Contact

Dr. Astrid Barkleit

a.barkleitAthzdr.de
Phone: +49 351 260 3136
+49 351 260 2512
+49 351 260 2518

Speciation and transfer of radionuclides in the human organism especially taking into account decorporation agents (RADEKOR)


Financed by:
Federal Ministry of Education and Research (grant number 02NUK057A)
Funding period:
2020/07/01 – 2023/12/31
Cooperation Partner:
HZDR, Institute of Resource Ecology (coordinator)
Technische Universität Dresden, Central Radionuclide Laboratory (TUD)
Leibniz Universität Hannover, Institute of Radioecology and Radiation Protection (LUH)
VKTA – Radiation Protection, Analytics & Disposal (VKTA)
Karlsruhe Institute of Technology, Safety and Environment (KIT)
People:
Astrid Barkleit (joint project coordinator), Sebastian Friedrich (Ph.D. student) & Daniel Butscher (Ph.D. student)

Summary

In case radionuclides (RN) enter the food chain and are incorporated by humans, they pose a possible health risk due to their radio- and chemotoxicity. To precisely assess the health risk after oral incorporation of RN with food and beverages and to apply effective decontamination methods, it is mandatory to understand the processes of RN biokinetics on both cellular and molecular scale. Within the planned joint research project, quantitative excretion analysis and biokinetic modeling of orally incorporated RN are combined with molecular speciation studies of RN in the alimentary tract of humans in the absence and presence of decorporation agents. Aim of the joint research project is to expand the knowledge of processes underlying RN interactions within the human alimentary tract on a cellular and molecular scale to establish a precise biokinetic model as well as to contribute to the development and improvement of nuclide specific decontamination methods.

RADEKOR image ©Copyright: Dr. Barkleit, Astrid

Foto: Astrid Barkleit

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The part of HZDR is to investigate experimentally the speciation of trivalent lanthanides and actinides (Ln(III)/An(III)) as well as uranium in model fluids of the alimentary tract in the absence and presence of decorporation agents by spectroscopic methods and to calculate the speciation by thermodynamic modeling.

Selected Publications

2023

RADEKOR - Speziation und Transfer von Radionukliden im Menschen unter besonderer Berücksichtigung von Dekorporationsmitteln

Barkleit, A.

  • Lecture (Conference)
    KERNthemen2023 - Impulse. Kompetenzen. Projekte, 03.-04.05.2023, Dresden, Deutschland

Influence of EDTA and EGTA on the Eu(III)/Cm(III) speciation in the human digestive system

Friedrich, S.; Kretzschmar, J.; Drobot, B.; Stumpf, T.; Barkleit, A.

  • Lecture (Conference)
    7th International Conference on Environmental Radioactivity (ENVIRA 2023), 17.-22.09.2023, Sevilla, España

Influence of Eu(III) and U(VI) on rat and human kidney cells

Butscher, D.; Senwitz, C.; Heller, A.; Stumpf, T.; Barkleit, A.

  • Lecture (Conference)
    7th International Conference on Environmental Radioactivity (ENVIRA), 17.-22.09.2023, Seville, España

Eu(III) and Cm(III) Complexation by the Aminocarboxylates NTA, EDTA, and EGTA Studied with NMR, TRLFS, and ITC – An Improved Approach to More Robust Thermodynamics

Friedrich, S.; Sieber, C.; Drobot, B.; Tsushima, S.; Barkleit, A.; Schmeide, K.; Stumpf, T.; Kretzschmar, J.


2022

NMR spectroscopy of selected aqueous systems investigated at HZDR–IRE

Kretzschmar, J.; Stumpf, T.

Related publications

  • Lecture (Conference)
    Actinides revisited 2022, 21.-23.09.2022, Dresden, Deutschland

Complexation of Eu(III) and Cm(III) by EGTA related aminopolycarboxylic acids

Friedrich, S.; Kretzschmar, J.; Drobot, B.; Stumpf, T.; Barkleit, A.

  • Open Access Logo Lecture (Conference)
    ATAS-AnXAS 2022 - Joint Workshop, 17.-21.10.2022, Grenoble, France

Complexation of Eu(III) and Cm(III) by EGTA related aminopolycarboxylic acids

Friedrich, S.; Holtmann, L.; Kretzschmar, J.; Drobot, B.; Stumpf, T.; Barkleit, A.

  • Poster
    Actinides revisited 2022, 21.-23.09.2022, Dresden, Deutschland

Investigation of the interaction of uranium(VI) with the biofluids of the human digestive system

Butscher, D.; Steudtner, R.; Stumpf, T.; Barkleit, A.

  • Lecture (Conference)
    ATAS-AnXAS workshop 2022, 17.-21.10.2022, Grenoble, Frankreich

Untersuchung der Wechselwirkung von Uran(VI) mit den Biofluiden des menschlichen Verdauungssystems sowie mit Nierenzellen

Butscher, D.; Senwitz, C.; Steudtner, R.; Heller, A.; Stumpf, T.; Barkleit, A.

  • Poster
    Jahrestagung der Fachgruppe Nuklearchemie 2022, 04.-06.10.2022, Bergisch Gladbach, Deutschland

RADEKOR: Speciation and transfer of radionuclides in the human organism especially taking into account decorporation agents – a joint project

Barkleit, A.; Heller, A.; Walther, C.; Walther, D.; Raskob, W.

  • Poster
    5th International Conference on Radioecology & Environmental Radioactivity (ICRER), 04.-09.09.2022, Oslo, Norway

Complexation of Eu(III) in artificial digestive media by aminopolycarboxylic acid EGTA

Friedrich, S.; Holtmann, L.; Kretzschmar, J.; Barkleit, A.; Stumpf, T.

  • Open Access Logo Lecture (Conference)
    19th Radiochemical Conference, 15.-20.05.2022, Marienbad, Tschechien

Spectroscopic investigation of the speciation of uranium(VI) in the biofluids of the human digestive system

Butscher, D.; Barkleit, A.; Stumpf, T.

  • Lecture (Conference)
    RadChem 2022 / 19th Radiochemical Conference, 15.-20.05.2022, Marianske Lazne, Czech Republic

Speciation and transfer of radionuclides in the human organism especially taking into account decorporation agents (RADEKOR) – a joint project

Barkleit, A.; Heller, A.; Walther, C.; Walther, D.; Raskob, W.

  • Contribution to proceedings
    19th Radiochemical Conference RadChem, 15.-20.05.2022, Marianske Lazne, Czech Republic
  • Poster
    19th Radiochemical Conference RadChem, 15.-20.05.2022, Marianske Lazne, Czech Republic

Internal type of HZDR-publication(s): Thesis / Students' report
"Online First" included
Search title/ authors: ("Zilbermann, M. E.")

Comparative structural and (radio-)chemical investigations of activated cement and concrete samples

Zilbermann, M. E.

To help with the decommissioning of the unit 2 of the Greifswald NPP, this study aims at determining the activities of 3H, 14C, 60Co, 152Eu and 154Eu in the concrete to estimate the maximal activity in the entire bioshield.
The study will focus on the activity as a function of depth in the concrete layer, as well as composition of the mineral phases. As the flux of neutrons generated during fission reaction encounters the mineral phases of concrete, the natural elements present in these phases absorb neutrons, which leads to the formation of their radioactive isotopes. Therefore, the elemental composition of each mineral phase in the concrete is important in the activation process, and the concrete being a heterogeneous material, different phases will present different activities.
A precise knowledge of the activities and of the elemental composition of the concrete and its mineral phases helps refining the models to calculate and predict the activities in a long-term scale. The calculations and the experimental results support the sorting of the materials for disposal.
This study will analyze the concrete with three main objectives:

  • Activation;
  • Chemical composition;
  • Structure of the concrete and mineral phases.
  • Master thesis
    TU Dresden, 2023
    Mentor: Prof. Dr. Thorsten Stumpf, Dr. Astrid Barkleit