Comparison of in-beam and off-beam PET experiments at hard photons


Comparison of in-beam and off-beam PET experiments at hard photons

Möckel, D.; Kluge, T.; Pawelke, J.; Enghardt, W.

In-beam positron emission tomography (in-beam PET) is a valuable in situ method for quality assurance in radiation therapy. It is well investigated for therapy with carbon ions and has been successfully clinically implemented at the Gesellschaft für Schwerionenforschung (GSI), Darmstadt, Germany. The extension of this efficient technique to other radiation treatment modalities may be worthwhile. For protons and 3-He the feasibility has already been investigated. Furthermore, it seems possible for the case of radiotherapy with high-energy photons, since positron emitters are generated by photons with energies above ~20 MeV due to (gamma, n) reactions (predominantly 11-C and 15-O in tissue).
In this regard, promising conclusions have been obtained by Geant4 simulations as well as by off-beam PET experiments using a conventional PET scanner. However, in the case of off-beam PET the time delay between irradiation and measurement causes a decrease of the number of positron emitters resulting in reduced counting statistics. At worst short-lived isotopes cannot be detected. Thus, a small double head PET camera consisting of two BGO block detectors was built up at the irradiation site to measure the generated beta+ activity distribution simultaneously to the irradiation. The relation between deposited dose and beta+ activity density was quantified. The obtained results are presented and compared to that of off-beam PET experiments. Higher activities as well as an improved contrast between materials of different stoichiometry is achieved by measuring in-beam showing the advantage of in-beam PET over off-beam PET. Thus, the application of in-beam PET at radiation therapy with high-energy photons can be useful for quality assurance, comprising monitoring of dose delivery, patient positioning and tumour response.

  • Lecture (Conference)
    2007 Nuclear Science Symposium and Medical Imaging Conference, 27.10.-03.11.2007, Honolulu, Hawaii, USA
  • Contribution to proceedings
    2007 Nuclear Science Symposium and Medical Imaging Conference, 27.10.-03.11.2007, Honolulu, Hawaii, USA, 1-4244-0923-3

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Publ.-Id: 10646