A novel Dibenzoazacyclooctyne precursor in regioselective Copper-free click chemistry. An innovative 3-step synthesis.


A novel Dibenzoazacyclooctyne precursor in regioselective Copper-free click chemistry. An innovative 3-step synthesis.

Starke, F.; Walther, M.; Pietzsch, H.-J.

A novel carboxylic acid substituted dibenzoazacyclooctyne precursor has been synthesized using a fast and innovative three-step synthesis. It can be easily converted into the corresponding alkyne through UV-irradiation. Due to its fast and regioselective reaction with azides, the alkyne is a promising agent for copper-free "click chemistry". The second order reaction rate constant was determined by 1H-NMR.

  • Open Access Logo ARKIVOC (2010), 350-359
    ISSN: 1551-7012

Permalink: https://www.hzdr.de/publications/Publ-14724
Publ.-Id: 14724