Contact
Dr. Astrid Barkleit
a.barkleit
hzdr.de
Phone: +49 351 260 3136
+49 351 260 2512
+49 351 260 2518
Social Media
Speciation and transfer of radionuclides in the human organism especially taking into account decorporation agents (RADEKOR)
Technische Universität Dresden, Central Radionuclide Laboratory (TUD)
Leibniz Universität Hannover, Institute of Radioecology and Radiation Protection (LUH)
VKTA – Radiation Protection, Analytics & Disposal (VKTA)
Karlsruhe Institute of Technology, Safety and Environment (KIT)
Summary
In case radionuclides (RN) enter the food chain and are incorporated by humans, they pose a possible health risk due to their radio- and chemotoxicity. To precisely assess the health risk after oral incorporation of RN with food and beverages and to apply effective decontamination methods, it is mandatory to understand the processes of RN biokinetics on both cellular and molecular scale. Within the joint research project, quantitative excretion analysis and biokinetic modeling of orally incorporated RN are combined with molecular speciation studies of RN in the alimentary tract of humans in the absence and presence of decorporation agents. Aim of the joint research project is to expand the knowledge of processes underlying RN interactions within the human alimentary tract on a cellular and molecular scale to establish a precise biokinetic model as well as to contribute to the development and improvement of nuclide specific decontamination methods.
Foto: Astrid Barkleit
The part of HZDR is to investigate experimentally the speciation of trivalent lanthanides and actinides (Ln(III)/An(III)) as well as uranium in model fluids of the alimentary tract in the absence and presence of decorporation agents by spectroscopic methods and to calculate the speciation by thermodynamic modeling.
Selected Publications
2024
Effect of decorporation agents on the speciation of lanthanides and actinides in artificial biofluids of the human digestive system
Barkleit, A.; Friedrich, S.; Butscher, D.; Kretzschmar, J.; Drobot, B.; Stumpf, T.
-
Lecture (Conference)
10th International Conference on Nuclear and Radiochemistry (NRC), 25.-30.08.2024, Brighton, United Kingdom
Effect of Ba(II), Eu(III), and U(VI) on rat NRK-52E and human HEK-293 kidney cells in vitro
Senwitz, C.; Butscher, D.; Holtmann, L.; Vogel, M.; Steudtner, R.; Drobot, B.; Stumpf, T.; Barkleit, A.; Heller, A.
-
Science of the Total Environment 923(2024), 171374-171394
DOI: 10.1016/j.scitotenv.2024.171374
2023
Eu(III) and Cm(III) Complexation by the Aminocarboxylates NTA, EDTA, and EGTA Studied with NMR, TRLFS, and ITC – An Improved Approach to More Robust Thermodynamics
Friedrich, S.; Sieber, C.; Drobot, B.; Tsushima, S.; Barkleit, A.; Schmeide, K.; Stumpf, T.; Kretzschmar, J.
-
Molecules 28(2023)12, 4881
DOI: 10.3390/molecules28124881
Cited 5 times in Scopus
2022
NMR spectroscopy of selected aqueous systems investigated at HZDR–IRE
Related publications
-
Dimeric and Trimeric Uranyl(VI)–Citrate Complexes in Aqueous Solution
ROBIS: 28980 is referenced by this (Id 35617) publication -
Uranium(VI) Complexes of Glutathione Disulfide Forming in Aqueous Solution
ROBIS: 28981 is referenced by this (Id 35617) publication -
Network-like arrangement of mixed-valence uranium oxide nanoparticles after …
ROBIS: 22173 is referenced by this (Id 35617) publication -
Trimeric uranyl(VI)–citrate forms Na+, Ca2+, and …
ROBIS: 31389 is referenced by this (Id 35617) publication -
2-Phosphonobutane-1,2,4,-Tricarboxylic Acid (PBTC): pH-Dependent Behavior …
ROBIS: 34485 is referenced by this (Id 35617) publication
-
Lecture (Conference)
Actinides revisited 2022, 21.-23.09.2022, Dresden, Deutschland
Untersuchung der Wechselwirkung von Uran(VI) mit den Biofluiden des menschlichen Verdauungssystems sowie mit Nierenzellen
Butscher, D.; Senwitz, C.; Steudtner, R.; Heller, A.; Stumpf, T.; Barkleit, A.
-
Poster
Jahrestagung der Fachgruppe Nuklearchemie 2022, 04.-06.10.2022, Bergisch Gladbach, Deutschland
RADEKOR: Speciation and transfer of radionuclides in the human organism especially taking into account decorporation agents – a joint project
Barkleit, A.; Heller, A.; Walther, C.; Walther, D.; Raskob, W.
-
Poster
5th International Conference on Radioecology & Environmental Radioactivity (ICRER), 04.-09.09.2022, Oslo, Norway
Speciation and transfer of radionuclides in the human organism especially taking into account decorporation agents (RADEKOR) – a joint project
Barkleit, A.; Heller, A.; Walther, C.; Walther, D.; Raskob, W.
-
Contribution to proceedings
19th Radiochemical Conference RadChem, 15.-20.05.2022, Marianske Lazne, Czech Republic -
Poster
19th Radiochemical Conference RadChem, 15.-20.05.2022, Marianske Lazne, Czech Republic
