Nicole Seifert
Personnel Affairs
Phone: +49 351 260 2083
Fax: +49 351 260 12083

More Information


Eye catcher

For any questions, do not hesitate to ask:
Prof. Dr. Anna Dubrovska
Prof. Dr. Mechthild Krause Tel.: +49 351 458 2095,
Dr. Nicole Klein Tel.: +49 351 458 7440

Place of work:

Working hours:
19,5 h/week

15 April 2019

Online application
English / German
Job-Id: 21/2019 (792)

The HZDR is committed to equal opportunity employment and we strongly encourage applications from qualified female candidates. We also carefully consider all applications from job candidates with severe disabilities.

Bautzner Landstraße 400
01328 Dresden

PhD Student (m/f/d) in the field of translational biomedicine

A member of the Helmholtz Association of German Research Centers, the HZDR employs about 1,100 people. The Center's focus is on interdisciplinary research in the areas energy, health, and matter.

At the Institute of Radiooncology – OncoRay scientists specializing in medicine, physics, biology and IT work together to crucially improve the treatment of cancer by administering radiation therapy that is biologically personilized and technically optimizied.

As part of the Institute, the Department of Radiobiology, invites applications as PhD Student (m/f/d) in the field of translational biomedicine.

The position will be available as soon as possible and is embedded in a joint project between two groups with a strong experience in radiation biology and radiation oncology. The employment contract is limited to three years. The weekly working time will be total 50% of the regular weekly working time according to the collective agreement TVöD.


  • We invite applications for a PhD Student (m/f/d) highly motivated to work in the field of translational bio-medicine to identify cancer-specific metabolic pathways that can be employed as new biomarkers for radiotherapy and potential targets for tumor radiosensitization.
  • Our groups are working on identifying tumor biomarkers for radiation oncology which can be used to aid cancer prognosis and treatment. Biomarkers that are deregulated in cancer stem cells (CSC) are of special interest because they may be used to predict treatment outcome and serve as potential targets for cancer therapy. This PhD project aims:
    • to validate the role of distinct metabolic pathways in radioresistance and tumorigenic capacity of prostate cancer cells
    • to develop new experimental radiosensitizing therapy for the most essential metabolic regulators
    • to analyze the impact of the distinct metabolic signatures on response of cancer patients to radiotherapy
  • This project will employ different in vitro models including established radioresistant cell lines, primary cell cultures as well as tumor xenograft models and tissue microarray analysis.


  • strong interest in tumor biology and translational radiooncology
  • very good university degree (Master/Diploma) in biology, biochemistry, biotechnology, molecular medicine or related fields
  • experience in molecular and cell biology techniques
  • high motivation to work in ambitious, multi-disciplinary and international research group
  • ability to work independently, as part of a team and in collaboration with others
  • strong problem-solving skills and creative thinking
  • experience in working with laboratory animals (mice) is desirable but not essential
  • fluency in spoken and written English

We offer:

  • interesting and motivating workplace
  • arranging for flexible working hours to find a balance between work and family life
  • participating in job-oriented educational courses

Kindly submit your completed application (including cover letter, CV, diplomas/transcripts, reference letters etc.) by 15 April 2019 only via Online application (English / German).