Publications Repository - Helmholtz-Zentrum Dresden-Rossendorf
2 PublicationsCerebral Oxygen Metabolism Measurements with MRI in Adults with Sickle Cell Disease: PF742
Vaclavu, L.; Petersen, E.; Mutsaerts, H.; Petr, J.; Majoie, C.; Wood, J.; Vanbavel, E.; Nederveen, A.; Biemond, B.
MRI studies have demonstrated a high prevalence of silent cerebral infarcts (SCI) in both children and adults with sickle cell disease (SCD). SCI are associated with cognitive impairment and lesion progression in adults with SCD. Disrupted oxygen transport can contribute to cerebral ischemic lesions, despite the compensatory elevation in cerebral blood flow (CBF) in SCD. Investigating the cerebral metabolic rate of oxygen (CMRO2) may therefore give insight into the hemodynamic etiology of SCI in SCD patients. We hypothesized that CMRO2 is reduced in adult patients with SCD as a result of chronic anemia and that vasodilation can improve CMRO2 by generating an increase in blood and oxygen flow.
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Poster
24th Annual Congress of the European Hematology Association, 13.06.2019, Amsterdam, The Netherlands -
Contribution to proceedings
24th Annual Congress of the European Hematology Association, 13.06.2019, Amsterdam, The Netherlands
Hemasphere, 324-325
DOI: 10.1097/01.HS9.0000561252.50212.c6
Permalink: https://www.hzdr.de/publications/Publ-29373
Publ.-Id: 29373