Event details

Title: FWP Institutskolloquium "AY27 cells / Fischer Rats - an orthotopic, immunocompetent bladder carcinoma model"
Category: Colloquium
Begin: 22.03.2019 13:00
End: 22.03.2019 14:00
Speaker: Prof. Dr. rer. nat. habil. Jochen Neuhaus, Universität Leipzig, Klinik und Poliklinik für Urologie, Leiter des Forschungslabors, Gastprofessor an der "Shanghai University of Medicine and Health Sciences"
Contact: Prof. Dr. P. Brust, p.brust@hzdr.de
Location: L9.3/216 - Bibliothek
Content: Bladder cancer is the fifth leading cancer in Germany. About 30% of the cases are muscle invasive (MIBC) at first diagnosis, requiring radical cystectomy. The novel photosensitizer Tetrahydroporphyrin-Tetratosylate (THPTS) is excitable at near-infrared wavelength of 760nm) and may thus be suitable for Photodynamic Therapy (PDT) of MIBC up to 15 mm thickness. We tested the tumoricidal effect of THPTS-PDT in an orthotopic animal model, and explored cellular mechanisms of action in cultured cells. Single PDT of invasive bladder cancer led to a significant reduction of tumor size and pT-grade at 14 days after treatment. Apoptosis was the predominant modality of cell death. In addition, we found an immunostimulatory effect of THPTS-PDT in the rat model.

Documents and links

FWP Ankündigung Kolloquium Prof. J. Neuhaus 220319 in Leipzig.pdf 282,1 kByte