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Dr. Astrid Barkleit

a.barkleitAthzdr.de
Phone: +49 351 260 3136
+49 351 260 2512
+49 351 260 2518

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Speciation and transfer of radionuclides in the human organism especially taking into account decorporation agents (RADEKOR)

Financed by:
Federal Ministry of Education and Research (grant number 02NUK057A)
Funding period:
2020/07/01 – 2024/08/31
Cooperation Partner:
HZDR, Institute of Resource Ecology (coordinator)
Technische Universität Dresden, Central Radionuclide Laboratory (TUD)
Leibniz Universität Hannover, Institute of Radioecology and Radiation Protection (LUH)
VKTA – Radiation Protection, Analytics & Disposal (VKTA)
Karlsruhe Institute of Technology, Safety and Environment (KIT)
People:
Astrid Barkleit (joint project coordinator), Sebastian Friedrich (Ph.D. student) & Daniel Butscher (Ph.D. student)

Summary

In case radionuclides (RN) enter the food chain and are incorporated by humans, they pose a possible health risk due to their radio- and chemotoxicity. To precisely assess the health risk after oral incorporation of RN with food and beverages and to apply effective decontamination methods, it is mandatory to understand the processes of RN biokinetics on both cellular and molecular scale. Within the joint research project, quantitative excretion analysis and biokinetic modeling of orally incorporated RN are combined with molecular speciation studies of RN in the alimentary tract of humans in the absence and presence of decorporation agents. Aim of the joint research project is to expand the knowledge of processes underlying RN interactions within the human alimentary tract on a cellular and molecular scale to establish a precise biokinetic model as well as to contribute to the development and improvement of nuclide specific decontamination methods.

RADEKOR image ©Copyright: Dr. Barkleit, Astrid

Foto: Astrid Barkleit

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The part of HZDR is to investigate experimentally the speciation of trivalent lanthanides and actinides (Ln(III)/An(III)) as well as uranium in model fluids of the alimentary tract in the absence and presence of decorporation agents by spectroscopic methods and to calculate the speciation by thermodynamic modeling.

Selected Publications

2025

Data publication: In vitro bioaccessibility and speciation of toxic and nutritional trace elements in Brazil nuts

Barkleit, A.; Eum, J.; Walther, D.; Butscher, D.; Friedrich, S.; Müller, K.; Kretzschmar, J.

Related publications

Data publication: Efficacy of various complexing agents for displacing biologically important ligands from Eu(III) and Cm(III) complexes in artificial body fluids – an in vitro decorporation study

Friedrich, S.; Drobot, B.; Müller, K.; Stumpf, T.; Kretzschmar, J.; Barkleit, A.

Related publications

In Vitro Bioaccessibility and Speciation of Toxic and Nutritional Trace Elements in Brazil Nuts

Barkleit, A.; Eum, J.; Walther, D.; Butscher, D.; Friedrich, S.; Müller, K.; Kretzschmar, J.

Related publications

Efficacy of various complexing agents for displacing biologically important ligands from Eu(III) and Cm(III) complexes in artificial body fluids – an in vitro decorporation study

Friedrich, S.; Barberon, A.; Shamoun, A.; Drobot, B.; Müller, K.; Stumpf, T.; Kretzschmar, J.; Barkleit, A.

Related publications

Lanthanide Complexes of Aminopolycarboxylates Reveal Deuteration of Aminoacetate Carbons In Alkaline Aqueous Media

Friedrich, S.; Waurick, L.; Drobot, B.; Steudtner, R.; Müller, K.; Barkleit, A.; Stumpf, T.; Kretzschmar, J.

Data publication: Synthesis of nonadentate ligand diethylene glycol-bis(3-aminopropyl ether)-N,N,N′,N′-tetraacetic acid DEGTA and its complexation behavior towards trivalent lanthanides and actinides

Friedrich, S.; Näder, A.; Drobot, B.; Kretzschmar, J.; Stumpf, T.; Barkleit, A.

Related publications

BMBF-Verbundprojekt RADEKOR: Speziation und Transfer von Radionukliden im Menschen unter besonderer Berücksichtigung von Dekorporationsmitteln. Teilprojekt A

Barkleit, A.

Synthesis of nonadentate ligand diethylene glycol-bis(3-aminopropyl ether)-N,N,N′,N′-tetraacetic acid DEGTA and its complexation behavior towards trivalent lanthanides and actinides

Friedrich, S.; Näder, A.; Drobot, B.; Kretzschmar, J.; Stumpf, T.; Barkleit, A.

Related publications

2024

RADEKOR: Speciation and Transfer of Radionuclides (RN) in the Human Organism Especially Taking into Account Decorporation Agents (DA) – a Joint Project, Part II

Heller, A.; Senwitz, C.; Acker, M.; Taut, S.; Stumpf, T.; Barkleit, A.

  • Poster
    Jahrestagung der Fachgruppe Nuklearchemie 2024, 05.-07.11.2024, Karlsruhe, Deutschland

RADEKOR: Speciation and Transfer of Radionuclides (RN) in the Human Organism Especially Taking into Account Decorporation Agents (DA) – a Joint Project, Part I

Barkleit, A.; Friedrich, S.; Butscher, D.; Kretzschmar, J.; Stumpf, T.; Heller, A.

  • Poster
    Jahrestagung der Fachgruppe Nuklearchemie 2024, 05.-07.11.2024, Karlsruhe, Deutschland

Influence of chelating agents on lanthanide and actinide speciation in artificial bodyfluids

Barkleit, A.; Friedrich, S.; Butscher, D.; Kretzschmar, J.; Drobot, B.; Steudtner, R.; Stumpf, T.

  • Lecture (Conference)
    ATAS-AnXAS, 07.-11.10.2024, Karlsruhe, Deutschland

Effect of decorporation agents on the speciation of lanthanides and actinides in artificial biofluids of the human digestive system

Barkleit, A.; Friedrich, S.; Butscher, D.; Kretzschmar, J.; Drobot, B.; Stumpf, T.

  • Lecture (Conference)
    10th International Conference on Nuclear and Radiochemistry (NRC), 25.-30.08.2024, Brighton, United Kingdom

Effect of Ba(II), Eu(III), and U(VI) on rat NRK-52E and human HEK-293 kidney cells in vitro

Senwitz, C.; Butscher, D.; Holtmann, L.; Vogel, M.; Steudtner, R.; Drobot, B.; Stumpf, T.; Barkleit, A.; Heller, A.

2023

RADEKOR - Speziation und Transfer von Radionukliden im Menschen unter besonderer Berücksichtigung von Dekorporationsmitteln

Barkleit, A.

  • Lecture (Conference)
    KERNthemen2023 - Impulse. Kompetenzen. Projekte, 03.-04.05.2023, Dresden, Deutschland

Influence of EDTA and EGTA on the Eu(III)/Cm(III) speciation in the human digestive system

Friedrich, S.; Kretzschmar, J.; Drobot, B.; Stumpf, T.; Barkleit, A.

  • Lecture (Conference)
    7th International Conference on Environmental Radioactivity (ENVIRA 2023), 17.-22.09.2023, Sevilla, España

Influence of Eu(III) and U(VI) on rat and human kidney cells

Butscher, D.; Senwitz, C.; Heller, A.; Stumpf, T.; Barkleit, A.

  • Lecture (Conference)
    7th International Conference on Environmental Radioactivity (ENVIRA), 17.-22.09.2023, Seville, España

Eu(III) and Cm(III) Complexation by the Aminocarboxylates NTA, EDTA, and EGTA Studied with NMR, TRLFS, and ITC – An Improved Approach to More Robust Thermodynamics

Friedrich, S.; Sieber, C.; Drobot, B.; Tsushima, S.; Barkleit, A.; Schmeide, K.; Stumpf, T.; Kretzschmar, J.

2022

NMR spectroscopy of selected aqueous systems investigated at HZDR–IRE

Kretzschmar, J.; Stumpf, T.

Related publications

  • Lecture (Conference)
    Actinides revisited 2022, 21.-23.09.2022, Dresden, Deutschland

Complexation of Eu(III) and Cm(III) by EGTA related aminopolycarboxylic acids

Friedrich, S.; Kretzschmar, J.; Drobot, B.; Stumpf, T.; Barkleit, A.

  • Open Access Logo Lecture (Conference)
    ATAS-AnXAS 2022 - Joint Workshop, 17.-21.10.2022, Grenoble, France

Complexation of Eu(III) and Cm(III) by EGTA related aminopolycarboxylic acids

Friedrich, S.; Holtmann, L.; Kretzschmar, J.; Drobot, B.; Stumpf, T.; Barkleit, A.

  • Poster
    Actinides revisited 2022, 21.-23.09.2022, Dresden, Deutschland

Investigation of the interaction of uranium(VI) with the biofluids of the human digestive system

Butscher, D.; Steudtner, R.; Stumpf, T.; Barkleit, A.

  • Lecture (Conference)
    ATAS-AnXAS workshop 2022, 17.-21.10.2022, Grenoble, Frankreich

Untersuchung der Wechselwirkung von Uran(VI) mit den Biofluiden des menschlichen Verdauungssystems sowie mit Nierenzellen

Butscher, D.; Senwitz, C.; Steudtner, R.; Heller, A.; Stumpf, T.; Barkleit, A.

  • Poster
    Jahrestagung der Fachgruppe Nuklearchemie 2022, 04.-06.10.2022, Bergisch Gladbach, Deutschland

RADEKOR: Speciation and transfer of radionuclides in the human organism especially taking into account decorporation agents – a joint project

Barkleit, A.; Heller, A.; Walther, C.; Walther, D.; Raskob, W.

  • Poster
    5th International Conference on Radioecology & Environmental Radioactivity (ICRER), 04.-09.09.2022, Oslo, Norway

Complexation of Eu(III) in artificial digestive media by aminopolycarboxylic acid EGTA

Friedrich, S.; Holtmann, L.; Kretzschmar, J.; Barkleit, A.; Stumpf, T.

  • Open Access Logo Lecture (Conference)
    19th Radiochemical Conference, 15.-20.05.2022, Marienbad, Tschechien

Spectroscopic investigation of the speciation of uranium(VI) in the biofluids of the human digestive system

Butscher, D.; Barkleit, A.; Stumpf, T.

  • Lecture (Conference)
    RadChem 2022 / 19th Radiochemical Conference, 15.-20.05.2022, Marianske Lazne, Czech Republic

Speciation and transfer of radionuclides in the human organism especially taking into account decorporation agents (RADEKOR) – a joint project

Barkleit, A.; Heller, A.; Walther, C.; Walther, D.; Raskob, W.

  • Contribution to proceedings
    19th Radiochemical Conference RadChem, 15.-20.05.2022, Marianske Lazne, Czech Republic
  • Poster
    19th Radiochemical Conference RadChem, 15.-20.05.2022, Marianske Lazne, Czech Republic