Synthesis and receptor binding of novel progestin-rhenium complexes


Synthesis and receptor binding of novel progestin-rhenium complexes

Wüst, F.; Skaddan, M. B.; Carlson, K. E.; Leibnitz, P.; Katzenellenbogen, J. A.; Spies, H.; Johannsen, B.

A series of rhenium "n+1" mixed-ligand, thioether-carbonyl and organometallic complexes of 21-substituted progesterone have been synthesized. The conjugates contain the rhenium metal at several oxidation states, being +5, +3 and +1. The complexes were used in a competitive receptor-binding assay (rat-uterus, 0°C) to determine their binding to the progesterone receptor. The best affinity of 9% (RU 5020=100%) was obtained with a "3+1" mixed-ligand complex, containing a NMe group as the central donor atom in the tridentate ligand part.

  • Book (Authorship)
    Technetium, Rhenium and Other Metals in Chemistry and Nuclear Medicine (Edited by Nicolini M., Mazzi U.) SGE Editoriali Padova (1999) pp. 491-495

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Publ.-Id: 1823