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Title:
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FWP Institutskolloquium "AY27 cells / Fischer Rats - an orthotopic, immunocompetent bladder carcinoma model"
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Category:
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Colloquium
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Begin:
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22.03.2019 13:00
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End:
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22.03.2019 14:00
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Speaker:
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Prof. Dr. rer. nat. habil. Jochen Neuhaus,
Universität Leipzig, Klinik und Poliklinik für Urologie,
Leiter des Forschungslabors,
Gastprofessor an der "Shanghai University of Medicine and Health Sciences"
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Contact:
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Prof. Dr. P. Brust,
p.brust@hzdr.de
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Location:
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L9.3/216 - Bibliothek
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Content:
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Bladder cancer is the fifth leading cancer in Germany. About 30% of the cases are muscle invasive (MIBC) at first diagnosis, requiring radical cystectomy. The novel photosensitizer Tetrahydroporphyrin-Tetratosylate (THPTS) is excitable at near-infrared wavelength of 760nm) and may thus be suitable for Photodynamic Therapy (PDT) of MIBC up to 15 mm thickness. We tested the tumoricidal effect of THPTS-PDT in an orthotopic animal model, and explored cellular mechanisms of action in cultured cells. Single PDT of invasive bladder cancer led to a significant reduction of tumor size and pT-grade at 14 days after treatment. Apoptosis was the predominant modality of cell death. In addition, we found an immunostimulatory effect of THPTS-PDT in the rat model.
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