Influence of different chelators on the radiochemical properties of a 68-Gallium labelled bombesin analogue.


Influence of different chelators on the radiochemical properties of a 68-Gallium labelled bombesin analogue.

Asti, M.; Iori, M.; Capponi, P. C.; Atti, G.; Rubagotti, S.; Martin, R.; Brennauer, A.; Müller, M.; Bergmann, R.; Erba, P. A.; Versari, A.

The radiolabelled bombesin analogue AMBA shows high potential for diagnosis and treatment of prostate and breast cancer, but the influence of different chelators, which differ in terms of radiochemical reactivity and stability, have not been explored so far. In order to find the best suitable chelator for labelling of AMBA, we synthesized AMBA analogues linked to the most commonly used chelators DOTA, NOTA and NODAGA and compared their reactivity and stability after labelling with 68-Gallium.

Keywords: 68Ga-labelling; AMBA-chelators; Bombesin analogues; 68Ga-NODAGA-AMBA; Gallium radionuclides

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Publ.-Id: 20165