SYNTHESIS OF A NEW TRACER FOR CANCER IMAGING: 16alpha-[18F]FLUOROESTRADIOL-3,17beta-DISULPHAMATE


SYNTHESIS OF A NEW TRACER FOR CANCER IMAGING: 16alpha-[18F]FLUOROESTRADIOL-3,17beta-DISULPHAMATE

Römer, J.; Füchtner, F.; Steinbach, J.

The synthesis of 16alpha-[18F]fluoroestradiol-3,17beta-disulphamate ([18F]FESDS) being a new potential radiotracer for investigations in positron emission tomography is described. 16alpha-[18F]Fluoroestradiol ([18F]FES) is converted with excessive sulphamoyl chloride in absolute acetonitrile in presence of an alkali. Using kryptofix 2.2.2 and K2CO3 as alkali, [18F]FESDS was obtained in yields of 50 - 60%.

Keywords: Synthesis; 18F labelling; radiotracer

  • Lecture (Conference)
    8th Conference of Central European Division of International Isotope Society, Bad Soden, 10.-11.6.1999

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Publ.-Id: 2057