For any questions, do not hesitate to ask:
Dr. Kristof Zarschler Tel.: +49 351 260 3678,
+49 351 260 2651
Place of work:
28 October 2021
The HZDR is committed to equal opportunity employment and we strongly encourage applications from qualified female candidates. We also carefully consider all applications from job candidates with severe disabilities.
Bautzner Landstraße 400
PostDoc (f/m/d) Functionalization, radiolabeling and characterization of complex protein assemblies
As a member of the Helmholtz Association of German Research Centers, the HZDR employs about 1,400 people. The Center's focus is on interdisciplinary research in the areas energy, health and matter.
At the Institute of Radiopharmaceutical Cancer Research scientists from the fields of physics, chemistry, biology, pharmacy, immunology, medicine and IT develop innovative radiopharmaceuticals and novel tools for functional characterization, improved imaging and personalized treatment of tumors.
As part of the Institute, the Department of Radionuclide Theragnostics invites applications as PostDoc (f/m/d) Functionalization, radiolabeling and characterization of complex protein assemblies.
The position will be available from 1 January 2022. The employment contract is limited to two years.
The successful candidate (f/m/d) will work on an interdisciplinary European project as part of a well-established radiopharmaceutical science research team and the responsibilities will include, but are not limited to:
- Carry out cutting-edge research in the areas of radiochemistry, biology and biochemistry with particular focus on the modification and characterization of protein assemblies and nanoparticle-protein complexes
- Propose, evaluate, interpret and validate appropriate radiolabeling protocols for complex protein assemblies
- Investigate and evaluate the stability and functionality of radiolabeled molecules in vitro by cell binding and uptake studies
- Perform experiments in a state-of-the-art radiochemistry laboratory infrastructure, deploy novel technologies and collaborate with internal and external partners to promote the project
- Quality control and quantification of radioconjugates by Radio High Performance Liquid Chromatography (Radio-HPLC), Radio Thin Layer Chromatography (Radio-TLC) and Size Exclusion Chromatography (SEC) in the radiochemistry lab environment
- Implement radiation safety regulations (e.g. trainings, dosimetry, release of radioactive waste)
- Analyze experimental data and communicate the results in work in progress reports, international conferences and publications in academic and peer-reviewed journals
- Supervise students and apply for third-party funding
- PhD degree in Biology, Biochemistry, Pharmaceutical or Radiopharmaceutical Sciences or a related field
- Practical experience in (Radio-)Biology, (Radio-)Pharmaceutical Sciences as well as bioconjugation, protein modification and purification
- Expertise in the functionalization and radiolabeling of biomolecules as well as experience in evaluating protein-cell interactions are desirable
- Hands-on experience with unsealed radioactive substances
- Extensive cell culture practice
- Demonstrated scientific productivity
- Excellent written and oral communication skills (English and German)
- Reliable team player, with very good organization skills
- A vibrant research community in an open, diverse and international work environment
- Scientific excellence and extensive professional networking opportunities
- The employment contract is limited to two years
- Salary and social benefits in conformity with the provisions of the Collective Agreement TVöD-Bund
- 30 days of paid holiday leave
- Company pension scheme (VBL)
- A good work/life balance for which we offer assistance in the form of:
Possibility to work part-time
Flexible working hours
In-house health management
Kindly submit your completed application (including cover letter, CV, diplomas/transcripts, etc.) only via our Online-application-system.