Radiobiology of ultra-high dose rates

Radiobiology of ultra-high dose rates / Strahlenbiologie ultra-hoher Dosisleistungen

The project "Radiobiology of ultra-high dose rates" focusses on the investigation of radiobiological effects of radiation delivered at dose rates that exceed clinical dose delivery by several orders of magnitude. In close cooperation with the research groups of the Oncoray - National Center for Radiation Research in Oncology, especially the group of Laser-Radiooncology the group performed radiobiological studies in vitro and in vivo to understand the biological action of ultra-high dose rate irradiation.

For experiments, the different accelerators assembled under the “Dresden platform for high dose-rate radiobiology”.

Dresden Platform for high dose-rate radiobiology: Assembling of the different accelelerators available for radiobiological research. On the one side, the clinical accelerators, Linac´s and the proton cyclotron of the University Proton Therapy Dresden (bue) tha offer established methods and protocols for dosimetry and beam delivery and serve as reference radiation sources. On the other side, the research accelerators ELBE and Draco (red) that provide electron and proton beam parameters beyond the clinical range. Whereas the latter are applied for radiobiological research of high dose-rate effects, the clinical machines serves for radiation therapy and as reference for new radiation regimes.

Contact: Dr. Elke Beyreuther

Publications:

2023

Horst F, Brand M, Hans S, Karsch, L, Lessmann E, Löck S, Schürer M, Pawelke J, Beyreuther e (2023) In regard to Böhlen et al. Zebrafish Embryo Model of the FLASH Effect. International Journal of Radiation Oncology, Biology, Physics 115.4, 1006-1007.

2022

Kroll F, Brack FE, Bernert C, Bock S, Bodenstein E, Brüchner K, Cowan TE, Gaus L, Gebhardt R, Helbig U, Karsch L, Kluge T, Kraft S, Krause M, Lessmann E, Masood U, Meister S, Metzkes-Ng J, Nossula A, Pawelke J, Pietzsch J, Püschel T, Reimold M, Rehwald M, Richter C, Schlenvoigt HP, Schramm U, Umlandt MEP, Ziegler T, Zeil K, Beyreuther E (2022) Nature Physics 18, 316-22

Jansen J, Beyreuther E, García-Calderón D, Karsch L, Knoll J, Pawelke J, Schürer M, Seco J (2022) Changes in Radical Levels as a Cause for the FLASH effect: Impact of beam structure parameters at ultra-high dose rates on oxygen depletion in water. Radiotherapy and Oncology 175, 193-19

Karsch L, Pawelke J, Brand M, Hans S, Hideghéty K, Jansen J, Lessmann E, Löck S, Schürer M, Schurig R, Seco J, Szabó ER, Beyreuther E (2022) Beam pulse structure and dose rate as determinants for the flash effect observed in zebrafish embryo. Radiotherapy and Oncology 173, 49-54

2021

Pawelke J, Brand M, Hans S, Hideghéty K, Karsch L, Lessmann E, Löck S, Schürer M, Szabó ER, Beyreuther E (2021) Electron dose rate and oxygen depletion protect zebrafish embryos from radiation damage. Radiotherapy and Oncology.

Jansen J, Knoll J, Beyreuther E, Pawelke J, Skuza R, Hanley R, Brons S, Pagliari F, Seco J (2021) Does FLASH deplete Oxygen? Experimental Evaluation for Photons, Protons and Carbon Ions. Medical Physics

Suckert T, Beyreuther E, Müller J, Azadegan B, Meinhardt M, Raschke F, Bodenstein E, von Neubeck C, Lühr A, Krause M, Dietrich A (2021) Late side effects in normal mouse brain tissue after proton irradiation. Frontiers in Oncology.

doi: 10.3389/fonc.2020.598360

2020

Görte J, Beyreuther E, Danen EJH, Cordes N (2020) Comparative proton and photon irradiation combined with pharmacological inhibitors in 3D pancreatic cancer tumoroids. Cancers 2020, 12(11), 3216. doi: 10.3390/cancers12113216

Brunner S, Tőkés T, Szabó ER, Polanek R, Szabó IZ, Reisz Z, Konczné Gubán B, Szijártó AL, Brand M, Hans S, Karsch L, Leßmann E, Pawelke J, Schürer M, Beyreuther E and Hideghéty K (2020) Dose-Dependent Changes after Proton and Photon Irradiation in Zebrafish Model. Anticancer Res 2020, 40(11) 6123-6135. doi: 10.21873/anticanres.14633

Suckert T, Müller J, Beyreuther E, Azadegan B, Brüggemann A, Bütof R, Dietrich A, Gotz M, Haase R, Schürer M, Tillner F, von Neubeck C, Krause M, Lühr A (2020) High-precision image-guided proton irradiation of mouse brain sub-volumes. Radiother Oncol 146 (2020): 205-12. DOI: 10.1016/j.radonc.2020.02.023

Brack FE, Kroll F, Gaus L, Bernert C, Beyreuther E, Cowan TE, Karsch L, Kraft S, Kunz-Schughart LA, Lessmann E, Metzkes-Ng J, Obst-Hübl L, Pawelke J, Rehwald M, Schlenvoigt HP, Schramm U, Sobiella M, Szabó ER, Ziegler T, Zeil K (2020) Spectral and spatial shaping of laser-driven proton beams using a pulseded high-field magnet beamline. Sci Rep 10 (2020): 9118
DOI: 10.1038/s41598-020-65775-7

Müller J, Schürer M, Neubert C, Tillner F, Beyreuther E, Suckert T, Peters N, von Neubeck C, Lühr A, Krause M, Bütof R, Dietrich A (2020) Multi-modality bedding platform for combined imaging and irradiation of mice. Biomed Phys Eng Express 6 (2020): 037003. DOI: 10.1088/2057-1976/ab79f1

Dombrowsky AC, Burger K, Porth AK, Stein M, Dierolf M, Günther B, Achterhold K, Gleich B, Feuchtinger A, Bartzsch S, Beyreuther E, Combs SE, Pfeiffer F, Wilkens JJ, Schmid TE (2020) A proof of principle experiment for microbeam radiation therapy at the Munich compact light source. Radiat Environ Biophys 59(1) (2020): 111-120. DOI: 10.1007/s00411-019-00816-y

Suckert T, Rassamegevanon T, Müller J, Dietrich A, Graja A, Reiche M, Löck S, Krause M, Beyreuther E, von Neubeck C (2020) Applying Tissue Slice Culture in Cancer Research – Insights from Preclinical Proton Radiotherapy. Cancers 2020, 12(6), 1589
DOI: 10.3390/cancers12061589

2019

Beyreuther E, Brand M, Hans S, Hideghety K, Karsch L, Lessmann E, Schuerer M, Szabó ER, Pawelke J (2019) Feasibility of proton FLASH effect tested by zebrafish embryo irradiation. Radiother Oncol 139 (2019):46-50. doi: 10.1016/j.radonc.2019.06.024

Karsch L, Beyreuther E, Eger Passos D, Pawelke J, Löck S (2020) Analysing tumour growth delay data from animal irradiation experiments with deviations from the prescribed dose. Cancers (Basel) 11(9) (2019): E1281.
DOI: 10.3390/cancers11091281