Synthesis of Benzoate-Functionalized Phosphanes as Novel Building Blocks for the Traceless Staudinger Ligation
Synthesis of Benzoate-Functionalized Phosphanes as Novel Building Blocks for the Traceless Staudinger Ligation
Mamat, C.; Flemming, A.; Köckerling, M.; Steinbach, J.; Wuest, F.
A new synthetic pathway for the preparation of benzoate-functionalized phosphanes for microwave-mediated traceless Staudinger ligations is described. Novel phosphane derivatives based on 4-substituted iodophenyl benzoates were prepared via palladium(II)-catalyzed PC cross-coupling reaction strategy in high yields. The application of microwave conditions for the ligation reactions reduced the reaction time considerably. An approach to fast and facile labeling strategies using this ligation was established.
Keywords: Staudinger ligation; traceless; click chemistry; PC cross-coupling; palladium-catalyzed
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Synthesis 19(2009), 3311-3321
DOI: 10.1055/s-0029-1216947
Cited 26 times in Scopus
Permalink: https://www.hzdr.de/publications/Publ-13218
Publ.-Id: 13218