Contact

Prof. Dr. Klaus Kopka

Director Institute of Radiopharmaceuticel Cancer Research
k.kopkaAthzdr.de
Phone: +49 351 260 2060

Dr. Sven Stadlbauer

Scientific Head
Translational TME Ligands
s.stadlbauerAthzdr.de
Phone: +49 351 260 3249

Kathrin Wewers

Project Management Coordinator for Translational Research Projects
Translational TME Ligands
k.wewersAthzdr.de
Phone: +49 351 260 2143
+49 176 12494442
Fax: +49 351 260 12143

T. Kanagasundaram, C. S. Kramer, E. Boros, K. Kopka

Radiolabeled near-infrared (NIR) fluorescence dyes for optical and radio imaging

Radiolabeled near-infrared (NIR) fluorescence dyes

Bimodal imaging combines PET or SPECT imaging with optical imaging, allowing for a clinical application such as fluorescence-guided robotic surgery after non-invasive PET or SPECT staging. Therefore, low-molecuar-weight near-infrared dyes are synthesized and labeled with a PET or SPECT isotope (fluorine-18, technetium-99m, gallium-68). The resulting dyes should show high water solubility, near-infrared optical properties, large quantum yields and high extinction coefficients. Furthermore, the fluorescence dyes are further modified for conjugation with a tumor targeting entity, e.g. PSMA to achieve the required accumulation in the tumor tissue. The radiolabeled fluorescence dye conjugates are tested in vitro on tumor cell lines and in vivo in tumor-bearing small animals with µPET, µSPECT and optical imaging methods as well as biodistribution studies with regard to their potential application in nuclear medicine.

References:

Contact

Prof. Dr. Klaus Kopka

Director Institute of Radiopharmaceuticel Cancer Research
k.kopkaAthzdr.de
Phone: +49 351 260 2060

Dr. Sven Stadlbauer

Scientific Head
Translational TME Ligands
s.stadlbauerAthzdr.de
Phone: +49 351 260 3249

Kathrin Wewers

Project Management Coordinator for Translational Research Projects
Translational TME Ligands
k.wewersAthzdr.de
Phone: +49 351 260 2143
+49 176 12494442
Fax: +49 351 260 12143