Characterization of superparamagnetic nanoparticles for bone-tissue engineering


Characterization of superparamagnetic nanoparticles for bone-tissue engineering

Uhlarz, M.; Herrmannsdörfer, T.; de Santis, R.; Sandri, M.; Tampieri, A.; Figallo, E.; D’Alessandro, T.; Keshari-Samal, S.; Rischitor, G.; Collaboration Magister

Currently, large bone or cartilage defects are stabilized by massivelyinvasive surgery. The permanent implants used for this purpose are either metallic prostheses, or body tissue taken elsewhere from the patient. In a novel tissue-engineering approach, autologous tissue regeneration is guided by implanted magnetic scaffolds under external magnetic field. These scaffolds attract superparamagnetic Fe3O4 (magnetite) nanoparticles tagged with Vascular Endothelial Growth Factor (VEGF) molecules. Release of the growth-factor molecules at the scaffold (optionally triggered by ac-field induced hyperthermia) attracts autologous chondrocytes and osteoblasts, which build up fresh bone and cartilage tissue. We report on the magnetic characterization of several biocompatible and biodegradable materials that might serve as scaffold materials.
This project is supported by the European Union’s FP7-Cooperation Programme through the MAGISTER project (Magnetic Scaffolds for in-vivo Tissue Engineering), Large Collaborative Project FP7 - 21468.

  • Poster
    Frühjahrstagung der DPG, 26.-30.03.2012, Berlin, Deutschland

Permalink: https://www.hzdr.de/publications/Publ-16944
Publ.-Id: 16944