The traceless Staudinger ligation with fluorine-18: a novel and versatile labeling technique for the synthesis of PET-radiotracers
The traceless Staudinger ligation with fluorine-18: a novel and versatile labeling technique for the synthesis of PET-radiotracers
Pretze, M.; Wuest, F.; Peppel, T.; Köckerling, M.; Mamat, C.
The development of rapid radiolabeling techniques under mild reaction conditions involving the short-lived positron emitter fluorine-18 remains a special challenge in organic PET chemistry. This work describes a novel and facile application of the traceless Staudinger ligation as a mild and versatile labeling method for preparation of various radiotracers labeled with fluorine-18.
Keywords: Radiolabeling; Traceless Staudinger ligation; Bioorthogonal; Fluorine-18
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Tetrahedron Letters 51(2010), 6410-6414
DOI: 10.1016/j.tetlet.2010.09.134
Cited 43 times in Scopus
Permalink: https://www.hzdr.de/publications/Publ-14849
Publ.-Id: 14849