopsin to transducin Lehmann N, Krishna Aradhyam G, Fahmy K. Biophys J (2002) 82:793-802

Receptor-dependent G-protein activation in lipidic cubic phase Navarro J, Landau EM, Fahmy K. Biopolymers (2002) 67:167-77

Drugs against cancer and molecules that make us see Fahmy, K., Lehmann, N. G.I.T. Laboratory J (2001) 5:171-173

Application of ATR-FTIR-spectroscopy for studies of molecular interactions Fahmy, K. Recent Research Developments in Biophysical Chemistry. Vol 2, Transworld Research Network, 2001, 1-17. Review.

Transducin-dependent protonation of glutamic acid 134 in rhodopsin. Fahmy K, Sakmar TP, Siebert F. Biochemistry (2000) 39:10607-12

Structural determinants of active state conformation of rhodopsin: molecular biophysics approaches. Fahmy K, Sakmar TP, Siebert F. Methods Enzymol (2000) 315:178-96

Photoactivated state of rhodopsin and how it can form. Fahmy K, Siebert F, Sakmar TP. Biophys Chem (1995) 56:171-81. Review.

Properties and photoactivity of rhodopsin mutants. Sakmar, T.P., Fahmy, K. Isr J Chem (1995) 35:325-337

A conserved carboxylic acid group mediates light-dependent proton uptake and signaling by rhodopsin. Arnis S, Fahmy K, Hofmann KP, Sakmar TP. J Biol Chem (1994) 269:23879-81

Identification of the proton acceptor of Schiff base deprotonation in bacteriorhodopsin: an FTIR study on the mutant Asp85-> Glu in its natural lipid environment. Fahmy, K., O. Weidlich, M. Engelhard, J. Tittor, D. Oesterhelt, & F. Siebert. Photochem Photobiol (1992) 56:1073-1083

The photoreaction of the deionized form of the purple membrane investigated by FTIR difference spectroscopy. Fahmy, K., & F. Siebert. Photochem Photobiol (1990) 51 459-64

The photoisomerization of bacteriorhodopsin studied by FTIR linear dichroism and photoselection experiments combined with quantum chemical theoretical analysis. Fahmy, K., M. F. Großjean, F. Siebert, & P. Tavan J Mol Struct (1998) 214:257-88