First 4D in-beam PET measurement for beam tracking of a moving phantom with a scanned carbon ion beam


First 4D in-beam PET measurement for beam tracking of a moving phantom with a scanned carbon ion beam

Parodi, K.; Saito, N.; Richter, C.; Chaudhri, N.; Enghardt, W.; Rietzel, E.; Bert, C.

More than 10 years of clinical operation of in-beam PET at GSI Darmstadt have proven its positive impact on quality assurance of carbon ion therapy, mostly for head-and-neck sites. Due to the promise of ion beam therapy for indications such as lung and liver tumors which are influenced by respiratory motion we started to investigate the potential of time-resolved, 4D in-beam PET. 4D in-beam PET is expected to facilitate in-vivo assessment of tumor miss or unwanted involvement of nearby critical structures in the presence of organ motion. In a first experiment performed at GSI, in-beam PET was used in combination with beam tracking. A homogeneous PMMA phantom was placed in the center of the field of view of the PET camera and moved parallel to the two detector heads (left-right in beam's eye view, amplitude: 3 cm peak-to-peak, period: ~ 3 s). Dose was delivered by beam tracking as a two-dimensionally spread-out Bragg-peak of 5 x 5 cm2 extension, centered at a depth of 10 cm in the central plane of the phantom. The dynamic PET acquisition was performed during the 6 min of beam delivery and for 25 min after irradiation. The data stream was synchronized with the time course of the dynamic beam application and with the phantom motion. Additional 18 min of decay were acquired with the activated phantom kept steady, for comparison with a separate measurement of the same treatment field without motion. Reconstruction of the data taken with a steady phantom yielded comparable activation patterns for beam tracking and stationary irradiation. 4D PET reconstruction is currently in progress. Motion phase sorted data as well as results for imaging performance in dependence on the amount of reconstructed events will be presented. First conclusions on the feasibility of in-beam PET for monitoring ion treatment of moving targets will be discussed.

  • Lecture (Conference)
    IEEE MIC 2008, 19.-25.10.2008, Dresden, Deutschland
  • Contribution to proceedings
    IEEE Dresden 2008, 19.-25.10.2008, Dresden, Deutschland
    IEEE Conference Report

Permalink: https://www.hzdr.de/publications/Publ-12339
Publ.-Id: 12339