Solution structure of technetium(V) and rhenium(V) peptide complexes as studied by EXAFS spectroscopy and capillary electrophoresis (CE)


Solution structure of technetium(V) and rhenium(V) peptide complexes as studied by EXAFS spectroscopy and capillary electrophoresis (CE)

Jankowsky, R.; Kirsch, S.; Spies, H.; Johannsen, B.

Structural investigations on rhenium and technetium peptide complexes have been carried out using X-ray absorption spectroscopy (EXAFS) and capillary electrophoresis. Small cysteine containing peptides with altered amino acid sequences were used as model systems to study the metal complexation behaviour. By means of capillary electrophoresis, complex species existing over the pH range could be identified as well as protonable groups in these complexes. EXAFS measurements in solution delivered information about the complex coordination spheres. The metal complexation modes and complex stoichiometries of directly labelled metal complexes of large biologically active peptides could be elucidated.

  • Book (Authorship)
    Technetium, Rhenium and Other Metals in Chemistry and Nuclear Medicine (Edited by Nicolini M., Mazzi, U.) SGE Editoriali Padova (1999) pp.229-235

Permalink: https://www.hzdr.de/publications/Publ-1820
Publ.-Id: 1820