Contact

Prof. Dr. Mechthild Krause
Director Institute of Radiooncology - OncoRay
Director, Institute of Radiooncology - Oncoray
m.krauseAthzdr.de
Phone: +49 351 4585441
Fax: +49 351 4585716

Prof. Dr. Nils Cordes
Head Radiobiology
n.cordesAthzdr.de
Phone: +49 351 4587401
Fax: +49 351 4585716

Prof. Dr. Wolfgang Enghardt
Head Medical Radiation Physics

Phone: +49 351 260 - 3653, +49 351 458 7411
Fax: +49 351 260 - 13653, +49 351 458 5716

Prof. Dr. Esther Gera Cornelia Troost
Head Image-guided Radiooncology
e.troostAthzdr.de
Phone: +49 351 458 2394
Fax: +49 351 458 5716

Departments

Translational Radiooncology and Clinical Radiotherapy, Professor Mechthild Krause Comparison Proton- and Photon-Therapy

  • Research into combination therapies, e.g. radiotherapy and targeted drugs (pre-clinical and clinical)
  • Research into biomarkers with the help of which it is possible to predict the success of radiation treatment and tailor the therapy to the individual patient
  • Comparative studies of the effectiveness of classic radiotherapy using photons with proton therapy
  • In-vivo experiments on combined therapies and biological personalization using innovative imaging methods
  • Development of statistical models to predict the success of radiation therapy

Figure: Comparison of proton therapy with classic radiotherapy using ultra hard x-ray beams (photons); comparably good irradiation of the brain tumor (red and yellow areas), less impact on the surrounding healthy tissue with proton therapy @Baumann et al., Nature Review Cancer 16:234, 2016


Radiobiology, Professor Nils Cordes Radiobiologie: Tumor cells

  • Investigation of target molecules that are responsible for radioresistance in tumor cells and development of strategies to inhibit these molecules
  • Research into biomarkers for cancer stem cells to predict the success of radiotherapy and be able to offer patients personalized therapy
  • Investigation of the micro environment in tumor tissue as well as potential regulatory intervention to reduce resistance to therapies

Figure: Left: Survival of tumor cells in 3D matrix after combined treatment with radiation and molecular drugs. Right: immunofluorescence of integrins in tumor cells; transcriptome and proteome analyses in tumor cells after treatment.


Medical Radiation Physics, Professor Wolfgang Enghardt Slit camera

  • Technological optimization of proton therapy, including laser-accelerated particle therapy, and the use of modern imaging techniques for therapy planning and monitoring
  • Modelling of treatment effects for the personalized selection of patients for particle therapy and differing beam quality
  • Precision measurement of the proton beam range in a patient during treatment
  • Image-guided, high-precision radiation technology for experimental radiotherapy using a small animal model

Figure: Initial measurement of the proton beam range with a prompt gamma camera during patient treatment. http://www.sciencedirect.com/science/article/pii/S0167814016000074


Image Guided High Precision Radiotherapy, Professor Esther Troost PET-MRT

  • Investigation of three- and four-dimensional imaging techniques for high-precision radiotherapy in moving tumors
  • Research into methods of compensating movement in moving tumors (radiation while holding breath, use of an abdominal corset)
  • Development of methods to predict the occurrence and extent of the finest tumor extensions and research into new dosage strategies based on these methods
  • Use of MRI for the objective representation of normal tissue damage

Combined PET-MRI full-body scanner at Carl Gustav Carus University Hospital Dresden: Magnetic resonance imaging (MRI) and positron emission tomography (PET) are two different imaging techniques which allow anatomical, structural and metabolic changes in the tissue under observation to be visualized. @NCT Dresden/Philip Benjamin


Contact

Prof. Dr. Mechthild Krause
Director Institute of Radiooncology - OncoRay
Director, Institute of Radiooncology - Oncoray
m.krauseAthzdr.de
Phone: +49 351 4585441
Fax: +49 351 4585716

Prof. Dr. Nils Cordes
Head Radiobiology
n.cordesAthzdr.de
Phone: +49 351 4587401
Fax: +49 351 4585716

Prof. Dr. Wolfgang Enghardt
Head Medical Radiation Physics

Phone: +49 351 260 - 3653, +49 351 458 7411
Fax: +49 351 260 - 13653, +49 351 458 5716

Prof. Dr. Esther Gera Cornelia Troost
Head Image-guided Radiooncology
e.troostAthzdr.de
Phone: +49 351 458 2394
Fax: +49 351 458 5716