Multimeric cyclam derivatives with tunable surface modification for radiopharmaceutical applications


Multimeric cyclam derivatives with tunable surface modification for radiopharmaceutical applications

Kuhlmann, M.; Stephan, H.; Steinbach, J.; Röhrich, A.

1,4,8,11-Tetraazacyclotetradecane (cyclam) derivatives with one to four appending dipeptide residues (Arg-Tyr) have been synthesized. Kinetics of complex formation with copper(II) was investigated by UV/vis spectroscopy to show a deceleration with increasing substitution degree of the cyclam core. Radiolabeling experiments with 64CuII on the peptide tetramer 5 revealed a smooth and efficient complexation. Challenge studies of 64Cu5 in the presence of cyclam as competing ligand prove the high kinetic inertness of the radiocopper(II) complex formed with 5.

Keywords: cyclam; peptide; multimers; copper-64

  • Poster
    International Symposium on Technetium and other Radiometals in Chemistry and Medicine, 08.-11.09.2010, Bressanone, Italy
  • Abstract in refereed journal
    Nuclear Medicine and Biology 37(2010)6, 681
    DOI: 10.1016/j.nucmedbio.2010.04.066
  • Contribution to external collection
    Ulderico Mazzi, William V. Eckelman, Wynn A. Volkert: Technetium and Other Radiometals in Chemistry and Medicine, Padova: SGEditoriali, 2010, 77-80

Permalink: https://www.hzdr.de/publications/Publ-14303
Publ.-Id: 14303