Publications Repository - Helmholtz-Zentrum Dresden-Rossendorf

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33891 Publications

Microfocus X-ray tomography data set of boiling flow in vertical rod bundle with spacer grid at constant heat flux condition

Tas-Köhler, S.; Franz, R.; Boden, S.; Hampel, U.

The test section of the rod bundle experimental facility at HZDR consists of a vertically aligned PMMA channel with an upward flow of the working fluid. The cross-section of the channel is quadratic (inner edge length: 37 mm) and contains nine directly electrically heated rods (material: titanium-alloy, diameter: 10 mm, wall thickness: 0.3 mm) which are arranged in an orthogonal 3 by 3 matrix (rod axis distance: 12.8 mm). Circa 190 mm downstream of the start of the heating zone a 30 mm long spacer for the rods with tilted flow guiding vanes is mounted. These vanes are aimed to increase lateral flow velocities within the subchannels. Working fluid was octafluorocyclobutane (CAS 115-25-3, RC318). The experimental facility is comprehensively instrumented for measurement of flow, temperature and pressure/pressure difference. For non-invasive three-dimensional high-resolution measurement of a temporally averaged volumetric void fraction within the working fluid flowing around the heating rods in the subchannels an X-ray computer tomography measurement system was set up.
The presented dataset contains measurement data of the experimental facility's instrumentation and tomographic void fraction data of experiments with four different configurations of the flow guiding vanes (without vanes, 20°, 29°, 40°) for four different flow velocities between 0.4 m/s and 1.3 m/s at a heat flow density of 85.7 kW/m².


Keywords: X-Ray Computed Tomography; Phase fraction; Rod bundle; Boiling flow

  • Reseach data in the HZDR data repository RODARE
    Publication date: 2020-07-08
    DOI: 10.14278/rodare.378


Publ.-Id: 31307

Two types of alternating spin-1/2 chains and their field-induced transitions in ε-LiVOPO4

Mukharjee, P. K.; Ranjith, K. M.; Baenitz, M.; Scurschii, I.; Tsirlin, A. A.; Nath, R.

Thermodynamic properties, 31P nuclear magnetic resonance (NMR) measurements, and density-functional band-structure calculations for ε-LiVOPO4 are reported. This quantum magnet features a singlet ground state and comprises two types of alternating spin-1/2 chains that manifest themselves by the double maxima in the susceptibility and magnetic specific heat, and by the two-step magnetization process with an intermediate 1/2-plateau. From thermodynamic data and band-structure calculations, we estimate the leading couplings of J1 ≃ 20 K and J2 ≃ 60 K and the alternation ratios of α1 = J’1/J1 ≃ 0.6 and α2 = J’2/J2 ≃ 0.3 within the two chains, respectively. The zero-field spin gap Δ0/kB ≃ 7.3 K probed by thermodynamic and NMR measurements is caused by the J1-J’1 spin chains and can be closed in the applied field of μ0Hc1 ≃ 5.6 T, giving rise to a field-induced long-range order. The NMR data reveal predominant three-dimensional spin-spin correlations at low temperatures. Field-induced magnetic ordering transition observed above Hc1 is attributed to the Bose-Einstein condensation of triplons in the sublattice formed by the J1-J’1 chains with weaker exchange couplings.

Publ.-Id: 31303

Magnetization dynamics and mutual spin-pumping in SAFs

Sorokin, S.; Gallardo, R.; Fowley, C.; Lenz, K.; Titova, A.; Dennehy, G.; Atchenson, G.; Rode, K.; Faßbender, J.; Lindner, J.; Deac, A. M.

Primary data related to the publication in PRB: Article Link.  Pre-release version is available at: Arxiv, ResearchGate.


Some of the file are auxiliary or analisys files for faster display of the main results (like .opj, .ods files). Main raw data files are in the archives.



Keywords: Magnetization dynamics; Spin-pumping; SAFs, SAF; synthetic antiferromagnets; coupled magnetic trilayers; magnetic multilayers; ferromagnetic resonance; electrically-detected ferromagnetic resonance; FMR; ED-FMR; ST-FMR

Related publications
Magnetization dynamics in synthetic antiferromagnets: the … (Id 30089) is supplemented by this publication
  • Reseach data in the HZDR data repository RODARE
    Publication date: 2019-12-09
    DOI: 10.14278/rodare.390
    License: CC-BY-4.0


Publ.-Id: 31295

The influence of an applied magnetic field on the self-assembly of magnetic nanogels

Novikau, I. S.; Sanchez Romero, P. A.; Kantorovich, S. S.

Using Langevin dynamics simulations, we investigate the self-assembly of magnetic nanogels in the presence of applied magnetic fields of moderate strength. We find that even weak fields lead to drastic changes in the structure factors of both, the embedded magnetic nanoparticles and of whole nanogel particles. Nanogels assemble by uniting magnetic particle clusters forming inter-gel bridges. At zero field the average amount of such bridges for a pair of nanogels is close to one, whereas even for weak fields it fastly doubles. Rapid growth of cluster size at low values of the applied field is followed by a broad region of slow increase, caused by the mechanical constraints imposed the polymer matrix. The influence of the latter manifests itself in both, the slow growth of the magnetisation curve at intermediate fields and the slow decay of the total Zeeman energy.

Keywords: Magnetic nanogels; Self-assembly; Molecular dynamics

Publ.-Id: 31294

Diffusion of single active-dipolar cubes in applied fields

Kaiser, M.; Martinez, Y.; Schmidt, A. M.; Sanchez Romero, P. A.; Kantorovich, S. S.

“Active matter” refers to a class of out-of-equilibrium systems whose ability to transform environmental energy to kinetic energy is sought after in multiple fields of science and at very different length scales. At microscopic scales, an important challenge lies in overpowering the particles reorientation due to thermal fluctuations, especially in nano-sized systems, to create non-random, directed motion, needed for a wide range of possible applications. In this article, we employ molecular dynamics simulations to show that the diffusion of a self-propelling dipolar nanocube can be enhanced in a pre-defined direction with the help of a moderately strong applied magnetic field, overruling the effect of the thermal fluctuations. Furthermore, we show that the direction of diffusion is given by the orientation of the net internal magnetisation of the cube. This can be used to determine experimentally the latter in synthetically crafted active cobalt ferrite nanocubes.

Keywords: Active matter; Magnetic cubes; Molecular dynamics

Publ.-Id: 31293

Measuring FORCs diagrams in computer simulations as a mean to gain microscopic insight

Dobroserdova, A. B.; Sanchez Romero, P. A.; Shapochkin, V. E.; Smagin, D. A.; Zverev, V. S.; Odenbach, S.; Kantorovich, S. S.

FORCs (first-order reversal curves) diagrams prove to be an efficient experimental technique to investigate magnetic interactions in complex systems. In experiments, as a rule, it is difficult to relate actual microstructural changes to the evolution of FORCs diagrams. Here, using Molecular Dynamics simulations, we calculate FORCs for two simple models of a magnetic elastomer. The simplicity of these models allows to relate directly both, the rigidity of the matrix and the magnetoelastic coupling to the shape and intensity of FORCs diagrams.

Keywords: FORC Molecular dynamics; Magnetic elastomers; Magneto-elastic coupling

Publ.-Id: 31292

Unknotting of quasi-two-dimensional ferrogranular networks by in-plane homogeneous magnetic fields

Sanchez Romero, P. A.; Miller, J.; Kantorovich, S. S.; Richter, R.

Our ongoing research addresses, by means of experiments and computer simulations, the aggregation process that takes place in a shaken granular mixture of glass and magnetized ferrous alloy beads when the shaking amplitude is suddenly decreased. After this quenching, the magnetized beads form a transient network that coarsens in time into compact clusters, following a viscoelastic phase separation. Here we focus on the quasi-two-dimensional case, analyzing in computer simulations the effects of a magnetic field parallel to the system plane. Our results evidence that the field drastically changes the structure of the forming network: chains and elongated clusters parallel to the field are favored whereas perpendicular connecting structures tend to be suppressed, leading to the unknotting of the networks which are observed at zero field. Importantly, we found that moderate field strengths lead to the formation of larger clusters at intermediate time intervals than in the case of weak and strong fields. Moreover, the latter tend to limit the overall growth of the clusters at longer time scales. These results may be relevant in different systems governed by similar magnetically driven aggregation processes as, for example, in the formation of iron-rich planetesimals in protoplanetary discs or for magnetic separation systems.

Keywords: Ferrogranulate mixture; Field induced network unknotting; Susceptible dipolar hard spheres; Langevin dynamics simulations; Viscoelastic phase separation; Transient network

Publ.-Id: 31291

The influence of crosslinkers and magnetic particle>distribution along the filament backbone on the magnetic properties of supracolloidal linear polymer-like chains

Mostarac, D.; Vaughan, L.; Sanchez Romero, P. A.; Kantorovich, S. S.

Diverse polymer crosslinking techniques allow the synthesis of linear polymer-like structures whose monomers are colloidal particles. In the case where all or part of these colloidal particles are magnetic, one can control the behaviour of these supracolloidal polymers, known as magnetic filaments (MFs), by applied magnetic fields. However, the response of MFs strongly depends on the crosslinking procedure. In the present study, we employ Langevin dynamics simulations to investigate the influence of the type of crosslinking and the distribution of magnetic particles within MFs on their response to an external magnetic field. We found that if the rotation of the dipole moment of particles is not coupled to the backbone of the filament, the impact of the magnetic content is strongly decreased.

Keywords: Supracolloidal magnetic polymers; Magnetisation; Crosslinking methods; Langevin dynamics simulations

Publ.-Id: 31290

Itinerant metamagnetic transition in the ferromagnet LuCo3 induced by high field: Instability of the 3d-electron subsystem

Neznakhin, D. S.; Radzivonchik, D. I.; Gorbunov, D.; Andreev, A. V.; Sebek, J.; Lukoyanov, A. V.; Bartashevich, M. I.

LuCo3 is an itinerant ferromagnet whose magnetic properties strongly depend on the position of the 3d electronic states relative to the Fermi level. Here, we report on the magnetization of a LuCo3 single crystal in pulsed magnetic fields up to 58 T. We find a field-induced phase transition just below 50 T from a low-spin to a high-spin state. The transition shows a pronounced anisotropy of the magnetization jump and hysteresis. A series of ab initio calculations based on the density functional theory show that the transition is due to a significant change in the occupancies of the Co 3d electronic states. At the same time, some features in the majority spin density of the Co 3d states are slightly modified and pass through the Fermi level when the spin state is changed, which leads to the instability of the 3d-electron subsystem. Thereby, the applied magnetic field causes a significant redistribution in the majority and minority spin states in the Co 3d subsystem, which results in the sharp change in the magnetization.

Publ.-Id: 31284

Enhanced magnetocaloric effect in distilled terbium and emergence of novel properties after severe plastic deformation

Tereshina-Chitrova, E. A.; Korneeva, Y. V.; Ozherelkov, D. Y.; Dolezal, P.; Tereshina, I. S.; Kaminskaya, T. P.; Gorbunov, D.; Dobatkin, S. V.; Minarik, P.

We report the magneto-structural and magnetocaloric properties study of Tb purified by distillation and further processed by severe plastic deformation (SPD). Both parent and the SPD-processed Tb contain nanosized structural elements and have a very pronounced (00 l ) texture. We observe an improved magnetocaloric effect (MCE) in the distilled nanocrystalline Tb while novel properties emerge in the sample after severe plastic deformation. The latter demonstrates zero thermal expansion over a wide temperature range while its MCE vanishes. We show that the absolutely new physical properties in Tb result from the structural transformation and modification of magnetic interactions.

Publ.-Id: 31283

Intrinsic plasticity of silicon nanowire neurotransistors: plots of the figures 1-2

Baraban, L.

Data and Figures supporting the publication

Related publications
Intrinsic plasticity of silicon nanowire neurotransistors … (Id 31265) has used this publication of HZDR-primary research data
  • Reseach data in the HZDR data repository RODARE
    Publication date: 2020-07-01
    DOI: 10.14278/rodare.388
    License: CC-BY-4.0


Publ.-Id: 31280

Development and In Vivo Application of a Water-Soluble Anticancer Copper Ionophore System Using a Temperature-Sensitive Liposome Formulation

Gaál, A.; Garay, T. M.; Horváth, I.; Máthé, D.; Szöllösi, D.; Veres, D. S.; Mbuotidem, J.; Kovacs, T.; Tóvári, J.; Bergmann, R.; Streli, C.; Szakács, G.; Mihály, J.; Varga, Z.; Szoboszlai, N.

Liposomes containing copper and the copper ionophore neocuproine were prepared and characterized for in vitro and in vivo anticancer activity. Thermosensitive PEGylated liposomes were prepared with di_erent molar ratios of 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine (DPPC) and hydrogenated soybean phosphatidylcholine (HSPC) in the presence of copper(II) ions. Optimal, temperature dependent drug release was obtained at 70:30 DPPC to HSPC weight ratio. Neocuproine (applied at 0.2 mol to 1 mol phospholipid) was encapsulated through a pH gradient while using unbuffered solution at pH 4.5 inside the liposomes, and 100 mM HEPES bu_er pH 7.8 outside the liposomes. Copper ions were present in excess, yielding 0.5 mM copper-(neocuproine)2 complex and 0.5 mM free copper. Pre-heating to 45 °C increased the toxicity of the heat-sensitive liposomes in short-term in vitro experiments, whereas at 72 h all investigated liposomes exhibited similar in vitro toxicity to the copper(II)-neocuproine complex (1:1 ratio). Thermosensitive liposomes were found to be more effective in reducing tumor growth in BALB/c mice engrafted with C26 cancer cells, regardless of the mild hyperthermic treatment. Copper uptake of the tumor was verified by PET/CT imaging following treatment with [64Cu]Cu-neocuproine liposomes. Taken together, our results demonstrate the feasibility of targeting a copper nanotoxin that was encapsulated in thermosensitive liposomes containing an excess of copper.

Keywords: eocuproine; themosensitive liposomal formulation; mild hyperthermia; copper nanotoxin; MRPS; in vivo antitumor effect

Publ.-Id: 31278

Heisenberg limit for detecting vacuum birefringence

Ahmadiniaz, N.; Cowan, T.; Sauerbrey, R.; Schramm, U.; Schlenvoigt, H.-P.; Schützhold, R.

Quantum electrodynamics predicts the vacuum to behave as a nonlinear medium, including effects such as birefringence. However, for experimentally available field strengths, this vacuum polarizability is extremely small and thus very hard to measure. In analogy to the Heisenberg limit in quantum metrology, we study the minimum requirements for such a detection in a given strong field (the pump field). Using a laser pulse as the probe field, we find that its energy must exceed a certain threshold depending on the interaction time. However, a detection at that threshold, i.e., the Heisenberg limit, requires highly nonlinear measurement schemes--while for ordinary linear-optics schemes, the required energy (Poisson or shot noise limit) is much larger. Finally, we discuss several currently considered experimental scenarios from this point of view.

Keywords: Quantum Electrodynamics; Vacuum birefringence; Heisenberg limit


Publ.-Id: 31277

Status of the STM-FPGA-DAQ HLS-Cores for LaBr Peak Detection and Zero Suppression

Knodel, O.

Brief overview and status of the STM-FPGA-DAQ HLS-Cores for LaBr peak detection, moving window deconvolution and zero suppression

Keywords: Data Management; DAQ; FPGA; Mu2e

  • Invited lecture (Conferences) (Online presentation)
    Mu2e Collaboration Meeting, STM Workshop, 16.06.2020, Online, Online

Publ.-Id: 31275

Interprofessionelle Kooperation: Bedarf und Komplexizität bei prospektiv-nuklearmedizinischen Studien am Beispiel des DKTK-Multicenter-Trials mit [68Ga]Ga-PSMA-11

Zippel, C.; Neels, O.; Biedenstein, S.; Giesel, F. L.; Kopka, K.

Ziel/Aim: Um neue PET-Tracer in die Patientenversorgung überführen zu können, werden in der nuklearmedizinischen Forschung zunehmend prospektiv-klinische Studien mit den vielversprechendsten Radioliganden initiiert. Damit diese Studien möglichst effizient und effektiv durchgeführt werden können, bedarf es der möglichst engen Kooperation und Kommunikation von Expert*innen aus verschiedenen Berufsgruppen.

Methodik/Methods: Wir beleuchten am Beispiel der Multicenter-Studie „Ga-68-PSMA-11 in Hochrisiko-Prostatakrebs“ der Phasen-I/-II, welche wesentlichen Professionen aus forschender Klinik, Wirkstoffherstellung und Verwaltung bei der Planung, Vorbereitung und Durchführung prospektiv-nuklearmedizinischer Studien involviert sein können und welche Aufgaben diese zur Studienverwirklichung wahrnehmen. Darauf aufbauend leiten wir organisatorische Maßnahmen ab, durch die die interprofessionelle Kooperation bei prospektiven Bildgebungsstudien (auch über mehrere Prüfzentren) gefördert werden kann.

Ergebnisse/Results: In die Beispielstudie sind im engeren fachlichen Kreis Mediziner aus Nuklearmedizin/Urologie/Pathologie, MTA-Rs, Studienassistenten, Radiochemiker/-pharmazeuten, BTA/CTA, MTA und Gesundheits-/Krankenpfleger involviert. Im weiteren fachlichen Kreis sind ferner Strahlenschutzbeauftragte, Qualitätsmanager, klinische Monitore, Juristen, Datenschutzbeauftragte, Projektmanager und Studienkoordinatoren eingebunden, und dies jeweils an bis zu elf Prüfzentren in Deutschland, Österreich und der Schweiz.

Schlussfolgerungen/Conclusions: Interprofessionelle Kooperation ist für die Durchführung prospektiv-nuklearmedizinischer Studien essentiell. Hierzu bedarf es u.a. der grundlegenden Bereitschaft, sich in andere (Tätigkeits-)Rollen hineinzuversetzen und über Professionsgrenzen hinaus kooperieren zu wollen, ausreichend Zeit zum gegenseitigen Austausch, Fähigkeit/Fertigkeiten zum berufsübergreifenden Projektmanagement und eine integrale Betrachtung benötigter Expertisen mit Stärkung professionsübergreifender Kommunikation insbesondere über die Leitungsebene.

  • Lecture (Conference) (Online presentation)
    58. DGN-Jahrestagung 2020, 06.-09.07.2020, Leipzig, Deutschland
    DOI: 10.1055/s-0040-1708427

Publ.-Id: 31274

GMP Requirements for a Clinical Trial with 68Ga-PSMA-11 - Experience from a Multi-Centre Trial

Neels, O.

Without abstract

  • Invited lecture (Conferences)
    Annual Congress of the European Association of Nuclear Medicine, 15.-19.10.2016, Barcelona, Spanien
    DOI: 10.1007/s00259-016-3484-4

Publ.-Id: 31273

Molecular Imaging of Prostate Cancer: A direct comparison of the preclinical characteristics of [18F]DCFPyL and [18F]PSMA-1007 and the impact of glutamic acids on [18F]PSMA-1007

Roscher, M.; Remde, Y.; Schäfer, M.; Bauder-Wüst, U.; Giesel, F.; Neels, O.; Cardinale, J.; Kopka, K.

Aim: For the imaging of PSMA-positive prostate cancer, several fluorine-18 (18F)-labelled compounds have been developed and translated into the clinics. Next to a clinical study comparing the tracer-specific characteristics of [18F]DCFPyL and [18F]PSMA-1007 intra-individually(1), a direct comparison of their preclinical characteristics has only recently been published(2). In this work, the importance of glutamic acids in the structure of [18F]PSMA-1007 is further elucidated using derivatives with none to three glutamic acids (Glu), respectively. Furthermore, [18F]DCFPyL and [18F]PSMA-1007 are evaluated regarding their preclinical characteristics using the in vitro and in vivo methods established at DKFZ Heidelberg, Germany. Materials and Methods: The precursors for radiofluorination containing different amino acid linkers (0-3 Glu) were synthesized by means of solid phase chemistry. The radiolabeling of [18F]PSMA-1007, its derivatives, and [18F]DCFPyL were performed prior to each experiment as described(3,4). The binding affinities of non-radioactive reference compounds were determined by competitive binding assays against [68Ga]Ga-PSMA-10 in LNCaP cells. The internalization of the respective radioligands in LNCaP cells was compared. Biodistribution and pharmacokinetics were evaluated in vivo in LNCaP-tumor bearing BALB/c Nude mice using μPET. Results: The Glu variation in the linker structure resulted in similar binding affinities (Ki 3-14 nM) whereby the insertion of three Glu showed the highest Ki values. Internalization assays revealed that the insertion of Glu influences the internalization rate, whereby the insertion of two Glu ([18F]PSMA-1007) leads to the highest internalization rate (54.04±13.7%) in a total range between 27.3±3% to 54±13.7%. In comparison to [18F]PSMA-1007, a higher proportion of [18F]DCFPyL remains cell surface bound; only 27.83 ± 4.31% of the radiotracer is internalized. [18F]DCFPyL also has a slightly lower binding affinity (18.02±9.63 nM). μPET imaging showed outstanding imaging properties, especially of [18F]DCFPyL and [18F]PSMA-1007. In mice, the liver uptake is reduced by introduction of Glu linkers. The data will be analysed more detailed soon. Conclusion: Comparative cell experiments revealed a high binding affinity for all tracers and the highest internalization rate for [18F]PSMA-1007. The insertion of Glu in the linker structure plays an important role in pharmacokinetics due to the decreased lipophilicity of the respective radiotracer. Especially [18F]DCFPyL and [18F]PSMA-1007 are of excellent imaging quality. Their apparent non-inferiority is currently under further assessment in clinical trials. References: (1) Giesel F et al (2017): JNM, doi: 10.2967/jnumed.117.204669. (2) Robu S et al (2018): EJNMMI Res., 8(1):30. (3) Cardinale J et al. (2017): JNM, 58(3):425-431. (4) Chen Y et al. (2011): Clin Cancer Res., 17(24):7645-53.

  • Lecture (Conference)
    Annual Congress of the European Association of Nuclear Medicine, 13.-17.10.2018, Düsseldorf, Deutschland
    DOI: 10.1007/s00259-018-4148-3

Publ.-Id: 31272

Initiation Of A Prospective Clinical Multicentre Trial With Local Production Of A Short-Lived PSMA-PET Radiopharmaceutical In The D-A-CH-Region: Chances And Experiences

Neels, O.; Zippel, C.; Giesel, F. L.; Kopka, K.

Aim/Introduction: The development of innovative radiotracers targeting PSMA for non-invasive imaging of prostate cancer and successive treatment results in an increasing number of multicentre clinical trials using the most promising PSMA ligand candidates. For prospective studies with short-lived radiopharmaceuticals like [68Ga]Ga-PSMA-11, a regulatory and country-specific structure has to be established before recruitment of patients is possible. This structure allows the decentralized manufacturing of the investigational medicinal product (IMP) according to Good Manufacturing (GMP) and subsequent implementation of the respective tracer compliant with Good Clinical Practice (GCP). Materials and Methods: For the multicenter clinical trial (phases-I/-II) ,,Ga-68-PSMA-11 in high-risk prostate cancer“ (NCT03362359) within DKTK a harmonized decentralized radiotracer production in multiple radiopharmacies has been set up for the very first time in the German speaking Radiopharmacy/Nuclear Medicine Community. In this prospective clinical study Nuclear Medicine physicians, radiopharmacists, urologists, pathologists and study related experts like lawyers and study nurses out of eleven study sites within the so-called D-A-CH region (Germany-Austria-Switzerland) have been involved. The basis for the accurately specified radioactive IMP manufacturing procedure was defined by EU-GMP requirements plus national standards (e.g. Medicinal Products Act and Radiation Protection Law). Results: For the recruiting study sites the required allowances, e.g. manufacturing authorization from local authorities as well as approval from ethics committees and national regulatory bodies such as BfS and BfArM in Germany, BASG in Austria as well as BAG and Swissmedic in Switzerland, have been obtained. The challenge of manufacturing a short-lived radiopharmaceutical at each of the participating geographically different sites with identical specification by adaption of production and quality control processes and parameters according to the IMP dossier (IMPD) during the starting phase of the clinical trial under a centralized quality assurance management has been achieved. Conclusion: The initiation and establishment of a multicentre clinical trial including the manufacturing of a short-lived radiopharmaceutical IMP across local study sites is very complex, but manageable. In view of the high European and national regulatory and legal burdens and the number of involved partners it is feasible in a defined time frame. Based on the achieved structures, the decentralized manufacture of novel short-lived radiopharmaceuticals can be established in the D-A-CH region and even on a European level for further investigator initiated multicentre clinical trials. We estimate our experiences important for the development of the field Nuclear Medicine at the national and international level taking into account the new EU regulation No 536/2014. References: None.

  • Poster
    Annual Congress of the European Association of Nuclear Medicine, 12.-16.10.2019, Barcelona, Spanien
    DOI: 10.1007/s00259-019-04486-2

Publ.-Id: 31271

Too many regulations

Neels, O.

Without abstract

  • Invited lecture (Conferences)
    Annual Congress of the European Association of Nuclear Medicine, 12.-16.10.2019, Barcelona, Spanien
    DOI: 10.1007/s00259-019-04486-2

Publ.-Id: 31270

Supplmentary Video sets for the publication

Baraban, L.

6 supplementary videos

Related publications
Inverse Solidification Induced by Active Janus Particles (Id 31267) has used this publication of HZDR-primary research data
  • Reseach data in the HZDR data repository RODARE
    Publication date: 2020-06-29
    DOI: 10.14278/rodare.384
    License: CC-BY-4.0


Publ.-Id: 31268

Intrinsic plasticity of silicon nanowire neurotransistors for dynamic memory and learning functions

Baek, E.; Ranjan Das, N.; Vittorio Cannistraci, C.; Rim, T.; Santiago Cañón Bermúdez, G.; Nych, K.; Cho, H.; Kim, K.; Baek, C.-K.; Makarov, D.; Tetzlaff, R.; Chua, L.; Baraban, L.; Cuniberti, G.

Neuromorphic architectures merge learning and memory functions within a single unit cell and in a neuron-like fashion. Research in the field has been mainly focused on the plasticity of artificial synapses. However, the intrinsic plasticity of the neuronal membrane is also important in the implementation of neuromorphic information processing. Here we report a neurotransistor made from a silicon nanowire transistor coated by an ion-doped sol–gel silicate film that can emulate the intrinsic plasticity of the neuronal membrane. The neurotransistors are manufactured using a conventional complementary metal–oxide–semiconductor process on an 8-inch (200 mm) silicon-on-insulator wafer. Mobile ions allow the film to act as a pseudo-gate that generates memory and allows the neurotransistor to display plasticity. We show that multiple pulsed input signals of the neurotransistor are non-linearly processed by sigmoidal transformation into the output current, which resembles the functioning of a neuronal membrane. The output response is governed by the input signal history, which is stored as ionic states within the silicate film, and thereby provides the neurotransistor with learning capabilities.

Related publications
Intrinsic plasticity of silicon nanowire neurotransistors … (Id 31280) HZDR-primary research data are used by this publication

Publ.-Id: 31265

Nanosensors-Assisted Quantitative Analysis of Biochemical Processes in Droplets

Belyaev, D.; Schütt, J.; Ibarlucea, B.; Rim, T.; Baraban, L.; Cuniberti, G.

Here, we present a miniaturized lab-on-a-chip detecting system for an all-electric and label-free analysis of the emulsion droplets incorporating the nanoscopic silicon nanowires-based field-effect transistors (FETs). We specifically focus on the analysis of β-galactosidase activity, which is an important enzyme in the glycolysis metabolic pathway. Furthermore, the efficiency of the synthesis and action of β-galactosidase can be one of the markers for several diseases, eg., cancer, hyper/hypoglycemia, cell senescence, or other disruptions in cell functioning. We measure the reaction and reaction kinetics-associated shift of the source-to-drain current I sd in the system, which is caused by the change of the ionic strength of the microenvironment. With these results, we demonstrate that the ion-sensitive FETs are able to sense the interior of the aqueous reactors; thus, the conjunction of miniature nanosensors and droplet-based microfluidic systems conceptually opens a new route toward a sensitive, optics-less analysis of biochemical processes.

Publ.-Id: 31264

Experimental control of laser proton acceleration beyond 50 MeV

Ziegler, T.; Bernert, C.; Bock, S.; Brack, F.-E.; Cowan, T.; Garten, M.; Gaus, L.; Gebhardt, R.; Helbig, U.; Irman, A.; Kiriyama, H.; Kluge, T.; Kraft, S.; Kroll, F.; Metzkes-Ng, J.; Nishiuchi, M.; Obst-Hübl, L.; Püschel, T.; Rehwald, M.; Schlenvoigt, H.-P.; Schramm, U.; Zeil, K.

We report on the ongoing plasma accelerator development at the HZDR, moving from plasma-acceleration studies towards real plasma-accelerators that can be controlled and applied in the lab.
We show experimental investigations of proton acceleration from laser-irradiated solid foils with the DRACO PW laser, where highest proton cut-off energies were achieved for temporal pulse shape parameters well different from that of a Fourier transform limited (FTL) pulse. Controlled spectral phase modulation of the driver laser by means of an acousto-optic programmable dispersive filter enabled us to manipulate the temporal laser pulse shape and to study the effect on proton acceleration from thin foil targets. The results show that short and asymmetric pulses generated by positive third order dispersion values are favourable for proton acceleration and can lead to maximum energies of 60 MeV for thin plastic foils. Assuming appropriate control of the spectral phase of the laser and comparable temporal contrast conditions, we believe that the presented method can be universally applied to improve the proton acceleration performance using any other laser system operated in the PW regime.

  • Lecture (Conference) (Online presentation)
    6. Annual Matter and Technology Meeting, 17.-18.06.2020, Jülich, Deutschland

Publ.-Id: 31263

Synthesis, characterization and evaluation of 68Ga labelled monomeric and dimeric quinazoline derivatives of the HBED-CC chelator targeting the epidermal growth factor receptor

Liolios, C.; Shegani, A.; Roupa, I.; Kiritsis, C.; Makarem, A.; Paravatou-Petsotas, M.; Pelecanou, M.; Bouziotis, P.; Papadopoulos, M.; Kopka, K.; Pirmettis, I.

Tyrosine kinase (TK) receptors including epidermal growth factor receptors (EGFRs) are known to be overexpressed in a wide variety of solid tumors associated with poor prognosis. The HBED-CC chelator N,N′-bis[2-hydroxy-5-(carboxyethyl)benzyl]ethylenediamine-N,N′-diacetic acid 1 was coupled via one or both its propionic acid moieties with the quinazoline EGFR-TK inhibiting pharmacophore 4-amino-N-(4-((3-bromophenyl)amino)quinazolin-6-yl)butanamide 3 resulting in either a monomeric 4 or a dimeric 5 species. Ligands 4 and 5 reacted with Ga3+ generating the corresponding complexes Ga4 and Ga5. Both ligands and complexes were characterized with mass spectrometry and NMR spectroscopy and evaluated in vitro with MTT assays in A431 cells, where they showed IC50 values in the range 51.6 to 68.8 μM. Labeling of ligands 4 and 5 with the PET radionuclide 68Ga was quantitative and resulted in tracers [68Ga]Ga4 and [68Ga]Ga5 with radiochemical purities greater than 98%, which were also characterised by comparative RP-HPLC studies with Ga4 and Ga5 respectively. Radiotracers [68Ga]Ga4 and [68Ga]Ga5 were stable (in tact tracer over 98%) in the reaction mixture (120 min) and in human serum (30 min). Both tracers were evaluated in vivo with biodistribution experiments in SCID mice bearing A431 tumors presenting tumor uptake of 1.34 for [68Ga]Ga4 and 1.01 %ID/g for [68Ga]Ga5 at 5 min, which was slightly decreased at 60 min p.i. and then remained stable until 120 min p.i. To the best of our knowledge, this is the first report of monomeric and dimeric quinazoline conjugates with the chelator HBED-CC, which can serve as a basis for further development of EGFR-TKI targeting tracers.

Keywords: Epidermal growth factor tyrosine kinase (EGFR-TK); tyrosinekinase inhibitors (TKIs); Quinazoline Gallium complexes; 68Ga; HBED-CC

Publ.-Id: 31262

Fingerprinting mean composition of lithium polysulfide standard solutions by applying high energy resolution fluorescence detected X-ray Absorption Spectroscopy

Robba, A.; Barchasza, C.; Bučar, K.; Petric, M.; Žitnik, M.; Kvashnina, K.; Vaughan, G. B. M.; Bouchet, R.; Alloin, F.; Kavčič, M.

In a lithium/sulfur (Li/S) battery, the reduction of sulfur during discharge involves a particular mechanism, where the active material successively dissolves into the electrolyte to form lithium polysulfide intermediate species (Li2Sx), with x being a function of the state of charge. In this work, sulfur K-edge Resonant Inelastic X-ray Scattering measurements were performed for the characterization of different Li2Sx polysulfide standard solutions. High Energy Resolution Fluorescence Detected X-ray Absorption Spectroscopy allowed clear separation the pre-edge absorption peak corresponding to terminal sulfur atoms from the main absorption peak due to internal atoms, and to evaluate quantitatively the evolution of the peak area ratio as a function of the polysulfide chain length. Results of this experimental work demonstrate that the normalized area of the pre-edge is a reliable fingerprint of Li2Sx mean chain length in agreement with recent theoretical predictions. As a perspective, this work confirms that operando HERFD XAS can be used to differentiate mean polysulfide composition, which is key issue in the characterization of Li/S cells.


  • Secondary publication expected from 25.06.2021

Publ.-Id: 31259

Study of nanoscopic porosity in black metals by positron annihilation spectroscopy

Melikhova, O.; Cížek, J.; Hruška, P.; Liedke, M. O.; Butterling, M.; Wagner, A.; Novotný, M.; More-Chevalier, J.

Black and smooth Al films were characterized by the variable energy positron annihilation spectroscopy (VEPAS). It was found that in smooth films positronium (Ps) is formed on the surface only while in black metal films, it is formed also in nanoscopic pores inside the film. The mean pore size increases from the substrate to the surface due to increasing film roughness.

Keywords: positron annihilation spectroscopy; positron annihilation lifetime spectroscopy; black metals; Positronium

Publ.-Id: 31258

A secret luminescence killer in deepest QWs of InGaN/GaN multiple quantum well structures

Hospodková, A.; Hájek, F.; Pangrác, J.; Slavická Zíková, M.; Hubáček, T.; Kuldová, K.; Oswald, J.; Vaněka, T.; Vetushka, A.; Čížek, J.; Liedke, M. O.; Butterling, M.; Wagner, A.

This work suggests new alternative explanation why a single InGaN quantum well (QW) or the deepest QWs in the multiple quantum well (MQW) structures suffer with a high non-radiative recombination rate. According to SIMS results, positron annihilation spectroscopy and photoluminescence measurements we suggest that vacancy of Ga in complex with hydrogen atoms can play a dominant role in non-radiative Shockley-Read-Hall recombination of the deepest QWs in InGaN/GaN MQW structures. Vacancy of gallium originate dominantly in GaN buffer layers grown at higher temperatures in H2 atmosphere and are transported to the InGaN/GaN MQW region by diffusion, where they are very effectively trapped in InGaN layers and form complex defects with hydrogen atoms during epitaxy of InGaN layers. Trapping of gallium vacancies is another suggested mechanism explaining why the widely used In containing prelayers help to increase the luminescence efficiency of the InGaN/GaN MQW active region grown above them. Understanding the mechanism why the luminescence efficiency is suppressed in deeper QWs may be very important for LED community and can help to develop new improved technologies for the growth of InGaN/GaN MQW active region.

Keywords: positron annihilation spectroscopy; positron annihilation lifetime spectroscopy; quantum wells; InGaN; hydrogen complexes; GaN; vacancy

Publ.-Id: 31257

P1819 - Verfahren zur Herstellung eines keramischen Materials mit lokal einstellbarem Permeabilitätsgradienten, dessen Anwendung in einem Beschichtungsverfahren sowie dessen Verwendung

Bürger, D.; Krüger, S.; Skorupa, I.; Schmidt, H.; Du, N.

Die Erfindung betrifft ein Verfahren zur Herstellung eines keramischen Materials mit lokal einstellbarem Permeabilitätsgradienten, dessen Anwendung in einem Beschichtungsverfahren- Materialbearbeitungsverfahren sowie dessen Verwendung. Die Aufgabe ein Material zur Verfügung zu stellen, welches zum Leiten und Isolieren von Magnetfeldern geeignet ist sowie in magnetischen Kopplungselementen verwendet werden kann, wird durch ein Verfahren zur Herstellung eines keramischen Materials mit lokal einstellbarem Permeabilitätsgradienten gelöst, wobei das Verfahren folgende Schritte umfasst: - Erzeugen eines keramischen Materials mittels Erhitzen einer Ausgangsmaterialkomposition bis zu einer Temperatur unterhalb der Schmelztemperatur der Ausgangsmaterialkomposition, - Abkühlen des erzeugten keramischen Materials auf Raumtemperatur nach einer definierten Abkühlrate zur Einstellung einer Vortex-Dichte in dem erzeugten keramischen Material, und - nachfolgende lokale Temperaturbehandlung zum Erhitzen des keramischen Materials über dessen ferroelektrische Ordnungstemperatur und zum Einstellen des lokalen Permeabilitätsgradienten.

  • Patent
    DE102018125270 - Offenlegung 16.04.2020; Nachanmeldungen: WO

Publ.-Id: 31256

Boosting Room-Temperature Magneto-Ionics in a Non-Magnetic Oxide Semiconductor

de Rojas, J.; Quintana, A.; Lopeandía, A.; Salguero, J.; Costa-Krämer, J. L.; Abad, L.; Liedke, M. O.; Butterling, M.; Wagner, A.; Henderick, L.; Dendooven, J.; Detavernier, C.; Sort, J.; Menéndez, E.

Voltage control of magnetism through electric field-induced oxygen motion (magneto-ionics) could represent a significant breakthrough in the pursuit for new strategies to enhance energy efficiency in magnetically actuated devices. Boosting the induced changes in magnetization, magneto-ionic rates and cyclability continue to be key challenges to turn magneto-ionics into real applications. Here, it is demonstrated that room-temperature magneto-ionic effects in electrolyte-gated paramagnetic Co3O4 films can be largely increased both in terms of generated magnetization (6 times larger) and speed (35 times faster) if the electric field is applied using an electrochemical capacitor configuration (utilizing an underlying conducting buffer layer) instead of placing the electric contacts at the side of the semiconductor (electricdouble-layer transistor-like configuration). This is due to a greater uniformity and strength of the electric field in the capacitor design. These results are appealing to widen the use of ion migration in technological applications such as neuromorphic computing or iontronics in general.

Keywords: positron annihilation spectroscopy; Co3O4; Doppler broadening; ionic transport; magnetic switch; defects

Publ.-Id: 31255

Procedures for the GMP-Compliant Production and Quality Control of [18F]PSMA-1007: A Next Generation Radiofluorinated Tracer for the Detection of Prostate Cancer

Cardinale, J.; Martin, R.; Remde, Y.; Schäfer, M.; Hienzsch, A.; Hübner, S.; Zerges, A.-M.; Marx, H.; Hesse, R.; Weber, K.; Smits, R.; Hoepping, A.; Müller, M.; Neels, O.; Kopka, K.

Radiolabeled tracers targeting the prostate-specific membrane antigen (PSMA) have become important radiopharmaceuticals for the PET-imaging of prostate cancer. In this connection, we recently developed the fluorine-18-labelled PSMA-ligand [18F]PSMA-1007 as the next generation radiofluorinated Glu-ureido PSMA inhibitor after [18F]DCFPyL and [18F]DCFBC. Since radiosynthesis so far has been suffering from rather poor yields, novel procedures for the automated radiosyntheses of [18F]PSMA-1007 have been developed. We herein report on both the two-step and the novel one-step procedures, which have been performed on different commonly-used radiosynthesisers. Using the novel one-step procedure, the [18F]PSMA-1007 was produced in good radiochemical yields ranging from 25 to 80% and synthesis times of less than 55 min. Furthermore, upscaling to product activities up to 50 GBq per batch was successfully conducted. All batches passed quality control according to European Pharmacopoeia standards. Therefore, we were able to disclose a new, simple and, at the same time, high yielding production pathway for the next generation PSMA radioligand [18F]PSMA-1007. Actually, it turned out that the radiosynthesis is as easily realised as the well-known [18F]FDG synthesis and, thus, transferable to all currently-available radiosynthesisers. Using the new procedures, the clinical daily routine can be sustainably supported in-house even in larger hospitals by a single production batch.

Keywords: [18F]PSMA-1007; fluorine-18; PSMA; automation; prostate cancer; PET

Publ.-Id: 31252

Carbon ion radiotherapy: impact of tumor differentiation on local control in experimental prostate carcinomas

Glowa, C.; Peschke, P.; Brons, S.; Neels, O.; Kopka, K.; Debus, J.; Karger, C. P.

Background: To summarize the research activities of the “clinical research group heavy ion therapy”, funded by the German Research Foundation (DFG, KFO 214), on the impact of intrinsic tumor characteristics (grading, hypoxia) on local tumor control after carbon (12C-) ion- and photon irradiations. Methods: Three sublines of syngeneic rat prostate tumors (R3327) with various differentiation levels (highly (-H), moderately (-HI) or anaplastic (-AT1), (diameter 10 mm) were irradiated with 1, 2 and 6 fractions of either 12C-ions or 6 MV photons using increasing dose levels. Primary endpoint was local tumor control at 300 days. The relative biological effectiveness (RBE) of 12C-ions was calculated from TCD50-values (dose at 50% tumor control probability) of photons and 12C-ions and correlated with intrinsic tumor parameters. For the HI-subline, larger tumors (diameter 18 mm) were irradiated with either carbon ions, oxygen ions or photons under ambient as well as hypoxic conditions to determine the variability of the RBE under different oxygenation levels. In addition, imaging, histology and molecular analyses were performed to decipher the underlying mechanisms. Results: Experimental results revealed (i) a smaller variation of the TCD50-values between the three tumor sublines for 12C-ions (23.6 - 32.9 Gy) than for photons (38.2 - 75.7 Gy), (ii) steeper dose-response curves for 12C-ions, and (iii) an RBE that increased with tumor grading (1.62 ± 0.11 (H) vs 2.08 ± 0.13 (HI) vs 2.30 ± 0.08 (AT1)). Large HI-tumors resulted in a marked increase of TCD50, which was increased further by 15% under hypoxic relative to oxic conditions. Noninvasive imaging, histology and molecular analyses identified hypoxia as an important radioresistance factor in photon therapy. Conclusions: The dose-response studies revealed a higher efficacy of 12C-ions relative to photon therapy in the investigated syngeneic tumor model. Hypoxia turned out to be at least one important radioresistance factor, which can be partly overridden by high-LET ion beams. This might be used to increase treatment effectiveness also in patients. The results of this project served as a starting point for several ongoing research projects.

Keywords: Carbon ion radiotherapy; relative biological effectiveness (RBE); prostate tumor; hypoxia imaging

Publ.-Id: 31250

Diagnostic performance of 68Ga-PSMA-11 (HBED-CC) PET/CT in patients with recurrent prostate cancer: evaluation in 1007 patients

Afshar-Oromieh, A.; Holland-Letz, T.; Giesel, F. L.; Kratochwil, C.; Mier, W.; Haufe, S.; Debus, N.; Eder, M.; Eisenhut, M.; Schäfer, M.; Neels, O.; Hohenfellner, M.; Kopka, K.; Kauczor, H.-U.; Debus, J.; Haberkorn, U.

Purpose Since the clinical introduction of 68Ga-PSMA-11 PET/CT, this imaging method has rapidly spread and is now regarded as a significant step forward in the diagnosis of recurrent prostate cancer (PCa). The aim of this study was to analyse the influence of several variables with possible influence on PSMA ligand uptake in a large cohort. Methods We performed a retrospective analysis of 1007 consecutive patients who were scanned with 68Ga-PSMA-11 PET/CT (1 h after injection) from January 2014 to January 2017 to detect recurrent disease. Patients with untreated primary PCa or patients referred for PSMA radioligand therapy were excluded. The possible effects of different variables including PSA level and PSA doubling time (PSADT), PSA velocity (PSAVel), Gleason score (GSC, including separate analysis of GSC 7a and 7b), ongoing androgen deprivation therapy (ADT), patient age and amount of injected activity were evaluated. Results In 79.5% of patients at least one lesion with characteristics suggestive of recurrent PCa was detected. A pathological (positive) PET/CT scan was associated with PSA level and ADT. GSC, amount of injected activity, patient age, PSADT and PSAVel were not associated with a positive PET/CT scan in multivariate analysis. Conclusion 68Ga-PSMA-11 PET/CT detects tumour lesions in a high percentage of patients with recurrent PCa. Tumour detection is clearly associated with PSA level and ADT. Only a tendency for an association without statistical significance was found between higher GSC and a higher probability of a pathological PET/CT scan. No associations were found between a pathological 68Ga-PSMA-11 PET/CT scan and patient age, amount of injected activity, PSADT or PSAVel.

Keywords: Prostate cancer; PET/CT; positron emission tomography; PSMA; prostate-specific membrane antigen

Publ.-Id: 31249

Tracer uptake in mediastinal and paraaortal thoracic lymph nodes as a potential pitfall in image interpretation of PSMA ligand PET/CT

Afshar-Oromieh, A.; Sattler, L. P.; Steiger, K.; Holland-Letz, T.; Livorsi Da Cunha, M.; Mier, W.; Neels, O.; Kopka, K.; Weichert, W.; Haberkorn, U.

Purpose Since the introduction of 68Ga-PSMA-11 PET/CT for imaging prostate cancer (PC) we have frequently observed mediastinal lymph nodes (LN) showing tracer uptake despite being classified as benign. The aim of this evaluation was to further analyze such LN. Methods Two patient groups with biphasic 68Ga-PSMA-11 PET/CT at 1 h and 3 h p.i. were included in this retrospective evaluation. Group A (n = 38) included patients without LN metastases, and group B (n = 43) patients with LN metastases of PC. SUV of mediastinal/paraaortal LN of group A (n = 100) were compared to SUV of LN metastases of group B (n = 91). Additionally, 22 randomly selected mediastinal and paraaortal LN of patients without PC were immunohistochemically (IHC) analyzed for PSMA expression. Results In group A, 7/38 patients (18.4%) presented with at least one PSMA-positive mediastinal LN at 1 h p.i. and 3/38 (7.9%) positive LN at 3 h p.i. with a SUVmax of 2.3 ± 0.7 at 1 h p.i. (2.0 ± 0.7 at 3 h p.i.). A total of 11 PSMA-positive mediastinal/paraaortal LN were detected in nine patients considering both imaging timing points. SUVmax of LN-metastases was 12.5 ± 13.2 at 1 h p.i. (15.8±17.0 at 3 h p.i.). SUVmax increased clearly (> 10%) between 1 h and 3 h p.i. in 76.9% of the LN metastases, and decreased significantly in 72.7% of the mediastinal/paraaortal LN. By IHC, PSMA-expression was observed in intranodal vascular endothelia of all investigated LN groups and to differing degrees within germinal centers of 15/22 of them (68.1%). Expression was stronger in mediastinal nodes (p = 0.038) and when follicular hyperplasia was present (p = 0.050). Conclusion PSMA-positive mediastinal/paraaortal benign LN were visible in a notable proportion of patients. PSMA-positivity on the histopathological level was associated with the activation state of the LN. However, in contrast to LN metastases of PC, they presented with significantly lower uptake, which, in addition, usually decreased over time.

Keywords: Prostate cancer; PET/CT; Mediastinal; Mediastinal/paraaortal; Lymph nodes; PSMA; Prostate-specific membrane antigen; 68Ga-PSMA-11

Publ.-Id: 31248

Vacancy-Hydrogen Interaction in Niobium during Low-Temperature Baking

Wenskat, M.; Čižek, J.; Liedke, M. O.; Butterling, M.; Bate, C.; Haušild, P.; Hirschmann, E.; Wagner, A.; Weise, H.

A recently discovered modified low-temperature baking leads to reduced surface losses and an increase of the accelerating gradient of superconducting TESLA shape cavities. We will show that the dynamics of vacancy-hydrogen complexes at low-temperature baking lead to a suppression of lossy nanohydrides at 2 K and thus a significant enhancement of accelerator performance. Utilizing Doppler broadening Positron Annihilation Spectroscopy, Positron Annihilation Lifetime Spectroscopy and instrumented nanoindentation, samples made from European XFEL niobium sheets were investigated. We studied the evolution of vacancies in bulk samples and in the sub-surface region and their interaction with hydrogen at different temperature levels during in-situ and ex-situ annealing.

Keywords: positron annihilation spectroscopy; PALS; Doppler broadening; Nb RF cavities; superconductivity

Publ.-Id: 31247

Quenched-in Vacancies and Hardening of Fe–Al Intermetallics

Prochazka, I.; Vlasak, T.; Cizek, J.; Lukac, F.; Liedke, M. O.; Anwand, W.; Jiraskova, Y.; Janickovice, D.

The role of vacancies in hardening of Fe–Al intermetallic alloys were studied in the present work for a wide range of Al concentrations from 20 to 50 at%. The alloys quenched from 1000 ◦C as well as those annealed subsequently at 520 ◦C for 1 h were subject to study. Slow-positron beam experiments combined with Vicker’s microhardness tests were utilised. Hardness of Fe–Al alloys exhibited a somewhat complex dependence on Al content which could not be fully explained purely by consideration of intermetallic phases formed. This happens due to additional hardening effect caused by quenched-in vacancies. The concentrations of vacancies were estimated from positron back-diffusion data and found to rise for Al content above 25 at%. Correlation of vacancy concentrations with hardness data for the quenched and annealed alloys has revealed that hardening of alloys with a low Al content (< 30 at%) is originated predominantly by anti-phase boundaries while hardening induced by quenched-in vacancies dominates for alloys with a higher Al content (30–50 at%).

Keywords: positron annihilation spectroscopy; Doppler broadening; FeAl; defetcs; SPONSOR


  • Secondary publication expected from 30.06.2021

Publ.-Id: 31246

Investigation of Optical Properties and Defects Structure of Rare Earth (Sm, Gd, Ho) Doped Zinc Oxide Thin Films Prepared by Pulsed Laser Deposition

Novotny, M.; Hruska, P.; Fitl, P.; Maresova, E.; Havlova, S.; Bulir, J.; Fekete, L.; Yatskiv, R.; Vrnata, M.; Cizek, J.; Liedke, M. O.; Lancok, J.

Rare earths (RE = Sm, Gd, Ho) doped ZnO thin films were grown by pulsed laser deposition in oxygen ambient at pressure of 10 Pa on fused silica and Si(100) substrates at room temperature. A good optical quality of the films was confirmed by transmittance measurement in the visible spectral region. Photoluminescence suggested RE3+ oxidation state as confirmed at ZnO:Sm, where local structure was inhomogeneous. ZnO:Sm film exhibited the highest electrical resistivity while ZnO:Ho the lowest. Nanocrystalline structure of the films was observed by atomic force microscopy and X-ray diffraction. Defects structure was examined by variable energy positron annihilation spectroscopy. All ZnO:RE films exhibited significantly higher values of the S parameter as well as shorter positron diffusion lengths compared to ZnO monocrystal reference due to trapping of positrons at open volumes associated with grain boundaries. We observed the impact of the type of RE dopant on optical and electrotransport properties while the defect structure remained unchanged.

Keywords: Doped Zinc Oxide; Sm; positron annihilation spectroscopy; ZnO; Gd; Ho; defects

Publ.-Id: 31245

Tailored fabrication of iridium nanoparticle-sensitized titanium oxynitride nanotubes for solar-driven water splitting: Experimental insights on the photocatalytic-activity-defects relationship

Eid, K.; Soliman, K. A.; Abdulmalik, D.; Mitoraj, D.; Sleim, M. H.; Liedke, M. O.; El-Sayed, H. A.; Aljaber, A. S.; Al-Qaradawi, I. Y.; Mendoza Reyes, O.; Abdullah, A. M.

Understanding the photocatalytic–activity–defects relationship of titanium oxynitride nanotubes (TiON-NTs) is important for tailoring their photocatalytic performance. Herein, we fabricated highly ordered and vertically aligned nanotube arrays of TiON-NT-functionalized with iridium nanoparticles denoted as (Ir/TiON-NTs) for solar-driven water splitting. Positron annihilation lifetime spectroscopy (PALS) and variable-energy positron annihilation spectroscopy (VEPAS) were performed to quantify the vacancy-type defects of Ir/TiON-NTs relative to TiON-NTs and TiO2-NTs. The results display that the Ir/TiON-NTs exhibit abundant defects such as small nitrogen vacancies, larger size vacancy clusters, and small voids. The obtained photocurrent density of the Ir/TiON-NTs (11.3 mA cm−2) is about 3.97, 5, and 11.89 times higher than that of Ir/TiO2-NTs, TiON-NTs, and TiO2-NTs, respectively. The Mott–Schottky analysis revealed the highest significant negative shift in the band potential and the lowest donor density of Ir/TiON-NTs compared to its counterparts. This result is attributed to the unique structural and compositional merits of Ir/TiON-NTs despite the abundant defects, which delay the charge recombination and improve the photocatalytic activity. The presented study may open new frontiers on engineering the defects of metal oxynitrides with metal-based catalysts for photocatalytic applications.

Keywords: titanium oxynitride; PALS; positron annihilation spectroscopy; nanotubes; iridium nanoparticles

Publ.-Id: 31244

F-18 labelled PSMA-1007: biodistribution, radiation dosimetry and histopathological validation of tumor lesions in prostate cancer patients

Giesel, F. L.; Hadaschik, B.; Cardinale, J.; Radtke, J.; Vinsensia, M.; Lehnert, W.; Kesch, C.; Tolstov, Y.; Singer, S.; Grabe, N.; Duensing, S.; Schäfer, M.; Neels, O.; Mier, W.; Haberkorn, U.; Kopka, K.; Kratochwil, C.

Purpose The prostate-specific membrane antigen (PSMA) targeted positron-emitting-tomography (PET) tracer 68Ga-PSMA-11 shows great promise in the detection of prostate cancer. However, 68Ga has several shortcomings as a radiolabel including short half-life and non-ideal energies, and this has motivated consideration of 18F-labelled analogs. 18F-PSMA-1007 was selected among several 18F-PSMA-ligand candidate compounds because it demonstrated high labelling yields, outstanding tumor uptake and fast, non-urinary background clearance. Here, we describe the properties of 18F-PSMA-1007 in human volunteers and patients. Methods Radiation dosimetry of 18F-PSMA-1007 was determined in three healthy volunteers who underwent whole-body PET-scans and concomitant blood and urine sampling. Following this, ten patients with high-risk prostate cancer underwent 18F-PSMA-1007 PET/CT (1 h and 3 h p.i.) and normal organ biodistribution and tumor uptakes were examined. Eight patients underwent prostatectomy with extended pelvic lymphadenectomy. Uptake in intra-prostatic lesions and lymph node metastases were correlated with final histopathology, including PSMA immunostaining. Results With an effective dose of approximately 4.4–5.5 mSv per 200–250 MBq examination, 18F-PSMA-1007 behaves similar to other PSMA-PET agents as well as to other 18F-labelled PET-tracers. In comparison to other PSMA-targeting PET-tracers, 18F-PSMA-1007 has reduced urinary clearance enabling excellent assessment of the prostate. Similar to 18F-DCFPyL and with slightly slower clearance kinetics than PSMA-11, favorable tumor-to-background ratios are observed 2–3 h after injection. In eight patients, diagnostic findings were successfully validated by histopathology. 18F-PSMA-1007 PET/CT detected 18 of 19 lymph node metastases in the pelvis, including nodes as small as 1 mm in diameter. Conclusion 18F-PSMA-1007 performs at least comparably to 68Ga-PSMA-11, but its longer half-life combined with its superior energy characteristics and non-urinary excretion overcomes some practical limitations of 68Ga-labelled PSMA-targeted tracers.

Keywords: 18F-PSMA; F-18-PSMA; PSMA-1007; PET/CT; Positron emission tomography

Publ.-Id: 31242

Small Crown-Ether Complexes as Molecular Models for Dihydrogen Adsorption in Undercoordinated Extraframework Cations in Zeolites

Wulf, T.; Heine, T.

1:1 metal complexes of small crown ethers are structurally similar to extraframework sites in metal-exchanged zeolites. Using ab initio calculations, we show that adsorbed molecular hydrogen follows the same trends in adsorption energies and vibrational frequencies at both types of metal sites. Unlike zeolites, crown ethers can be characterized in the gas phase, which opens new possibilities for understanding the bonding of dihydrogen at undercoordinated metal sites to help guide the rational design of porous materials for hydrogen isotope separation. Because more strongly binding adsorbates affect the geometry of the hosts, the similarity of crown ethers and zeolites with regard to the vibrational spectra of the adsorbed molecule seems to be limited to H₂.


Publ.-Id: 31241

18F-Labelled PSMA-1007 shows similarity in structure, biodistribution and tumour uptake to the theragnostic compound PSMA-617

Giesel, F. L.; Cardinale, J.; Schäfer, M.; Neels, O.; Benesova, M.; Mier, W.; Haberkorn, U.; Kopka, K.; Kratochwil, C.

Without Abstract

Publ.-Id: 31240

Radiosynthesis of a Novel PET Fluoronicotinamide for Melanoma Tumour PET Imaging; [18F]MEL050

Greguric, I.; Taylor, S.; Pham, T.; Wyatt, N.; Jiang, C. D.; Bourdier, T.; Loch, C.; Roselt, P.; Neels, O.; Katsifis, A.

[18F]6-Fluoro-N-[2-(diethylamino)ethyl]nicotinamide [18F]MEL050 is a novel nicotinamide-based radiotracer, designed to target random metastatic dissemination of melanoma tumours by targeting melanin. Preclinical studies suggest that [18F]MEL050 has an excellent potential to improve diagnosis and staging of melanoma. Here we report the radiochemical optimization conditions of [18F]MEL050 and its large scale automated synthesis using a GE FXFN automated radiosynthesis module for clinical, phase-1 investigation. [18F]MEL050 was prepared via a one-step synthesis using no-carrier added K[18F]F-Kryptofix® 222 (DMSO, 170° C, 5 min) followed by HPLC purification. Using 6-chloro-N-[2-(diethylamino)ethyl]nicotinamide as precursor, [18F]MEL050 was obtained in 40-46% radiochemical yield (non-decay corrected), in greater than 99.9% radiochemical purity and specific activity ranging from 240 to 325 GBq µmol(-1). Total synthesis time including formulation was 40 min and [18F]MEL050 was stable (99.8%) in PBS for 6 h.

Publ.-Id: 31239

Convection Caused Symmetry Breaking of Azimuthal Magnetorotational Instability in a Liquid Metal Taylor Couette Flow

Seilmayer, M.; Ogbonna, J. E.; Stefani, F.

This are the experimental and numerical results for the publication "Convection Caused Symmetry Breaking of Azimuthal Magnetorotational Instability in a Liquid Metal Taylor Couette Flow ". It contains pictures, experimental results, tex files, COMSOL simulation file and PDF.

Keywords: MRI, magnetohydrodynamic, thermal convection, Taylor Couette

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Convection Caused Symmetry Breaking of Azimuthal … (Id 28445) has used this publication of HZDR-primary research data
  • Reseach data in the HZDR data repository RODARE
    Publication date: 2020-06-25
    DOI: 10.14278/rodare.380
    License: CC-BY-4.0


Publ.-Id: 31238

Biochemical recurrence of prostate cancer: initial results with 18F-PSMA-1007 PET/CT

Giesel, F. L.; Will, L.; Kesch, C.; Freitag, M.; Kremer, C.; Merkle, J.; Neels, O.; Cardinale, J.; Hadaschik, B.; Hohenfellner, M.; Kopka, K.; Haberkorn, U.; Kratochwil, C.

Biochemical recurrence (BCR) is a concern for prostate cancer patients after local treatment. 68Ga-labeled prostate-specific membrane antigen (PSMA) ligands have significantly improved prostate cancer imaging. However, several 18F-labeled ligands that were developed as fluorinated tracers might present advantages. In this study, we analyzed the potential of 18F-PSMA-1007 in patients with BCR. Methods: Twelve patients with BCR after local treatment underwent PET/CT scans 1 and 3 h after injection of 18F-PSMA-1007. Results: 18F-PSMA-1007 PET/CT detected lesions in 9 of 12 patients (75%). A significant difference was observed when comparing the tracer uptake in 18F-PSMA-1007–positive lesions 1 and 3 h after injection (median SUVmax, 7.00 vs. 11.34; P < 0.001; n = 76). Fortyfour (88%) of 50 18F-PSMA-1007–positive lymph nodes had a shortaxis diameter of less than 8 mm. Conclusion: In this pilot study, 18F-PSMA-1007 PET/CT presented high potential for localization of recurrent disease in prostate cancer patients with BCR.

Keywords: peptides; PET/CT; biochemical recurrence; 18F-PSMA-1007; PSMA-PET; prostate cancer

Publ.-Id: 31237

Intra-individual comparison of 18F-PSMA-1007 and 18F-DCFPyL PET/CT in the prospective evaluation of patients with newly diagnosed prostate carcinoma: A pilot study

Giesel, F. L.; Will, L.; Lawal, I.; Lengana, T.; Kratochwil, C.; Vorster, M.; Neels, O.; Reyneke, F.; Haberkorn, U.; Kopka, K.; Sathekge, M.

The introduction of 18F-labeled prostate-specific membrane antigen (PSMA)–targeted PET/CT tracers, first 18F-DCFPyL (2-(3-{1-carboxy-5-[(6-18F-fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid) andmore recently 18F-PSMA-1007 (((3S,10S,14S)-1-(4-(((S)-4-carboxy-2-((S)-4-carboxy-2-(6-18F-fluoronicotinamido)butanamido)butanamido)methyl)phenyl)-3-(naphthalen-2-ylmethyl)-1,4,12-trioxo-2,5,11,13-tetraazahexadecane-10,14,16-tricarboxylic acid)), have demonstrated promising results for the diagnostic workup of prostate cancer. This clinical study presents an intraindividual comparison to evaluate tracer-specific characteristics of 18F-DCFPyL versus 18F-PSMA-1007. Methods: Twelve prostate cancer patients, drug-na¨ıve or before surgery, received similar activities of about 250 MBq of 18F-DCFPyL and 18F-PSMA-1007 48 h apart and were imaged 2 h after injection on the same PET/CT scanner using the same reconstruction algorithm. Normal-organ biodistribution and tumor uptake were quantified using SUVmax. Results: PSMA-positive lesions were detected in 12 of 12 prostate cancer patients. Both tracers, 18F-DCFPyL and 18F-PSMA-1007, detected the same lesions. No statistical significance could be observed when comparing the SUVmax of 18F-DCFPyL and 18F-PSMA-1007 for local tumor, lymph node metastases, and bone metastases. With regard to normal organs, 18F-DCFPyL had statistically significant higher uptake in kidneys, urinary bladder, and lacrimal gland. Vice versa, significantly higher uptake of 18F-PSMA-1007 in muscle, submandibular and sublingual gland, spleen, pancreas, liver, and gallbladder was observed. Conclusion: Excellent imaging quality was achieved with both 18F-DCFPyL and 18F-PSMA-1007, resulting in identical clinical findings for the evaluated routine situations. Nonurinary excretion of 18F-PSMA-1007 might present some advantage with regard to delineation of local recurrence or pelvic lymph node metastasis in selected patients; the lower hepatic background might favor 18F-DCFPyL in late stages, when rare cases of liver metastases can occur.

Keywords: 18F-PSMA-1007; 18F-DCFPyL; prostate carcinoma; PET/CT; PSMA

Publ.-Id: 31236

Intra-individual comparison of 18F-PSMA-1007-PET/CT, multi-parametric MRI and radical prostatectomy specimen in patients with primary prostate cancer - a retrospective, proof of concept study

Kesch, C.; Vinsensia, M.; Radtke, J. P.; Schlemmer, H. P.; Heller, M.; Ellert, E.; Holland-Letz, T.; Duensing, S.; Grabe, N.; Afshar-Oromieh, A.; Wieczorek, K.; Schäfer, M.; Neels, O.; Cardinale, J.; Kratochwil, C.; Hohenfellner, M.; Kopka, K.; Haberkorn, U.; Hadaschik, B.; Giesel, F. L.

68Ga-prostate-specific membrane antigen (PSMA)-11 PET/CT represents an advanced method for the staging of primary prostate cancer (PCa) and diagnosis of recurrent or metastatic PCa. However, because of the narrow availability of 68Ga the development of alternative tracers is of high interest. The objective of this study was to examine the value of the new PET tracer 18F-PSMA-1007 for the staging of local disease by comparing it with multiparametric MRI (mpMRI) and radical prostatectomy (RP) histopathology. Methods: In 2016, 18F-PSMA-1007 PET/CT was performed in 10 men with biopsy-confirmed high-risk PCa. Nine patients underwent mpMRI in the process of primary diagnosis. Consecutively, RP was performed in all 10 men. Agreement analysis was performed retrospectively. PSMA staining was added for representative sections in RP specimen slices. Localization and agreement analysis of 18F-PSMA-1007 PET/CT, mpMRI, and RP specimens was performed by dividing the prostate into 38 sections as described in the prostate imaging reporting and data system (PI-RADS) (version 2). Sensitivity, specificity, positive predictive values, negative predictive values (NPVs), and accuracy were calculated for total and near-total agreement. Results: 18F-PSMA-1007 PET/CT had an NPV of 68% and an accuracy of 75%, and mpMRI had an NPV of 88% and an accuracy of 73% for total agreement. Near-total agreement analysis resulted in an NPV of 91% and an accuracy of 93% for 18F-PSMA-1007 PET/CT and 91% and 87% for mpMRI, respectively. Retrospective combination of mpMRI and PET/CT had an accuracy of 81% for total and 93% for near-total agreement. Conclusion: Comparison with RP histopathology demonstrates that 18F-PSMA-1007 PET/CT is promising for accurate local staging of PCa.

Keywords: 18F-PSMA; PSMA-1007; prostate cancer; PET/CT; mpMRI

Publ.-Id: 31235

Preclinical Evaluation of 18F-PSMA-1007: A New PSMA-Ligand for Prostate Cancer Imaging

Cardinale, J.; Schäfer, M.; Benesova, M.; Bauder-Wüst, U.; Leotta, K.; Eder, M.; Neels, O.; Haberkorn, U.; Giesel, F. L.; Kopka, K.

In recent years, several radiotracers targeting the prostate-specific membrane antigen (PSMA) have been introduced. Some of them have had a high clinical impact on the treatment of patients with prostate cancer. However, the number of 18F-labeled tracers addressing PSMA is still limited. Therefore, we aimed to develop a radiofluorinated molecule resembling the structure of therapeutic PSMA-617. Methods: The nonradioactive reference compound PSMA-1007 and the precursor were produced by solid-phase chemistry. The radioligand 18F-PSMA-1007 was produced by a 2-step procedure with the prosthetic group 6-18F-fluoronicotinic acid 2,3,5,6-tetrafluorophenyl ester. The binding affinity of the ligand for PSMA and its internalization properties were evaluated in vitro with PSMA-positive LNCaP (lymph node carcinoma of the prostate) cells. Further, organ distribution studies were performed with mice bearing LNCaP and PC-3 (prostate cancer cell line; PSMA-negative) tumors. Finally, small-animal PET imaging of an LNCaP tumor–bearing mouse was performed. Results: The identified ligand had a binding affinity of 6.7 ± 1.7 nM for PSMA and an exceptionally high internalization ratio (67% ± 13%) in vitro. In organ distribution studies, high and specific tumor uptake (8.0 ± 2.4 percentage injected dose per gram) in LNCaP tumor–bearing mice was observed. In the small-animal PET experiments, LNCaP tumors were clearly visualized. Conclusion: The radiofluorinated PSMA ligand showed promising characteristics in its preclinical evaluation, and the feasibility of prostate cancer imaging was demonstrated by small-animal PET studies. Therefore, we recommend clinical transfer of the radioligand 18F-PSMA-1007 for use as a diagnostic PET tracer in prestaging and monitoring of prostate cancer.

Keywords: PSMA; 18F; prostate cancer; PET

Publ.-Id: 31234

The Theranostic PSMA Ligand PSMA-617 in the Diagnosis of Prostate Cancer by PET/CT: Biodistribution in Humans, Radiation Dosimetry, and First Evaluation of Tumor Lesions

Afshar-Oromieh, A.; Hetzheim, H.; Kratochwil, C.; Benesova, M.; Eder, M.; Neels, O.; Eisenhut, M.; Kübler, W.; Holland-Letz, T.; Giesel, F. L.; Mier, W.; Kopka, K.; Haberkorn, U.

PET imaging with the prostate-specific membrane antigen (PSMA)–targeted radioligand 68Ga-PSMA-11 is regarded as a significant step forward in the diagnosis of prostate cancer (PCa). More recently, a PSMA ligand was developed that can be labeled with 68Ga, 111In, 177Lu, and 90Y. This ligand, named PSMA-617, therefore enables both diagnosis and therapy of PCa. The aims of this evaluation were to clinically investigate the distribution of 68Ga-PSMA-617 in normal tissues and in PCa lesions as well as to evaluate the radiation exposure by the radioligand in PET imaging. Methods: Nineteen patients, most of them with recurrent PCa, were referred for 68Ga-PSMA-617 PET/CT. The quantitative assessment of tracer uptake of several organs and of 53 representative tumor lesions was performed in 15 patients at 1 and 3 h after injection. In 4 additional patients, the same procedure was conducted at 5 min, 1 h, 2 h, 3 h, 4 h, and 5 h after injection. On the basis of the data for these 4 patients (mean injected dose, 231 MBq), the radiation exposure of a 68Ga-PSMA-617 PET/CT was identified. Results: Intense tracer uptake was observed in the kidneys and salivary glands. In 14 of 19 patients (73.7%), at least 1 lesion suspected of being a tumor was detected at 3 h after injection. Of 53 representative tumor lesions selected at 3 h after injection, 47 lesions were visible at 1 h after injection. The mean tumor-to-background ratio for maximum standardized uptake value was 20.4 ± 17.3 (range, 2.3–84.0) at 1 h after injection and 38.2 ± 38.6 (range, 3.6–154.3) at 3 h after injection. The average radiation exposure (effective dose) was approximately 0.021 mSv/MBq. Conclusion: Within healthy organs, the kidneys and salivary glands showed the highest 68Ga-PSMA-617 uptake. The radiation exposure was relatively low. 68Ga-PSMA-617 shows PCa lesions with high contrast. Images obtained between 2 and 3 h after injection seem to be the best option with regard to radiotracer uptake and tumor contrast. Later images can help to clarify unclear lesions.

Keywords: prostate cancer; PET/CT; positron emission tomography; PSMA; prostate-specific membrane antigen; dosimetry

Publ.-Id: 31233

Investigation of Epothilone B-Induced Cell Death Mechanisms in Human Epithelial Cancer Cells –in Consideration of Combined Treatment With Ionizing Radiation

Baumgart, T.; Kriesen, S.; Neels, O.; Hildebrandt, G.; Manda, K.

Epothilone B was shown to have promising chemo- and radiosensitizing effects on cells, but the mechanisms underlying cell death remain ambiguous. The aim of the study was to examine selected cell death pathways on the basis of FaDu and A549 cells. Western blot analyses were used for investigation of specific apoptotic markers. Immunofluorescence imaging and flow cytometry were utilized for examination of cell death mechanisms. DNA-staining was used for studying influence of epothilone B on micronucleus rate. We showed that epothilone B can initiate cell death via apoptosis and mitotic catastrophe, but induction of cell death was cell type specific.

Keywords: Apoptosis; Epothilone B; Irradiation; Micronucleus; Mitotic catastrophe

Publ.-Id: 31230

ExploreASL/ExploreASL: First stable release

Mutsaerts, H.; Petr, J.; Stritt, M.; Vandemaele, P.; Groot, P.

ExploreASL v1.0.0

  • Software in external data repository
    Publication year 2020
    Programming language: Matlab
    System requirements: Windows/Linux/OS X
    License: Other (Open)
    Hosted on
    DOI: 10.5281/zenodo.3905263

Publ.-Id: 31229

Life on a Mesoarchean marine shelf – insights from the world’s oldest known granular iron formation

Smith, A. J. B.; Beukes, N. J.; Gutzmer, J.; Johnson, C. M.; Czaja, A. D.; Nhleko, N.; de Beer, F.; Hoffman, J. W.; Awramik, S. M.

The Nconga Formation of the Mesoarchean (~2.96-2.84 Ga) Mozaan Group of the Pongola Supergroup of southern Africa contains the world’s oldest known granular iron formation. Three dimensional reconstructions of the granules using micro-focus X-ray computed tomography reveal that these granules are microstromatolites coated by magnetite and calcite, and can therefore be classified as oncoids. The reconstructions also show damage to the granule coatings caused by sedimentary transport during formation of the granules and eventual deposition as density currents. The detailed, three dimensional morphology of the granules in conjunction with previously published geochemical and isotope data indicate a biogenic origin for iron precipitation around chert granules on the shallow shelf of one of the oldest supracratonic environments on Earth almost three billion years ago. It broadens our understanding of biologically-mediated iron precipitation during the Archean by illustrating that it took place on the shallow marine shelf coevally with deeper water, below-wave base iron precipitation in micritic iron formations.

Publ.-Id: 31228

P1818 - Verfahren zur gezielten Auswahl eines Sensors zur sensorbasierten Sortierung eines Materialgemisches durch Simulation der sensorbasierten Sortierung des Materialgemisches

Kern, M.; Tusa, L.; Gutzmer, J.; van den Boogaart, K. G.

Es wird Verfahren zur Auswahl eines Sensors (1) aus einer Mehrzahl von Sensoren zur sensorbasierten Sortierung eines Materialgemischs (10) anhand einer Materialeigenschaft zur Konzentration eines Wertstoffes vorgeschlagen, wobei in einem ersten Schritt aus dem Materialgemisch (10) repräsentative Einzelproben gewonnen werden (20), in einem zweiten Schritt Materialeigenschaften der Einzelproben gemessen werden (30), in einem dritten Schritt auf Grundlage der gemessenen Materialeigenschaften eine Mehrzahl von simulierten Sortierungen anhand jeweils unterschiedlicher Materialeigenschaften simuliert wird (40), in einem vierten Schritt eine simulierte Sortierung mit einer hohen Wertstoffkonzentration aus der Mehrzahl von simulierten Sortierungen ausgewählt wird, in einem fünften Schritt ein Sensor (1) zur Messung der Materialeigenschaft ausgewählt wird (50), welcher geeignet ist, mindestens eine der Materialeigenschaften, welche für die ausgewählte simulierte Sortierung genutzt wurde, zu messen.

  • Patent
    DE102018217548 - Offenlegung 16.04.2020; Nachanmeldungen: WO

Publ.-Id: 31227

P1816 - Reaktor und Verfahren zur kontinuierlichen Gewinnung amphiphiler Siderophore aus einer Mikroorganismenkultur

Schrader, S.; Kutschke, S.; Pollmann, K.; Rudolph, M.

Die Erfindung betrifft einen Reaktor, ein Verfahren und die Verwendung dieses Reaktors in dem Verfahren zur Gewinnung amphiphiler Siderophore aus einer Mikroorganismenkultur. Der Reaktor umfasst die Bauteile: (a) Vorrichtung (40) zum Rühren und/oder Begasen, und (b) Ablauf (70) für Schaum, enthaltend die amphiphilen Siderophore, in der Seitenwand des Reaktors, (c) Deckel (90) wobei die Unterkante des Ablaufs (70) für Schaum als Überlauf in einer Höhe liegt, die im Bereich von 40-75% der Gesamthöhe des Reaktors (10), von unten gemessen, liegt, und wobei der Ablauf (70) für Schaum horizontal nach außen oder schräg nach unten außen verläuft oder als Überlauf ausgestaltet ist.

  • Patent
    DE102018122029 - Offenlegung 12.03.2020; Nachanmeldungen: WO

Publ.-Id: 31226

P1814 - Kühlvorrichtung sowie Kühlverfahren basierend auf magnetoelektrischer Kopplung

Hornung, J.; Gottschall, T.

Verschiedene Ausführungsformen betreffen ein Verfahren (700) zum Betreiben einer Kühlvorrichtung (300), das Verfahren (700) aufweisend: ein erstes Verändern eines elektrischen Feldes (304) in einem Feldbereich (306), wobei in dem Feldbereich (306) mindestens ein Magnetsystem mit magnetoelektrischer Kopplung angeordnet ist, und dadurch Erwärmen des mindestens einen Magnetsystems; und, anschließend, ein zweites Verändern des elektrischen Feldes (304) in dem Feldbereich (306) und dadurch Abkühlen des mindestens einen Magnetsystems.

  • Patent
    DE102018118813 - Erteilung 21.11.2019

Publ.-Id: 31225

P1813 - Schichtabfolge zur Erzeugung von Elektrolumineszenz und deren Verwendung

Bogusz, A.; Rayapati, V. R.; Skorupa, I.; Schmidt, H.; Bürger, D.; Krüger, S.; Rebohle, L.

Die Erfindung betrifft eine Schichtabfolge zur Erzeugung von Elektrolumineszenz und deren Verwendung, beispielsweise in einem Pixelarray oder in textilen Materialien. Die Aufgabe eine Schichtstruktur anzugeben, die einfach realisierbar bzw. herstellbar sowie einfach aufgebaut ist, mit der Elektrolumineszenz einfach erzeugt werden kann und langzeitstabil einsetzbar ist, wird durch eine Schichtabfolge zur Erzeugung von Elektrolumineszenz gelöst, die mindestens eine polykristalline Seltene-Erd-Manganat-Schicht sowie einen ersten Kontakt, der auf einer Seite der Seltene-Erd-Manganat-Schicht angeordnet ist sowie einen zweiten Kontakt, der auf der gegenüberliegenden Seite des ersten Kontaktes oder auf der gleichen Seite wie der erste Kontakt angeordnet ist, aufweist, wobei in der Seltene-Erd-Manganat-Schicht zwischen dem ersten Kontakt und dem zweiten Kontakt ein Widerstand größer als 100 Ohm ausgebildet ist und wobei die Seltene-Erd-Manganat-Schicht geeignet ist, bei Anlegen einer elektrischen Gleichspannung, lokal im Bereich des sich zwischen den beiden elektrisch leitenden Kontakten ausbildenden elektrischen Feldes in der Seltene-Erd-Manganat-Schicht eine Elektrolumineszenz aufgrund von Stoßionisation auszubilden.

  • Patent
    DE102018117210 - Offenlegung 20.02.2020

Publ.-Id: 31224

P1812 - Fluidik-Detektionssystem

Illing, R.; Makarov, D.

Die Erfindung betrifft ein Fluidik-Detektionssystem zur magnetisch-elektrischen Messung einer fluiden Probe, wobei das System jeweils mindestens ein Probenmodul, einen Magnetfeldsensor und einen Magneten umfasst, welche voneinander beabstandet angeordnet sind. Dabei weist das Probenmodul mindestens einen Kanal auf, der zum Befördern einer fluiden Probe entlang einer Fließrichtung ausgebildet ist. Der Magnet erzeugt ein Magnetfeld in einem Mess- und Anregungsbereich des Kanals. Dabei entspricht der Detektionsbereich des Magnetfeldsensors dem Mess- und Anregungsbereich des Kanals. Beim Befördern der fluiden Probe im Mess- und Anregungsbereich des Kanals wird das Magnetfeld von der zu untersuchenden fluiden Probe modifiziert, wobei der Magnetfeldsensor das modifizierte Magnetfeld erfasst. Die Erfindung betrifft weiterhin ein Verfahren zum Betrieb des erfindungsgemäßen Fluidik-Detektionssystems zur magnetisch-elektrischen Messung einer fluiden Probe.

  • Patent
    DE102018116918 - Offenlegung 16.01.2020; Nachanmeldungen: WO

Publ.-Id: 31223

P1810 - 2-Phenoxypyridin-3-amin-Derivate und deren Verwendung

Moldovan, R.-P.; Wenzel, B.; Teodoro, R.; Dukic-Stefanovic, S.; Deuther-Conrad, W.; Brust, P.

Die Erfindung betrifft eine Verbindung der allgemeinen Formel I worin R¹ aus der Gruppe ausgewählt ist, die aus einer C₁-C₁₂-Alkylgruppe, einer C₃-C₁₂-Cycloalkylgruppe und einer Hetrocycloalkylgruppe mit 5 bis 12 Ringatomen, wobei die Ringatome Kohlenstoff und 1 bis 4 Heteroatome, ausgewählt aus N, O und S, sind, besteht; R² Wasserstoff oder Fluor ist, R³ eine Gruppe der Formel II oder eine Gruppe der Formel III ist: X¹ aus der Gruppe ausgewählt ist, die aus -(CR⁵R⁶)ₘ-, -(CR⁵R⁶)ₙC(O)-(CR⁵R⁶)ₚ- und -(CR⁵R⁶)q-X2-(CR⁵R⁶)ᵣ- besteht, wobei m, n, p, q und r unabhängig voneinander jeweils 0 oder eine Ganzzahl von 1 bis 6 sind; R⁴ aus der Gruppe ausgewählt ist, die aus einer Arylgruppe, einer Heteroarylgruppe mit 5 bis 12 Ringatomen, wobei die Ringatome Kohlenstoff und 1 bis 4 Heteroatome, ausgewählt aus N, O und S, sind, einer C₃-C₁₂-Cycloalkylgruppe und einer Heterocycloalkylgruppe mit 5 bis 12 Ringatomen, wobei die Ringatome Kohlenstoff und 1 bis 4 Heteroatome, ausgewählt aus N, O und S, sind, besteht; Ring A eine Arylgruppe oder eine Heteroarylgruppe mit 5 bis 12 Ringatomen, wobei die Ringatome Kohlenstoff und 1 bis 4 Heteroatome, ausgewählt aus N, O und S, sind, ist.

  • Patent
    DE102018113646 - Offenlegung 12.12.2019

Publ.-Id: 31222

P1809 - Verfahren zur Rekonfiguration einer Vortex-Dichte in einem Seltenen-Erd-Manganat, ein nichtflüchtiger Impedanzschalter und dessen Verwendung

Bogusz, A.; Krüger, S.; Skorupa, I.; Schmidt, H.; Du, N.

Die Erfindung beschreibt ein Verfahren zur Rekonfiguration einer Vortex-Dichte in einem Seltene-Erd-Manganat sowie einen nichtflüchtigen Impedanzschalter mit rekonfigurierbarer Impedanz. Die Aufgabe ein Verfahren anzugeben, mittels dem in speziellen Materialien deren Impedanz in Abhängigkeit von einer Vortex-Dichte ohne großen Aufwand beeinflusst und eingestellte werden kann, wird durch ein Verfahren zur Rekonfiguration einer Vortex-Dichte in einem Seltene-Erd-Manganat gelöst, wobei ein einmaliges Spannungs-Zeit-Profil zwischen einem ersten und einem zweiten, an das Seltene-Erd-Manganat angebrachten elektrisch leitenden Kontakt angelegt wird, so dass das Seltene-Erd-Manganat in einem Bereich eines sich zwischen den beiden elektrisch leitenden Kontakten ausbildenden elektrischen Feldes während eines Abkühlvorganges während und nach Anlegen des Spannungspulses oder der Spannungsrampe eine Ordnungstemperatur durchläuft und damit die Vortex-Dichte lokal im Bereich des sich zwischen den beiden elektrisch leitenden Kontakten ausbildenden elektrischen Feldes beeinflusst und eingestellt wird.

  • Patent
    DE102018112605 - Offenlegung 28.11.2019; Nachanmeldungen: WO

Publ.-Id: 31221

P1808 - Festbettreaktor

Schubert, M.

Die Erfindung betrifft einen Festbettreaktor (1) mit einem rohrförmigen Reaktionsbehälter (2), der einen Rohrmantel (7), der einen Innenraum (14) begrenzt, und eine Längsachse (B) aufweist, die gegen die Horizontale geneigt ist und um die der Reaktionsbehälter (2) drehbar ist. Dabei ist vorgesehen, dass in dem Innenraum (14) ein Verdrängungskörper (15) unter Ausbildung eines umlaufenden Spaltes (20) zwischen dem Verdrängungskörper (15) und dem Rohrmantel (7) angeordnet ist, wobei im Betriebszustand des Festbettreaktors (1) ein Festbett (13) aus einem Katalysatormaterial in dem Spalt (20) fixiert ist, das von zumindest einer Flüssigkeit (51) und zumindest einem Gas (52) durchströmt ist.

  • Patent
    DE102018110091 - Offenlegung 31.10.2019

Publ.-Id: 31220

P1807 - Multisensorisches therapeutisch-diagnostisches System zum Monitoring des orthopädischen Trainings und der sportlichen Leistung

Canon Bermudez, G. S.; Voitsekhivska, T.; Makarov, D.; Fuchs, H.; Tsvyakh, A.; Hospodarskyy, A.; Shevchuk, O.

Die Erfindung betrifft ein multisensorisches therapeutisch-diagnostisches System zum Monitoring des orthopädischen Trainings und der sportlichen Leistung mit voneinander beabstandeten elektrischen Komponenten, welche eine Datenverarbeitungseinrichtung, einen Energiespeicher, ein Sensorsystem zur Erfassung von Daten sowie eine Trageeinrichtung aufweisen, wobei die elektrischen Komponenten zumindest teilweise in oder an der Trageeinrichtung angeordnet sind. Weiterhin betrifft die Erfindung ein Verfahren zum Monitoring des orthopädischen Trainings und der sportlichen Leistung sowie ein Computerprogrammprodukt zur Durchführung des Verfahrens.

  • Patent
    DE102018109913 - Offenlegung 31.10.2019; Nachanmeldungen: WO

Publ.-Id: 31219

P1806 - Rückgewinnung von Metallen aus Industrieabwässern geringer Metall-Konzentration

Jain, R.; Pollmann, K.; Lehmann, F.

Die Erfindung stellt ein mehrstufiges Verfahren bereit, zur selektiven, umweltfreundlichen und kostengünstigen Rückgewinnung von Nichteisenmetallen aus Industrieabwässern. Das Verfahren basiert auf dem Prinzip der Komplexierung der Nichteisenmetalle, Abtrennung der Komplexe und anschließender Dekomplexierung der Nichteisenmetalle. Zur Anwendung kommen als Komplexbildner Siderophore, die innerhalb des Prozesses zurückgewonnen werden. Das Verfahren ist insbesondere auch bei geringen Nichteisenmetall-Konzentrationen anwendbar. Es ist effizient, umweltfreundlich und kostengünstig.

  • Patent
    DE102018107923 - Offenlegung 10.10.2019; Nachanmeldungen: WO, EP, JP, KR, US

Publ.-Id: 31218

P1805 - Transparenter Objektträger

Rebohle, L.; Wiesenhütter, K.; Skorupa, I.; Schmidt, H.

Die Erfindung betrifft einen transparenten Objektträger. Die Aufgabe der Erfindung einen Objektträger anzugeben, an dem die Reichweite sowie die Stärke der oberflächennahen, elektrostatischen Kräfte, während eines Herstellungsprozesses des Objektträgers zu beeinflussen und einzustellen sind, wird durch einen transparenten Objektträger gelöst, welcher eine aufnahmeseitige Oberfläche und eine von der Aufnahmeseite abgewandte, also rückseitige Oberfläche ausweist und mindestens drei Schichten umfasst: eine elektrisch isolierende erste Schicht, eine auf der ersten Schicht angeordnete siliziumhaltige zweite Schicht sowie eine auf der zweiten Schicht angeordnete elektrisch isolierende dritte Schicht, wobei sich jeweils eine Grenzfläche zwischen der ersten und zweiten Schicht sowie zwischen der zweiten und dritten Schicht ausbildet, wobei die Grenzfläche zwischen der ersten und zweiten Schicht eine erste Flächenladungsdichte aufweist und die Grenzfläche zwischen der zweiten und dritten Schicht eine zweite Flächenladungsdichte aufweist, wobei die erste und zweite Flächenladungsdichte gleiche oder unterschiedliche Vorzeichen aufweisen und der Objektträger oberflächennahe, elektrostatischen Kräfte auf beiden Oberflächenseiten aufweist, deren Reichweite sowie Stärke während des Herstellungsprozesses zu beeinflussen und einzustellen sind.

  • Patent
    DE102018107810 - Offenlegung 10.10.2019; Nachanmeldungen: WO

Publ.-Id: 31217

P1804 - Verfahren zur kontinuierlichen Bestimmung sämtlicher Komponenten eines Widerstandstensors von Dünnschichten

Kosub, T.

Die Erfindung betrifft ein Verfahren zur kontinuierlichen Bestimmung sämtlicher Komponenten eines Widerstandstensors von Dünnschichten, wie Dünnschichtwiderständen und Dünnschichtsensoren aller Art. Durch die Erfindung soll ein Verfahren zur kontinuierlichen Bestimmung sämtlicher Komponenten eines Widerstandstensors von Dünnschichten, wie Dünnschichtwiderständen und Dünnschichtsensoren aller Art, geschaffen werden, bei dem mit einer minimierten Anzahl von Kontakten eine kontinuierliche Bestimmung aller Komponenten des Widerstandstensors ohne Umschalten der Kontaktpunkte ermöglicht wird. Erreicht wird das dadurch, dass ein beliebig geformtes homogenes Teilstück (T) der Dünnschicht mit mindestens drei in Abständen zueinander angeordneten Kontaktpunkten (K₁ bis K₃) versehen wird, wobei an jedem der Kontaktpunkte (K₁ bis K₃) eine Eingangsspannung Uᵢ(t) angelegt wird, dass die die Kontaktpunkte (K₁ bis K₃) durchfließenden Ströme Iᵢ(t) erfasst werden und dass aus den Spannungs- und Stromwerten der vollständige Widerstandstensor p des Teilstücks (T) der Dünnschicht bestimmt wird.

  • Patent
    DE102018106466 - Erteilung 25.04.2019; Nachanmeldungen: WO

Publ.-Id: 31216

P1803 - Teilchenspektrometer und Teilchenspektrometrieverfahren

Klingner, N.; Wilhelm, R. A.

Die Erfindung betrifft ein Teilchenspektrometer und Teilchenspektrometrieverfahren zum Analysieren eines entlang eines Teilchenpfades verlaufenden Teilchenpulses, wobei der Teilchenpuls an einer Kreuzungsposition zur Überlagerung mit einem Photonenpuls gebracht wird, sodass ein Teil der Teilchen des Teilchenpulses mittels des Photonenpulses elektrisch umgeladen wird, und wobei anschließend mittels eines Analysators die umgeladenen Teilchen separiert und die umgeladenen oder die nicht umgeladenen Teilchen separat mittels eines Teilchendetektors detektiert werden.

  • Patent
    DE102018106412 - Offenlegung 26.09.2019

Publ.-Id: 31215

Magnetic phase diagram and magnetoelastic coupling of NiTiO3

Dey, K.; Sauerland, S.; Werner, J.; Scurschii, I.; Abdel-Hafiez, M.; Bag, R.; Singh, S.; Klingeler, R.

We report high-resolution dilatometry on high-quality single crystals of NiTiO3 grown by means of the optical floating-zone technique. The anisotropic magnetic phase diagram is constructed from thermal expansion and magnetostriction studies up toB=15 T and magnetization studies in static (15-T) and pulsed (60-T) magnetic fields. Our data allow us to quantitatively study magnetoelastic coupling and to determine uniaxial pressure dependencies. While the entropy changes are found to be of magnetic nature, Grüneisen analysis implies only one relevant energy scale in the whole low-temperature regime. Thereby, our data suggest that the observed structural changes due to magnetoelastic coupling and previously reported magnetodielectric coupling [L. Balhorn, J. Hazi, M. C. Kemei, and R. Seshadri, Phys. Rev. B93, 104404(2016)] are driven by the same magnetic degrees of freedom that lead to long-range magnetic order in NiTiO3.

Publ.-Id: 31214

Extremely slow nonequilibrium monopole dynamics in classical spin ice

Stöter, T.; Doerr, M.; Granovsky, S.; Rotter, M.; Goennenwein, S. T. B.; Zherlitsyn, S.; Petrenko, O. A.; Balakrishnan, G.; Zhou, H. D.; Wosnitza, J.

We report on the nonequilibrium monopole dynamics in the classical spin ice Dy2Ti2O7 detected by means of high-resolution magnetostriction measurements. Significant lattice changes occur at the transition from the kagome-ice to the saturated-ice phase, visible in the longitudinal and transverse magnetostriction. A hysteresis opening at temperatures below 0.6 K suggests a first-order transition between the kagome and saturated state. Extremely slow lattice relaxations, triggered by changes of the magnetic field, were observed. These latticerelaxation effects result from nonequilibrium monopole formation or annihilation processes. The relaxation times extracted from our experiment are in good agreement with theoretical predictions with decay constants of the order of 104 s at 0.3K.


Publ.-Id: 31213

Splitting of the magnetic monopole pair-creation energy in spin ice

Hornung, J.; Gottschall, T.; Opherden, L.; Antlauf, M.; Schwarz, M.; Kroke, E.; Herrmannsdörfer, T.; Wosnitza, J.

The thermodynamics in spin-ice systems are governed by emergent magnetic monopole excitations and, until now, the creation of a pair of these topological defects was associated with one specific pair-creation energy. Here, we show that the electric dipole moments inherent to the magnetic monopoles lift the degeneracy of their creation process and lead to a splitting of the pair-creation energy. We consider this finding to extend the model of magnetic relaxation in spin-ice systems and show that an electric dipole interaction in the theoretically estimated order of magnitude leads to a splitting which can explain the controversially discussed discrepancies between the measured temperature dependence of the magnetic relaxation times and previous theory. By applying our extended model to experimental data of, various spin-ice systems, we show its universal applicability and determine a dependence of the electric dipole interaction on the systemparameters, which is in accordance with the theoretical model of electric dipole formation.

Publ.-Id: 31212

A Dual Radiologic Contrast Agent Protocol for 18F-FDG and 18F-FLT PET/CT Imaging of Mice Bearing Abdominal Tumors

Aide, N.; Kinross, K.; Beauregard, J.-M.; Neels, O.; Potdevin, T.; Roselt, P.; Dorow, D.; Cullinane, C.; Hicks, R. J.

Purpose: The aim of the study was to improve abdominal tumor detection by use of a dual radiologic contrast protocol. Procedures: eXia160® (Benitio international) was mixed with 2-deoxy-2-[18F]fluoro-D-glucose or 3′-[18F]fluoro-3′-deoxythymidine for intravenous (IV) injections. Omnipaque® 300 (GE healthcare) was used for intraperitoneal (IP) injections. Positron emission tomography/computed tomography (PET/CT) scans were acquired on a Siemens Biograph® equipped with point spread function reconstruction. The optimal concentration and injection schedule of IP contrast agent was studied in 12 mice. The impact of IP contrast media on PET quantitative accuracy was investigated by phantom studies and by imaging six mice before and after IP injection of Omnipaque®. The impact of a dual contrast media protocol on tumor delineation and quantitation was evaluated in 15 tumor-bearing mice using ex vivo counting as the reference. Results: The optimal sequence was a mixture of tracer plus IV contrast agent followed by 1 mL of IP contrast agent (20 mg iodine/mL) administered 10 min before PET/CT acquisition. Phantom studies showed that the use of a 20-mg iodine/mL concentration of Omnipaque® led to a 4.8% overestimation of radioactivity concentration, as compared to saline. This was confirmed by animal studies that demonstrated a 4.3% overestimation. Tumor detection was excellent and correlation between PET/CT quantitative data and ex vivo counting was good (r2=0.91, slope=0.7). Conclusions: A dual radiologic contrast protocol is useful in PET/CT scanning of mice bearing abdominal tumors. Contrast agents used in this manner lead to a small but acceptable overestimation of quantitative PET data.

Keywords: PET/CT; Preclinical studies; Abdominal tumors; Contrast media

Publ.-Id: 31209

18F-FLT PET as a Surrogate Marker of Drug Efficacy During mTOR Inhibition by Everolimus in a Preclinical Cisplatin-Resistant Ovarian Tumor Model

Aide, N.; Kinross, K.; Cullinane, C.; Roselt, P.; Waldeck, K.; Neels, O.; Dorow, D.; Mcarthur, G.; Hicks, R. J.

Targeting the mammalian target of rapamycin (mTOR) pathway is a potential means of overcoming cisplatin resistance in ovarian cancer patients. Because mTOR inhibition affects cell proliferation, we aimed to study whether 39-deoxy-39-18F-fluorothymidine (18F-FLT) PET could be useful for monitoring early response to treatment with mTOR inhibitors in an animal model of cisplatin-resistant ovarian tumor. Methods: BALB/c nude mice bearing subcutaneous human SKOV3 ovarian cancer xenografts were treated with either the mTOR inhibitor everolimus (5 mg/kg) or vehicle, and 18F-FLT PET was performed at baseline, day 2, and day 7 of treatment. 18F-FLT uptake was evaluated by calculation of mean standardized uptake value (SUVmean) corrected for partial-volume effect. Ex vivo immunohistochemistry studies were performed on separate cohorts of mice treated as above and sacrificed at the same time points as for the PET studies. The ex vivo analysis included bromodeoxyuridine incorporation as a marker of cell proliferation, and phosphorylation of ribosomal protein S6 as a downstream marker of mTOR activation. Results: During the treatment period, no significant change in tumor 18F-FLT uptake was observed in the vehicle group, whereas in everolimus-treated mice, 18F-FLT SUVmean decreased by 33% (P = 0.003) at day 2 and 66% (P < 0.001) at day 7, compared with baseline. Notably, the reduction of 18F-FLT uptake observed at day 2 in the everolimus group preceded changes in tumor volume, and a significant difference in 18F-FLT uptake was observed between vehicle and drug-treated tumors at both day 2 (P = 0.0008) and day 7 (P = 0.01). In ex vivo studies, everolimus treatment resulted in a 98% reduction in phosphorylated ribosomal protein S6 immunostaining at day 2 (P = 0.02) and 91% reduction at day 7 (P = 0.003), compared with the vehicle group. Bromodeoxyuridine incorporation was reduced by 65% at day 2 (not significant) and by 41% at day 7 (P = 0.02) in drug versus vehicle groups. Conclusion: Reduction in 18F-FLT uptake correlates well with the level of mTOR inhibition by everolimus in the SKOV3 ovarian tumor model. These data suggest that early treatment monitoring by 18F-FLT PET may be of use in future preclinical or clinical trials evaluating treatment of cisplatinresistant ovarian tumors by mTOR inhibitors.

Keywords: animal imaging; oncology; PET; FLT; mTOR inhibition; ovarian cancer; small-animal PET

Publ.-Id: 31208

Improved Detection of Regional Melanoma Metastasis Using 18F-6-Fluoro-N-[2-(Diethylamino)Ethyl] Pyridine-3-Carboxamide, a Melanin-Specific PET Probe, by Perilesional Administration

Denoyer, D.; Potdevin, T.; Roselt, P.; Neels, O.; Kirby, L.; Greguric, I.; Katsifis, A.; Dorow, D. S.; Hicks, R. J.

The efficacy of differing routes of administration of 18F-6-fluoro-N-[2-(diethylamino)ethyl] pyridine-3-carboxamide (18F-MEL050), a new benzamide-based PET radiotracer for imaging regional lymph node metastasis in melanoma, was assessed. Methods: B16-Black/6 metastatic melanoma cells harboring an mCherry transgene were implanted into the left-upper-foot surface of 49 C57 Black/6 mice as a model of popliteal lymph node (PLN) metastasis. Ultrasound scanning of the left PLN was performed at baseline and in combination with 18F-MEL050 PET on days 5, 9, and 14. Mice were divided into 2 groups to compare the results of tracer administration either subcutaneously at the tumor site (local) or in the lateral tail vein (systemic). After PET on each imaging day, 5 mice per group—including any with evidence of metastasis—were sacrificed for ex vivo validation studies including assessment of retained radioactivity and presence of the mCherry transgene as a surrogate of nodal tumor burden. Results: Nine mice were judged as positive for PLN metastasis by ultrasound at day 5, and 8 PLNs were positive on 18F-MEL050 PET, 3 after systemic and 5 after local administration. Ex vivo analysis showed that ultrasound correctly identified 90% of positive PLNs, with 1 false-positive. 18F-MEL050 PET correctly identified 60% of positive PLNs after systemic administration and 100% after local administration with no false-positive results by either route. The average node-to-background ratio for positive PLNs was 6.8 in the systemic-administration group and correlated with disease burden. In the local-administration group, the mean uptake ratio was 48, without clear relation to metastatic burden. Additional sites of metastatic disease were also correctly identified by 18F-MEL050 PET. Conclusion: In addition to its potential for systemic staging, perilesional administration of 18FMEL050 may allow sensitive and specific, noninvasive identification of regional lymph node metastasis in pigmented malignant melanomas.

Keywords: MEL050; benzamide; melanoma imaging; lymphoscintigraphy; small-animal PET; fluoro-nicotinamide analog

Publ.-Id: 31207

68Ga PET/CT Ventilation–Perfusion Imaging for Pulmonary Embolism: A Pilot Study with Comparison to Conventional Scintigraphy

Hofman, M. S.; Beauregard, J.-M.; Barber, T. W.; Neels, O.; Eu, P.; Hicks, R. J.

Ventilation–perfusion (V/Q) scintigraphy is established for regional assessment of lung function in a variety of diseases, including pulmonary embolism (PE). PET/CT may further improve the accuracy and utility of V/Q imaging because of its superior technical characteristics. This pilot study assessed the feasibility of performing V/Q PET/CT and compared diagnostic utility with conventional V/Q imaging in patients with clinical suspicion of PE. Methods: Ten patients undergoing conventional V/Q imaging were prospectively recruited. PET/CT V/Q imaging was performed after inhalation of 68Ga-carbon nanoparticles (“Galligas”) and administration of 68Ga-macroaggregated albumin. Blinded to the results of the other study, SPECT/CT (n = 9) or SPECT (n = 1) images and PET/CT images were graded by a predefined scoring system for scan quality. The number of matched or unmatched defects and diagnosis were also measured and compared with a final diagnosis. Results: PET image quality was equivalent or superior to SPECT in all patients, with more homogeneous radiotracer distribution for both ventilation and perfusion studies (P < 0.01). Based on conventional V/Q imaging, the diagnosis was acute PE in 2 patients and no PE in 7 patients, and the imaging results were nondiagnostic in 1 patient. The PET/CT diagnosis was concordant in 8 patients, and these studies demonstrated a similar number and distribution of matched and unmatched defects. In 1 discordant case, a patient with a SPECT/CT study that was nondiagnostic because of severe airway disease showed no PE on PET/CT. In another, the diagnosis of PE established on SPECT/CT was not reported on PET/CT 2 d later, possibly because of interval clot lysis or migration. Conclusion: This intraindividual comparative study demonstrated that V/Q PET/CT with 68Ga-labeled radiotracers can be performed in clinical practice. Compared with conventional V/Q imaging, advantages include higher-resolution, fully tomographic images with potentially better regional quantitation of lung function. The short half-life of 68Ga also enables more flexible acquisition protocols with the option of performing ventilation studies selectively on patients with abnormal perfusion. On the basis of our results, further studies are indicated to assess whether V/Q PET/CT can improve diagnostic algorithms for patients with suspected PE.

Keywords: PET/CT; ventilation; perfusion; V/Q; 68Ga; pulmonary embolism

Publ.-Id: 31206

Fermi surface investigation of the noncentrosymmetric superconductor α-PdBi

Klotz, J.; Butcher, T.; Förster, T.; Hornung, J.; Sheikin, I.; Wisniewski, P.; Jesche, A.; Wosnitza, J.; Kaczorowski, D.

The noncentrosymmetric superconductor α-PdBi is a candidate material for the realization of topological superconductivity. Here, we present a detailed de Haas–van Alphen (dHvA) study together with band-structure calculations within the framework of density functional theory. The rich dHvA spectra are a manifestation of the 13 bands that cross the Fermi energy EF . We find excellent agreement between calculated and experimentally observed dHvA frequencies with moderately enhanced effective masses. One of the bands crossing EF, the so-called α band, exhibits topological character with Weyl nodes lying 43 meV below EF .


Publ.-Id: 31203

High-field magnetization study of (Nd,Dy)2Fe14B: Intrinsic properties and promising compositions

Kostychenko, N. V.; Tereshina, I. S.; Gorbunov, D.; Tereshina-Chitrova, E. A.; Rogacki, K.; Andreev, A. V.; Doerr, M.; Politova, G. A.; Zvezdin, A. K.

The crystal-electric field and exchange parameters are determined for the (Nd0.5Dy0.5)2Fe14B compound by analyzing experimental magnetization curves obtained in high magnetic fields up to 58 T. The series (NdxDy1-x)2Fe14B compounds were analyzed theoretically to achieve a temperature stability while maintaining a large maximum energy product (BH)max. We demonstrate that computational simulations is an important tool in the materials design.

Publ.-Id: 31202

Direct measurements of the magnetocaloric effect of Fe49Rh51 using the mirage effect

Amirov, A. A.; Cugini, F.; Kamantsev, A. P.; Gottschall, T.; Solzi, M.; Aliev, A. M.; Spichkin, Y. I.; Koledov, V. V.; Shavrov, V. G.

The magnetocaloric effect in the Fe49Rh51 alloy was systematically studied using three different approaches: in-field differential scanning calorimetry, standard direct measurement of the adiabatic temperature change, and a non-contact method based on a thermo-optical phenomenon, the mirage effect, which was able to directly test the magnetocaloric response induced by a fast magnetic field variation. The metamagnetic phase transition of Fe49Rh51 was studied in the temperature range of 290–330 K at magnetic fields up to 1.8 T through magnetic and calorimetric measurements. The estimated parameters of phase transition were comparable with the literature data. The values of adiabatic temperature change obtained with the three methods (calorimetry, standard direct measurement, and mirage-based technique), which explore three different time scales of the field variation (static field, 1 T s−1, 770 T s−1), were consistent, proving the absence of dynamic constraints in the first-order magnetostructural transition at the maximum field sweep rate.

Publ.-Id: 31201

Detection Efficacy of 18F-PSMA-1007 PET/CT in 251 Patients with Biochemical Recurrence of Prostate Cancer After Radical Prostatectomy

Giesel, F. L.; Knorr, K.; Spohn, F.; Will, L.; Maurer, T.; Flechsig, P.; Neels, O.; Schiller, K.; Amaral, H.; Weber, W.; Haberkorn, U.; Schwaiger, M.; Kratochwil, C.; Choyke, P.; Kramer, V.; Kopka, K.; Eiber, M.

Prostate-specific membrane antigen (PSMA)–targeted PET imaging recently emerged as a new method for the staging and restaging of prostate cancer. Most published studies investigated the diagnostic potential of 68Ga-labeled PSMA agents that are excreted renally 18F-PSMA-1007 is a novel PSMA ligand that has excellent preclinical characteristics and that is only minimally excreted by the urinary tract, a potential advantage for pelvic imaging. The aim of this study was to investigate the diagnostic efficacy of 18F-PSMA-1007 for biochemical recurrence (BCR) after radical prostatectomy. Methods: From 3 academic centers, 251 patients with BCR after radical prostatectomy were evaluated in a retrospective analysis. Patients who had received second-line androgen deprivation therapy (ADT) or chemotherapy were excluded, but prior first-line ADT exposure was allowed. The median prostate-specific antigen (PSA) level was 1.2 ng/mL (range, 0.2–228 ng/mL). All patients underwent PSMA PET/CT at 92 ± 26 min after injection of 301 ± 46 MBq of 18FPSMA-1007. The rate of detection of presumed recurrence sites was correlated with the PSA level and original primary Gleason score. A comparison to a subset of patients treated previously with ADT was undertaken. Results: Of the 251 patients, 204 (81.3%) had evidence of recurrence on 18F-PSMA-1007 PET/CT. The detection rates were 94.0% (79/84), 90.9% (50/55), 74.5% (35/47), and 61.5% (40/65) for PSA levels of greater than or equal to 2, 1 to less than 2, 0.5 to less than 1, and 0.2 to less than 0.5 ng/mL, respectively. 18FPSMA-1007 PET/CT revealed local recurrence in 24.7% of patients (n = 62). Lymph node metastases were present in the pelvis in 40.6% of patients (n = 102), in the retroperitoneum in 19.5% of patients (n = 49), and in supradiaphragmatic locations in 12.0% of patients (n = 30). Bone and visceral metastases were detected in 40.2% of patients (n = 101) and in 3.6% of patients (n = 9), respectively. In tumors with higher Gleason scores (≤7 vs. ≥8), detection efficacy trended higher (76.3% vs. 86.7%) but was not statistically significant (P = 0.32). However, detection efficacy was higher in patients who had received ADT (91.7% vs. 78.0%) within 6 mo before imaging (P = 0.0179). Conclusion: 18F-PSMA-1007 PET/CT offers high detection rates for BCR after radical prostatectomy that are comparable to or better than those published for 68Ga-labeled PSMA ligands.

Keywords: 18F-PSMA-1007; PET/CT; hybrid imaging; prostate cancer; biochemical recurrence

  • Open Access Logo Journal of Nuclear Medicine 60(2019), 362-368
    DOI: 10.2967/jnumed.118.212233
  • Lecture (Conference)
    Annual Congress of the European Association of Nuclear Medicine, October 13 – 17, 2018, Düsseldorf, Germany, 13.-17.10.2018, Düsseldorf, Deutschland
    DOI: 10.1007/s00259-018-4148-3

Publ.-Id: 31200

High management impact of Ga-68 DOTATATE (GaTate) PET/CT for imaging neuroendocrine and other somatostatin expressing tumours

Hofman, M. S.; Kong, G.; Neels, O.; Eu, P.; Hong, E.; Hicks, R. J.

Introduction: Ga-68 DOTATATE (Ga-octreotate, GaTate) positron emission tomography (PET)/CT has multiple advantages compared with conventional and In-111 octreotide imaging for neuroendocrine tumours and other somatostatin-receptor expressing tumours. This study assesses the management impact of incremental diagnostic information obtained from this technique compared with conventional staging. Methods: Fifty-nine GaTate PET/CT studies were performed over an 18-month period (52 proven or suspected gastro-entero-pancreatic or bronchial neuroendocrine tumours and seven neural crest/mesenchymal tumours). A retrospective blinded review was performed on the number of abnormalities (1, 2–5 or >5) within defined regions with comparison to conventional imaging to assess incremental diagnostic information. Subsequent management impact (high, moderate or low) was determined by clinical review and follow up to assess pre-PET stage, treatment intent and post-PET management change. Results: Eighty-eight percent of GaTate studies were abnormal. Compared with conventional and In-111 octreotide imaging, additional information was provided by GaTate PET/CT in 68 and 83% of patients, respectively. Management impact was high (inter-modality change) in 47%, moderate (intra-modality change) in 10% and low in 41% (not assessable in 2%). High management impact included directing patients to curative surgery by identifying a primary site and directing patients with multiple metastases to systemic therapy. Conclusion: GaTate PET/CT imaging provides additional diagnostic information in a high proportion of patients with consequent high management impact. GaTate PET/CT could replace 1In-111 octreotide scintigraphy at centres where it is available given its superior accuracy, faster acquisition and lower radiation exposure. Rapid implementation could be achieved by allowing substitutional funding in the Medicare Benefit Schedule.

Keywords: DOTATATE; Ga-68; octreoscan; octreotate; PET/CT; somatostatin-receptor imaging

Publ.-Id: 31199

Laboratory Study of Bilateral Supernova Remnants and Continuous MHD Shocks

Mabey, P.; Albertazzi, B.; Rigon, G.; Marquès, J. R.; Palmer, C. A. J.; Topp-Mugglestone, J.; Perez-Martin, P.; Kroll, F.; Brack, F.-E.; Cowan, T.; Schramm, U.; Falk, K.; Gregori, G.; Falize, E.; Koenig, M.

Many supernova remnants (SNRs), such as G296.5+10.0, exhibit an axisymmetric or barrel shape. Such morphologies have previously been linked to the direction of the Galactic magnetic field, although this remains uncertain. These SNRs generate magnetohydrodynamic shocks in the interstellar medium, modifying its physical and chemical properties. The ability to study these shocks through observations is difficult due to the small spatial scales involved. In order to answer these questions, we perform a scaled laboratory experiment in which a lasergenerated blast wave expands under the influence of a uniform magnetic field. The blast wave exhibits a spheroidal shape, whose major axis is aligned with the magnetic field, in addition to a more continuous shock front. The implications of our results are discussed in the context of astrophysical systems.

Keywords: Supernova remnants (1667); Shocks (2086); Magnetic fields (994); Astrophysical magnetism (102); Magnetohydrodynamics (1964); Galaxy magnetic fields (604); Interstellar magnetic fields (845)

Publ.-Id: 31198

Preclinical characterization of 18F-D-FPHCys, a new amino acid-based PET tracer

Denoyer, D.; Kirby, L.; Waldeck, K.; Roselt, P.; Neels, O.; Bourdier, T.; Shepherd, R.; Katsifis, A.; Hicks, R. J.

Purpose The imaging potential of a new 18F-labelled methionine derivative, S-(3-[18F]fluoropropyl)-D-homocysteine (18F-D-FPHCys), and its selectivity for amino acid transporter subtypes were investigated in vitro and by imaging of human tumour xenografts. Methods Expression of members of the system L (LAT isoforms 1–4 and 4F2hc) and ASCT (ASCT isoforms 1 and 2) amino acid transporter subclasses were assessed by quantitative real-time PCR in four human tumour models, including A431 squamous cell carcinoma, PC3 prostate cancer, and Colo 205 and HT-29 colorectal cancer lines. The first investigations for the characterization of 18F-D-FPHCys were in vitro uptake studies by comparing it with [1-14C]-L-methionine (14C-MET) and in vivo by PET imaging. In addition, the specific involvement of LAT1 transporters in 18F-DFPHCys accumulation was tested by silencing LAT1 mRNA transcription with siRNAs. To determine the proliferative activity in tumour xenografts ex vivo, Ki-67 staining was used as a biomarker. Results A431 cells showed the highest 18F-D-FPHCys uptake in vitro and in vivo followed by Colo 205, PC3 and HT-29. A similar pattern of retention was observed with 14C-MET. 18F-D-FPHCys retention was strongly correlated with LAT1 expression both in vitro R2=0.85) and in vivo (R2=0.99). Downregulation of LAT1 by siRNA inhibited 18F-DFPHCys uptake, demonstrating a clear dependence on this transporter for tumour uptake. Furthermore, 18F-D-FPHCys accumulation mirrored cellular proliferation. Conclusion The favourable properties of 18F-D-FPHCys make this tracer a promising imaging probe for detection of tumours as well as for the noninvasive evaluation and monitoring of tumour growth.

Keywords: S-(3-[18F]fluoropropyl)-D-homocysteine; LAT1 amino acid transporter; In vitro uptake; Small-animal PET; Cancer imaging

Publ.-Id: 31197

High throughput static and dynamic small animal imaging using clinical PET/CT: potential preclinical applications

Aide, N.; Desmonts, C.; Beauregard, J.-M.; Beyer, T.; Kinross, K.; Roselt, P.; Neels, O.; Agostini, D.; Bardet, S.; Bouvard, G.; Hicks, R. J.

Purpose The objective of the study was to evaluate state-of-the-art clinical PET/CT technology in performing static and dynamic imaging of several mice simultaneously. Methods A mouse-sized phantom was imaged mimicking simultaneous imaging of three mice with computation of recovery coefficients (RCs) and spillover ratios (SORs). Fifteen mice harbouring abdominal or subcutaneous tumours were imaged on clinical PET/CT with point spread function (PSF) reconstruction after injection of [18F]fluorodeoxyglucose or [18F]fluorothymidine. Three of these mice were imaged alone and simultaneously at radial positions –5, 0 and 5 cm. The remaining 12 tumour-bearing mice were imaged in groups of 3 to establish the quantitative accuracy of PET data using ex vivo gamma counting as the reference. Finally, a dynamic scan was performed in three mice simultaneously after the injection of 68Ga-ethylenediaminetetraacetic acid (EDTA). Results For typical lesion sizes of 7–8 mm phantom experiments indicated RCs of 0.42 and 0.76 for ordered subsets expectation maximization (OSEM) and PSF reconstruction, respectively. For PSF reconstruction, SORair and SORwater were 5.3 and 7.5%, respectively. A strong correlation (r2=0.97, p<0.0001) between quantitative data obtained in mice imaged alone and simultaneously in a group of three was found following PSF reconstruction. The correlation between ex vivo counting and PET/CT data was better with PSF reconstruction (r2=0.98; slope=0.89, p<0.0001) than without (r2=0.96; slope=0.62, p<0.001). Valid time-activity curves of the blood pool, kidneys and bladder could be derived from 68Ga-EDTA dynamic acquisition.Conclusion New generation clinical PET/CT can be used for simultaneous imaging of multiple small animals in experiments requiring high throughput and where a dedicated small animal PET system is not available.

Keywords: Molecular imaging; PET/CT; PSF reconstruction; Cancer research; Preclinical studies

Publ.-Id: 31196

High-Contrast PET of Melanoma Using 18F-MEL050, a Selective Probe for Melanin with Predominantly Renal Clearance

Denoyer, D.; Greguric, I.; Roselt, P.; Neels, O.; Aide, N.; Taylor, S. R.; Katsifis, A.; Dorow, D. S.; Hicks, R. J.

The aim of this study was to evaluate the novel probe 18F-6-fluoro-N-[2-(diethylamino)ethyl] pyridine-3-carboxamide (18F-MEL050) for the imaging of primary and metastatic melanoma. Methods: PET using 18F-MEL050 was performed in murine models of melanoma. The specificity of 18F-MEL050 was studied by comparing its accumulation in pigmented B16-F0 allograft tumors with that of human amelanotic A375 xenografts using PET and high-resolution autoradiography. 18F-MEL050 PET results were compared with 18F-FDG PET, the current standard in melanoma molecular imaging. To test the ability of 18F-MEL050 to assess the metastatic spread of melanoma, a murine model of lung metastasis was imaged by PET/CT, and results correlated with physical assessment of tumor burden in the lungs. Results: In pigmented B16-F0 grafts, 18F-MEL050 PET yielded a tumor-to-background ratio of approximately 20:1 at 1 h and greater than 50:1 at 2 and 3 h. In the B16-F0 melanoma allograft model, tumor-to-background ratio was more than 9-fold higher for 18F-MEL050 than for 18F-FDG (50.9 ± 6.9 vs. 5.8 ± 0.5). No uptake was observed in the amelanotic melanoma xenografts. Intense uptake of 18F-MEL050 was evident in metastatic lesions in the lungs of B16-BL6 tumor–bearing mice on PET at 2 h after tracer injection, with high concordance between 18F-MEL050 accumulation on PET/CT and tumor burden determined at necroscopy. Conclusion: 18F-MEL050 has a rapid tumor uptake and high retention with specificity for melanin, suggesting great potential for noninvasive clinical evaluation of suspected metastatic melanoma.

Keywords: melanoma imaging; small-animal PET; PET/CT; high-resolution autoradiography; fluoronicotinamide analogue

Publ.-Id: 31195

Discovery of [18F]N-(2-(Diethylamino)ethyl)-6-fluoronicotinamide: A Melanoma Positron Emission Tomography Imaging Radiotracer with High Tumor to Body Contrast Ratio and Rapid Renal Clearance

Greguric, I.; Taylor, S. R.; Denoyer, D.; Ballantyne, P.; Berghofer, P.; Roselt, P.; Pham, T. Q.; Mattner, F.; Bourdier, T.; Neels, O.; Dorow, D. S.; Loch, C.; Hicks, R. J.; Katsifis, A.

The high melanoma uptake and rapid body clearance displayed by our series of [123I]iodonicotinamides prompted the development of [18F]N-(2-(diethylamino)ethyl)-6-fluoronicotinamide ([18F]2), a novel radiotracer for PET melanoma imaging. Significantly, unlike fluorobenzoates, [18F]fluorine incorporation on the nicotinamide ring is one step, facile, and high yielding. [18F]2 displayed high tumor uptake, rapid body clearance via predominantly renal excretion, and is currently being evaluated in preclinical studies for progression into clinical trials to assess the responsiveness of therapeutic agents.

Publ.-Id: 31194

High-Performance Bismuth-Doped Nickel Aerogel Electrocatalyst for the Methanol Oxidation Reaction

Dubale, A. A.; Zheng, Y.; Wang, H.; Hübner, R.; Li, Y.; Yang, J.; Zhang, J.; Sethi, N. K.; He, L.; Zheng, Z.; Liu, W.

Low-cost, non-noble-metal electrocatalysts are required for direct methanol fuel cells, but their development has been hindered by limited activity, high onset potential, low conductivity, and poor durability. A surface electronic structure tuning strategy is presented, which involves doping of a foreign oxophilic post-transition metal onto transition metal aerogels to achieve a non-noble-metal aerogel Ni97Bi3 with unprecedented electrocatalytic activity and durability in methanol oxidation. Trace amounts of Bi are atomically dispersed on the surface of the Ni97Bi3 aerogel, which leads to an optimum shift of the d-band center of Ni, large compressive strain of Bi, and greatly increased conductivity of the aerogel. The electrocatalyst is endowed with abundant active sites, efficient electron and mass transfer, resistance to CO poisoning, and outstanding performance in methanol oxidation. This work sheds light on the design of high-performance non-noble-metal electrocatalysts

Keywords: aerogels; bismuth dopants; methanol oxidation; nickel; single atoms

Publ.-Id: 31193

High PerformanceComputing: 35th International Conference, ISC High Performance 2020

Sadayappan, P.; Chamberlain, B. L.; Juckeland, G.; Ltaief, H.

This book constitutes the refereed proceedings of the 35th International Conference on High Performance Computing, ISC High Performance 2020, held in Frankfurt/Main, Germany, in June 2020.*

The 27 revised full papers presented were carefully reviewed and selected from 87 submissions. The papers cover a broad range of topics such as architectures, networks & infrastructure; artificial intelligence and machine learning; data, storage & visualization; emerging technologies; HPC algorithms; HPC applications; performance modeling & measurement; programming models & systems software.

*The conference was held virtually due to the COVID-19 pandemic.

Keywords: artificial intelligence; computer hardware; computer networks; computer programming; computer systems; distributed computer systems; microprocessor chips; parallel algorithms; parallel architectures; parallel processing

Publ.-Id: 31181

P1802 - Universal Building Blocks for Radiolabeling

Pietzsch, H.-J.; Walther, M.

The present invention describes novel chelators (multidentate ligands) and precompounds for complexation of radiometals and non-radioactive counterparts, for use in radiopharmacy. The invention includes a process and a kit involving such chelators.
Active moieties directing to a pharmaceutical target (such as peptides or proteins) can be attached to the chelator very easily via the so called “click-chemistry” forming a triazole-ring moiety. The aromatic triazole-nitrogen itself acts as a new and “soft” nucleophilic site enabling for complexation of various radiometals or non-radioactive counterparts. The chelators are capable of fast complexation at low temperature.

  • Patent
    PCT/EP2019/054954 - Offenlegung 06.09.2019; Nachanmeldungen: EP

Publ.-Id: 31180

P1801 - Method for the preparation of nanoscale DNA-encircled lipid bilayers

Fahmy, K.; TU Dresden

The present invention relates to a method for the preparation of nanoscale nucleic acid-encircled lipid bilayers, the nanoscale nucleic acid-encircled lipid bilayers and their use.

  • Patent
    PCT/EP2019/054271 - Offenlegung 29.08.2019; Nachanmeldungen: EP

Publ.-Id: 31179

P1714 - Verfahren zur Trennung von Mineralien

Babel, B. M.; Kupka, N.; Rudolph, M.

Die Erfindung betrifft ein Verfahren zur Trennung von Mineralien aus Mineralgemengen mittels Flotation unter Verwendung eines Drückers. Dabei ist vorgesehen, dass kolloidales Siliciumdioxid einem wässerigen, das Mineralgemenge enthaltenden Gemisch als Drücker zugesetzt wird.

  • Patent
    DE102017129673 - Erteilung 13.12.2018

Publ.-Id: 31178

P1713 - Verfahren zum Herstellen eines Probenpräparats, Probenpräparat und Verfahren zum Untersuchen eines Probenmaterials

Bartzsch, A.; Gilbricht, S.; Bachmann, K.; Heinig, T.

Die Erfindung betrifft ein Verfahren zum Herstellen eines Probenpräparats, ein Probenpräparat und ein Verfahren zum Untersuchen eines Probenmaterials, wobei das Probenpräparat zur Untersuchung eines granularen Probenmaterials dient und herstellbar ist, indem das granulare Probenmaterial mit einem flüssigen ersten Einbettmaterial vermengt wird, das Einbettmaterial unter Ausbildung eines Vorpräparats verfestigt wird und unter Ausbildung von Trennflächen in mehrere Teilstücke zertrennt wird, die Teilstücke mit mehreren Trennflächen in einer gemeinsamen Ebene liegend in einem flüssigen zweiten Einbettmaterial eingebettet werden, und das zweite Einbettmaterial verfestigt wird.

  • Patent
    DE102017128355 - Erteilung 17.01.2019

Publ.-Id: 31177

P1712 - Method for determining the level of molten magnesium in a titanium reduction cell

in Russian

Stefani, F.; Krauter, N.; Wondrak, T.; Gundrum, T.; Eckert, S.

FIELD: metallurgy. SUBSTANCE: invention relates to the metallurgy industry. Magnesium level and the skull characteristics in the titanium reduction reactor determining method, based on the EMF measurements in the receiving coil, induced by the electromagnetic field from located around the retort the exciting windings set, contains the steps, on which for the determination currents of different frequencies are used, at that, first, by the electrodynamics equations numerical solving, developing the reference base of the EMF calculated values in the located above the reactor receiving coil, with the molten magnesium different specified levels, different titanium skull given positions and sizes for the supply current given set of frequencies in the range of 1–50 Hz, and then, in the process of titanium reduction, with the same set of current parameters in the excitation coils, measuring the EMF values in the receiving coil, which are compared with the reference ones, and the least standard deviation is determined by the smallest standard deviation method, and the molten magnesium level, the titanium skull position and size are judged by it. EFFECT: increase in the molten metal level determining accuracy and the expansion in the method possibilities. 5 cl, 13 dwg

  • Patent
    RU2676845 - Erteilung 11.01.2019

Publ.-Id: 31176

P1711 - Peptid-Trägermaterialien als biofunktionalisierte Sammler

Lederer, F.; Pollmann, K.; Rudolph, M.

Die Erfindung betrifft ein Verfahren zur selektiven Abtrennung von Submikro- oder Mikropartikeln mittels eines biofunktionalisierten Sammlers, ein biofunktionalisierter Sammler umfassend mindestens ein selektiv bindendes Peptid, ein selektiv bindendes Peptid und die Verwendung eines Verfahrens oder eines biofunktionalisierten Sammlers zur Gewinnung oder Rückgewinnung von Submikro- oder Mikropartikeln.

  • Patent
    DE102017219800 - Offenlegung 09.05.2019

Publ.-Id: 31175

P1710 - 4-(Furan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-amin-Derivate und deren Verwendung

Moldovan, R.-P.; Lai, T. H.; Schröder, S.; Dukic-Stefanovic, S.; Deuther-Conrad, W.; Brust, P.; Fischer, S.; Ludwig, F.-A.

Die Erfindung betrifft eine Verbindung der allgemeinen Formel I worin eine Phenylgruppe oder eine Pyridylgruppe ist, R1 aus der Gruppe ausgewählt ist, die aus Wasserstoff, Halogen und -CN besteht; R2 aus der Gruppe ausgewählt ist, die aus Fluor, einer fluorierten Alkylgruppe mit 1 bis 12 Kohlenstoffatomen, einer fluorierten Alkoxygruppe mit 1 bis 12 Kohlenstoffatomen und einer fluorierten Ethergruppe besteht; Z -(CH2)n- oder -(CH2)m-C(O)-(CH2)p- ist, wobei n eine Ganzzahl von 1 bis 12 ist und wobei m und p gleich oder verschieden sein können und jeweils 0 oder eine Ganzzahl von 1 bis 12 sind.

  • Patent
    DE102017125533 - Offenlegung 02.05.2019; Nachanmeldungen: WO

Publ.-Id: 31174

P1709 - Vorrichtung und Verfahren zum Erzeugen von Ionenpulsen

Wilhelm, R. A.; Klingner, N.; Facsko, S.

Die Erfindung betrifft eine Vorrichtung und ein Verfahren zum Erzeugen von Ionenpulsen, insbesondere von ultrakurzen Ionenpulsen, wobei die Vorrichtung eine Vakuumkammer, eine in der Vakuumkammer angeordnete Kathode, einen Laser zum Erzeugen von Laserpulsen, die auf die Kathode auftreffen und aus dieser Elektronen herauslösen, eine erste Beschleunigungseinrichtung zum Beschleunigen der Elektronen unter Erzeugung von Ionenpulsen in ein Ionisationsvolumen, eine Zuführeinrichtung zum Zuführen einer zu ionisierenden Substanzen das Ionisationsvolumen und eine zweite Beschleunigungseinrichtung zum Beschleunigen der Ionen unter Ausbildung von Ionenpulsen aus dem Ionisationsvolumen heraus aufweist.

  • Patent
    DE102017218456 - Erteilung 22.11.2018

Publ.-Id: 31173

P1708 - Justiereinrichtung

Bartheld, U.

Die Erfindung betrifft eine Justiereinrichtung zur räumlichen Lageeinstellung eines Objekts (4), umfassend eine 10 Mehrzahl übereinander angeordneter Plattenelemente (11,12,13,14), die an einander zugewandten Seiten ineinandergreifende Radialführungsstrukturen (21,22) aufweisen, wobei auf einer Grundplatte (11) zumindest ein Paar von Verschiebungsplatten (12) und ein Paar von 15 Neigungsplatten (13) angeordnet sind, wobei Verschiebungsplatten (12) eine konstante Dicke aufweisen und ihre jeweilige obere Radialführungsstruktur (21) und untere Radialführungsstruktur (22) exzentrisch versetzt zueinander angeordnet sind und Neigungsplatten (13) eine variable Dicke 20 aufweisen und ihre jeweilige obere Radialführungsstruktur (21) und untere Radialführungsstruktur (22) konzentrisch zueinander angeordnet sind.

  • Patent
    DE102017123920 - Erteilung 20.12.2018; Nachanmeldungen: WO, US

Publ.-Id: 31172

P1707 - 3-Methylbenzo[e]imidazo[5,1-c][1,2,4]triazin-Derivate zur Verwendung als Inhibitoren von Phosphodiesterase 2A

Scheunemann, M.; Ritawidya, R.; Brust, P.; Schröder, S.

Die Erfindung betrifft eine Verbindung der allgemeinen Formel I oder ein pharmazeutisch akzeptables Salz davon, wobei A1, A2 und A3 unabhängig voneinander jeweils CH oder N sind; R1 -OR2 oder eine (3-Methyloxetan-3-yl)methyloxy-Gruppe ist, wobei R2 eine substituierte oder unsubstituierte Alkylgruppe mit 1 bis 12 Kohlenstoffatomen ist; X1 aus der Gruppe ausgewählt ist, die aus Wasserstoff, Halogen, Methyl -NO2 und einer kationischen Trialkylammoniumgruppe besteht; X2 aus der Gruppe ausgewählt ist, die aus Halogen, -NO2, einer Boronsäureester-Gruppe, einer Aryliodonium-Gruppe und einer spirocyclischen Iodoniumylid-Gruppe besteht, wobei die Boronsäureester-Gruppe eine Boronsäurepinakolester-Gruppe ist.

  • Patent
    DE102017119516 - Offenlegung 28.02.2019

Publ.-Id: 31171

P1705 - Wärmeübertrager

TU Dresden; Hampel, U.

Die Erfindung betrifft einen Wärmeübertrager mit wenigstens einer Trennwand und von wenigstens einer Seite der Trennwand abstehenden und die Oberfläche der Trennwand vergrößernden Oberflächenelementen, die von einem Fluid umströmbar sind. Es ist die Aufgabe der vorliegenden Erfindung, massearme Wärmeübertrager mit großer thermischer Übertragungsleistung vorzuschlagen. Diese Aufgabe wird durch einen Wärmeübertrager gelöst, bei dem die Oberflächenelemente flossenartig von der Trennwand abstehend ausgebildet sind und die Oberflächenelemente Verstärkungswülste aufweisen, wobei sich die Verstärkungswülste bis zu der Trennwand hin erstrecken.

  • Patent
    DE102017214261 - Offenlegung: 21.02.2019; Nachanmeldungen: WO, EP, JP, US

Publ.-Id: 31170

P1704 - Vorrichtung, Anordnung und Verfahren zum Charakterisieren der Torsion, der Rotation und/oder der Positionierung einer Welle

Buchenau, D.

Die Erfindung betrifft eine Vorrichtung, eine Anordnung und ein Verfahren zum Charakterisieren der Torsion, Rotation und/oder Positionierung einer Welle, wobei von einem zwischen mindestens zwei Magnetfelddetektoren angeordneten Magnetfelderzeuger mittels eines periodischen Erregersignals ein periodisches Magnetfeld erzeugt wird, das von der Welle modifiziert wird und an jedem der Magnetfelddetektoren ein Ausgangssignal hervorruft, wobei die amplitudenmäßige oder phasenmäßige Differenz zwischen dem Erregersignal und dem ersten Ausgangssignal als erste Messgröße und zwischen dem Erregersignal und dem zweiten Ausgangssignal als zweite Messgröße erfasst wird, die Summe und/oder die Differenz der ersten und der zweiten Messgröße gebildet wird, und basierend darauf die Torsion, Rotation und/oder Positionierung der Welle charakterisiert wird.

  • Patent
    DE102017111055 - Erteilung 06.09.2018; Nachanmeldungen: WO, CN, EP, US

Publ.-Id: 31169

Moisture repelling perovskite nanowires for higher stability in energy applications

Rajbhar, M. K.; Das, P.; Satpati, B.; Möller, W.; Ramgir, N.; Chatterjee, S.

Perovskite nanowires are known to be strongly interacting with the moisture. In this work, we demonstrate that strontium manganate (SrMnO3) nanowire, an oxide perovskite, which is initially superhydrophilic, becomes a water repellent upon suitable modification by the ion beam. Highly crystalline SrMnO3 nanowires have been synthesized hydrothermally with an average diameter of about 60 nm and possess 4H crystal structure. The nanowires have been systematically irradiated with nitrogen ions at different energies and in a specific range of ion fluence. For low energy (5 keV), and at a relatively high threshold ion fluence, the nanowire surface starts to become hydrophobic, and the hydrophobicity increases with the ion fluence. However, at higher energies (50–100 keV), the sample surface becomes superhydrophobic at relatively low fluence, and beyond this point, the contact angle is almost independent of the ion fluence. Using state-of-the-art TRI3DYN computer-based simulation, and by employing density functional theory based calculations, we have shown that at low ion energy, the defects turn out to be a dominating factor for the samples to become hydrophobic. At higher ion energies, nanowelding and porous structure lead the way to become superhydrophobic.

Publ.-Id: 31168

P1703 - Schichtanordnung, elektronisches Bauteil mit einer Schichtanordnung und Verwendung einer Schichtanordnung

TU Bergakademie Freiberg; Rebohle, L.

Gemäß verschiedenen Ausführungsformen wird eine Schichtanordnung (100) bereitgestellt, welche Folgendes aufweist: eine erste Barriereschicht (102a) und eine zweite Barriereschicht (102b), wobei die beiden Barriereschichten (102a, 102b) elektrisch isolierend sind, und eine Schichtstruktur (110), welche zwischen den beiden Barriereschichten (102a, 102b) angeordnet ist und derart eingerichtet ist, dass diese mittels eines elektrischen Feldes einer ersten Polarität (311a) und mittels eines elektrischen Feldes einer der ersten Polarität entgegengesetzten zweiten Polarität (311b) remanent polarisierbar ist, wobei die Schichtstruktur (110) mindestens eine erste Ladungsspeicherschicht (104a), eine zweite Ladungsspeicherschicht (104b) und eine zwischen der ersten Ladungsspeicherschicht (104a) und der zweiten Ladungsspeicherschicht (104b) angeordnete elektrisch isolierende Tunnelbarriereschicht (106) aufweist.

  • Patent
    DE102017109082 - Offenlegung 31.10.2018

Publ.-Id: 31167

P1702 - Vorrichtung zum Charakterisieren des elektrischen Widerstandes eines Messobjekts

Kosub, T.; Makarov, D.

Die Erfindung betrifft eine Messvorrichtung zum Charakterisieren des elektrischen Widerstandes eines Messobjekts, aufweisend eine elektrische Energiequelle mit zwei Polen, eine Spannungsmesseinrichtung mit zwei Messeingängen, vier Anschlusskontakte zum Anschließen von vier Kontaktelektroden, und eine Schalteinrichtung zum variablen paarweisen elektrischen Verbinden je eines der Pole und Messeingänge mit je einem der Anschlusskontakte unter Ausbildung unterschiedlicher Beschaltungskonfigurationen, wobei die Messvorrichtung zum Durchführen von mindestens vier Messsequenzen mit unterschiedlichen Beschaltungskonfigurationen und zum Ermitteln des Längswiderstandes des Messobjekts unter Einbeziehung von in diesen Beschaltungskonfigurationen erfassten Strom- und Spannungssignalen ausgebildet ist.

  • Patent
    DE102017105317 - Erteilung 09.05.2018, Nachanmeldungen: WO, CN, EP, US

Publ.-Id: 31166

PIConGPU setup: Gas-foil target for ion acceleration

Pausch, R.; Levy, D.; Andriyash, I.; Schultze-Makuch, A.; Bernert, C.; Zeil, K.; Bussmann, M.; Kluge, T.; Garten, M.; Steiniger, K.; Debus, A.

This data set contains the PIConGPU source code used for the simulations presented in "Gas-foil target for ion acceleration" and the setup files.

Keywords: PIConGPU

  • Software in the HZDR data repository RODARE
    Publication date: 2020-06-18
    DOI: 10.14278/rodare.374
    License: GPL-3.0-only


Publ.-Id: 31165

P1701 - In vivo stable Hg-197(m) compounds, method for the production thereof and use thereof in nuclear medical diagnostics and endoradionuclide therapy (theranostics)

Pietzsch, H.-J.; Walther, M.; Wünsche, T.

The present invention relates to in vivo stable 197(m)Hg compounds according to formula (I) for use in nuclear medical diagnostics and endoradionuclide therapy (theranostics), particularly the treatment of cancer, a method for the production of the 197(m)Hg compounds comprising the step of radiolabeling of organic precursor compounds with NCA 197(m)Hg by electrophilic substitution; and the use of the 197(m)Hg compounds for nuclear medical diagnostics and endoradionuclide therapy (theranostics), particularly the treatment of cancer.

  • Patent
    PCT/EP2018/052996 - Offenlegung 16.08.2018, Nachanmeldungen: CA, EP, US

Publ.-Id: 31164

P1611 - Method and system for calibration-free determination of a flow velocity of an electrically conductive fluid

Krauter, N.; Stefani, F.; Eckert, S.; Gerbeth, G.

The present invention refers to a method and a system for calibration-free determination of a flow velocity of an electrically conductive fluid (7). Each of two field coils (1a, 1b), which are designed to be positioned at a distance from each other in the respective fluid (7) and electrically insulated from the respective fluid (7), is provided simultaneously with a pulsed electrical current, wherein the two pulsed electrical currents are oppositely directed, so that a primary magnetic field is created leading to oppositely directed eddy currents induced by the primary magnetic field in the surrounding fluid (7), thereby creating a secondary magnetic field in the respective fluid (7). The secondary magnetic field is measured after the pulsed electrical currents by two magnetic field sensors (3a, 3b), which are designed to be positioned at a distance from each other in the respective fluid (7) and electrically insulated from the respective fluid (7), wherein the flow velocity is calculated from a measured time-dependent strength of the secondary magnetic field and/or its time derivative.

  • Patent
    PCT/EP2016/076967 - Offenlegung 17.05.2018; Nachanmeldungen: EP

Publ.-Id: 31163

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