Research Interest   -   Selected Publications
Work Experience

Current Research Interest

Synthesis of novel neuroreceptor ligands in view of a radiolabelling with PET nuclides (18F, 11C).

  • Main focus on vesicular acetylcholin transporter (VAChT) and serotonin transporter (SERT)
  • Restriction of conformational flexibility in order to improve receptor binding properties

Diastereoselective approaches to monocyclic or ring-fused piperazin-2-ones and morpholin-3-ones

  • Formation of heteroatom–carbon bonds via ring-opening of strained electrophiles (oxiranes, aziridines, thiolactones)
  • Cyclic pseudopeptides; Synthesis of natural products

Development of radiolabelling methods applying readily available 18F labelled precursors

  • Use of 4-[18F]fluorobenzaldehyde for “one-pot/one-step” reductive etherification
  • Use of 4-[18F]fluoronitrobenzene for “one-pot/two-step” reductive amination

Selected Publications


  • M. Scheunemann, D. Sorger, E. Kouznetsova, O. Sabri, R. Schliebs, B. Wenzel, J. Steinbach Sequential ring-opening of trans-1,4-cyclohexadiene dioxide for an expedient modular approach to 6,7-disubstituted (±)-hexahydro-benzo[1,4]oxazin-3-ones. Tetrahedron Lett. 2007, 48, 5497-5501.
  • A. Hoepping, M. Scheunemann, S. Fischer, W. Deuther-Conrad, A. Hiller, F. Wegner, M. Dieker, J. Steinbach, P. Brust Radiosynthesis and biological evaluation of an 18F-labeled derivative of the novel pyrazolopyrimidine sedative–hypnotic agent indiplon. Nucl. Med. Biol. 2007, 34, 559-570.


  • U. Funke, H.-M. Jia, S. Fischer, M. Scheunemann, J. Steinbach One-step reductive etherification of 4-[18F]fluoro-benzaldehyde with decaborane. J. Lab. Comp. Radiopharm. 2006, 49, 745-755.


  • H.-M. Jia, D.-C. Fang, M. Scheunemann Theoretical studies on reductive etherification reactions between aromatic aldehydes and alcohols. J. Org. Chem. 2005, 70, 4478-4483.


  • M. Scheunemann, D. Sorger, B. Wenzel, K. Heinitz, R. Schliebs, M. Klingner, O. Sabri, J. Steinbach Synthesis of novel 4- and 5-substituted benzyl ether derivatives of vesamicol and in vitro evaluation of their binding properties to the vesicular acetylcholine transporter site. Bioorg. Med. Chem. 2004, 12, 1459-1465.
  • R. Bergmann, M. Scheunemann, C. Heichert, P. Mäding, H. Wittrisch, M. Kretzschmar, H. Rodig, D. Tourwe, K. Iterbeke, K. Chavatte, D. Zips, J. C. Reubi, B. Johannsen Biodistribution and catabolism of 18F-labeled neurotensin(8 –13) analogs. Nucl. Med. Biol. 2002, 29, 61-72.
  • M. Patt, D. Sorger, M. Scheunemann, G. Stöcklin Adduct of 2-[18F]FDG and 2-nitroimidazole as a putative radiotracer for the detection of hypoxia with PET: Synthesis, in vitro- and in vivo-characterization. Appl. Rad. Isot. 2002, 57, 705-712.
  • R. Bergmann,P. Brust, M. Scheunemann, H.-J. Pietzsch, S. Seifert, F. Roux, B. Johannsen, Assessment of the in vitro and in vivo properties of a 99mTc-labeled inhibitor of the multidrug resistant gene product P-glycoprotein. Nucl. Med. Biol. 2000, 27, 135-141.

Before 2000

  • H.-J. Pietzsch, M. Scheunemann, M. Kretzschmar, S. Elz, H. H. Pertz, S. Seifert, P. Brust,H. Spies, R. Syhre, B. Johannsen Synthesis and autoradiographic evaluation of a novel high-affinity Tc-99m ligand for the 5-HT2A receptor, Nucl. Med. Biol, 1999, 26, 865-875.
  • M. Scheunemann, B. Johannsen A simple and efficient synthesis of a derivatized pseudotripeptide containing a methylene thioether isostere and its use for the design of bifunctional rhenium and technetium chelating agents. Tetrahedron Lett, 1997, 38, 1371-1372.
  • J. Martens, M. Scheunemann EPC-Synthese von Verruculotoxin. Tetrahedron Lett. 1991, 32, 1417-1418.

Ausbildung und Praxis

Institution Period Location
Institute of Interdisciplinary Isotope Research, Leipzig; Senior Scientist; (Head: Prof. G. Stöcklin, Prof. J. Steinbach [since 06/2001]) 06/2000 - present Leipzig,Germany
Research Center Rossendorf, Institute of Bioinorganic and Radiopharmaceutical Chemistry; Department PET-Radiotracer; Research Assisitant; (Head: Dr. PD. J. Steinbach) 07/1998 – 05/2000 Dresden,Germany
Research Center Rossendorf, Institute of Bioinorganic and Radiopharmaceutical Chemistry; Department SPECT-Radiotracer; Research Assisitant; (Head: Dr. PD. H. Spies) 07/1993 - 06/1998 Dresden,Germany
Carl von Ossietzky University of Oldenburg, Department of Organic Chemistry; PhD Student; (Head: Prof. J. Martens) 07/1988 - 08/1992 Oldenburg,Germany